KR20050033653A - Ｈｃｖ 감염의 치료 또는 예방에 유용한 피리딜 치환 헤테로사이클 - Google Patents
Ｈｃｖ 감염의 치료 또는 예방에 유용한 피리딜 치환 헤테로사이클 Download PDFInfo
- Publication number
- KR20050033653A KR20050033653A KR1020057003019A KR20057003019A KR20050033653A KR 20050033653 A KR20050033653 A KR 20050033653A KR 1020057003019 A KR1020057003019 A KR 1020057003019A KR 20057003019 A KR20057003019 A KR 20057003019A KR 20050033653 A KR20050033653 A KR 20050033653A
- Authority
- KR
- South Korea
- Prior art keywords
- substituted
- compound
- hydrogen
- methyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40546702P | 2002-08-23 | 2002-08-23 | |
| US60/405,467 | 2002-08-23 | ||
| US41783702P | 2002-10-11 | 2002-10-11 | |
| US60/417,837 | 2002-10-11 | ||
| US47137303P | 2003-05-15 | 2003-05-15 | |
| US60/471,373 | 2003-05-15 | ||
| US10/646,348 US7157473B2 (en) | 2002-08-23 | 2003-08-22 | Pyridyl substituted heterocycles useful for treating or preventing HCV infection |
| US10/646,348 | 2003-08-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20050033653A true KR20050033653A (ko) | 2005-04-12 |
Family
ID=31950772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057003019A Ceased KR20050033653A (ko) | 2002-08-23 | 2003-08-22 | Ｈｃｖ 감염의 치료 또는 예방에 유용한 피리딜 치환 헤테로사이클 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US7157473B2 (https=) |
| EP (1) | EP1530569A2 (https=) |
| JP (1) | JP2006501312A (https=) |
| KR (1) | KR20050033653A (https=) |
| AU (1) | AU2003262831A1 (https=) |
| BR (1) | BR0313755A (https=) |
| CA (1) | CA2494164A1 (https=) |
| HR (1) | HRP20050168A2 (https=) |
| IL (1) | IL166639A0 (https=) |
| MX (1) | MXPA05002082A (https=) |
| NO (1) | NO20051404L (https=) |
| NZ (1) | NZ537980A (https=) |
| PL (1) | PL374536A1 (https=) |
| RS (1) | RS20050175A (https=) |
| WO (1) | WO2004018463A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY151199A (en) | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
| HRP20050168A2 (en) | 2002-08-23 | 2005-10-31 | Rigel Pharmaceuticals | Pyridyl substituted heterocycles useful for treating or preventing hcv infection |
| US7326790B2 (en) | 2003-05-02 | 2008-02-05 | Rigel Pharmaceuticals, Inc. | Diphenylisoxazole compounds and hydro isomers thereof |
| WO2004099164A1 (en) * | 2003-05-02 | 2004-11-18 | Rigel Pharmaceuticals, Inc. | Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating hcv infection |
| US7220745B2 (en) | 2003-05-15 | 2007-05-22 | Rigel Pharmaceuticals | Heterocyclic compounds useful to treat HCV |
| EP1658302B1 (en) | 2003-07-25 | 2010-08-25 | IDENIX Pharmaceuticals, Inc. | Purine nucleoside analogues for treating diseases caused by flaviviridae including hepatitis c |
| US7410979B2 (en) * | 2003-11-19 | 2008-08-12 | Rigel Pharmaceuticals, Inc. | Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections |
| ES2308302T3 (es) * | 2003-12-19 | 2008-12-01 | Rigel Pharmaceuticals, Inc. | Composiciones y procedimientos para el tratamiento de la infeccion por el virus de la hepatitis c (vhc). |
| US7514434B2 (en) | 2004-02-23 | 2009-04-07 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof |
| WO2005097760A1 (en) * | 2004-03-26 | 2005-10-20 | Rigel Pharmaceuticals, Inc. | Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses |
| CA2606106A1 (en) * | 2005-05-02 | 2007-03-08 | Rigel Pharmaceuticals, Inc. | Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses |
| EP2954847B1 (en) * | 2005-08-10 | 2019-02-06 | C.R. Bard Inc. | Single-insertion, multiple sample biopsy device with integrated markers |
| KR100890862B1 (ko) * | 2005-11-07 | 2009-03-27 | 주식회사 엘지화학 | 유기 발광 소자 및 이의 제조 방법 |
| BRPI0909288A2 (pt) * | 2008-03-14 | 2015-08-18 | Otsuka Pharma Co Ltd | Inibidores da mmp-2 e/ou da mmp-9 |
| US8362020B2 (en) * | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| AU2016281346B2 (en) | 2015-06-23 | 2020-01-02 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivative, or pharmaceutically acceptable salt thereof |
| CN116535399B (zh) * | 2022-01-25 | 2024-02-27 | 中国药科大学 | 3-羟基-5-(异噁唑-5-基)吡啶甲酰甘氨酸类化合物、制法、药物组合物和应用 |
| WO2025037036A1 (en) * | 2023-08-17 | 2025-02-20 | Sanofi | Pyridyl imidazoles, their preparation and their therapeutic application |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2852503A (en) * | 1953-12-31 | 1958-09-16 | American Cyanamid Co | 2, 5-bis (p-aminophenyl) furan azo derivatives |
| BE581861A (https=) * | 1958-08-20 | |||
| US3335149A (en) * | 1963-08-21 | 1967-08-08 | Monsanto Co | Thiazole diamines |
| FR1459375A (fr) | 1965-10-20 | 1966-04-29 | Westinghouse Electric Corp | Copolymères linéaires oxadiazole-imide |
| SU508198A3 (ru) | 1971-07-22 | 1976-03-25 | Группо Лепетит С.П.А. (Фирма) | Способ получени производных 1,2,4-триазола |
| DE2137719A1 (de) | 1971-07-28 | 1973-02-08 | Basf Ag | Verfahren zur herstellung von aminobenzonitrilen |
| US3964896A (en) * | 1971-08-09 | 1976-06-22 | Uniroyal, Inc. | Oxadiazole benzoic acid derivatives as herbicides |
| US3853893A (en) * | 1973-04-02 | 1974-12-10 | Squibb & Sons Inc | Anthelmintic 5-(pyridyl)-3-(isothiocyanophenyl) oxadiazoles |
| DE2721955A1 (de) | 1977-05-14 | 1978-11-23 | Basf Ag | Azofarbstoffe |
| DE3623302A1 (de) * | 1985-11-09 | 1987-05-14 | Bayer Ag | Nicotinsaeurederivate |
| DE4016049A1 (de) * | 1990-05-18 | 1991-11-21 | Basf Ag | 3-isoxazolylbenzylester, ihre herstellung und ihre verwendung |
| JPH04124178A (ja) | 1990-09-12 | 1992-04-24 | Sds Biotech Kk | 複素環式化合物および該化合物を含有する除草剤 |
| DE4124942A1 (de) * | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE4137940A1 (de) * | 1991-11-18 | 1993-05-19 | Basf Ag | 3-isoxazolylphenylverbindungen, ihre herstellung und ihre verwendung |
| BR9306040A (pt) | 1992-03-06 | 1997-11-18 | Statens Seruminstitut | Tratamento e profilaxia de doenças provocadas por parasitos ou bactérias |
| DE4210502A1 (de) | 1992-03-31 | 1993-10-07 | Bayer Ag | Verwendung von 3-aminosubstituierten Isoxazolderivaten zur Bekämpfung von Endoparasiten, neue 3-aminosubstituierte Isoxazolderivate und Verfahren zu ihrer Herstellung |
| AU5891494A (en) | 1993-01-29 | 1994-08-15 | Nippon Soda Co., Ltd. | Heterocyclic derivative |
| DE4408084A1 (de) * | 1994-03-10 | 1995-09-14 | Hoechst Ag | 3,5-Disubstituierte und 3,4,5-trisubstituierte 2-Isoxazoline und Isoxazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU3087195A (en) | 1994-08-02 | 1996-03-04 | Nippon Soda Co., Ltd. | Oxazole derivative, process for producing the same, and herbicide |
| RO115522B1 (ro) * | 1995-02-02 | 2000-03-30 | Smithkline Beecham P.L.C. | Derivaţi de indolină, procedee pentru prepararea acestora, compoziţii farmaceutice care îi conţin şi metodă de tratament |
| DE19643037A1 (de) | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
| EA199900837A1 (ru) | 1997-04-18 | 2000-10-30 | Дж.Д.Сирл Энд Ко. | Способ применения ингибиторов циклооксигеназы-2 для предупреждения сердечно-сосудистых расстройств |
| US20020035156A1 (en) * | 1997-04-18 | 2002-03-21 | Barbara Roniker | Combination therapy in the prevention of cardiovascular disorders |
| WO1999004390A1 (en) | 1997-07-17 | 1999-01-28 | Sony Corporation | Magnetic recording medium and magnetic recorder/reproducer comprising the same |
| CA2307613A1 (en) * | 1997-10-22 | 1999-04-29 | Eisai Co., Ltd. | Retinoic acid agonist as a prophylactic and therapeutic agent for nephritis |
| DE19860802A1 (de) | 1998-12-30 | 2000-10-26 | Virgene Pharmaceuticals Ag | Herstellung eines Mittels gegen Hepatitis B-, HI-, Paramyxo und Orthomyxo-Viren |
| DE19904389A1 (de) | 1999-02-04 | 2000-08-10 | Bayer Ag | Verwendung von substituierten Isoxazolcarbonsäuren und Derivate und neue Stoffe |
| WO2000064894A1 (en) * | 1999-04-23 | 2000-11-02 | Takeda Chemical Industries, Ltd. | 5-pyridyl-1,3-azole compounds, process for producing the same and use thereof |
| GB2351081A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Pharmaceutically active imidazoline compounds and analogues thereof |
| DE10032874A1 (de) | 2000-07-06 | 2002-01-17 | Bayer Ag | Arzneimittelkombinationen gegen virale Erkrankungen |
| WO2001074811A2 (en) * | 2000-03-30 | 2001-10-11 | Takeda Chemical Industries, Ltd. | Substituted 1,3-thiazole compounds, their production and use |
| US6608058B2 (en) | 2000-04-17 | 2003-08-19 | Dong Wha Pharm. Ind. Co., Ltd. | 6-methylnicotinamide derivatives as antiviral agents |
| US6579880B2 (en) * | 2000-06-06 | 2003-06-17 | Ortho-Mcneil Pharmaceutical, Inc. | Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8 |
| GB0017676D0 (en) * | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
| US20020077491A1 (en) | 2000-09-05 | 2002-06-20 | Shipps Gerald W. | Methods for forming combinatorial libraries combining amide bond formation with epoxide opening |
| WO2002046186A1 (en) | 2000-12-08 | 2002-06-13 | Takeda Chemical Industries, Ltd. | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof |
| EP1399163B1 (en) | 2001-01-13 | 2007-10-10 | University Of North Carolina At Chapel Hill | Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (bvdv) infection and hepatitis c virus (hcv) infection |
| CN1516695A (zh) * | 2001-04-19 | 2004-07-28 | 用作抗病毒剂的芳基磺酰胺类化合物 | |
| DE10148598A1 (de) | 2001-04-19 | 2002-10-24 | Bayer Ag | Neue Arylsulfonamide als antivirale Mittel |
| DE60226756D1 (de) * | 2001-10-04 | 2008-07-03 | Merck & Co Inc | Heteroarylsubstituierte tetrazolmodulatoren des metabotropischen glutamatrezeptors-5 |
| MY151199A (en) | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
| HRP20050168A2 (en) * | 2002-08-23 | 2005-10-31 | Rigel Pharmaceuticals | Pyridyl substituted heterocycles useful for treating or preventing hcv infection |
| US7220745B2 (en) | 2003-05-15 | 2007-05-22 | Rigel Pharmaceuticals | Heterocyclic compounds useful to treat HCV |
-
2003
- 2003-08-22 HR HR20050168A patent/HRP20050168A2/hr not_active Application Discontinuation
- 2003-08-22 NZ NZ537980A patent/NZ537980A/en not_active IP Right Cessation
- 2003-08-22 BR BR0313755-4A patent/BR0313755A/pt not_active IP Right Cessation
- 2003-08-22 KR KR1020057003019A patent/KR20050033653A/ko not_active Ceased
- 2003-08-22 MX MXPA05002082A patent/MXPA05002082A/es unknown
- 2003-08-22 EP EP03793349A patent/EP1530569A2/en not_active Withdrawn
- 2003-08-22 RS YUP-2005/0175A patent/RS20050175A/sr unknown
- 2003-08-22 PL PL03374536A patent/PL374536A1/xx not_active Application Discontinuation
- 2003-08-22 WO PCT/US2003/026478 patent/WO2004018463A2/en not_active Ceased
- 2003-08-22 CA CA002494164A patent/CA2494164A1/en not_active Abandoned
- 2003-08-22 US US10/646,348 patent/US7157473B2/en not_active Expired - Lifetime
- 2003-08-22 AU AU2003262831A patent/AU2003262831A1/en not_active Abandoned
- 2003-08-22 JP JP2005501778A patent/JP2006501312A/ja active Pending
-
2005
- 2005-02-01 IL IL16663905A patent/IL166639A0/xx unknown
- 2005-03-17 NO NO20051404A patent/NO20051404L/no not_active Application Discontinuation
-
2006
- 2006-11-21 US US11/561,991 patent/US7332602B2/en not_active Expired - Lifetime
-
2007
- 2007-12-20 US US11/960,990 patent/US7714137B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20040127497A1 (en) | 2004-07-01 |
| WO2004018463A3 (en) | 2004-05-06 |
| EP1530569A2 (en) | 2005-05-18 |
| US20070155966A1 (en) | 2007-07-05 |
| RS20050175A (sr) | 2007-09-21 |
| BR0313755A (pt) | 2005-06-21 |
| US7157473B2 (en) | 2007-01-02 |
| HRP20050168A2 (en) | 2005-10-31 |
| JP2006501312A (ja) | 2006-01-12 |
| MXPA05002082A (es) | 2005-06-08 |
| AU2003262831A1 (en) | 2004-03-11 |
| US20080171871A1 (en) | 2008-07-17 |
| IL166639A0 (en) | 2006-01-15 |
| NO20051404L (no) | 2005-05-10 |
| NZ537980A (en) | 2007-08-31 |
| US7714137B2 (en) | 2010-05-11 |
| CA2494164A1 (en) | 2004-03-04 |
| PL374536A1 (en) | 2005-10-31 |
| WO2004018463A2 (en) | 2004-03-04 |
| US7332602B2 (en) | 2008-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20050222 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20080822 Comment text: Request for Examination of Application |
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| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20100930 Patent event code: PE09021S01D |
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| PE0601 | Decision on rejection of patent |
Patent event date: 20101209 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20100930 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |