NO20076465L - PIGG YBAC som et verktoy for genetisk manipulasjon og analyser i vertebrater - Google Patents
PIGG YBAC som et verktoy for genetisk manipulasjon og analyser i vertebraterInfo
- Publication number
- NO20076465L NO20076465L NO20076465A NO20076465A NO20076465L NO 20076465 L NO20076465 L NO 20076465L NO 20076465 A NO20076465 A NO 20076465A NO 20076465 A NO20076465 A NO 20076465A NO 20076465 L NO20076465 L NO 20076465L
- Authority
- NO
- Norway
- Prior art keywords
- vertebrates
- ybac
- pigg
- tool
- analysis
- Prior art date
Links
- 241000251539 Vertebrata <Metazoa> Species 0.000 title abstract 2
- 238000012252 genetic analysis Methods 0.000 title 1
- 238000010353 genetic engineering Methods 0.000 title 1
- 230000009261 transgenic effect Effects 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Environmental Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Biochemistry (AREA)
- Animal Husbandry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Den foreliggende oppfinnelsen vedrører transgene virveldyr, inkludert pattedyr, celler, hvis genomer omfatter én eller flere elementer av piggyBac-farnilietransposonsystemet. Transgene, ikke-humane virveldyr inkludert transgene, ikke-humane pattedyr, hvis genom omfatter ett eller flere elementer av piggyBac-familietransposonsystemet, ble også tilveiebrakt. Fremgangsmåter for å lage og anvende cellene og dyrene i oppfinnelsen inkludert søknader i det medisinske, veterinære og landbruksfeltet, blir også tilveiebrakt. Den foreliggende oppfinnelsen vedrører også kitt som er nyttige for å utføre slike fremgangsmåter.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2005/000674 WO2006122442A1 (en) | 2005-05-14 | 2005-05-14 | Piggybac as a tool for genetic manipulation and analysis in vertebrates |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20076465L true NO20076465L (no) | 2008-02-04 |
Family
ID=37430916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20076465A NO20076465L (no) | 2005-05-14 | 2007-12-14 | PIGG YBAC som et verktoy for genetisk manipulasjon og analyser i vertebrater |
Country Status (11)
Country | Link |
---|---|
US (1) | US20100154070A1 (no) |
EP (1) | EP1896578A4 (no) |
JP (1) | JP2008545375A (no) |
CN (1) | CN101297031B (no) |
AU (1) | AU2005331864A1 (no) |
BR (1) | BRPI0520212A2 (no) |
CA (1) | CA2608481A1 (no) |
IL (1) | IL187348A0 (no) |
MX (1) | MX2007014139A (no) |
NO (1) | NO20076465L (no) |
WO (1) | WO2006122442A1 (no) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10087463B2 (en) * | 2000-10-31 | 2018-10-02 | University Of Notre Dame Du Lac | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector piggyBac |
WO2008027384A1 (en) * | 2006-08-28 | 2008-03-06 | University Of Hawaii | Methods and compositions for transposon-mediated transgenesis |
WO2008098181A2 (en) * | 2007-02-09 | 2008-08-14 | University Of Utah Research Foundation | In vivo genome-wide mutagenesis |
US20090042297A1 (en) * | 2007-06-01 | 2009-02-12 | George Jr Alfred L | Piggybac transposon-based vectors and methods of nucleic acid integration |
EP2185692A4 (en) | 2007-08-10 | 2012-05-02 | Medarex Inc | HCO32 AND HCO27 AND RELATED EXAMPLES |
WO2010099296A1 (en) | 2009-02-26 | 2010-09-02 | Transposagen Biopharmaceuticals, Inc. | Hyperactive piggybac transposases |
HUE055817T2 (hu) * | 2009-07-08 | 2021-12-28 | Kymab Ltd | Állatmodellek és terápiás molekulák |
US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
CN101851637B (zh) * | 2010-01-15 | 2011-12-14 | 中国农业科学院北京畜牧兽医研究所 | 一种制备同时表达多个基因的转基因动物的方法 |
US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
SI3095871T1 (sl) | 2010-02-08 | 2019-06-28 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
RS61946B1 (sr) | 2011-08-05 | 2021-07-30 | Regeneron Pharma | Humanizovani miševi univerzalnog lakog lakca |
CA2846319A1 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Antibodies, variable domains & chains tailored for human use |
WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
CN102943092B (zh) * | 2012-11-20 | 2014-12-10 | 西北农林科技大学 | 一种通用型PiggyBac转座子转基因载体及其制备方法 |
US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
WO2014196931A1 (en) * | 2013-06-06 | 2014-12-11 | Agency For Science, Technology And Research | A transposon for genome manipulation |
CA2919503C (en) * | 2013-07-12 | 2019-06-25 | University Of South Alabama | Minimal piggybac vectors for genome integration |
TW201546284A (zh) | 2013-10-01 | 2015-12-16 | Kymab Ltd | 動物模式及治療分子 |
AU2014348291A1 (en) * | 2013-11-18 | 2016-05-19 | Yale University | Compositions and methods of using transposons |
WO2015108993A1 (en) * | 2014-01-14 | 2015-07-23 | Lam Therapeutics, Inc. | Mutagenesis methods |
US10881085B2 (en) | 2014-03-21 | 2021-01-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
US9534234B2 (en) * | 2014-04-09 | 2017-01-03 | Dna2.0, Inc. | Enhanced nucleic acid constructs for eukaryotic gene expression |
US10344285B2 (en) | 2014-04-09 | 2019-07-09 | Dna2.0, Inc. | DNA vectors, transposons and transposases for eukaryotic genome modification |
EP3271403A1 (en) | 2015-03-19 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
CN106521638A (zh) * | 2015-09-09 | 2017-03-22 | 潘雨堃 | 一种基因突变大鼠资源库及其制备方法 |
CN106544359B (zh) * | 2015-09-22 | 2019-07-19 | 复旦大学 | Gpr45基因的用途 |
CA3001312A1 (en) | 2015-10-08 | 2017-04-13 | Dna2.0, Inc. | Dna vectors, transposons and transposases for eukaryotic genome modification |
MX2018007203A (es) * | 2015-12-14 | 2018-11-12 | Genomefrontier Therapeutics Inc | Sistema de transposon, kit que comprende el mismo, y sus usos. |
CN108779469A (zh) * | 2016-03-25 | 2018-11-09 | 基因体先驱生医股份有限公司 | 用以建构转位子的套组及其用途 |
EP3556855A4 (en) * | 2016-12-14 | 2020-07-15 | Shinshu University | GENE-MODIFIED LYMPHOCYT WITH CHIMERAL ANTIGENT RECEPTOR WITH CELL-DESTRUCTING EFFECT |
JP7203367B2 (ja) * | 2017-12-14 | 2023-01-16 | 公益財団法人実験動物中央研究所 | 哺乳動物細胞用遺伝子導入ベクター |
EP3794128A1 (en) * | 2018-05-18 | 2021-03-24 | Sorbonne Universite | Molecular tools and methods for transgene integration and their transposition dependent expression |
WO2020047124A1 (en) * | 2018-08-28 | 2020-03-05 | Flagship Pioneering, Inc. | Methods and compositions for modulating a genome |
CN113348248A (zh) | 2018-10-24 | 2021-09-03 | 思兰克斯有限公司 | 表达系统、重组细胞及其用途 |
JP7418469B2 (ja) * | 2019-04-08 | 2024-01-19 | ディーエヌエー ツーポイントオー インク. | アミエロイス由来のトランスポザーゼを用いた核酸コンストラクトの真核生物のゲノムへの転移 |
KR20210143897A (ko) * | 2019-04-08 | 2021-11-29 | 디앤에이 투포인토 인크. | 오리지아스로부터의 트랜스포사제를 이용한 핵산 작제물의 진핵세포로의 통합 |
CN111909986B (zh) * | 2019-05-10 | 2024-03-26 | 潘雨堃 | 一种基因治疗安全评估与毒副作用预防的方法 |
JP2021016371A (ja) * | 2019-07-23 | 2021-02-15 | 株式会社東芝 | Car−t細胞の製造方法、核酸導入キャリア及びキット |
JP2021016370A (ja) * | 2019-07-23 | 2021-02-15 | 株式会社東芝 | 核酸導入キャリア、核酸導入キャリアセット、核酸導入組成物及び核酸導入方法 |
US20230203530A1 (en) * | 2020-02-19 | 2023-06-29 | WuXi Biologics Ireland Limited | Enhanced expression system and methods of use thereof |
CN113584083A (zh) | 2020-04-30 | 2021-11-02 | 深圳市深研生物科技有限公司 | 用于逆转录病毒载体的生产细胞和包装细胞及其制备方法 |
CN111534542A (zh) * | 2020-05-07 | 2020-08-14 | 西南大学 | piggyBac转座子系统介导的真核生物转基因细胞系及构建方法 |
CN113930447A (zh) * | 2020-07-13 | 2022-01-14 | 黄菁 | 对非人动物进行基因改造和构建免疫缺陷动物模型的方法 |
AU2022343729A1 (en) | 2021-09-09 | 2024-03-21 | Iovance Biotherapeutics, Inc. | Processes for generating til products using pd-1 talen knockdown |
WO2023147488A1 (en) | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | Cytokine associated tumor infiltrating lymphocytes compositions and methods |
WO2024112571A2 (en) | 2022-11-21 | 2024-05-30 | Iovance Biotherapeutics, Inc. | Two-dimensional processes for the expansion of tumor infiltrating lymphocytes and therapies therefrom |
WO2024118836A1 (en) | 2022-11-30 | 2024-06-06 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes with shortened rep step |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6218185B1 (en) * | 1996-04-19 | 2001-04-17 | The United States Of America As Represented By The Secretary Of Agriculture | Piggybac transposon-based genetic transformation system for insects |
US20030150007A1 (en) * | 2000-03-21 | 2003-08-07 | Charalambos Savakis | Method of generating transgenic organisms using transposons |
US6962810B2 (en) * | 2000-10-31 | 2005-11-08 | University Of Notre Dame Du Lac | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector piggyBac |
DE60329366D1 (de) * | 2002-01-09 | 2009-11-05 | Univ Erasmus Medical Ct | Induktierbare transposition beim transgenen organismus mit transposon-vektor |
CN1234871C (zh) * | 2003-03-27 | 2006-01-04 | 成都天创生物科技有限责任公司 | 一种解毒酶基因在家蚕中稳定表达系统的构建方法 |
-
2005
- 2005-05-14 CA CA002608481A patent/CA2608481A1/en not_active Abandoned
- 2005-05-14 US US11/920,410 patent/US20100154070A1/en not_active Abandoned
- 2005-05-14 CN CN2005800510732A patent/CN101297031B/zh active Active
- 2005-05-14 WO PCT/CN2005/000674 patent/WO2006122442A1/en active Application Filing
- 2005-05-14 BR BRPI0520212-4A patent/BRPI0520212A2/pt not_active IP Right Cessation
- 2005-05-14 JP JP2008510382A patent/JP2008545375A/ja not_active Abandoned
- 2005-05-14 MX MX2007014139A patent/MX2007014139A/es not_active Application Discontinuation
- 2005-05-14 AU AU2005331864A patent/AU2005331864A1/en not_active Abandoned
- 2005-05-14 EP EP05745159A patent/EP1896578A4/en not_active Withdrawn
-
2007
- 2007-11-13 IL IL187348A patent/IL187348A0/en unknown
- 2007-12-14 NO NO20076465A patent/NO20076465L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL187348A0 (en) | 2008-04-13 |
US20100154070A1 (en) | 2010-06-17 |
EP1896578A4 (en) | 2008-11-05 |
CA2608481A1 (en) | 2006-11-23 |
CN101297031B (zh) | 2013-06-05 |
AU2005331864A1 (en) | 2006-11-23 |
MX2007014139A (es) | 2008-10-09 |
BRPI0520212A2 (pt) | 2009-08-18 |
JP2008545375A (ja) | 2008-12-18 |
WO2006122442A1 (en) | 2006-11-23 |
EP1896578A1 (en) | 2008-03-12 |
CN101297031A (zh) | 2008-10-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20076465L (no) | PIGG YBAC som et verktoy for genetisk manipulasjon og analyser i vertebrater | |
Xiang et al. | The evolutionary road from wild moth to domestic silkworm | |
de Paula et al. | Energy, ageing, fidelity and sex: oocyte mitochondrial DNA as a protected genetic template | |
Wells et al. | Genome‐editing technologies to improve research, reproduction, and production in pigs | |
NO20076024L (no) | Anti-IL-6 antistoffer, sammensetninger, fremgangsmater og anvendelser | |
NO20074916L (no) | P-cadherin antistoff | |
DK1049372T3 (da) | Full-term udvikling af dyr fra enukleerede oocyter rekonstitueret med adulte somatiske cellekerner | |
NO20073905L (no) | Middsammensetning, anvendelse derav, fremgangsmate for a fremavle en phytoseiid predatorisk midd, fremavlingssystem for a fremavle den phytoseiide predatoriske midden og fremgangsmater for biologisk pestkontroll pa en avling | |
DK1954811T3 (da) | Inducerbare ekspressionssystemer | |
Arnqvist et al. | Genome size correlates with reproductive fitness in seed beetles | |
Sandrin et al. | Multiple paternity and mating group size in the E uropean earwig, F orficula auricularia | |
EP1534066A4 (en) | CELLS WITHOUT ALPHA (1,3) -GALACTOSYLTRANSFERASE, METHODS OF SELECTION, AND PORK HAVING ALPHA (1,3) -GALACTOSYLTRANSFERASE THUS OBTAINED | |
Pineda et al. | Opportunities and challenges for improving the productivity of swamp buffaloes in Southeastern Asia | |
Simmons et al. | Nongenetic paternal effects via seminal fluid | |
Todd et al. | A genome-wide scan for candidate lethal variants in Thoroughbred horses | |
Atkinson et al. | An assessment of the genetic diversity of the founders of the European captive population of Asian lion (Panthera leo leo), using microsatellite markers and studbook analysis | |
Iqbal et al. | Conservation of endangered species through somatic cell nuclear transfer (SCNT) | |
Brandies et al. | Disentangling the mechanisms of mate choice in a captive koala population | |
NO20074061L (no) | DNA markorer for storfevekst | |
CY1112746T1 (el) | Κρυοσυντηρηση ηπατοκυτταρων | |
JP2005538685A5 (no) | ||
Chen et al. | Marker-assisted mapping enables effective forward genetic analysis in the arboviral vector Aedes aegypti, a species with vast recombination deserts | |
Rueger et al. | Resolving genealogical relationships in the Pyjama cardinalfish, Sphaeramia nematoptera (Apogonidae) with 23 novel microsatellite markers | |
Mongue et al. | Population differentiation and structural variation in the genome of Manduca sexta across the United States | |
Yang et al. | Divergent methylation pattern in adult stage between two forms of Tetranychus urticae (Acari: Tetranychidae) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |