KR20050042162A - 야생형 또는 변이체 ｅＮＯＳ를 사용한 위급한 사지 허혈에대한 유전자 요법 - Google Patents
야생형 또는 변이체 ｅＮＯＳ를 사용한 위급한 사지 허혈에대한 유전자 요법 Download PDFInfo
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
- C12N9/0075—Nitric-oxide synthase (1.14.13.39)
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
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- Genetics & Genomics (AREA)
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- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US40363702P | 2002-08-16 | 2002-08-16 | |
| US60/403,637 | 2002-08-16 |
Publications (1)
| Publication Number | Publication Date |
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| KR20050042162A true KR20050042162A (ko) | 2005-05-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| KR1020057002657A Ceased KR20050042162A (ko) | 2002-08-16 | 2003-08-15 | 야생형 또는 변이체 ｅＮＯＳ를 사용한 위급한 사지 허혈에대한 유전자 요법 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20040120930A1 (enExample) |
| EP (1) | EP1536689A4 (enExample) |
| JP (1) | JP2005539031A (enExample) |
| KR (1) | KR20050042162A (enExample) |
| CN (2) | CN101391105A (enExample) |
| AU (1) | AU2003263844A1 (enExample) |
| BR (1) | BR0313515A (enExample) |
| CA (1) | CA2494845A1 (enExample) |
| IL (1) | IL166362A0 (enExample) |
| MX (1) | MXPA05001763A (enExample) |
| NO (1) | NO20051351L (enExample) |
| PL (1) | PL375446A1 (enExample) |
| RU (1) | RU2005107414A (enExample) |
| WO (1) | WO2004016761A2 (enExample) |
| ZA (1) | ZA200502181B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014123749A1 (en) * | 2013-01-30 | 2014-08-14 | Board Of Regents Of The University Of Nebraska | Compositions and methods for treating complications associated with diabetes |
| US20190284263A1 (en) * | 2016-04-29 | 2019-09-19 | Inovio Pharmaceuticals, Inc. | In vivo use of chondroitinase and/or hyaluronidase to enhance delivery of an agent |
| CN105944243A (zh) * | 2016-05-12 | 2016-09-21 | 段俊丽 | 一种eNOS表达与活化的调控装置及周围动脉疾病的治疗装置 |
| KR20200013674A (ko) * | 2017-05-02 | 2020-02-07 | 유니버시티 오브 마이애미 | 허혈 조직을 치료하는 방법 |
| CN107802826B (zh) * | 2017-10-26 | 2020-02-18 | 首都医科大学宣武医院 | eNOS突变体在促进血管生成中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1061800A4 (en) * | 1998-03-09 | 2004-10-06 | Caritas St Elizabeths Boston | COMPOSITIONS AND METHODS FOR MODULATING THE VASCULARIZATION |
| EP1016726A1 (en) * | 1998-12-30 | 2000-07-05 | Introgene B.V. | Gene therapy to promote angiogenesis |
| WO2000062605A1 (en) * | 1999-04-16 | 2000-10-26 | Yale University | eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING |
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2003
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- 2003-08-15 BR BR0313515-2A patent/BR0313515A/pt not_active IP Right Cessation
- 2003-08-15 EP EP03788540A patent/EP1536689A4/en not_active Withdrawn
- 2003-08-15 CA CA002494845A patent/CA2494845A1/en not_active Abandoned
- 2003-08-15 WO PCT/US2003/025626 patent/WO2004016761A2/en not_active Ceased
- 2003-08-15 CN CNA2008101259592A patent/CN101391105A/zh active Pending
- 2003-08-15 PL PL03375446A patent/PL375446A1/xx not_active Application Discontinuation
- 2003-08-15 US US10/642,255 patent/US20040120930A1/en not_active Abandoned
- 2003-08-15 KR KR1020057002657A patent/KR20050042162A/ko not_active Ceased
- 2003-08-15 AU AU2003263844A patent/AU2003263844A1/en not_active Abandoned
- 2003-08-15 MX MXPA05001763A patent/MXPA05001763A/es not_active Application Discontinuation
- 2003-08-15 CN CNB038194945A patent/CN100408101C/zh not_active Expired - Fee Related
- 2003-08-15 RU RU2005107414/13A patent/RU2005107414A/ru not_active Application Discontinuation
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2005
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- 2005-03-15 NO NO20051351A patent/NO20051351L/no not_active Application Discontinuation
- 2005-03-15 ZA ZA200502181A patent/ZA200502181B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1536689A4 (en) | 2006-09-06 |
| IL166362A0 (en) | 2006-01-16 |
| MXPA05001763A (es) | 2005-08-19 |
| JP2005539031A (ja) | 2005-12-22 |
| AU2003263844A1 (en) | 2004-03-03 |
| US20040120930A1 (en) | 2004-06-24 |
| EP1536689A2 (en) | 2005-06-08 |
| CA2494845A1 (en) | 2004-02-26 |
| NO20051351L (no) | 2005-04-28 |
| WO2004016761A3 (en) | 2005-03-17 |
| CN100408101C (zh) | 2008-08-06 |
| BR0313515A (pt) | 2005-10-18 |
| PL375446A1 (en) | 2005-11-28 |
| CN101391105A (zh) | 2009-03-25 |
| CN1688197A (zh) | 2005-10-26 |
| WO2004016761A2 (en) | 2004-02-26 |
| RU2005107414A (ru) | 2006-01-27 |
| ZA200502181B (en) | 2006-09-27 |
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