JP2006501312A5 - - Google Patents

Download PDF

Info

Publication number
JP2006501312A5
JP2006501312A5 JP2005501778A JP2005501778A JP2006501312A5 JP 2006501312 A5 JP2006501312 A5 JP 2006501312A5 JP 2005501778 A JP2005501778 A JP 2005501778A JP 2005501778 A JP2005501778 A JP 2005501778A JP 2006501312 A5 JP2006501312 A5 JP 2006501312A5
Authority
JP
Japan
Prior art keywords
substituted
compound
compound according
hydrogen
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2005501778A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006501312A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/026478 external-priority patent/WO2004018463A2/en
Publication of JP2006501312A publication Critical patent/JP2006501312A/ja
Publication of JP2006501312A5 publication Critical patent/JP2006501312A5/ja
Pending legal-status Critical Current

Links

JP2005501778A 2002-08-23 2003-08-22 Hcv感染を治療または予防するのに有用なピリジル置換複素環 Pending JP2006501312A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40546702P 2002-08-23 2002-08-23
US41783702P 2002-10-11 2002-10-11
US47137303P 2003-05-15 2003-05-15
PCT/US2003/026478 WO2004018463A2 (en) 2002-08-23 2003-08-22 Pyridyl substituted heterocycles useful for treating or preventing hcv infection
US10/646,348 US7157473B2 (en) 2002-08-23 2003-08-22 Pyridyl substituted heterocycles useful for treating or preventing HCV infection

Publications (2)

Publication Number Publication Date
JP2006501312A JP2006501312A (ja) 2006-01-12
JP2006501312A5 true JP2006501312A5 (https=) 2006-09-28

Family

ID=31950772

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2005501778A Pending JP2006501312A (ja) 2002-08-23 2003-08-22 Hcv感染を治療または予防するのに有用なピリジル置換複素環

Country Status (15)

Country Link
US (3) US7157473B2 (https=)
EP (1) EP1530569A2 (https=)
JP (1) JP2006501312A (https=)
KR (1) KR20050033653A (https=)
AU (1) AU2003262831A1 (https=)
BR (1) BR0313755A (https=)
CA (1) CA2494164A1 (https=)
HR (1) HRP20050168A2 (https=)
IL (1) IL166639A0 (https=)
MX (1) MXPA05002082A (https=)
NO (1) NO20051404L (https=)
NZ (1) NZ537980A (https=)
PL (1) PL374536A1 (https=)
RS (1) RS20050175A (https=)
WO (1) WO2004018463A2 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
HRP20050168A2 (en) * 2002-08-23 2005-10-31 Rigel Pharmaceuticals Pyridyl substituted heterocycles useful for treating or preventing hcv infection
US7115642B2 (en) 2003-05-02 2006-10-03 Rigel Pharmaceuticals, Inc. Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection
US7326790B2 (en) * 2003-05-02 2008-02-05 Rigel Pharmaceuticals, Inc. Diphenylisoxazole compounds and hydro isomers thereof
US7220745B2 (en) 2003-05-15 2007-05-22 Rigel Pharmaceuticals Heterocyclic compounds useful to treat HCV
US20050075309A1 (en) 2003-07-25 2005-04-07 Richard Storer Purine nucleoside analogues for treating Flaviviridae including hepatitis C
WO2005049065A2 (en) * 2003-11-19 2005-06-02 Rigel Pharmaceuticals, Inc. Synergistic combinations of dihaloacetamide with interferon or ribavirin for treatment hcv infections
JP2007514763A (ja) * 2003-12-19 2007-06-07 ライジェル ファーマシューティカルズ, インコーポレイテッド C型肝炎ウイルス(hcv)の感染を処置するための組成物および方法
US7514434B2 (en) 2004-02-23 2009-04-07 Rigel Pharmaceuticals, Inc. Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof
JP2007530582A (ja) * 2004-03-26 2007-11-01 ライジェル ファーマシューティカルズ, インコーポレイテッド 代謝可能部分を含む複素環抗ウイルス化合物およびその使用
JP2008540425A (ja) * 2005-05-02 2008-11-20 ライジェル ファーマシューティカルズ, インコーポレイテッド 代謝可能部分を含む複素環式抗ウイルス性化合物およびその使用
US8267868B2 (en) * 2005-08-10 2012-09-18 C. R. Bard, Inc. Single-insertion, multiple sample biopsy device with integrated markers
KR100890862B1 (ko) * 2005-11-07 2009-03-27 주식회사 엘지화학 유기 발광 소자 및 이의 제조 방법
RU2487131C2 (ru) * 2008-03-14 2013-07-10 Оцука Фармасьютикал Ко., Лтд. Ингибитор ммр-2 и/или ммр-9
US8362020B2 (en) * 2009-12-30 2013-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
AU2016281346B2 (en) 2015-06-23 2020-01-02 Kissei Pharmaceutical Co., Ltd. Pyrazole derivative, or pharmaceutically acceptable salt thereof
CN116535399B (zh) * 2022-01-25 2024-02-27 中国药科大学 3-羟基-5-(异噁唑-5-基)吡啶甲酰甘氨酸类化合物、制法、药物组合物和应用
IL326496A (en) * 2023-08-17 2026-04-01 Sanofi Sa Pyridyl imidazoles – their preparation and therapeutic application

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2852503A (en) * 1953-12-31 1958-09-16 American Cyanamid Co 2, 5-bis (p-aminophenyl) furan azo derivatives
NL242505A (https=) * 1958-08-20
US3335149A (en) * 1963-08-21 1967-08-08 Monsanto Co Thiazole diamines
FR1459375A (fr) 1965-10-20 1966-04-29 Westinghouse Electric Corp Copolymères linéaires oxadiazole-imide
SU508198A3 (ru) 1971-07-22 1976-03-25 Группо Лепетит С.П.А. (Фирма) Способ получени производных 1,2,4-триазола
DE2137719A1 (de) 1971-07-28 1973-02-08 Basf Ag Verfahren zur herstellung von aminobenzonitrilen
US3964896A (en) * 1971-08-09 1976-06-22 Uniroyal, Inc. Oxadiazole benzoic acid derivatives as herbicides
US3853893A (en) * 1973-04-02 1974-12-10 Squibb & Sons Inc Anthelmintic 5-(pyridyl)-3-(isothiocyanophenyl) oxadiazoles
DE2721955A1 (de) 1977-05-14 1978-11-23 Basf Ag Azofarbstoffe
DE3623302A1 (de) * 1985-11-09 1987-05-14 Bayer Ag Nicotinsaeurederivate
DE4016049A1 (de) * 1990-05-18 1991-11-21 Basf Ag 3-isoxazolylbenzylester, ihre herstellung und ihre verwendung
JPH04124178A (ja) 1990-09-12 1992-04-24 Sds Biotech Kk 複素環式化合物および該化合物を含有する除草剤
DE4124942A1 (de) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4137940A1 (de) * 1991-11-18 1993-05-19 Basf Ag 3-isoxazolylphenylverbindungen, ihre herstellung und ihre verwendung
WO1993017671A1 (en) 1992-03-06 1993-09-16 Statens Seruminstitut Treatment and prophylaxis of diseases caused by parasites, or bacteria
DE4210502A1 (de) 1992-03-31 1993-10-07 Bayer Ag Verwendung von 3-aminosubstituierten Isoxazolderivaten zur Bekämpfung von Endoparasiten, neue 3-aminosubstituierte Isoxazolderivate und Verfahren zu ihrer Herstellung
WO1994017059A1 (fr) 1993-01-29 1994-08-04 Nippon Soda Co., Ltd. Derive heterocyclique
DE4408084A1 (de) 1994-03-10 1995-09-14 Hoechst Ag 3,5-Disubstituierte und 3,4,5-trisubstituierte 2-Isoxazoline und Isoxazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU3087195A (en) 1994-08-02 1996-03-04 Nippon Soda Co., Ltd. Oxazole derivative, process for producing the same, and herbicide
DK0808312T3 (da) * 1995-02-02 2001-02-12 Smithkline Beecham Plc Indolderivater som 5-HT-receptorantagonist
DE19643037A1 (de) 1996-10-18 1998-04-23 Boehringer Ingelheim Kg Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
US20020035156A1 (en) * 1997-04-18 2002-03-21 Barbara Roniker Combination therapy in the prevention of cardiovascular disorders
EE200300169A (et) 1997-04-18 2003-06-16 G.D. Searle & Co. Tsüklooksügenaas-2 inhibiitorite kasutamise meetod südame-veresoonkonna haiguste ärahoidmiseks
EP0927992A4 (en) 1997-07-17 1999-09-15 Sony Corp MAGNETIC RECORDING MEDIUM AND MAGNETIC RECORDING / REPRODUCING DEVICE COMPRISING SAME
EP1025857A4 (en) 1997-10-22 2003-11-12 Eisai Co Ltd RETINOIC ACID AGONISTS, PREVENTIVE AND THERAPEUTIC AGENTS FOR NEPHRITES
DE19860802A1 (de) 1998-12-30 2000-10-26 Virgene Pharmaceuticals Ag Herstellung eines Mittels gegen Hepatitis B-, HI-, Paramyxo und Orthomyxo-Viren
DE19904389A1 (de) 1999-02-04 2000-08-10 Bayer Ag Verwendung von substituierten Isoxazolcarbonsäuren und Derivate und neue Stoffe
DE60033028T2 (de) 1999-04-23 2007-11-15 Takeda Pharmaceutical Co. Ltd. 5-pyridyl-1,3-azol-derivate, verfahren zu ihrer herstellung und ihre verwendung
GB2351081A (en) 1999-06-18 2000-12-20 Lilly Forschung Gmbh Pharmaceutically active imidazoline compounds and analogues thereof
DE10032874A1 (de) 2000-07-06 2002-01-17 Bayer Ag Arzneimittelkombinationen gegen virale Erkrankungen
WO2001074811A2 (en) 2000-03-30 2001-10-11 Takeda Chemical Industries, Ltd. Substituted 1,3-thiazole compounds, their production and use
AU4890301A (en) * 2000-04-17 2001-10-30 Dong Wha Pharmaceutical Industrial Co., Ltd. 6-methylnicotinamide derivatives as antiviral agents
US6579880B2 (en) * 2000-06-06 2003-06-17 Ortho-Mcneil Pharmaceutical, Inc. Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8
GB0017676D0 (en) * 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
WO2002020436A2 (en) 2000-09-05 2002-03-14 Neogenesis Pharmaceuticals, Inc. Methods for forming combinatorial libraries combining amide bond formation with epoxide opening
CA2431171A1 (en) 2000-12-08 2002-06-13 Takeda Chemical Industries, Ltd. Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof
JP4368582B2 (ja) 2001-01-13 2009-11-18 ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 牛ウイルス性下痢ウイルス(bvdv)感染およびc型肝炎ウイルス(hcv)感染を処置するのに有用な化合物、方法、および組成物
RU2003133750A (ru) * 2001-04-19 2005-05-10 Байер АГ (DE) Арилсульфонамиды в качестве антивирусных агентов
DE10148598A1 (de) 2001-04-19 2002-10-24 Bayer Ag Neue Arylsulfonamide als antivirale Mittel
JP4303109B2 (ja) 2001-10-04 2009-07-29 メルク エンド カムパニー インコーポレーテッド 代謝共役型グルタミン酸受容体−5のヘテロアリール置換テトラゾール調節剤
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
HRP20050168A2 (en) * 2002-08-23 2005-10-31 Rigel Pharmaceuticals Pyridyl substituted heterocycles useful for treating or preventing hcv infection
US7220745B2 (en) 2003-05-15 2007-05-22 Rigel Pharmaceuticals Heterocyclic compounds useful to treat HCV

Similar Documents

Publication Publication Date Title
JP2006501312A5 (https=)
EP1224185B1 (en) Thiazole and imidazo[4,5-b]pyridine compounds and their pharmaceutical use
AU2025275331A1 (en) Aldose reductase inhibitors and methods of use thereof
JP2009527501A5 (https=)
JP2008530099A5 (https=)
JP2007502845A5 (https=)
EP2597089A1 (en) Tricyclic heterocyclic compounds
HK1201255A1 (en) Use of an isoxazole derivative for the treatment of withdrawal symptoms
JP2009507849A (ja) 非環状IKurインヒビター
EP3096762B1 (en) Pyrazolo[1,5-a]pyrimidines as antiviral compounds
CN102361868A (zh) 作为1-磷酸-鞘氨醇激动剂的吡唑-1,2,4-噁二唑衍生物
WO2013071693A1 (zh) 噁二唑类化合物及其制备方法、药物组合物及其用途
US20250361218A1 (en) Agents and methods for treating dysproliferative diseases
KR20070045272A (ko) 2-페닐피리딘 유도체
AU2005315849B2 (en) Pyrazolo-heteroaryl compounds useful to treat TNF-Alpha and IL-1 mediated diseases
DE3247118A1 (de) Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US5747484A (en) Crystalline cepham acid addition salts and processes for their preparation
JPH0225486A (ja) 新規イミダゾキノキサリン化合物、その製造方法並びにその使用
CN104540810B (zh) 具有抗病毒活性的甲硫酮化合物
GB2352630A (en) Inverse agonist of GABA-A alpha-5 receptor subtype/amyloid ß aggregation inhibitor combination & treating neurodegenerative conditions eg Alzheimer's disease
KR20120113886A (ko) 잔틴 옥시다아제 저해제로서 효과적인 신규 화합물 및 그를 함유한 약제학적 조성물
SK285679B6 (sk) Derivát benzamidu, liečivo s jeho obsahom a ich použitie
EP0413289B1 (en) Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
EP0577218A1 (en) Heterocyclyl-phenoxyalkyl-piperidinylpyridazines as antiviral agents
US4246272A (en) Benzamidine derivatives