JP2005532089A - 自動整合式膝人工装具 - Google Patents
自動整合式膝人工装具 Download PDFInfo
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- JP2005532089A JP2005532089A JP2004502872A JP2004502872A JP2005532089A JP 2005532089 A JP2005532089 A JP 2005532089A JP 2004502872 A JP2004502872 A JP 2004502872A JP 2004502872 A JP2004502872 A JP 2004502872A JP 2005532089 A JP2005532089 A JP 2005532089A
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- 210000003127 knee Anatomy 0.000 title claims abstract description 40
- 241000469816 Varus Species 0.000 claims abstract description 10
- 210000000689 upper leg Anatomy 0.000 claims abstract description 10
- 210000000988 bone and bone Anatomy 0.000 claims description 15
- 238000005452 bending Methods 0.000 claims description 14
- 210000002303 tibia Anatomy 0.000 claims description 10
- 230000007704 transition Effects 0.000 claims description 6
- 210000000629 knee joint Anatomy 0.000 claims 3
- 241001227561 Valgus Species 0.000 abstract description 7
- 238000013519 translation Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 4
- 230000002146 bilateral effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002271 resection Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 229910001182 Mo alloy Inorganic materials 0.000 description 1
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 description 1
- MTHLBYMFGWSRME-UHFFFAOYSA-N [Cr].[Co].[Mo] Chemical compound [Cr].[Co].[Mo] MTHLBYMFGWSRME-UHFFFAOYSA-N 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011440 grout Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000013150 knee replacement Methods 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
- A61F2/3868—Joints for elbows or knees with sliding tibial bearing
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/42—Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes
- A61F2/4202—Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes for ankles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30604—Special structural features of bone or joint prostheses not otherwise provided for modular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
- A61F2002/30884—Fins or wings, e.g. longitudinal wings for preventing rotation within the bone cavity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
- A61F2002/3895—Joints for elbows or knees unicompartimental
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2002/4631—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor the prosthesis being specially adapted for being cemented
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00029—Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
Abstract
Description
12 ペグ
14 構造部材
16 外面
16X 第1領域
16F 第2領域
18 構造線
20 インサート
24,24’ 脛骨面
26 大腿骨面
30 脛骨トレイ
32 隆起部
34,34’ 上部摺動面
36 キール
Claims (19)
- 大腿骨に装着するための構造を持つ固定面と、摺動面とを有する大腿骨コンポーネントと、
脛骨に装着するための構造を持つ固定面と、摺動面とを有する脛骨トレイと、
人工装具が対象に取り付けられる時に前記大腿骨コンポーネントと前記脛骨トレイとの間に設けるインサートであって、大腿骨側と脛骨側とを有し、前記大腿骨側が、膝の屈曲する間に前記大腿骨コンポーネントの前記面と摺動界面を形成するとともに、前記脛骨側が、前記脛骨トレイの前記面と摺動界面を形成するインサートとを含み、
膝の伸張の間と初期屈曲域において前記大腿骨コンポーネントの前記面が前記インサートと界面接触する領域では、屈曲回転のための前記大腿骨コンポーネントの前記面の曲率半径(R1)が内反/外反回転のための前記大腿骨コンポーネントの前記面の曲率半径(R3)よりも長く、
前記脛骨トレイの前記面が球状またはトロイド状に湾曲している膝関節人工装具。 - 前記脛骨トレイの前記面が凸状であり、前記インサートの前記脛骨側が凹状である請求項1に記載の人工装具。
- R1がR3の約1.5から1.9倍である請求項1に記載の人工装具。
- 前記膝の屈曲が前記初期域を越える時に前記大腿骨コンポーネントの前記面が前記インサートと界面接触する領域では、屈曲回転のための前記大腿骨コンポーネントの前記面の曲率半径(R2)がR1より短い請求項1に記載の人工装具。
- 前記膝の屈曲が前記初期域を越える時に前記大腿骨コンポーネントの前記面が前記インサートと界面接触する領域では、屈曲回転のための前記大腿骨コンポーネントの前記面の曲率半径(R2)がR3より長いかR3と等しく、R2がR1より短い請求項1に記載の人工装具。
- R1がR3の約1.5から1.9倍であり、R2がR3の約1から1.2倍であり、R1とR2との間の移行が近位−遠位軸に対して約28°から約55°の範囲で生じる請求項5に記載の人工装具。
- 前記脛骨トレイの前記面が凸状であり、前記インサートの前記脛骨側が凹状である請求項6に記載の人工装具。
- 大腿骨に装着するための構造を持つ固定面と、摺動面とを有する大腿骨コンポーネントと、
脛骨に装着するための構造を持つ固定面と、摺動面とを有する脛骨トレイと、
人工装具が対象に取り付けられる時に前記大腿骨コンポーネントと前記脛骨トレイとの間に設けるインサートであって、大腿骨側と脛骨側とを有し、前記大腿骨側が、膝の屈曲する間に前記大腿骨コンポーネントの前記面と摺動界面を形成するとともに、前記脛骨側が、前記脛骨トレイの前記面と摺動界面を形成するインサートとを含み、
膝の伸張の間と初期屈曲域において前記大腿骨コンポーネントの前記面が前記インサートと界面接触する領域では、屈曲回転のための前記大腿骨コンポーネントの前記面の曲率半径(R1)が内反/外反回転のための前記大腿骨コンポーネントの前記面の曲率半径(R3)よりも長く、
前記インサートが、前記脛骨トレイに対して、前後方向と中間から横方向の両方で自由に移動する膝関節人工装具。 - R1がR3の約1.5から1.9倍である請求項8に記載の人工装具。
- 膝の屈曲が前記初期域を越える時に前記大腿骨コンポーネントの前記面が前記インサートと界面接触する領域では、屈曲回転のための前記大腿骨コンポーネントの前記面の曲率半径(R2)がR1より短い請求項8に記載の人工装具。
- 膝の屈曲が前記初期域を越える時に前記大腿骨コンポーネントの前記面が前記インサートと界面接触する領域では、屈曲回転のための前記大腿骨コンポーネントの前記面の曲率半径(R2)がR3より長いかR3と等しく、R2がR1より短い請求項8に記載の人工装具。
- R1がR3の約1.5から1.9倍であり、R2がR3の約1から1.2倍であり、R1とR2の間の移行が、近位−遠位軸に対して約28°から約55°の間で生じる請求項11に記載の人工装具。
- 大腿骨に装着するための構造を持つ固定面と、摺動面とを有する大腿骨コンポーネントと、
脛骨に装着するための構造を持つ固定面と、摺動面とを有する脛骨トレイと、
人工装具が対象に取り付けられる時に前記大腿骨コンポーネントと前記脛骨トレイとの間に設けるインサートであって、大腿骨側と脛骨側とを有し、前記大腿骨側が、膝の屈曲する間に前記大腿骨コンポーネントの前記面と摺動界面を形成するとともに、前記脛骨側が、前記脛骨トレイの前記面と摺動界面を形成するインサートとを含み、
膝の伸張の間と初期屈曲域において前記大腿骨コンポーネントの前記面が前記インサートと界面接触する領域では、屈曲回転のための前記大腿骨コンポーネントの前記面の曲率半径(R1)が内反/外反回転のための前記大腿骨コンポーネントの前記面の曲率半径(R3)よりも長く、
前記脛骨トレイの前記面が球状に湾曲するか凸状であるとともに、前記インサートの前記脛骨側が凹状であり、
前記インサートが、前記脛骨トレイに対して前後方向と中間から横方向の両方で自由に移動する膝関節人工装具。 - R1がR3の約1.5から1.9倍である請求項13に記載の人工装具。
- 膝の屈曲が前記初期域を越える時に前記大腿骨コンポーネントの前記面が前記インサートと界面接触する領域では、屈曲回転のための前記大腿骨コンポーネントの前記面の曲率半径(R2)がR1より短い請求項13に記載の人工装具。
- 膝の屈曲が前記初期域を越える時に前記大腿骨コンポーネントの前記面が前記インサートと界面接触する領域では、屈曲回転のための前記大腿骨コンポーネントの前記面の曲率半径(R2)がR3より長いかR3と等しく、R2がR1より短い請求項13に記載の人工装具。
- R1がR3の約1.5から1.9倍であり、R2がR3の約1から1.2倍であり、R1とR2の間の移行が近位−遠位軸に対して約28°から約55°の間で生じる請求項16に記載の人工装具。
- 第1骨に装着するための構造を持つ固定面と、摺動面とを有する第1コンポーネントと、
第2骨に装着するための構造を持つ固定面と、摺動面とを有する第2コンポーネントと、
人工装具が対象に取り付けられる時に前記第1コンポーネントと前記第2コンポーネントとの間に設けるインサートであって、第1側と第2側とを有し、前記第1側が、関節の屈曲する間に前記第1コンポーネントの前記面と摺動界面を形成するとともに、前記第2側が、前記第2コンポーネントの前記面と摺動界面を形成するインサートとを含み、
関節の伸張の間と初期屈曲域において、前記第1コンポーネントの前記面が前記インサートと界面接触する領域では、屈曲回転のための前記第1コンポーネントの前記面の曲率半径(R1)が、前記対象の冠状面に対して垂直な軸を中心とする回転のための前記第1コンポーネントの前記面の曲率半径(R3)より長く、
前記第2コンポーネントの前記面が球状またはトロイド状に湾曲している関節人工装具。 - 第1骨に装着するための構造を持つ固定面と、摺動面とを有する第1コンポーネントと、
第2骨に装着するための構造を持つ固定面と、摺動面とを有する第2コンポーネントと、
人工装具が対象に取り付けられる時に前記第1コンポーネントと前記第2コンポーネントとの間に設けるインサートであって、第1側と第2側とを有し、前記第1側が、関節の屈曲する間に前記第1コンポーネントの前記面と摺動界面を形成するとともに、前記第2側が、前記第2コンポーネントの前記面と摺動界面を形成するインサートとを含み、
関節の伸張の間と初期屈曲域において、前記第1コンポーネントの前記面が前記インサートと界面接触する領域では、屈曲回転のための前記第1コンポーネントの前記面の曲率半径(R1)が、前記対象の冠状面に対して垂直な軸を中心とする回転のための前記第1コンポーネントの前記面の曲率半径(R3)より長く、
前記インサートが、前記第2コンポーネントに対して前後方向と中間から横方向の両方で自由に移動する関節人工装具。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10220591A DE10220591B4 (de) | 2002-05-08 | 2002-05-08 | Gelenkprothese mit Zwischenelement mit unterschiedlichen Krümmungsradien |
DE10220591.4 | 2002-05-08 | ||
PCT/EP2003/004831 WO2003094782A2 (en) | 2002-05-08 | 2003-05-08 | Self-aligning knee prosthesis |
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JP2010250307A Division JP2011050762A (ja) | 2002-05-08 | 2010-11-08 | 自動整合式膝人工装具 |
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JP2005532089A true JP2005532089A (ja) | 2005-10-27 |
JP4820547B2 JP4820547B2 (ja) | 2011-11-24 |
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JP2010250307A Pending JP2011050762A (ja) | 2002-05-08 | 2010-11-08 | 自動整合式膝人工装具 |
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JP2010250307A Pending JP2011050762A (ja) | 2002-05-08 | 2010-11-08 | 自動整合式膝人工装具 |
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US (1) | US7105027B2 (ja) |
EP (1) | EP1501446B1 (ja) |
JP (2) | JP4820547B2 (ja) |
AU (1) | AU2003232738B8 (ja) |
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Also Published As
Publication number | Publication date |
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DE10220591B4 (de) | 2004-03-18 |
US20040006394A1 (en) | 2004-01-08 |
JP4820547B2 (ja) | 2011-11-24 |
AU2003232738A1 (en) | 2003-11-11 |
DE10220591A1 (de) | 2003-12-04 |
EP1501446B1 (en) | 2011-11-23 |
WO2003094782A3 (en) | 2004-03-04 |
US7105027B2 (en) | 2006-09-12 |
AU2003232738B2 (en) | 2007-06-21 |
WO2003094782A2 (en) | 2003-11-20 |
EP1501446A2 (en) | 2005-02-02 |
JP2011050762A (ja) | 2011-03-17 |
AU2003232738B8 (en) | 2009-07-30 |
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