CN1633495A - 利用慢病毒载体产生基因修饰动物的方法和组合物 - Google Patents

利用慢病毒载体产生基因修饰动物的方法和组合物 Download PDF

Info

Publication number
CN1633495A
CN1633495A CNA028282469A CN02828246A CN1633495A CN 1633495 A CN1633495 A CN 1633495A CN A028282469 A CNA028282469 A CN A028282469A CN 02828246 A CN02828246 A CN 02828246A CN 1633495 A CN1633495 A CN 1633495A
Authority
CN
China
Prior art keywords
nucleotide sequence
virus
composition
lentiviral vectors
interested
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA028282469A
Other languages
English (en)
Chinese (zh)
Inventor
R·拉马哈德兰
F·科恩特金
J·维基菲尔德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ozgene Pty Ltd
Original Assignee
Ozgene Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ozgene Pty Ltd filed Critical Ozgene Pty Ltd
Publication of CN1633495A publication Critical patent/CN1633495A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/867—Retroviral vectors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Husbandry (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CNA028282469A 2001-12-21 2002-12-19 利用慢病毒载体产生基因修饰动物的方法和组合物 Pending CN1633495A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34484101P 2001-12-21 2001-12-21
US60/344,841 2001-12-21
US39847602P 2002-07-25 2002-07-25
US60/398,476 2002-07-25

Publications (1)

Publication Number Publication Date
CN1633495A true CN1633495A (zh) 2005-06-29

Family

ID=26994121

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA028282469A Pending CN1633495A (zh) 2001-12-21 2002-12-19 利用慢病毒载体产生基因修饰动物的方法和组合物

Country Status (8)

Country Link
US (1) US20030167500A1 (enExample)
EP (1) EP1465981A4 (enExample)
JP (1) JP2005538685A (enExample)
KR (1) KR20040089096A (enExample)
CN (1) CN1633495A (enExample)
AU (1) AU2002367024A1 (enExample)
CA (1) CA2470527A1 (enExample)
WO (1) WO2003059923A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102016029A (zh) * 2008-01-29 2011-04-13 学校法人庆应义墪 将外源基因导入灵长类动物的早期胚胎的方法和包含该方法的生产转基因灵长类动物的方法
CN101717788B (zh) * 2009-11-10 2012-06-20 中国农业大学 慢病毒感染胚胎的方法
WO2017214937A1 (zh) * 2016-06-16 2017-12-21 毛侃琅 一种促进 app 基因表达的慢病毒表达载体及其应用

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004316293A1 (en) 2003-11-21 2005-09-09 Revivicor, Inc. Use of interfering RNA in the production of transgenic animals
AU2005243169A1 (en) 2004-05-07 2005-11-24 University Of Pittsburgh Of The Commonwealth System Of Higher Education Porcine Forssman synthetase protein, cDNA, genomic organization, and regulatory region
EP1858332A4 (en) * 2005-02-16 2011-06-22 Lentigen Corp LENTIVIRUS VECTORS AND ITS USE
CA2617930A1 (en) 2005-08-09 2007-03-29 Revivicor, Inc. Transgenic ungulates expressing ctla4-ig and uses thereof
GB0702694D0 (en) * 2007-02-12 2007-03-21 Ark Therapeutics Ltd Vectors
NZ759163A (en) 2011-02-14 2023-03-31 Revivicor Inc Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
CA3054307A1 (en) 2017-02-22 2018-08-30 Io Biosciences, Inc. Nucleic acid constructs comprising gene editing multi-sites and uses thereof
US10828330B2 (en) 2017-02-22 2020-11-10 IO Bioscience, Inc. Nucleic acid constructs comprising gene editing multi-sites and uses thereof
KR20230107335A (ko) 2020-11-20 2023-07-14 레비비코르 인코포레이션 이종이식을 위한 성장 호르몬 수용체 녹아웃을 갖는 다중-전이유전자 돼지
JP2024534702A (ja) 2021-09-20 2024-09-20 レバイビコア，インコーポレイティド 異種移植のための１０個の遺伝子改変を含むマルチトランスジェニックブタ
WO2025158071A1 (en) * 2024-01-26 2025-07-31 Sartorius Albumedix Limited Retroviral preparations containing albumin for enhancing transduction efficiency, uses thereof for cell transduction

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633076A (en) * 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
EP0873415B1 (en) * 1995-04-14 2008-09-10 University Of Alabama Research Foundation Fusion protein delivery system and uses thereof
EP0941310A1 (en) * 1996-10-11 1999-09-15 THE TEXAS A&M UNIVERSITY SYSTEM Methods for the generation of primordial germ cells and transgenic animal species
US6080912A (en) * 1997-03-20 2000-06-27 Wisconsin Alumni Research Foundation Methods for creating transgenic animals
US6207455B1 (en) * 1997-05-01 2001-03-27 Lung-Ji Chang Lentiviral vectors
EP1030929B1 (en) * 1997-11-14 2009-03-18 Cedars-Sinai Medical Center Transfection and transfer of non-human male germ cells for generation of transgenic non-human mammals
US6555342B1 (en) * 1998-06-03 2003-04-29 Uab Research Foundation Fusion protein delivery system and uses thereof
WO2000026343A2 (en) * 1998-10-30 2000-05-11 Case Western Reserve University Tissue specific promoters and transgenic animals for the screening of pharmaceuticals

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102016029A (zh) * 2008-01-29 2011-04-13 学校法人庆应义墪 将外源基因导入灵长类动物的早期胚胎的方法和包含该方法的生产转基因灵长类动物的方法
CN102016029B (zh) * 2008-01-29 2014-11-26 学校法人庆应义墪 将外源基因导入灵长类动物的早期胚胎的方法和包含该方法的生产转基因灵长类动物的方法
CN102016029B8 (zh) * 2008-01-29 2017-08-01 学校法人庆应义塾 将外源基因导入灵长类动物的早期胚胎的方法和包含该方法的生产转基因灵长类动物的方法
CN101717788B (zh) * 2009-11-10 2012-06-20 中国农业大学 慢病毒感染胚胎的方法
WO2017214937A1 (zh) * 2016-06-16 2017-12-21 毛侃琅 一种促进 app 基因表达的慢病毒表达载体及其应用

Also Published As

Publication number Publication date
EP1465981A2 (en) 2004-10-13
KR20040089096A (ko) 2004-10-20
CA2470527A1 (en) 2003-07-24
EP1465981A4 (en) 2006-04-12
AU2002367024A1 (en) 2003-07-30
WO2003059923A2 (en) 2003-07-24
WO2003059923A3 (en) 2003-10-30
US20030167500A1 (en) 2003-09-04
JP2005538685A (ja) 2005-12-22

Similar Documents

Publication Publication Date Title
AU2002353231B2 (en) Method for producing a transgenic organism using a lentiviral expression vector such as EIAV
Park Lentiviral vectors: are they the future of animal transgenesis?
Pfeifer Lentiviral transgenesis
CN1633495A (zh) 利用慢病毒载体产生基因修饰动物的方法和组合物
US20020129393A1 (en) Transgenic animals
US20040234504A1 (en) Methods of inhibiting gene expression by RNA interference
CN1426477A (zh) 方法
CN1759182A (zh) 调节基因的组合物和系统
US20090210952A1 (en) Compositions and Methods Related to Controlled Gene Expression Using Viral Vectors
CN1820072A (zh) 转基因禽类中的蛋白质生产
US6372956B1 (en) Transgenic rats and rat cell lines expressing human CD4 and a human chemokine receptor
CN1643164A (zh) 以重组牛免疫缺陷病毒为基础的基因转移系统
Chandrashekran et al. Efficient generation of transgenic mice by lentivirus‐mediated modification of spermatozoa
US20120270773A1 (en) Trim5alpha mutants and uses thereof
CN1248286A (zh) 含有重组血管内皮生长因子b(vegf－b)dna的转基因动物及其用途
Morioka et al. Placenta‐specific gene activation and inactivation using integrase‐defective lentiviral vectors with the Cre/LoxP system
US20030121062A1 (en) Transgenic organism
HK1076483A (en) Methods and compositions for generating a genetically modified animal using lentiviral vectors
Cheng et al. Lentiviral transgenesis in mice via a simple method of viral concentration
Shaughnessy et al. Novel approaches to models of Alzheimer’s disease pathology for drug screening and development
Carlos et al. Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors
Nakagawa et al. Generation of lentiviral transgenic rats expressing glutamate receptor interacting protein 1 (GRIP1) in brain, spinal cord and testis
Pfeifer et al. Lentivirus transgenesis
WO2000030437A9 (en) Transgenic animals
Zhao et al. Production of transgenic pigs with an introduced missense mutation of the bone morphogenetic protein receptor type IB gene related to prolificacy

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1076483

Country of ref document: HK

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1076483

Country of ref document: HK