CA2484816C - Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds - Google Patents
Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds Download PDFInfo
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- CA2484816C CA2484816C CA2484816A CA2484816A CA2484816C CA 2484816 C CA2484816 C CA 2484816C CA 2484816 A CA2484816 A CA 2484816A CA 2484816 A CA2484816 A CA 2484816A CA 2484816 C CA2484816 C CA 2484816C
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- 108090000623 proteins and genes Proteins 0.000 description 1
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- 206010038038 rectal cancer Diseases 0.000 description 1
- 201000001275 rectum cancer Diseases 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 231100000004 severe toxicity Toxicity 0.000 description 1
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- 229940083575 sodium dodecyl sulfate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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- 238000013268 sustained release Methods 0.000 description 1
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- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/139,817 | 2002-05-06 | ||
| US10/139,817 US6703399B2 (en) | 2002-05-06 | 2002-05-06 | Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds |
| PCT/US2003/012650 WO2003095461A1 (en) | 2002-05-06 | 2003-04-22 | Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2484816A1 CA2484816A1 (en) | 2003-11-20 |
| CA2484816C true CA2484816C (en) | 2011-06-07 |
Family
ID=29399359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2484816A Expired - Fee Related CA2484816C (en) | 2002-05-06 | 2003-04-22 | Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6703399B2 (enExample) |
| EP (1) | EP1501836A1 (enExample) |
| JP (1) | JP2005536464A (enExample) |
| AU (1) | AU2003231068A1 (enExample) |
| CA (1) | CA2484816C (enExample) |
| WO (1) | WO2003095461A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100723454B1 (ko) * | 2004-08-21 | 2007-05-30 | 페어차일드코리아반도체 주식회사 | 높은 열 방출 능력을 구비한 전력용 모듈 패키지 및 그제조방법 |
| US20040204435A1 (en) * | 2003-04-09 | 2004-10-14 | Joachim Liehr | Alternating treatment with topoisomerase I and topoisomerase II inhibitors |
| US7517891B2 (en) * | 2005-10-27 | 2009-04-14 | Glyconix Corporation | Camptothecin derivatives and improved synthetic methods |
| MX2009001505A (es) * | 2006-08-11 | 2009-03-25 | Christus Stehlin Foundation Fo | Metodos para hacer esteres de camptotecinas. |
| WO2008070009A2 (en) * | 2006-12-01 | 2008-06-12 | Alza Corporation | Treating solid tumors and monocytic leukemia using topoisomerase inhibitors in liposomes |
| US7572803B2 (en) * | 2007-10-25 | 2009-08-11 | The Christus Stehlin Foundation For Cancer Research | Hydrated crystalline esters of camptothecin |
| CN102649795B (zh) * | 2011-06-23 | 2014-08-06 | 东北林业大学 | 10-甲氧基喜树碱衍生物、制备方法和用途 |
| WO2013071053A1 (en) | 2011-11-11 | 2013-05-16 | The Christus Stehlin Foundation For Cancer Research | Rodent therapeutic model humanized for liver and bone marrow |
| CN103864811A (zh) * | 2012-12-13 | 2014-06-18 | 天津科技大学 | 一种新颖的10-羟基喜树碱20位衍生物制备方法及其在抗肿瘤药物中的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612393A (en) * | 1979-07-10 | 1981-02-06 | Yakult Honsha Co Ltd | Novel camptothecin derivative |
| US4399282A (en) | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| US5552154A (en) | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
| US6080751A (en) | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
| US5880131A (en) | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5965566A (en) | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5646159A (en) | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
| US6096336A (en) | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| US6407118B1 (en) | 1996-01-30 | 2002-06-18 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US5731316A (en) | 1996-01-30 | 1998-03-24 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US5922877A (en) | 1997-08-05 | 1999-07-13 | The Stehlin Foundation For Cancer Research | Methods of preparing and purifying 9-nitro-20-camptothecin |
| US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
| US6350756B1 (en) | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
| GB0119578D0 (en) | 2001-08-10 | 2001-10-03 | Pharmacia & Upjohn Spa | Fluoro linkers |
-
2002
- 2002-05-06 US US10/139,817 patent/US6703399B2/en not_active Expired - Lifetime
-
2003
- 2003-04-22 JP JP2004503475A patent/JP2005536464A/ja active Pending
- 2003-04-22 EP EP03724193A patent/EP1501836A1/en not_active Withdrawn
- 2003-04-22 AU AU2003231068A patent/AU2003231068A1/en not_active Abandoned
- 2003-04-22 CA CA2484816A patent/CA2484816C/en not_active Expired - Fee Related
- 2003-04-22 WO PCT/US2003/012650 patent/WO2003095461A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2484816A1 (en) | 2003-11-20 |
| US6703399B2 (en) | 2004-03-09 |
| WO2003095461A1 (en) | 2003-11-20 |
| JP2005536464A (ja) | 2005-12-02 |
| AU2003231068A1 (en) | 2003-11-11 |
| EP1501836A1 (en) | 2005-02-02 |
| US20030212087A1 (en) | 2003-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20140422 |