JP2005537300A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005537300A5 JP2005537300A5 JP2004527055A JP2004527055A JP2005537300A5 JP 2005537300 A5 JP2005537300 A5 JP 2005537300A5 JP 2004527055 A JP2004527055 A JP 2004527055A JP 2004527055 A JP2004527055 A JP 2004527055A JP 2005537300 A5 JP2005537300 A5 JP 2005537300A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- atom
- compound according
- optionally substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000001204 N-oxides Chemical class 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 150000004677 hydrates Chemical class 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005059 halophenyl group Chemical group 0.000 claims 1
- -1 hydrate Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 0 CC(CC(C([C@]1*2C1*#C)=C(C)N(*(C)=C(C)CN(C)*=C)C2=O)=**)C1*C1 Chemical compound CC(CC(C([C@]1*2C1*#C)=C(C)N(*(C)=C(C)CN(C)*=C)C2=O)=**)C1*C1 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0218800.1A GB0218800D0 (en) | 2002-08-13 | 2002-08-13 | Chemical compounds |
| PCT/GB2003/003501 WO2004014920A1 (en) | 2002-08-13 | 2003-08-11 | Bicyclic heteroaromatic compounds as kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005537300A JP2005537300A (ja) | 2005-12-08 |
| JP2005537300A5 true JP2005537300A5 (https=) | 2006-09-14 |
Family
ID=9942221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004527055A Pending JP2005537300A (ja) | 2002-08-13 | 2003-08-11 | キナーゼ阻害剤としての二環式複素芳香族化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7592455B2 (https=) |
| EP (1) | EP1539769A1 (https=) |
| JP (1) | JP2005537300A (https=) |
| AU (1) | AU2003252990B2 (https=) |
| CA (1) | CA2495518A1 (https=) |
| GB (1) | GB0218800D0 (https=) |
| WO (1) | WO2004014920A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0214268D0 (en) * | 2002-06-20 | 2002-07-31 | Celltech R&D Ltd | Chemical compounds |
| GB0222743D0 (en) * | 2002-10-01 | 2002-11-06 | Celltech R&D Ltd | Chemical compounds |
| DE602004017609D1 (de) | 2003-06-20 | 2008-12-18 | Ucb Pharma Sa | Verfahren zur herstellung von 3-aminothienopyridon-derivaten |
| AU2004249498B2 (en) * | 2003-06-20 | 2009-11-19 | Ucb Pharma S.A. | Thienopyridone derivatives as kinase inhibitors |
| EP1641804A1 (en) * | 2003-06-20 | 2006-04-05 | Celltech R & D Limited | Thienopyridone derivatives as kinase inhibitors |
| AU2004285752A1 (en) * | 2003-10-24 | 2005-05-12 | Ucb Pharma S.A. | Thieno-pyridinone derivatives as kinase inhibitors |
| US8017781B2 (en) | 2005-11-15 | 2011-09-13 | Vertex Pharmaceuticals Incorporated | Azaindazoles useful as inhibitors of kinases |
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| JP2010513370A (ja) * | 2006-12-19 | 2010-04-30 | エフ．ホフマン−ラ ロシュ アーゲー | ピラゾロ［３，４−ｄ］ピリミジンｐ３８ＭＡＰキナーゼインヒビター |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| US8722894B2 (en) | 2007-09-14 | 2014-05-13 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
| US8252937B2 (en) | 2007-09-14 | 2012-08-28 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones |
| PL2203439T3 (pl) | 2007-09-14 | 2011-06-30 | Addex Pharmaceuticals Sa | 1',3'-dipodstawione-4-fenylo-3,4,5,6-tetrahydro-2H, 1'H-[1, 4']bipirydynylo-2'-ketony |
| RU2492170C9 (ru) | 2007-11-14 | 2013-12-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2 |
| JP5547194B2 (ja) | 2008-09-02 | 2014-07-09 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体 |
| RU2517181C2 (ru) | 2008-10-16 | 2014-05-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов |
| WO2010060589A1 (en) | 2008-11-28 | 2010-06-03 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| MY153912A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 1, 2, 4,-triazolo[4,3-a[pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CA2806670A1 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| US9845489B2 (en) | 2010-07-26 | 2017-12-19 | Biomatrica, Inc. | Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| PL2649069T3 (pl) | 2010-11-08 | 2016-01-29 | Janssen Pharmaceuticals Inc | Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2 |
| CN103261195B (zh) | 2010-11-08 | 2015-09-02 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| US9725703B2 (en) | 2012-12-20 | 2017-08-08 | Biomatrica, Inc. | Formulations and methods for stabilizing PCR reagents |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| CN105491883B (zh) | 2013-06-13 | 2018-11-02 | 生物马特里卡公司 | 细胞稳定化 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| KR20220049612A (ko) | 2014-01-21 | 2022-04-21 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
| HUE053734T2 (hu) | 2014-01-21 | 2021-07-28 | Janssen Pharmaceutica Nv | 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk |
| CN106572650B (zh) | 2014-06-10 | 2021-08-31 | 生物马特里卡公司 | 在环境温度下稳定凝血细胞 |
| SG11201804776SA (en) | 2015-12-08 | 2018-07-30 | Biomatrica Inc | Reduction of erythrocyte sedimentation rate |
| WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3935222A (en) * | 1975-04-16 | 1976-01-27 | E. R. Squibb & Sons, Inc. | 1,4,5,7-Tetrahydropyrazolo[3,4-b]pyridin-6-ones |
| US6048863A (en) * | 1994-04-19 | 2000-04-11 | Takeda Chemical Industries, Ltd. | Condensed-ring thiophene derivatives and thienopyrimidine derivatives, their production and use |
| GB9614718D0 (en) * | 1996-07-12 | 1996-09-04 | Bayer Ag | 3-ureido-pyridofurans and -pyridothiophenes |
| JP2002517486A (ja) * | 1998-06-12 | 2002-06-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | ｐ３８のインヒビター |
| MY141144A (en) * | 2000-03-02 | 2010-03-15 | Smithkline Beecham Corp | 1, 5-disubstituted-3,4-dihydro-1h-pyrimido 4,5-dipyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| GB0124848D0 (en) * | 2001-10-16 | 2001-12-05 | Celltech R&D Ltd | Chemical compounds |
| GB0214268D0 (en) | 2002-06-20 | 2002-07-31 | Celltech R&D Ltd | Chemical compounds |
| WO2004014375A2 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused bicyclic metalloproteinase inhibitors |
| EP1641804A1 (en) | 2003-06-20 | 2006-04-05 | Celltech R & D Limited | Thienopyridone derivatives as kinase inhibitors |
| AU2004249498B2 (en) | 2003-06-20 | 2009-11-19 | Ucb Pharma S.A. | Thienopyridone derivatives as kinase inhibitors |
| AU2004285752A1 (en) | 2003-10-24 | 2005-05-12 | Ucb Pharma S.A. | Thieno-pyridinone derivatives as kinase inhibitors |
-
2002
- 2002-08-13 GB GBGB0218800.1A patent/GB0218800D0/en not_active Ceased
-
2003
- 2003-08-11 AU AU2003252990A patent/AU2003252990B2/en not_active Ceased
- 2003-08-11 CA CA002495518A patent/CA2495518A1/en not_active Abandoned
- 2003-08-11 JP JP2004527055A patent/JP2005537300A/ja active Pending
- 2003-08-11 EP EP03784288A patent/EP1539769A1/en not_active Withdrawn
- 2003-08-11 US US10/524,199 patent/US7592455B2/en not_active Expired - Fee Related
- 2003-08-11 WO PCT/GB2003/003501 patent/WO2004014920A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005537300A5 (https=) | ||
| CN117881678A (zh) | 具有shp2蛋白降解活性的化合物及其医学用途 | |
| EP3461821B1 (en) | Indole carboxamide compounds useful as kinase inhibitors | |
| JP2006503082A5 (https=) | ||
| JP2010509356A5 (https=) | ||
| JP2007517807A5 (https=) | ||
| JP2012503018A5 (https=) | ||
| JP2010505881A5 (https=) | ||
| JP2011500638A5 (https=) | ||
| JP2008510828A5 (https=) | ||
| HRP20130155T1 (hr) | Fuzionirani heterocikliäśki spojevi korisni kao modulatori kinaze | |
| JP2014516360A5 (https=) | ||
| JP2020523388A5 (https=) | ||
| JP2007500129A5 (https=) | ||
| JP2005530722A5 (https=) | ||
| JP2010539110A5 (https=) | ||
| JP2012511564A5 (https=) | ||
| JP2012509263A5 (https=) | ||
| JP2004508304A5 (https=) | ||
| CA2568608A1 (en) | Six membered amino-amide derivatives as angiogenesis inhibitors | |
| JP2012505234A5 (https=) | ||
| JP2019537602A5 (https=) | ||
| JP2006509842A5 (https=) | ||
| JP2018529690A5 (https=) | ||
| CA2965516A1 (en) | Tricyclic atropisomer compounds |