JP2005538685A5 - - Google Patents
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- Publication number
- JP2005538685A5 JP2005538685A5 JP2003560026A JP2003560026A JP2005538685A5 JP 2005538685 A5 JP2005538685 A5 JP 2005538685A5 JP 2003560026 A JP2003560026 A JP 2003560026A JP 2003560026 A JP2003560026 A JP 2003560026A JP 2005538685 A5 JP2005538685 A5 JP 2005538685A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- embryo
- lentiviral vector
- interest
- nucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 37
- 239000013598 vector Substances 0.000 claims 28
- 210000001161 mammalian embryo Anatomy 0.000 claims 25
- 239000002773 nucleotide Substances 0.000 claims 16
- 125000003729 nucleotide group Chemical group 0.000 claims 16
- 210000000170 cell membrane Anatomy 0.000 claims 14
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 11
- 210000000287 oocyte Anatomy 0.000 claims 10
- 210000004340 zona pellucida Anatomy 0.000 claims 10
- 210000002459 blastocyst Anatomy 0.000 claims 7
- 239000013603 viral vector Substances 0.000 claims 7
- 241000725303 Human immunodeficiency virus Species 0.000 claims 4
- 241000713311 Simian immunodeficiency virus Species 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 4
- 210000000472 morula Anatomy 0.000 claims 3
- 241000271566 Aves Species 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 2
- 241000699670 Mus sp. Species 0.000 claims 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 2
- 241000700159 Rattus Species 0.000 claims 2
- 238000000520 microinjection Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000000625 blastula Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34484101P | 2001-12-21 | 2001-12-21 | |
| US39847602P | 2002-07-25 | 2002-07-25 | |
| PCT/US2002/041020 WO2003059923A2 (en) | 2001-12-21 | 2002-12-19 | Methods and compositions for generating a genetically modified animal using lentiviral vectors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005538685A JP2005538685A (ja) | 2005-12-22 |
| JP2005538685A5 true JP2005538685A5 (enExample) | 2006-02-09 |
Family
ID=26994121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003560026A Pending JP2005538685A (ja) | 2001-12-21 | 2002-12-19 | レンチウイルスベクターを使用して遺伝的に改変された動物を生成するための方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20030167500A1 (enExample) |
| EP (1) | EP1465981A4 (enExample) |
| JP (1) | JP2005538685A (enExample) |
| KR (1) | KR20040089096A (enExample) |
| CN (1) | CN1633495A (enExample) |
| AU (1) | AU2002367024A1 (enExample) |
| CA (1) | CA2470527A1 (enExample) |
| WO (1) | WO2003059923A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103397019A (zh) | 2003-11-21 | 2013-11-20 | 雷维维科公司 | 干扰rna在生产转基因动物中的用途 |
| US7732180B2 (en) | 2004-05-07 | 2010-06-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Porcine Forssman synthetase protein, cDNA, genomic organization, and regulatory region |
| EP2573185A3 (en) * | 2005-02-16 | 2013-06-05 | Lentigen Corporation | Lentiviral vectors and their use |
| AU2006292827B2 (en) | 2005-08-09 | 2013-02-14 | Revivicor, Inc. | Transgenic ungulates expressing CTLA4-IG and uses thereof |
| GB0702694D0 (en) * | 2007-02-12 | 2007-03-21 | Ark Therapeutics Ltd | Vectors |
| EP2246423B1 (en) * | 2008-01-29 | 2016-03-23 | Central Institute For Experimental Animals | Method for introducing a foreign gene into an early embryo of a marmoset, method for producing a transgenic marmoset comprising such method, and transgenic marmoset |
| CN101717788B (zh) * | 2009-11-10 | 2012-06-20 | 中国农业大学 | 慢病毒感染胚胎的方法 |
| EP2675901B1 (en) | 2011-02-14 | 2018-05-30 | Revivicor, Inc. | Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof |
| WO2017214937A1 (zh) * | 2016-06-16 | 2017-12-21 | 毛侃琅 | 一种促进 app 基因表达的慢病毒表达载体及其应用 |
| US10828330B2 (en) | 2017-02-22 | 2020-11-10 | IO Bioscience, Inc. | Nucleic acid constructs comprising gene editing multi-sites and uses thereof |
| US12440578B2 (en) | 2017-02-22 | 2025-10-14 | Io Biosciences, Inc. | Nucleic acid constructs comprising gene editing multi-sites and uses thereof |
| KR20230107335A (ko) | 2020-11-20 | 2023-07-14 | 레비비코르 인코포레이션 | 이종이식을 위한 성장 호르몬 수용체 녹아웃을 갖는 다중-전이유전자 돼지 |
| CN118434281A (zh) | 2021-09-20 | 2024-08-02 | 雷维维科公司 | 用于异种移植的包含十个基因修饰的多转基因猪 |
| WO2025158071A1 (en) * | 2024-01-26 | 2025-07-31 | Sartorius Albumedix Limited | Retroviral preparations containing albumin for enhancing transduction efficiency, uses thereof for cell transduction |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5633076A (en) * | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| ATE408015T1 (de) * | 1995-04-14 | 2008-09-15 | Univ Alabama Res Found | Transfer system basierend auf einem fusionsprotein und seine anwendungen. |
| AU4984697A (en) * | 1996-10-11 | 1998-05-11 | The Texas A & M University System | Methods for the generation of primordial germ cells and transgenic animal species |
| US6080912A (en) * | 1997-03-20 | 2000-06-27 | Wisconsin Alumni Research Foundation | Methods for creating transgenic animals |
| US6207455B1 (en) * | 1997-05-01 | 2001-03-27 | Lung-Ji Chang | Lentiviral vectors |
| ATE426036T1 (de) * | 1997-11-14 | 2009-04-15 | Cedars Sinai Medical Center | Transfektion und transfer nicht humaner mannlicher keimzellen zur generierung transgener nicht humaner saugetiere |
| US6555342B1 (en) * | 1998-06-03 | 2003-04-29 | Uab Research Foundation | Fusion protein delivery system and uses thereof |
| US6313373B1 (en) * | 1998-10-30 | 2001-11-06 | Case Western Reserve University | Tissue specific promoters and transgenic mouse for the screening of pharmaceuticals |
-
2002
- 2002-12-19 US US10/325,459 patent/US20030167500A1/en not_active Abandoned
- 2002-12-19 AU AU2002367024A patent/AU2002367024A1/en not_active Abandoned
- 2002-12-19 CN CNA028282469A patent/CN1633495A/zh active Pending
- 2002-12-19 CA CA002470527A patent/CA2470527A1/en not_active Abandoned
- 2002-12-19 KR KR10-2004-7009817A patent/KR20040089096A/ko not_active Withdrawn
- 2002-12-19 WO PCT/US2002/041020 patent/WO2003059923A2/en not_active Ceased
- 2002-12-19 JP JP2003560026A patent/JP2005538685A/ja active Pending
- 2002-12-19 EP EP02806493A patent/EP1465981A4/en not_active Withdrawn
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