JP2005539223A - クロマトグラフィーの吸着剤およびバイオチップアレイのための混合モード固体基材の調製および使用 - Google Patents

クロマトグラフィーの吸着剤およびバイオチップアレイのための混合モード固体基材の調製および使用 Download PDF

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JP2005539223A
JP2005539223A JP2004536206A JP2004536206A JP2005539223A JP 2005539223 A JP2005539223 A JP 2005539223A JP 2004536206 A JP2004536206 A JP 2004536206A JP 2004536206 A JP2004536206 A JP 2004536206A JP 2005539223 A JP2005539223 A JP 2005539223A
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solid substrate
heterocyclic
substrate according
solid
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JP2005539223A5 (https=
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エギスト ボシェッティ，
ピエール ジロット，
ピル−ジェ ウム，
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Pall Corp
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Pall Corp
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    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
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    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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  • Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2004536206A 2002-09-13 2003-09-12 クロマトグラフィーの吸着剤およびバイオチップアレイのための混合モード固体基材の調製および使用 Pending JP2005539223A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41027302P 2002-09-13 2002-09-13
PCT/US2003/028688 WO2004024318A1 (en) 2002-09-13 2003-09-12 Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays

Publications (2)

Publication Number Publication Date
JP2005539223A true JP2005539223A (ja) 2005-12-22
JP2005539223A5 JP2005539223A5 (https=) 2006-10-26

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US (2) US7144743B2 (https=)
EP (1) EP1578527A1 (https=)
JP (1) JP2005539223A (https=)
AU (1) AU2003270601A1 (https=)
CA (1) CA2500903A1 (https=)
WO (1) WO2004024318A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013500291A (ja) * 2009-07-28 2013-01-07 インストラクション・ゲーエムベーハー タンパク質及びペプチドと結合する特定の充填剤、並びに、それを用いた分離方法
JP2013033040A (ja) * 2011-07-27 2013-02-14 Pall Corp 混合モード配位子
JP2013518283A (ja) * 2010-01-27 2013-05-20 インターナショナル・ビジネス・マシーンズ・コーポレーション 分子を検出する半導体デバイスを形成する方法ならびに分子を検出する集積回路、クロマトグラフィ・デバイス及び半導体デバイス
JP2014507649A (ja) * 2011-01-18 2014-03-27 バクスター・インターナショナル・インコーポレイテッド ヒト血液中の抗βアミロイド抗体の測定

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1578527A1 (en) * 2002-09-13 2005-09-28 Ciphergen Biosystems, Inc. Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays
DE10302721A1 (de) * 2003-01-23 2004-08-05 Steag Microparts Gmbh Mikrofluidische Anordnung zum Dosieren von Flüssigkeiten
US20070082019A1 (en) * 2003-02-21 2007-04-12 Ciphergen Biosystems Inc. Photocrosslinked hydrogel surface coatings
JP3818277B2 (ja) * 2003-07-14 2006-09-06 株式会社日立製作所 化学反応デバイス、化学反応システムおよび化学反応方法
WO2005073711A2 (en) * 2004-01-20 2005-08-11 Pall Corporation Chromatographic material for the absorption of proteins at physiological ionic strength
DE102004053458A1 (de) * 2004-11-05 2006-05-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Strukturierte polymere Träger für die Massenspektrometrie und Verfahren zu deren Herstellung
US7358485B2 (en) * 2005-02-08 2008-04-15 Perkinelmer Las, Inc. Zirconia toughened alumina composition and use in ion and electron optical systems
US7396676B2 (en) * 2005-05-31 2008-07-08 Agilent Technologies, Inc. Evanescent wave sensor with attached ligand
US20080220968A1 (en) * 2005-07-05 2008-09-11 Ge Healthcare Bio-Sciences Ab [1, 2, 4] Triazolo [1, 5-A] Pyrimidine Derivatives as Chromatographic Adsorbent for the Selective Adsorption of Igg
US20070099180A1 (en) * 2005-10-31 2007-05-03 Robotti Karla M Evanescent wave sensor with attached ligand
CA2655873C (en) 2006-07-14 2017-10-17 Wisconsin Alumni Research Foundation Adsorptive membranes for trapping viruses
EP2099957A1 (en) * 2007-01-10 2009-09-16 GE Healthcare Bio-Sciences AB Multi-modal ion exchange chromotography resins
US20080170230A1 (en) * 2007-01-11 2008-07-17 Lamdagen Corporation Silanization of noble metal films
SG144809A1 (en) 2007-01-11 2008-08-28 Millipore U K Ltd Benzimidazole compounds and their use as chromatographic ligands
US20080220532A1 (en) * 2007-03-08 2008-09-11 Polylc Inc. Separation of Charged Solutes by Electrostatic Repulsion-Hydrophilic Interaction Chromatography
EP2152405B2 (de) * 2007-05-25 2017-04-05 Merck Patent GmbH Mischpfropfpolymere für die kationenaustauschchromatographie
EP2027875A1 (en) * 2007-08-23 2009-02-25 Octapharma AG A Process for Isolation and Purification of a Target Protein free of Prion Protein (PrPSC)
US8188242B2 (en) 2008-04-08 2012-05-29 Bio-Rad Laboratories, Inc. Chromatography purification of antibodies
CN101279242A (zh) * 2008-05-20 2008-10-08 大连理工大学 用于抗体清除的血液净化吸附剂
KR101048596B1 (ko) * 2009-01-07 2011-07-12 포항공과대학교 산학협력단 채널 용량 개선 방법
CN102348974B (zh) * 2009-03-12 2015-06-10 株式会社资生堂 填充剂的制造方法、填充剂及柱体
JP5954789B2 (ja) 2009-08-10 2016-07-20 ユーシーエル ビジネス パブリック リミテッド カンパニー 機能的分子の可逆的共有結合
EP2615452A4 (en) * 2010-09-09 2014-05-28 Daicel Corp PROCESS FOR SEPARATING BIOLOGICAL SOLUBLE MATERIAL IN WATER
CN102172519B (zh) * 2011-03-01 2012-11-14 北京化工大学 一种硅胶键合纤维素衍生物色谱填料、制备方法及其应用
FI20115279A0 (fi) * 2011-03-22 2011-03-22 Teknologian Tutkimuskeskus Vtt Oy Menetelmä hydrogeelin valmistamiseksi ksylaanipolysakkaridista ja hydrogeeli
WO2013001087A2 (en) * 2011-06-30 2013-01-03 Novozymes A/S Method for screening alpha-amylases
EP2684951A1 (en) 2012-07-13 2014-01-15 Sandoz Ag Method for producing a recombinant protein of interest
RU2015114330A (ru) 2012-09-17 2016-11-10 У.Р. Грейс Энд Ко.-Конн. Хроматографические среды и устройства
WO2014043644A1 (en) * 2012-09-17 2014-03-20 Alltech Associates, Inc. Functionalized particulate support material and methods of making and using the same
MX375145B (es) * 2013-09-24 2025-03-06 Entopsis Inc Matrices detectables, sistemas para el diagnóstico y sus métodos de preparación y uso.
US11229896B2 (en) 2014-01-16 2022-01-25 W.R. Grace & Co.—Conn. Affinity chromatography media and chromatography devices
JP6914189B2 (ja) 2014-05-02 2021-08-04 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ 官能化担体材料並びに官能化担体材料を作製及び使用する方法
US20160266134A1 (en) * 2015-03-11 2016-09-15 Clemson University Crosslinked polymer stationary phase for chromatography
CN107921407B (zh) 2015-06-05 2022-07-05 格雷斯公司 生物处理吸附澄清剂及其制备和使用方法
US10526367B2 (en) 2015-07-20 2020-01-07 W. L. Gore & Associates, Inc. Affinity chromatography devices
CN108191956B (zh) 2017-12-25 2020-10-30 浙江大学 组合型配基、组合型仿生层析介质及其制备方法和应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE629343A (https=) * 1962-03-08
US5234991A (en) 1975-07-29 1993-08-10 Pasteur Merieux Serums And Vaccines Porous mineral support coated with an aminated polysaccharide polymer
US4381239A (en) 1981-02-10 1983-04-26 Tanabe Seiyaku Co., Ltd. Method for reducing the pyrogen content of or removing pyrogens from substances contaminated therewith
SE451802B (sv) 1984-05-10 1987-11-02 Jerker Porath Produkt for adsorption av metalljoner
SE470261B (sv) 1984-05-17 1993-12-20 Jerker Porath Adsorbent för separation och immobilisering av proteiner, sätt att framställa ett adsorbent, samt dess användning för biopolymer fraktionering
SE470099B (sv) 1984-05-17 1993-11-08 Jerker Porath Sulfonaktiverade tioeteradsorbenter för separation av t ex protein
SE452557B (sv) 1984-10-30 1987-12-07 Exploaterings Ab Tbf Amfipatisk gelprodukt for kromatografisk och satsvis adsorption
FR2616437B1 (fr) 1987-06-11 1990-09-07 Ibf Polymeres composites, leur preparation et leur utilisation en chromatographie liquide
SE466534B (sv) 1988-12-30 1992-03-02 Exploaterings Ab Tbf Adsorptionsmedel foer metalljoner, proteiner och andra oorganiska och organiska substanser
DE3909018A1 (de) 1989-03-18 1990-09-20 Roehm Gmbh Protein-reinigungsverfahren
SE465155B (sv) 1989-12-19 1991-08-05 Exploaterings Ab Tbf Metallkelatbildande hydrofil polymer foer adsorption etc samt ett saett foer framstaellning av polymeren
DK52791D0 (da) 1991-03-22 1991-03-22 Kem En Tec As Adsorptionsmatricer
AU3664693A (en) 1992-02-13 1993-09-03 Bio-Metric Systems, Inc. Immobilization of chemical species in crosslinked matrices
US5268097A (en) 1992-06-19 1993-12-07 Sepracor Inc. Passivated and stabilized porous mineral oxide supports and method for the preparation and use of same
ATE242485T1 (de) 1993-05-28 2003-06-15 Baylor College Medicine Verfahren und massenspektrometer zur desorption und ionisierung von analyten
US5502022A (en) 1994-05-16 1996-03-26 Biosepra, Inc. Chromatography adsorbents utilizing mercapto heterocyclic ligands
US20040214157A1 (en) 1994-06-29 2004-10-28 Simon C. Burton Chromatographic resins and methods for using same
US5652348A (en) 1994-09-23 1997-07-29 Massey University Chromatographic resins and methods for using same
US5700630A (en) * 1995-03-03 1997-12-23 Fuji Photo Film Co., Ltd. Silver halide photographic material and method for processing the same
US5789578A (en) 1996-01-11 1998-08-04 Massey University Methods for the preparation of resins with ligands attached thereto through a linking group comprising sulfide, sulfoxide or sulfone functionality
ATE441476T1 (de) * 1996-08-30 2009-09-15 Upfront Chromatography As Isolierung von immunoglobulinen
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US6503359B2 (en) * 1999-03-05 2003-01-07 Burstein Technologies, Inc. Monomolecular adhesion methods for manufacturing microfabricated multilaminate devices
US6716445B2 (en) 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
WO2001083515A2 (en) 2000-04-28 2001-11-08 Accurate Polymers, Inc. Simulated activity of protein a displayed by ligands attached to a cellulose bead surface
WO2003064594A2 (en) 2002-01-25 2003-08-07 Ciphergen Biosystems, Inc. Monomers and polymers having energy absorbing moieties of use in desorption/ionization of analytes
US6783673B2 (en) * 2002-08-23 2004-08-31 Biotage, Inc. Composite chromatography column
EP1578527A1 (en) 2002-09-13 2005-09-28 Ciphergen Biosystems, Inc. Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013500291A (ja) * 2009-07-28 2013-01-07 インストラクション・ゲーエムベーハー タンパク質及びペプチドと結合する特定の充填剤、並びに、それを用いた分離方法
JP2013518283A (ja) * 2010-01-27 2013-05-20 インターナショナル・ビジネス・マシーンズ・コーポレーション 分子を検出する半導体デバイスを形成する方法ならびに分子を検出する集積回路、クロマトグラフィ・デバイス及び半導体デバイス
JP2014507649A (ja) * 2011-01-18 2014-03-27 バクスター・インターナショナル・インコーポレイテッド ヒト血液中の抗βアミロイド抗体の測定
JP2013033040A (ja) * 2011-07-27 2013-02-14 Pall Corp 混合モード配位子

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