JP2005535686A5 - - Google Patents
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- Publication number
- JP2005535686A5 JP2005535686A5 JP2004525348A JP2004525348A JP2005535686A5 JP 2005535686 A5 JP2005535686 A5 JP 2005535686A5 JP 2004525348 A JP2004525348 A JP 2004525348A JP 2004525348 A JP2004525348 A JP 2004525348A JP 2005535686 A5 JP2005535686 A5 JP 2005535686A5
- Authority
- JP
- Japan
- Prior art keywords
- amine functional
- matrix
- tds
- drug
- functional drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940079593 drug Drugs 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 150000001412 amines Chemical class 0.000 claims description 6
- 239000011159 matrix material Substances 0.000 claims description 6
- 230000037317 transdermal delivery Effects 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims 2
- 239000012458 free base Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000011888 foil Substances 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- CEXBONHIOKGWNU-NTISSMGPSA-N hydron;(6s)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol;chloride Chemical compound [Cl-].CCC[NH+]([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 CEXBONHIOKGWNU-NTISSMGPSA-N 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- KFQYTPMOWPVWEJ-INIZCTEOSA-N rotigotine Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 description 1
- 229960003179 rotigotine Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02016864A EP1386604A1 (en) | 2002-07-30 | 2002-07-30 | Improved transdermal delivery system |
| EP02016864.7 | 2002-07-30 | ||
| PCT/EP2003/008319 WO2004012719A1 (en) | 2002-07-30 | 2003-07-28 | Improved transdermal delivery system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005535686A JP2005535686A (ja) | 2005-11-24 |
| JP2005535686A5 true JP2005535686A5 (https=) | 2006-06-08 |
| JP4837915B2 JP4837915B2 (ja) | 2011-12-14 |
Family
ID=30011092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004525348A Expired - Lifetime JP4837915B2 (ja) | 2002-07-30 | 2003-07-28 | 改善された経皮送達系 |
Country Status (21)
| Country | Link |
|---|---|
| EP (2) | EP1386604A1 (https=) |
| JP (1) | JP4837915B2 (https=) |
| KR (1) | KR101016914B1 (https=) |
| CN (1) | CN100558350C (https=) |
| AT (1) | ATE343380T1 (https=) |
| AU (1) | AU2003266252B2 (https=) |
| BR (1) | BR0313092A (https=) |
| CA (1) | CA2490573C (https=) |
| CY (1) | CY1105878T1 (https=) |
| DE (1) | DE60309329T2 (https=) |
| DK (1) | DK1524971T3 (https=) |
| ES (1) | ES2273042T3 (https=) |
| IL (1) | IL165917A (https=) |
| MX (1) | MXPA05000349A (https=) |
| NO (1) | NO334187B1 (https=) |
| NZ (1) | NZ537476A (https=) |
| PL (1) | PL376999A1 (https=) |
| PT (1) | PT1524971E (https=) |
| SI (1) | SI1524971T1 (https=) |
| WO (1) | WO2004012719A1 (https=) |
| ZA (1) | ZA200500255B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10041478A1 (de) | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
| EP1386605A1 (en) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Improved transdermal delivery system for the administration of rotigotine |
| DE10361258A1 (de) | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson |
| DE102004014841B4 (de) | 2004-03-24 | 2006-07-06 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms |
| JP5546013B2 (ja) * | 2008-02-27 | 2014-07-09 | 久光製薬株式会社 | 貼付剤及び包装体 |
| EP2258369B1 (en) * | 2008-02-27 | 2015-04-08 | Hisamitsu Pharmaceutical Co., Inc. | Medicated patch |
| US9925150B2 (en) * | 2009-12-22 | 2018-03-27 | Lts Lohmann Therapie-Systeme Ag | Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine |
| DE102011090178A1 (de) | 2011-12-30 | 2013-07-04 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit geringer Neigung zur Spontankristallisation |
| TW201431570A (zh) | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片 |
| EP3016641B1 (de) | 2013-07-03 | 2018-09-05 | LTS Lohmann Therapie-Systeme AG | Transdermales therapeutisches system mit elektronischem bauteil |
| EP3145502B1 (en) | 2014-05-20 | 2022-07-06 | LTS Lohmann Therapie-Systeme AG | Transdermal delivery system containing rotigotine |
| WO2015177209A1 (en) | 2014-05-20 | 2015-11-26 | Lts Lohmann Therapie-Systeme Ag | Method for adjusting the release of active agent in a transdermal delivery system |
| US11752110B2 (en) | 2014-05-20 | 2023-09-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system including an interface mediator |
| DK3854388T3 (da) | 2020-01-24 | 2023-11-27 | Luye Pharma Switzerland Ag | Transdermalt terapeutisk system omfattende rotigotin og mindst et ikke-aminresistent silikoneklæbestof |
| EP3949956A1 (en) * | 2020-08-06 | 2022-02-09 | LTS Lohmann Therapie-Systeme AG | Esketamine-suspension-tts |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5736577A (en) * | 1995-01-31 | 1998-04-07 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin |
| US5989586A (en) * | 1992-10-05 | 1999-11-23 | Cygnus, Inc. | Two-phase matrix for sustained release drug delivery device |
| US5601839A (en) * | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
| DE19814084B4 (de) * | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
| DE19814083C2 (de) * | 1998-03-30 | 2002-02-07 | Lohmann Therapie Syst Lts | Verfahren zur Herstellung von transdermalen therapeutischen Systemen unter Verwendung von basischen Alkalimetallsalzen zur Umwandlung von Wirkstoffsalzen in die freien Basen |
| FR2792529B1 (fr) * | 1999-04-26 | 2001-09-28 | Sod Conseils Rech Applic | Nouvelles compositions pharmaceutiques comprenant des derives de 2-isoxazole-8-aminotetralines |
| IT1311696B1 (it) * | 1999-06-22 | 2002-03-19 | Zanussi Elettromecc | Compressore del fluido frigorigeno azionato da un motore elettricoa frequenza di alimentazione variabile |
| JP2002045699A (ja) * | 2000-08-08 | 2002-02-12 | Mitsubishi Electric Corp | 排ガス浄化用層状電気化学触媒 |
| US20020119187A1 (en) * | 2000-09-29 | 2002-08-29 | Cantor Adam S. | Composition for the transdermal delivery of fentanyl |
| DE10060550C1 (de) * | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten |
| ATE364380T1 (de) * | 2001-03-16 | 2007-07-15 | Alza Corp | Transdermales pflaster zur verabreichung von fentanyl |
| CA2441064A1 (en) * | 2001-03-16 | 2002-09-26 | Andrx Corporation | Controlled release sulfonylurea formulation |
| EP1256340B1 (en) * | 2001-05-08 | 2003-08-13 | Schwarz Pharma Ag | Improved transdermal therapeutic system for the treatment of Parkinson's disease |
| EP1386605A1 (en) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Improved transdermal delivery system for the administration of rotigotine |
-
2002
- 2002-07-30 EP EP02016864A patent/EP1386604A1/en not_active Withdrawn
-
2003
- 2003-07-28 CA CA2490573A patent/CA2490573C/en not_active Expired - Lifetime
- 2003-07-28 JP JP2004525348A patent/JP4837915B2/ja not_active Expired - Lifetime
- 2003-07-28 MX MXPA05000349A patent/MXPA05000349A/es active IP Right Grant
- 2003-07-28 CN CNB038184397A patent/CN100558350C/zh not_active Expired - Lifetime
- 2003-07-28 KR KR1020057001101A patent/KR101016914B1/ko not_active Expired - Lifetime
- 2003-07-28 AT AT03766330T patent/ATE343380T1/de active
- 2003-07-28 ES ES03766330T patent/ES2273042T3/es not_active Expired - Lifetime
- 2003-07-28 SI SI200330559T patent/SI1524971T1/sl unknown
- 2003-07-28 PT PT03766330T patent/PT1524971E/pt unknown
- 2003-07-28 NZ NZ537476A patent/NZ537476A/en not_active IP Right Cessation
- 2003-07-28 WO PCT/EP2003/008319 patent/WO2004012719A1/en not_active Ceased
- 2003-07-28 BR BR0313092-4A patent/BR0313092A/pt not_active Application Discontinuation
- 2003-07-28 EP EP03766330A patent/EP1524971B1/en not_active Expired - Lifetime
- 2003-07-28 AU AU2003266252A patent/AU2003266252B2/en not_active Expired
- 2003-07-28 DK DK03766330T patent/DK1524971T3/da active
- 2003-07-28 DE DE60309329T patent/DE60309329T2/de not_active Expired - Lifetime
- 2003-07-28 PL PL376999A patent/PL376999A1/pl not_active Application Discontinuation
-
2004
- 2004-12-22 IL IL165917A patent/IL165917A/en active IP Right Grant
-
2005
- 2005-01-11 ZA ZA2005/00255A patent/ZA200500255B/en unknown
- 2005-02-11 NO NO20050770A patent/NO334187B1/no not_active IP Right Cessation
-
2006
- 2006-12-21 CY CY20061101845T patent/CY1105878T1/el unknown
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