JP2005539031A - 野生型または変異型eNOSによる重症肢虚血の遺伝子療法 - Google Patents

野生型または変異型eNOSによる重症肢虚血の遺伝子療法 Download PDF

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JP2005539031A
JP2005539031A JP2004529471A JP2004529471A JP2005539031A JP 2005539031 A JP2005539031 A JP 2005539031A JP 2004529471 A JP2004529471 A JP 2004529471A JP 2004529471 A JP2004529471 A JP 2004529471A JP 2005539031 A JP2005539031 A JP 2005539031A
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enos
amino acid
polypeptide
mutation
position corresponding
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JP2005539031A5 (enExample
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ピー. ドール,ウィリアム
カウザー,カタリン
シェン キアン,フ
ルバニー,ガボー
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シエーリング アクチエンゲゼルシャフト
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C12N9/0075Nitric-oxide synthase (1.14.13.39)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Molecular Biology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
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  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2004529471A 2002-08-16 2003-08-15 野生型または変異型eNOSによる重症肢虚血の遺伝子療法 Pending JP2005539031A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40363702P 2002-08-16 2002-08-16
PCT/US2003/025626 WO2004016761A2 (en) 2002-08-16 2003-08-15 Gene therapy for critical limb ischemia with wild type or mutant enos

Publications (2)

Publication Number Publication Date
JP2005539031A true JP2005539031A (ja) 2005-12-22
JP2005539031A5 JP2005539031A5 (enExample) 2006-09-28

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JP2004529471A Pending JP2005539031A (ja) 2002-08-16 2003-08-15 野生型または変異型eNOSによる重症肢虚血の遺伝子療法

Country Status (15)

Country Link
US (1) US20040120930A1 (enExample)
EP (1) EP1536689A4 (enExample)
JP (1) JP2005539031A (enExample)
KR (1) KR20050042162A (enExample)
CN (2) CN101391105A (enExample)
AU (1) AU2003263844A1 (enExample)
BR (1) BR0313515A (enExample)
CA (1) CA2494845A1 (enExample)
IL (1) IL166362A0 (enExample)
MX (1) MXPA05001763A (enExample)
NO (1) NO20051351L (enExample)
PL (1) PL375446A1 (enExample)
RU (1) RU2005107414A (enExample)
WO (1) WO2004016761A2 (enExample)
ZA (1) ZA200502181B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150359862A1 (en) * 2013-01-30 2015-12-17 Board Of Regents Of The University Of Nebraska Compositions and Methods for Treating Complications Associated with Diabetes
CA3025146A1 (en) * 2016-04-29 2017-11-02 Inovio Pharmaceuticals, Inc. The in vivo use of chondroitinase and/or hyaluronidase to enhance delivery of an agent
CN105944243A (zh) * 2016-05-12 2016-09-21 段俊丽 一种eNOS表达与活化的调控装置及周围动脉疾病的治疗装置
IL270388B2 (en) * 2017-05-02 2024-03-01 Univ Miami A method for treating ischemic tissue
CN107802826B (zh) * 2017-10-26 2020-02-18 首都医科大学宣武医院 eNOS突变体在促进血管生成中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000062605A1 (en) * 1999-04-16 2000-10-26 Yale University eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING
JP2002506008A (ja) * 1998-03-09 2002-02-26 セント エリザベス メディカル センター 血管新生を調整するための組成物及び方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1016726A1 (en) * 1998-12-30 2000-07-05 Introgene B.V. Gene therapy to promote angiogenesis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506008A (ja) * 1998-03-09 2002-02-26 セント エリザベス メディカル センター 血管新生を調整するための組成物及び方法
WO2000062605A1 (en) * 1999-04-16 2000-10-26 Yale University eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FEBS LETTERS, vol. 443, JPN6009060777, 1999, pages 285 - 289, ISSN: 0001473917 *
JOURNAL OF CONTROLLED RELEASE, vol. 78, JPN6009060775, January 2002 (2002-01-01), pages 285 - 294, ISSN: 0001473916 *

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Publication number Publication date
EP1536689A2 (en) 2005-06-08
PL375446A1 (en) 2005-11-28
MXPA05001763A (es) 2005-08-19
EP1536689A4 (en) 2006-09-06
CA2494845A1 (en) 2004-02-26
BR0313515A (pt) 2005-10-18
ZA200502181B (en) 2006-09-27
CN1688197A (zh) 2005-10-26
WO2004016761A3 (en) 2005-03-17
CN101391105A (zh) 2009-03-25
NO20051351L (no) 2005-04-28
CN100408101C (zh) 2008-08-06
RU2005107414A (ru) 2006-01-27
KR20050042162A (ko) 2005-05-04
US20040120930A1 (en) 2004-06-24
IL166362A0 (en) 2006-01-16
AU2003263844A1 (en) 2004-03-03
WO2004016761A2 (en) 2004-02-26

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