JP2005536464A - カンプトテシンのハロアルキルエステルおよびこれらの化合物を使用する癌治療方法 - Google Patents
カンプトテシンのハロアルキルエステルおよびこれらの化合物を使用する癌治療方法 Download PDFInfo
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- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 229940063683 taxotere Drugs 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/139,817 US6703399B2 (en) | 2002-05-06 | 2002-05-06 | Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds |
| PCT/US2003/012650 WO2003095461A1 (en) | 2002-05-06 | 2003-04-22 | Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005536464A true JP2005536464A (ja) | 2005-12-02 |
| JP2005536464A5 JP2005536464A5 (enExample) | 2006-06-01 |
Family
ID=29399359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004503475A Pending JP2005536464A (ja) | 2002-05-06 | 2003-04-22 | カンプトテシンのハロアルキルエステルおよびこれらの化合物を使用する癌治療方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6703399B2 (enExample) |
| EP (1) | EP1501836A1 (enExample) |
| JP (1) | JP2005536464A (enExample) |
| AU (1) | AU2003231068A1 (enExample) |
| CA (1) | CA2484816C (enExample) |
| WO (1) | WO2003095461A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010500350A (ja) * | 2006-08-11 | 2010-01-07 | ザ クリストゥス ステーリン ファウンデーション フォー キャンサー リサーチ | カンプトテシンのエステルの製造法 |
| JP2014520125A (ja) * | 2011-06-23 | 2014-08-21 | 東北林業大学 | １０−メトキシカンプトテシン誘導体、その製造方法及び使用 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100723454B1 (ko) * | 2004-08-21 | 2007-05-30 | 페어차일드코리아반도체 주식회사 | 높은 열 방출 능력을 구비한 전력용 모듈 패키지 및 그제조방법 |
| US20040204435A1 (en) * | 2003-04-09 | 2004-10-14 | Joachim Liehr | Alternating treatment with topoisomerase I and topoisomerase II inhibitors |
| US7517891B2 (en) * | 2005-10-27 | 2009-04-14 | Glyconix Corporation | Camptothecin derivatives and improved synthetic methods |
| WO2008070009A2 (en) * | 2006-12-01 | 2008-06-12 | Alza Corporation | Treating solid tumors and monocytic leukemia using topoisomerase inhibitors in liposomes |
| US7572803B2 (en) * | 2007-10-25 | 2009-08-11 | The Christus Stehlin Foundation For Cancer Research | Hydrated crystalline esters of camptothecin |
| WO2013071053A1 (en) | 2011-11-11 | 2013-05-16 | The Christus Stehlin Foundation For Cancer Research | Rodent therapeutic model humanized for liver and bone marrow |
| CN103864811A (zh) * | 2012-12-13 | 2014-06-18 | 天津科技大学 | 一种新颖的10-羟基喜树碱20位衍生物制备方法及其在抗肿瘤药物中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612393A (en) * | 1979-07-10 | 1981-02-06 | Yakult Honsha Co Ltd | Novel camptothecin derivative |
| JP2004537592A (ja) * | 2001-08-10 | 2004-12-16 | フアルマシア・イタリア・エツセ・ピー・アー | フルオロリンカーおよび酵素によって活性化される薬剤抱合体のリンカーとしてのその使用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399282A (en) | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| US5552154A (en) | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
| US6080751A (en) | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
| US5880131A (en) | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5965566A (en) | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5646159A (en) | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
| US6096336A (en) | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| US6407118B1 (en) | 1996-01-30 | 2002-06-18 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US5731316A (en) | 1996-01-30 | 1998-03-24 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US5922877A (en) | 1997-08-05 | 1999-07-13 | The Stehlin Foundation For Cancer Research | Methods of preparing and purifying 9-nitro-20-camptothecin |
| US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
| US6350756B1 (en) | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
-
2002
- 2002-05-06 US US10/139,817 patent/US6703399B2/en not_active Expired - Lifetime
-
2003
- 2003-04-22 JP JP2004503475A patent/JP2005536464A/ja active Pending
- 2003-04-22 EP EP03724193A patent/EP1501836A1/en not_active Withdrawn
- 2003-04-22 AU AU2003231068A patent/AU2003231068A1/en not_active Abandoned
- 2003-04-22 CA CA2484816A patent/CA2484816C/en not_active Expired - Fee Related
- 2003-04-22 WO PCT/US2003/012650 patent/WO2003095461A1/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612393A (en) * | 1979-07-10 | 1981-02-06 | Yakult Honsha Co Ltd | Novel camptothecin derivative |
| JP2004537592A (ja) * | 2001-08-10 | 2004-12-16 | フアルマシア・イタリア・エツセ・ピー・アー | フルオロリンカーおよび酵素によって活性化される薬剤抱合体のリンカーとしてのその使用 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010500350A (ja) * | 2006-08-11 | 2010-01-07 | ザ クリストゥス ステーリン ファウンデーション フォー キャンサー リサーチ | カンプトテシンのエステルの製造法 |
| JP2014520125A (ja) * | 2011-06-23 | 2014-08-21 | 東北林業大学 | １０−メトキシカンプトテシン誘導体、その製造方法及び使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2484816A1 (en) | 2003-11-20 |
| US6703399B2 (en) | 2004-03-09 |
| WO2003095461A1 (en) | 2003-11-20 |
| CA2484816C (en) | 2011-06-07 |
| AU2003231068A1 (en) | 2003-11-11 |
| EP1501836A1 (en) | 2005-02-02 |
| US20030212087A1 (en) | 2003-11-13 |
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