AU2003231068A1 - Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds - Google Patents

Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds

Info

Publication number
AU2003231068A1
AU2003231068A1 AU2003231068A AU2003231068A AU2003231068A1 AU 2003231068 A1 AU2003231068 A1 AU 2003231068A1 AU 2003231068 A AU2003231068 A AU 2003231068A AU 2003231068 A AU2003231068 A AU 2003231068A AU 2003231068 A1 AU2003231068 A1 AU 2003231068A1
Authority
AU
Australia
Prior art keywords
camptothecins
halo
compounds
methods
alkyl esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003231068A
Other languages
English (en)
Inventor
C. Giovanella Beppino
Cao Zhisong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stehlin Foundation for Cancer Research
Original Assignee
Stehlin Foundation for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stehlin Foundation for Cancer Research filed Critical Stehlin Foundation for Cancer Research
Publication of AU2003231068A1 publication Critical patent/AU2003231068A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2003231068A 2002-05-06 2003-04-22 Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds Abandoned AU2003231068A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/139,817 2002-05-06
US10/139,817 US6703399B2 (en) 2002-05-06 2002-05-06 Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds
PCT/US2003/012650 WO2003095461A1 (en) 2002-05-06 2003-04-22 Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds

Publications (1)

Publication Number Publication Date
AU2003231068A1 true AU2003231068A1 (en) 2003-11-11

Family

ID=29399359

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003231068A Abandoned AU2003231068A1 (en) 2002-05-06 2003-04-22 Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds

Country Status (6)

Country Link
US (1) US6703399B2 (enExample)
EP (1) EP1501836A1 (enExample)
JP (1) JP2005536464A (enExample)
AU (1) AU2003231068A1 (enExample)
CA (1) CA2484816C (enExample)
WO (1) WO2003095461A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100723454B1 (ko) * 2004-08-21 2007-05-30 페어차일드코리아반도체 주식회사 높은 열 방출 능력을 구비한 전력용 모듈 패키지 및 그제조방법
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
US7517891B2 (en) * 2005-10-27 2009-04-14 Glyconix Corporation Camptothecin derivatives and improved synthetic methods
MX2009001505A (es) * 2006-08-11 2009-03-25 Christus Stehlin Foundation Fo Metodos para hacer esteres de camptotecinas.
WO2008070009A2 (en) * 2006-12-01 2008-06-12 Alza Corporation Treating solid tumors and monocytic leukemia using topoisomerase inhibitors in liposomes
US7572803B2 (en) * 2007-10-25 2009-08-11 The Christus Stehlin Foundation For Cancer Research Hydrated crystalline esters of camptothecin
CN102649795B (zh) * 2011-06-23 2014-08-06 东北林业大学 10-甲氧基喜树碱衍生物、制备方法和用途
WO2013071053A1 (en) 2011-11-11 2013-05-16 The Christus Stehlin Foundation For Cancer Research Rodent therapeutic model humanized for liver and bone marrow
CN103864811A (zh) * 2012-12-13 2014-06-18 天津科技大学 一种新颖的10-羟基喜树碱20位衍生物制备方法及其在抗肿瘤药物中的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612393A (en) * 1979-07-10 1981-02-06 Yakult Honsha Co Ltd Novel camptothecin derivative
US4399282A (en) 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US6080751A (en) 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US5880131A (en) 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5965566A (en) 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5646159A (en) 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
US6096336A (en) 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US5922877A (en) 1997-08-05 1999-07-13 The Stehlin Foundation For Cancer Research Methods of preparing and purifying 9-nitro-20-camptothecin
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
GB0119578D0 (en) 2001-08-10 2001-10-03 Pharmacia & Upjohn Spa Fluoro linkers

Also Published As

Publication number Publication date
CA2484816A1 (en) 2003-11-20
US6703399B2 (en) 2004-03-09
WO2003095461A1 (en) 2003-11-20
CA2484816C (en) 2011-06-07
JP2005536464A (ja) 2005-12-02
EP1501836A1 (en) 2005-02-02
US20030212087A1 (en) 2003-11-13

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase
TH Corrigenda

Free format text: IN VOL 18, NO 2, PAGE(S) 597 UNDER THE HEADING APPLICATIONS OPI - NAME INDEX UNDER THE NAME THE STEHLIN FOUNDATION FOR CANCER RESEARCH, APPLICATION NO. 2003231068, UNDER INID (43) CORRECT THE PUBLICATION DATE TO READ 24.11.2003