JP2006501204A - 薬物送達用及び撮像用複合リジン共重合体 - Google Patents

薬物送達用及び撮像用複合リジン共重合体 Download PDF

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Publication number
JP2006501204A
JP2006501204A JP2004524697A JP2004524697A JP2006501204A JP 2006501204 A JP2006501204 A JP 2006501204A JP 2004524697 A JP2004524697 A JP 2004524697A JP 2004524697 A JP2004524697 A JP 2004524697A JP 2006501204 A JP2006501204 A JP 2006501204A
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JP
Japan
Prior art keywords
molecule
acid
lysine
polypeptide
copolymer
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Pending
Application number
JP2004524697A
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English (en)
Japanese (ja)
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JP2006501204A5 (OSRAM
Inventor
ユージリス，エジディウス・エドワード
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General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by General Electric Co filed Critical General Electric Co
Publication of JP2006501204A publication Critical patent/JP2006501204A/ja
Publication of JP2006501204A5 publication Critical patent/JP2006501204A5/ja
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
JP2004524697A 2002-07-31 2003-07-23 薬物送達用及び撮像用複合リジン共重合体 Pending JP2006501204A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/209,993 US20040022733A1 (en) 2002-07-31 2002-07-31 Conjugated lysine copolymers
PCT/US2003/022913 WO2004011034A1 (en) 2002-07-31 2003-07-23 Conjugated lysine copolymers for drug delivery and imaging

Publications (2)

Publication Number Publication Date
JP2006501204A true JP2006501204A (ja) 2006-01-12
JP2006501204A5 JP2006501204A5 (OSRAM) 2006-09-14

Family

ID=31187190

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004524697A Pending JP2006501204A (ja) 2002-07-31 2003-07-23 薬物送達用及び撮像用複合リジン共重合体

Country Status (5)

Country Link
US (1) US20040022733A1 (OSRAM)
EP (1) EP1526873A1 (OSRAM)
JP (1) JP2006501204A (OSRAM)
AU (1) AU2003259208A1 (OSRAM)
WO (1) WO2004011034A1 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005063304A2 (en) * 2003-12-24 2005-07-14 Board Of Regents, The University Of Texas_System Poly (l-glutamic acid) paramagnetic material complex and use as a biodegradable mri contrast agent
US20050271585A1 (en) * 2004-06-07 2005-12-08 General Electric Company Extended conjugated polymers
RU2007140391A (ru) * 2005-04-01 2009-05-10 Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем (Us) Поли(пептид) как хелатор: способы получения и применения
CN103394101B (zh) * 2013-06-27 2014-10-29 浙江大学 一种基于赖氨酸的高分子mri造影剂及其制备方法
US10610608B2 (en) 2013-08-01 2020-04-07 Rochester Institute Of Technology Modular imaging agents containing amino acids and peptides
US10927132B2 (en) 2015-02-27 2021-02-23 Rochester Institute Of Technology Transmetalation methods for the synthesis of PET and SPECT imaging agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4431968A (en) * 1982-04-05 1984-02-14 General Electric Company Method of three-dimensional NMR imaging using selective excitation
US4665365A (en) * 1985-01-07 1987-05-12 General Electric Company Method for reversing residual transverse magnetization due to phase-encoding magnetic field gradients
US5554748A (en) * 1989-04-07 1996-09-10 Nycomed Salutar, Inc. Adducts of macrocyclic chelants
US5762909A (en) * 1995-08-31 1998-06-09 General Electric Company Tumor targeting with polymeric molecules having extended conformation
US6441025B2 (en) * 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
US6121775A (en) * 1998-06-16 2000-09-19 Beth Israel Deaconess Medical Center, Inc. MRI imaging method and apparatus
US6235264B1 (en) * 1999-12-01 2001-05-22 General Electric Company Medical imaging method for characterizing tumor angiogenesis using polymeric contrast agents
US6685915B2 (en) * 1999-12-01 2004-02-03 General Electric Company Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging

Also Published As

Publication number Publication date
EP1526873A1 (en) 2005-05-04
WO2004011034A1 (en) 2004-02-05
AU2003259208A1 (en) 2004-02-16
US20040022733A1 (en) 2004-02-05

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