JP2005537300A - キナーゼ阻害剤としての二環式複素芳香族化合物 - Google Patents

キナーゼ阻害剤としての二環式複素芳香族化合物 Download PDF

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JP2005537300A
JP2005537300A JP2004527055A JP2004527055A JP2005537300A JP 2005537300 A JP2005537300 A JP 2005537300A JP 2004527055 A JP2004527055 A JP 2004527055A JP 2004527055 A JP2004527055 A JP 2004527055A JP 2005537300 A JP2005537300 A JP 2005537300A
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ブルッキングス、ダニエル、クリストファー
デーヴィス、ジェレミー、マーティン
ランガム、バリー、ジョン
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セルテック アール アンド ディ リミテッド
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    • C07—ORGANIC CHEMISTRY
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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  • Diabetes (AREA)
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  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
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  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
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JP2004527055A 2002-08-13 2003-08-11 キナーゼ阻害剤としての二環式複素芳香族化合物 Pending JP2005537300A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0218800.1A GB0218800D0 (en) 2002-08-13 2002-08-13 Chemical compounds
PCT/GB2003/003501 WO2004014920A1 (en) 2002-08-13 2003-08-11 Bicyclic heteroaromatic compounds as kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2005537300A true JP2005537300A (ja) 2005-12-08
JP2005537300A5 JP2005537300A5 (https=) 2006-09-14

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JP2004527055A Pending JP2005537300A (ja) 2002-08-13 2003-08-11 キナーゼ阻害剤としての二環式複素芳香族化合物

Country Status (7)

Country Link
US (1) US7592455B2 (https=)
EP (1) EP1539769A1 (https=)
JP (1) JP2005537300A (https=)
AU (1) AU2003252990B2 (https=)
CA (1) CA2495518A1 (https=)
GB (1) GB0218800D0 (https=)
WO (1) WO2004014920A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005530838A (ja) * 2002-06-20 2005-10-13 セルテック アール アンド ディ リミテッド Ｐ３８キナーゼインヒビターとしてのアリールアミン置換二環式ヘテロ芳香族化合物
JP2010513370A (ja) * 2006-12-19 2010-04-30 エフ．ホフマン−ラ ロシュ アーゲー ピラゾロ［３，４−ｄ］ピリミジンｐ３８ＭＡＰキナーゼインヒビター

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* Cited by examiner, † Cited by third party
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GB0222743D0 (en) * 2002-10-01 2002-11-06 Celltech R&D Ltd Chemical compounds
DE602004017609D1 (de) 2003-06-20 2008-12-18 Ucb Pharma Sa Verfahren zur herstellung von 3-aminothienopyridon-derivaten
AU2004249498B2 (en) * 2003-06-20 2009-11-19 Ucb Pharma S.A. Thienopyridone derivatives as kinase inhibitors
EP1641804A1 (en) * 2003-06-20 2006-04-05 Celltech R & D Limited Thienopyridone derivatives as kinase inhibitors
AU2004285752A1 (en) * 2003-10-24 2005-05-12 Ucb Pharma S.A. Thieno-pyridinone derivatives as kinase inhibitors
US8017781B2 (en) 2005-11-15 2011-09-13 Vertex Pharmaceuticals Incorporated Azaindazoles useful as inhibitors of kinases
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
US8722894B2 (en) 2007-09-14 2014-05-13 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
US8252937B2 (en) 2007-09-14 2012-08-28 Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
PL2203439T3 (pl) 2007-09-14 2011-06-30 Addex Pharmaceuticals Sa 1',3'-dipodstawione-4-fenylo-3,4,5,6-tetrahydro-2H, 1'H-[1, 4']bipirydynylo-2'-ketony
RU2492170C9 (ru) 2007-11-14 2013-12-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2
JP5547194B2 (ja) 2008-09-02 2014-07-09 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体
RU2517181C2 (ru) 2008-10-16 2014-05-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
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