JP2006306885A5 - - Google Patents
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- Publication number
- JP2006306885A5 JP2006306885A5 JP2006175983A JP2006175983A JP2006306885A5 JP 2006306885 A5 JP2006306885 A5 JP 2006306885A5 JP 2006175983 A JP2006175983 A JP 2006175983A JP 2006175983 A JP2006175983 A JP 2006175983A JP 2006306885 A5 JP2006306885 A5 JP 2006306885A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- fluoro
- ethyl
- hydroxypropyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 9
- -1 t-butyl (2R) -2-fluoro -3-hydroxypropyl Chemical group 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- UROJZRVINWISIJ-GSVOUGTGSA-N chembl451922 Chemical compound NC[C@@H](O)CP(O)=O UROJZRVINWISIJ-GSVOUGTGSA-N 0.000 claims 2
- UROJZRVINWISIJ-VKHMYHEASA-N chembl492624 Chemical compound NC[C@H](O)CP(O)=O UROJZRVINWISIJ-VKHMYHEASA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- BLGIETSFOVDJCL-DMPGVRBJSA-N (2r)-1-amino-3-[1,1-diethoxyethyl(ethoxy)phosphoryl]propan-2-ol Chemical compound CCOC(C)(OCC)P(=O)(OCC)C[C@H](O)CN BLGIETSFOVDJCL-DMPGVRBJSA-N 0.000 claims 1
- HNKWGKMJXSVJAW-APDXDRDNSA-N (2r)-1-chloro-3-[1,1-diethoxyethyl(ethoxy)phosphoryl]propan-2-ol Chemical compound CCOC(C)(OCC)P(=O)(OCC)C[C@@H](O)CCl HNKWGKMJXSVJAW-APDXDRDNSA-N 0.000 claims 1
- KPELUVFYFBYKOB-QGZVFWFLSA-N (2r)-3-(dibenzylamino)-2-fluoropropan-1-ol Chemical compound C=1C=CC=CC=1CN(C[C@@H](F)CO)CC1=CC=CC=C1 KPELUVFYFBYKOB-QGZVFWFLSA-N 0.000 claims 1
- DTXCSCJRPZOOAQ-GSVOUGTGSA-N (2r)-3-amino-2-fluoropropan-1-ol Chemical compound NC[C@@H](F)CO DTXCSCJRPZOOAQ-GSVOUGTGSA-N 0.000 claims 1
- BLGIETSFOVDJCL-APDXDRDNSA-N (2s)-1-amino-3-[1,1-diethoxyethyl(ethoxy)phosphoryl]propan-2-ol Chemical compound CCOC(C)(OCC)P(=O)(OCC)C[C@@H](O)CN BLGIETSFOVDJCL-APDXDRDNSA-N 0.000 claims 1
- HNKWGKMJXSVJAW-DMPGVRBJSA-N (2s)-1-chloro-3-[1,1-diethoxyethyl(ethoxy)phosphoryl]propan-2-ol Chemical compound CCOC(C)(OCC)P(=O)(OCC)C[C@H](O)CCl HNKWGKMJXSVJAW-DMPGVRBJSA-N 0.000 claims 1
- KPELUVFYFBYKOB-KRWDZBQOSA-N (2s)-3-(dibenzylamino)-2-fluoropropan-1-ol Chemical compound C=1C=CC=CC=1CN(C[C@H](F)CO)CC1=CC=CC=C1 KPELUVFYFBYKOB-KRWDZBQOSA-N 0.000 claims 1
- DTXCSCJRPZOOAQ-VKHMYHEASA-N (2s)-3-amino-2-fluoropropan-1-ol Chemical compound NC[C@H](F)CO DTXCSCJRPZOOAQ-VKHMYHEASA-N 0.000 claims 1
- AOTIMMJHYAECNM-UHFFFAOYSA-O (3-amino-2-oxopropyl)-hydroxy-oxophosphanium Chemical compound NCC(=O)C[P+](O)=O AOTIMMJHYAECNM-UHFFFAOYSA-O 0.000 claims 1
- LURRNLZNRSNJQS-UHFFFAOYSA-N 3-[diethoxymethyl(ethoxy)phosphoryl]-2-fluorobutanamide Chemical compound CCOC(OCC)P(=O)(OCC)C(C)C(F)C(N)=O LURRNLZNRSNJQS-UHFFFAOYSA-N 0.000 claims 1
- WVTGPBOMAQLPCP-UHFFFAOYSA-O NCC(F)C[P+](O)=O Chemical compound NCC(F)C[P+](O)=O WVTGPBOMAQLPCP-UHFFFAOYSA-O 0.000 claims 1
- WVTGPBOMAQLPCP-GSVOUGTGSA-O [(2r)-3-amino-2-fluoropropyl]-hydroxy-oxophosphanium Chemical compound NC[C@@H](F)C[P+](O)=O WVTGPBOMAQLPCP-GSVOUGTGSA-O 0.000 claims 1
- WVTGPBOMAQLPCP-VKHMYHEASA-O [(2s)-3-amino-2-fluoropropyl]-hydroxy-oxophosphanium Chemical compound NC[C@H](F)C[P+](O)=O WVTGPBOMAQLPCP-VKHMYHEASA-O 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000000111 lower esophageal sphincter Anatomy 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9904508A SE9904508D0 (sv) | 1999-12-09 | 1999-12-09 | New compounds |
| SE0003640A SE0003640D0 (sv) | 2000-10-09 | 2000-10-09 | New compounds |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001543550A Division JP3914435B2 (ja) | 1999-12-09 | 2000-12-04 | 新規なアミノプロピルホスフィン酸 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006306885A JP2006306885A (ja) | 2006-11-09 |
| JP2006306885A5 true JP2006306885A5 (cg-RX-API-DMAC10.html) | 2008-01-17 |
Family
ID=26655259
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001543550A Expired - Fee Related JP3914435B2 (ja) | 1999-12-09 | 2000-12-04 | 新規なアミノプロピルホスフィン酸 |
| JP2006175983A Pending JP2006306885A (ja) | 1999-12-09 | 2006-06-27 | 新規なアミノプロピルホスフィン酸 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001543550A Expired - Fee Related JP3914435B2 (ja) | 1999-12-09 | 2000-12-04 | 新規なアミノプロピルホスフィン酸 |
Country Status (33)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904508D0 (sv) * | 1999-12-09 | 1999-12-09 | Astra Ab | New compounds |
| US7319095B2 (en) * | 1999-12-09 | 2008-01-15 | Astrazeneca Ab | Use of GABAB receptor agonists |
| MXPA03006998A (es) * | 2001-02-05 | 2004-10-15 | Michael Albert Kamm | Tratamiento de trastornos de motilidad esofagica y enfermedad de reflujo gastroesofagico. |
| AR033779A1 (es) * | 2001-06-08 | 2004-01-07 | Astrazeneca Ab | Compuestos utiles en la enfermedad de reflujo |
| SE0201939D0 (sv) * | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | New combination |
| SE0201940D0 (sv) * | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | New combination II |
| SE0401653D0 (sv) | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | New compounds |
| SE0402462D0 (sv) * | 2004-10-08 | 2004-10-08 | Astrazeneca Ab | New process |
| WO2006050471A2 (en) | 2004-11-03 | 2006-05-11 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use |
| WO2006050472A2 (en) * | 2004-11-03 | 2006-05-11 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids |
| US20060160777A1 (en) * | 2004-12-27 | 2006-07-20 | Anders Lehmann | New use of GABAbeta receptor agonists |
| BRPI0620464A2 (pt) | 2005-12-23 | 2011-11-16 | Astrazeneca Ab | composto, composição farmacêutica, uso de um composto, e, método para o tratamento de uma doença |
| CA2632016A1 (en) | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Imidazole derivatives for the treatment of gastrointestinal disorders |
| US7585996B2 (en) | 2006-09-15 | 2009-09-08 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| EP2155762B1 (en) | 2007-05-04 | 2011-10-12 | AstraZeneca AB | Process for the synthesis of alkyl phosphinic acids by initiation of an amine and an amineoxide |
| EP2217245A4 (en) * | 2007-07-25 | 2011-01-12 | Astrazeneca Ab | USE OF (3-AMINO-2-FLUOROPROPYL) -PHOSPHIC ACID FOR THE TREATMENT OF NERD |
| PE20091311A1 (es) * | 2007-12-21 | 2009-09-30 | Astrazeneca Ab | Nuevo proceso para preparar la forma a del acido (2r)-(3-amino-2-fluoropropil)fosfinico |
| WO2009082348A1 (en) * | 2007-12-21 | 2009-07-02 | Astrazeneca Ab | Novel crystalline form c of (2r)-(3-amino-2-fluoropropyl)phosphinic acid |
| EP2235027A4 (en) * | 2007-12-21 | 2011-06-22 | Astrazeneca Ab | NEW CRYSTALLINE FORM OF (2R) - (3-AMINO-2-FLUOROPROPYL) PHOSPHINIC ACID |
| WO2009145716A1 (en) * | 2008-05-28 | 2009-12-03 | Astrazeneca Ab | New pharmaceutical formulation useful in gerd therapy |
| WO2010051883A1 (de) | 2008-11-05 | 2010-05-14 | Clariant International Ltd | Verfahren zur herstellung von dialkylphosphinsäuren, -estern und -salzen mittels allylalkoholen/acroleinen und ihre verwendung |
| DE102008056341A1 (de) | 2008-11-07 | 2010-05-12 | Clariant International Limited | Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung |
| JP5570518B2 (ja) | 2008-11-07 | 2014-08-13 | クラリアント・ファイナンス・（ビーブイアイ）・リミテッド | アクリル酸誘導体を用いたジアルキルホスフィン酸、−エステル及び−塩の製造方法及びそれらの使用 |
| JP5743219B2 (ja) | 2008-11-11 | 2015-07-01 | クラリアント・ファイナンス・（ビーブイアイ）・リミテッド | アリル化合物を用いる、モノアリル官能性ジアルキルホスフィン酸、それらの塩およびエステルの製造方法およびそれらの使用 |
| DE102008060035A1 (de) | 2008-12-02 | 2010-06-10 | Clariant International Limited | Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung |
| DE102008060535A1 (de) | 2008-12-04 | 2010-06-10 | Clariant International Limited | Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylether und ihre Verwendung |
| DE102008063668A1 (de) | 2008-12-18 | 2010-07-01 | Clariant International Limited | Verfahren zur Herstellung von Alkylphosponsäuren, -estern und -salzen mittels Oxidation von Alkylphosphonigsäuren und ihre Verwendung |
| DE102008063627A1 (de) | 2008-12-18 | 2010-06-24 | Clariant International Limited | Verfahren zur Herstellung von monohydroxyfunktionalisierten Dialkylphosphinsäuren,-estern und -salzen mittels Ethylenoxid und ihre Verwendung |
| DE102008063642A1 (de) | 2008-12-18 | 2010-06-24 | Clariant International Limited | Verfahren zur Herstellung von monocarboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Alkylenoxiden und ihre Verwendung |
| CN103724372B (zh) | 2008-12-18 | 2017-03-01 | 科莱恩金融(Bvi)有限公司 | 亚乙基二烷基次膦酸、亚乙基二烷基次膦酸酯和亚乙基二烷基次膦酸盐的用途 |
| DE102008064003A1 (de) | 2008-12-19 | 2010-06-24 | Clariant International Limited | Verfahren zur Herstellung von mono-funktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung |
| WO2011113904A1 (en) | 2010-03-17 | 2011-09-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration |
| US20120016021A1 (en) | 2010-07-15 | 2012-01-19 | Xenoport, Inc. | Methods of treating fragile x syndrome, down's syndrome, autism and related disorders |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH449046A (de) | 1963-07-09 | 1967-12-31 | Ciba Geigy | Verfahren zur Herstellung neuer Aminosäuren |
| GB8425872D0 (en) | 1984-10-12 | 1984-11-21 | Ciba Geigy Ag | Chemical compounds |
| EP0250572A1 (en) | 1986-01-03 | 1988-01-07 | The University Of Melbourne | Gastro-oesophageal reflux composition |
| US4740332A (en) * | 1986-05-12 | 1988-04-26 | E. R. Squibb & Sons, Inc. | Process for preparing phosphonous acids |
| GB8820266D0 (en) * | 1988-08-26 | 1988-09-28 | Smith Kline French Lab | Compounds |
| US5567840A (en) | 1989-05-13 | 1996-10-22 | Ciba-Geigy Corporation | Substituted aminoalkylphosphinic acids |
| US5281747A (en) | 1989-05-13 | 1994-01-25 | Ciba-Geigy Corporation | Substituted aminoalkylphosphinic acids |
| GB8911017D0 (en) | 1989-05-13 | 1989-06-28 | Ciba Geigy Ag | Substituted aminoalkylphosphinic acids |
| US5006560A (en) | 1989-12-20 | 1991-04-09 | Schering Corporation | Use of GABA-B selective agonists as anti-tussive agents |
| IL98502A (en) * | 1990-06-22 | 1998-04-05 | Ciba Geigy Ag | Aminoalkane phosphinic acid derivatives, process for their preparation and pharmaceutical compositions containing them |
| FR2663934B1 (fr) | 1990-06-27 | 1994-06-03 | Adir | Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent. |
| GB9125615D0 (en) * | 1991-12-02 | 1992-01-29 | Wyeth John & Brother Ltd | Amines |
| AU662404B2 (en) * | 1992-05-08 | 1995-08-31 | Novartis Ag | Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids |
| FR2722192A1 (fr) | 1994-07-06 | 1996-01-12 | Adir | Nouveaux derives de l'acide 4-amino butyrique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB9420784D0 (en) | 1994-10-14 | 1994-11-30 | Glaxo Group Ltd | Medicaments |
| SE9603408D0 (sv) * | 1996-09-18 | 1996-09-18 | Astra Ab | Medical use |
| US7319095B2 (en) * | 1999-12-09 | 2008-01-15 | Astrazeneca Ab | Use of GABAB receptor agonists |
| SE9904508D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Ab | New compounds |
| SE9904507D0 (sv) * | 1999-12-09 | 1999-12-09 | Astra Ab | New compounds |
-
1999
- 1999-12-09 SE SE9904508A patent/SE9904508D0/xx unknown
-
2000
- 2000-04-12 UA UA2002064507A patent/UA71649C2/uk unknown
- 2000-11-27 TW TW089125135A patent/TWI228510B/zh not_active IP Right Cessation
- 2000-12-04 SI SI200030561T patent/SI1240172T1/xx unknown
- 2000-12-04 DE DE60015796T patent/DE60015796T2/de not_active Expired - Lifetime
- 2000-12-04 JP JP2001543550A patent/JP3914435B2/ja not_active Expired - Fee Related
- 2000-12-04 WO PCT/SE2000/002426 patent/WO2001042252A1/en not_active Ceased
- 2000-12-04 RU RU2002113909/04A patent/RU2260595C2/ru not_active IP Right Cessation
- 2000-12-04 CA CA2397583A patent/CA2397583C/en not_active Expired - Fee Related
- 2000-12-04 CN CNB008168989A patent/CN1198832C/zh not_active Expired - Fee Related
- 2000-12-04 IL IL14984000A patent/IL149840A0/xx active IP Right Grant
- 2000-12-04 SK SK764-2002A patent/SK286904B6/sk not_active IP Right Cessation
- 2000-12-04 PT PT00983634T patent/PT1240172E/pt unknown
- 2000-12-04 AR ARP000106418A patent/AR030541A1/es active IP Right Grant
- 2000-12-04 EP EP00983634A patent/EP1240172B1/en not_active Expired - Lifetime
- 2000-12-04 HU HU0300301A patent/HUP0300301A3/hu unknown
- 2000-12-04 KR KR1020027007355A patent/KR100689144B1/ko not_active Expired - Fee Related
- 2000-12-04 AU AU20364/01A patent/AU780459B2/en not_active Ceased
- 2000-12-04 HK HK03100457.3A patent/HK1048321B/en not_active IP Right Cessation
- 2000-12-04 PL PL364795A patent/PL201789B1/pl not_active IP Right Cessation
- 2000-12-04 AT AT00983634T patent/ATE282043T1/de active
- 2000-12-04 ES ES00983634T patent/ES2230174T3/es not_active Expired - Lifetime
- 2000-12-04 BR BR0016253-1A patent/BR0016253A/pt not_active IP Right Cessation
- 2000-12-04 DK DK00983634T patent/DK1240172T3/da active
- 2000-12-04 EP EP04021533A patent/EP1484333A1/en not_active Withdrawn
- 2000-12-04 CZ CZ20021983A patent/CZ20021983A3/cs unknown
- 2000-12-04 US US09/786,219 patent/US6576626B2/en not_active Expired - Fee Related
- 2000-12-04 MX MXPA02005536A patent/MXPA02005536A/es active IP Right Grant
- 2000-12-04 NZ NZ519376A patent/NZ519376A/en not_active IP Right Cessation
- 2000-12-04 EE EEP200200286A patent/EE05067B1/xx not_active IP Right Cessation
- 2000-12-07 MY MYPI20005746A patent/MY125414A/en unknown
-
2002
- 2002-05-23 ZA ZA200204127A patent/ZA200204127B/xx unknown
- 2002-06-06 IS IS6408A patent/IS2231B/is unknown
- 2002-06-07 NO NO20022728A patent/NO329595B1/no not_active IP Right Cessation
-
2003
- 2003-04-04 US US10/406,838 patent/US6841698B2/en not_active Expired - Fee Related
-
2004
- 2004-01-01 IL IL149840A patent/IL149840A/en not_active IP Right Cessation
- 2004-12-16 US US11/016,543 patent/US7034176B2/en not_active Expired - Fee Related
-
2006
- 2006-04-07 US US11/400,021 patent/US7807658B2/en not_active Expired - Fee Related
- 2006-06-27 JP JP2006175983A patent/JP2006306885A/ja active Pending
-
2007
- 2007-07-12 US US11/776,648 patent/US20080146836A1/en not_active Abandoned