CA2494845A1 - Gene therapy for critical limb ischemia with wild type or mutant enos - Google Patents
Gene therapy for critical limb ischemia with wild type or mutant enos Download PDFInfo
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- CA2494845A1 CA2494845A1 CA002494845A CA2494845A CA2494845A1 CA 2494845 A1 CA2494845 A1 CA 2494845A1 CA 002494845 A CA002494845 A CA 002494845A CA 2494845 A CA2494845 A CA 2494845A CA 2494845 A1 CA2494845 A1 CA 2494845A1
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- enos
- amino acid
- mutation
- polypeptide
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- 238000003860 storage Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical compound NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 239000005451 thionucleotide Substances 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 108010061238 threonyl-glycine Proteins 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- 108010080629 tryptophan-leucine Proteins 0.000 description 1
- 108010005834 tyrosyl-alanyl-glycine Proteins 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 108010015385 valyl-prolyl-proline Proteins 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 230000006444 vascular growth Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
- C12N9/0075—Nitric-oxide synthase (1.14.13.39)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40363702P | 2002-08-16 | 2002-08-16 | |
| US60/403,637 | 2002-08-16 | ||
| PCT/US2003/025626 WO2004016761A2 (en) | 2002-08-16 | 2003-08-15 | Gene therapy for critical limb ischemia with wild type or mutant enos |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2494845A1 true CA2494845A1 (en) | 2004-02-26 |
Family
ID=31888259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002494845A Abandoned CA2494845A1 (en) | 2002-08-16 | 2003-08-15 | Gene therapy for critical limb ischemia with wild type or mutant enos |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20040120930A1 (enExample) |
| EP (1) | EP1536689A4 (enExample) |
| JP (1) | JP2005539031A (enExample) |
| KR (1) | KR20050042162A (enExample) |
| CN (2) | CN101391105A (enExample) |
| AU (1) | AU2003263844A1 (enExample) |
| BR (1) | BR0313515A (enExample) |
| CA (1) | CA2494845A1 (enExample) |
| IL (1) | IL166362A0 (enExample) |
| MX (1) | MXPA05001763A (enExample) |
| NO (1) | NO20051351L (enExample) |
| PL (1) | PL375446A1 (enExample) |
| RU (1) | RU2005107414A (enExample) |
| WO (1) | WO2004016761A2 (enExample) |
| ZA (1) | ZA200502181B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150359862A1 (en) * | 2013-01-30 | 2015-12-17 | Board Of Regents Of The University Of Nebraska | Compositions and Methods for Treating Complications Associated with Diabetes |
| CA3025146A1 (en) * | 2016-04-29 | 2017-11-02 | Inovio Pharmaceuticals, Inc. | The in vivo use of chondroitinase and/or hyaluronidase to enhance delivery of an agent |
| CN105944243A (zh) * | 2016-05-12 | 2016-09-21 | 段俊丽 | 一种eNOS表达与活化的调控装置及周围动脉疾病的治疗装置 |
| IL270388B2 (en) * | 2017-05-02 | 2024-03-01 | Univ Miami | A method for treating ischemic tissue |
| CN107802826B (zh) * | 2017-10-26 | 2020-02-18 | 首都医科大学宣武医院 | eNOS突变体在促进血管生成中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002506008A (ja) * | 1998-03-09 | 2002-02-26 | セント エリザベス メディカル センター | 血管新生を調整するための組成物及び方法 |
| EP1016726A1 (en) * | 1998-12-30 | 2000-07-05 | Introgene B.V. | Gene therapy to promote angiogenesis |
| SK14692001A3 (sk) * | 1999-04-16 | 2002-09-10 | Yale University | Izolovaná molekula nukleovej kyseliny, izolovaný NOS polypeptid, spôsob stimulácie, spôsob liečby, spôsob identifikácie a nehumánne transgénne zviera |
-
2003
- 2003-08-15 KR KR1020057002657A patent/KR20050042162A/ko not_active Ceased
- 2003-08-15 US US10/642,255 patent/US20040120930A1/en not_active Abandoned
- 2003-08-15 WO PCT/US2003/025626 patent/WO2004016761A2/en not_active Ceased
- 2003-08-15 AU AU2003263844A patent/AU2003263844A1/en not_active Abandoned
- 2003-08-15 CN CNA2008101259592A patent/CN101391105A/zh active Pending
- 2003-08-15 EP EP03788540A patent/EP1536689A4/en not_active Withdrawn
- 2003-08-15 RU RU2005107414/13A patent/RU2005107414A/ru not_active Application Discontinuation
- 2003-08-15 MX MXPA05001763A patent/MXPA05001763A/es not_active Application Discontinuation
- 2003-08-15 JP JP2004529471A patent/JP2005539031A/ja active Pending
- 2003-08-15 PL PL03375446A patent/PL375446A1/xx not_active Application Discontinuation
- 2003-08-15 CN CNB038194945A patent/CN100408101C/zh not_active Expired - Fee Related
- 2003-08-15 BR BR0313515-2A patent/BR0313515A/pt not_active IP Right Cessation
- 2003-08-15 CA CA002494845A patent/CA2494845A1/en not_active Abandoned
-
2005
- 2005-01-18 IL IL16636205A patent/IL166362A0/xx unknown
- 2005-03-15 NO NO20051351A patent/NO20051351L/no not_active Application Discontinuation
- 2005-03-15 ZA ZA200502181A patent/ZA200502181B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1536689A2 (en) | 2005-06-08 |
| PL375446A1 (en) | 2005-11-28 |
| MXPA05001763A (es) | 2005-08-19 |
| EP1536689A4 (en) | 2006-09-06 |
| BR0313515A (pt) | 2005-10-18 |
| ZA200502181B (en) | 2006-09-27 |
| CN1688197A (zh) | 2005-10-26 |
| WO2004016761A3 (en) | 2005-03-17 |
| CN101391105A (zh) | 2009-03-25 |
| NO20051351L (no) | 2005-04-28 |
| CN100408101C (zh) | 2008-08-06 |
| RU2005107414A (ru) | 2006-01-27 |
| KR20050042162A (ko) | 2005-05-04 |
| US20040120930A1 (en) | 2004-06-24 |
| IL166362A0 (en) | 2006-01-16 |
| JP2005539031A (ja) | 2005-12-22 |
| AU2003263844A1 (en) | 2004-03-03 |
| WO2004016761A2 (en) | 2004-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |