|
TW200300350A
(en)
*
|
2001-11-14 |
2003-06-01 |
Bristol Myers Squibb Co |
C-5 modified indazolylpyrrolotriazines
|
|
CA2483164C
(en)
|
2002-04-23 |
2011-06-07 |
Bristol-Myers Squibb Company |
Pyrrolo-triazine aniline compounds useful as kinase inhibitors
|
|
AU2003221753A1
(en)
|
2002-04-23 |
2003-11-10 |
Bristol-Myers Squibb Company |
Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
|
|
TW200401638A
(en)
*
|
2002-06-20 |
2004-02-01 |
Bristol Myers Squibb Co |
Heterocyclic inhibitors of kinases
|
|
TWI329112B
(en)
*
|
2002-07-19 |
2010-08-21 |
Bristol Myers Squibb Co |
Novel inhibitors of kinases
|
|
EP1543009A4
(en)
*
|
2002-08-02 |
2007-08-08 |
Bristol Myers Squibb Co |
Pyrrolotriazine KINASE INHIBITORS
|
|
TW200420565A
(en)
*
|
2002-12-13 |
2004-10-16 |
Bristol Myers Squibb Co |
C-6 modified indazolylpyrrolotriazines
|
|
AU2004212435A1
(en)
|
2003-02-05 |
2004-08-26 |
Bristol-Myers Squibb Company |
Process for preparing pyrrolotriazine kinase inhibitors
|
|
US7419978B2
(en)
*
|
2003-10-22 |
2008-09-02 |
Bristol-Myers Squibb Company |
Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
|
|
JP2007517052A
(ja)
*
|
2003-12-23 |
2007-06-28 |
ノバルティス アクチエンゲゼルシャフト |
二環式ヘテロ環式p−38キナーゼ阻害剤
|
|
CA2557268A1
(en)
|
2004-02-27 |
2005-09-15 |
F. Hoffmann-La Roche Ag |
Indazole derivatives and pharmaceutical compositions containing them
|
|
MXPA06009462A
(es)
|
2004-02-27 |
2007-03-15 |
Hoffmann La Roche |
Derivados pirazolo heteroaril fusionados.
|
|
AU2005219525B2
(en)
|
2004-02-27 |
2011-08-18 |
F. Hoffmann-La Roche Ag |
Fused derivatives of pyrazole
|
|
US7067659B2
(en)
*
|
2004-04-23 |
2006-06-27 |
Duke University |
Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof
|
|
US7439246B2
(en)
*
|
2004-06-28 |
2008-10-21 |
Bristol-Myers Squibb Company |
Fused heterocyclic kinase inhibitors
|
|
US7253167B2
(en)
*
|
2004-06-30 |
2007-08-07 |
Bristol-Myers Squibb Company |
Tricyclic-heteroaryl compounds useful as kinase inhibitors
|
|
TW200600513A
(en)
*
|
2004-06-30 |
2006-01-01 |
Bristol Myers Squibb Co |
A method for preparing pyrrolotriazine compounds
|
|
US7504521B2
(en)
*
|
2004-08-05 |
2009-03-17 |
Bristol-Myers Squibb Co. |
Methods for the preparation of pyrrolotriazine compounds
|
|
US7148348B2
(en)
|
2004-08-12 |
2006-12-12 |
Bristol-Myers Squibb Company |
Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors
|
|
ATE517901T1
(de)
|
2004-09-06 |
2011-08-15 |
Bayer Schering Pharma Ag |
Pyrazolopyrimidine als hemmer der proteinkinase b (akt)
|
|
GB0425035D0
(en)
*
|
2004-11-12 |
2004-12-15 |
Novartis Ag |
Organic compounds
|
|
GB0427604D0
(en)
*
|
2004-12-16 |
2005-01-19 |
Novartis Ag |
Organic compounds
|
|
CA2594422A1
(en)
|
2005-01-14 |
2006-07-20 |
Janssen Pharmaceutica N.V. |
Pyrazolopyrimidines as cell cycle kinase inhibitors
|
|
AU2006205851A1
(en)
|
2005-01-14 |
2006-07-20 |
Janssen Pharmaceutica N.V. |
5-membered annelated heterocyclic pyrimidines as kinase inhibitors
|
|
US20060178388A1
(en)
|
2005-02-04 |
2006-08-10 |
Wrobleski Stephen T |
Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
|
|
GB0507575D0
(en)
|
2005-04-14 |
2005-05-18 |
Novartis Ag |
Organic compounds
|
|
US20060264431A1
(en)
*
|
2005-05-11 |
2006-11-23 |
Array Biopharma Inc. |
P38 inhibitors and methods of use thereof
|
|
AU2006283935A1
(en)
|
2005-08-25 |
2007-03-01 |
F. Hoffmann-La Roche Ag |
Fused pyrazole as p38 MAP kinase inhibitors
|
|
EP1919913A2
(en)
*
|
2005-08-25 |
2008-05-14 |
F.Hoffmann-La Roche Ag |
P38 map kinase inhibitors and methods for using the same
|
|
MX2008002588A
(es)
|
2005-08-25 |
2008-03-18 |
Hoffmann La Roche |
Inhibidores de p38-map-cinasa y los metodos para utilizarlos.
|
|
GB0522880D0
(en)
*
|
2005-11-09 |
2005-12-21 |
Glaxo Group Ltd |
Novel compounds
|
|
GB0524436D0
(en)
*
|
2005-11-30 |
2006-01-11 |
Novartis Ag |
Organic compounds
|
|
WO2007095161A2
(en)
*
|
2006-02-14 |
2007-08-23 |
New York University |
Methods and compositions for treating disorders associated with increased bone turnover and osteopenia
|
|
KR20080110783A
(ko)
|
2006-03-07 |
2008-12-19 |
어레이 바이오파마 인크. |
헤테로바이시클릭 피라졸 화합물 및 사용 방법
|
|
US8933089B2
(en)
|
2006-03-30 |
2015-01-13 |
Janssen R & D Ireland |
HIV inhibiting 5-amido substituted pyrimidines
|
|
WO2007139778A2
(en)
*
|
2006-05-22 |
2007-12-06 |
University Of Virginia Patent Foundation |
Rhamnose substituents of sl0101 and therapeutic uses thereof
|
|
RU2009118254A
(ru)
|
2006-10-16 |
2010-11-27 |
Новартис АГ (CH) |
Фенилацетамиды в качестве ингибиторов протеинкиназ
|
|
CN101600714B
(zh)
|
2006-11-10 |
2013-08-21 |
百时美施贵宝公司 |
吡咯并吡啶激酶抑制剂
|
|
CA2672719A1
(en)
*
|
2006-12-19 |
2008-06-26 |
F. Hoffmann-La Roche Ag |
Pyrazolo [3, 4 -d] pyrimidine p38 map kinase inhibitors
|
|
WO2009023053A2
(en)
*
|
2007-05-18 |
2009-02-19 |
University Of Virginia Patent Foundation |
Use of rsk inhibitors to impede intracellular pathogen infections
|
|
EA019869B1
(ru)
|
2007-11-28 |
2014-06-30 |
Дана Фарбер Кансер Инститьют, Инк. |
Низкомолекулярные миристатные ингибиторы тирозинкиназы bcr-abl и способы их применения
|
|
ES2494365T3
(es)
*
|
2008-01-30 |
2014-09-15 |
Genentech, Inc. |
Compuestos de pirazolopirimidina que inhiben PI3K y métodos de uso
|
|
US8188098B2
(en)
|
2008-05-19 |
2012-05-29 |
Hoffmann-La Roche Inc. |
GPR119 receptor agonists
|
|
KR20110017431A
(ko)
*
|
2008-06-10 |
2011-02-21 |
아보트 러보러터리즈 |
신규한 트리사이클릭 화합물
|
|
WO2010011620A1
(en)
*
|
2008-07-21 |
2010-01-28 |
Wyeth |
4-phenoxy-6-aryl-1h-pyrazolo[3,4-d]pyrimidine and n-aryl-6-aryl-1h-pyrazolo[3,4-d]pyrimidin-4-amine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses
|
|
WO2010059788A1
(en)
|
2008-11-20 |
2010-05-27 |
Genentech, Inc. |
Pyrazolopyridine pi3k inhibitor compounds and methods of use
|
|
CA2756871A1
(en)
|
2009-03-31 |
2010-10-07 |
Arqule, Inc. |
Substituted heterocyclic compounds
|
|
TWI500620B
(zh)
|
2009-12-01 |
2015-09-21 |
Abbvie Inc |
新穎三環化合物
|
|
NZ599938A
(en)
*
|
2009-12-01 |
2014-08-29 |
Abbvie Inc |
Novel tricyclic compounds
|
|
US8637529B2
(en)
|
2010-06-11 |
2014-01-28 |
AbbYie Inc. |
Pyrazolo[3,4-d]pyrimidine compounds
|
|
CN103313987A
(zh)
*
|
2010-11-19 |
2013-09-18 |
弗·哈夫曼-拉罗切有限公司 |
吡唑并吡啶化合物、吡唑并吡啶化合物以及它们作为tyk2抑制剂的用途
|
|
TWI399205B
(zh)
*
|
2011-01-14 |
2013-06-21 |
Univ Kaohsiung Medical |
茶鹼化合物之抑制骨質疏鬆症活性
|
|
EP2548878A1
(en)
*
|
2011-07-21 |
2013-01-23 |
Laboratorios Del. Dr. Esteve, S.A. |
Pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma ligands
|
|
CN102746306B
(zh)
*
|
2012-07-09 |
2014-11-19 |
四川国康药业有限公司 |
别嘌醇类衍生物及其制备方法和用途
|
|
CN103570723B
(zh)
*
|
2012-07-27 |
2016-07-13 |
广西梧州制药(集团)股份有限公司 |
吡唑并嘧啶衍生物及其制备方法和在药物制备中的用途
|
|
EA201500402A1
(ru)
|
2012-11-08 |
2016-05-31 |
Пфайзер Инк. |
Гетероароматические соединения в качестве лигандов допамина d1
|
|
CN103601722B
(zh)
*
|
2013-09-13 |
2016-03-02 |
南京华威医药科技开发有限公司 |
新型抗肿瘤化合物
|
|
US9957270B2
(en)
|
2014-03-13 |
2018-05-01 |
Agency For Science, Technology And Research |
Fused pyrimidine-based hydroxamate derivatives
|
|
US11524964B2
(en)
|
2015-10-16 |
2022-12-13 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
|
US12365689B2
(en)
|
2015-10-16 |
2025-07-22 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
|
US10550126B2
(en)
|
2015-10-16 |
2020-02-04 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
|
US11773106B2
(en)
|
2015-10-16 |
2023-10-03 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
|
CA3251507A1
(en)
|
2015-10-16 |
2025-05-21 |
Abbvie Inc. |
Use of a solid dosage form comprising (3s,4r)-3-ethyl-4-(3h-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide for treating rheumatoid arthritis
|
|
US11512092B2
(en)
|
2015-10-16 |
2022-11-29 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
|
US11365198B2
(en)
|
2015-10-16 |
2022-06-21 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
|
US11034689B2
(en)
*
|
2016-10-26 |
2021-06-15 |
The Trustees Of Indiana University |
Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment
|
|
US10342786B2
(en)
|
2017-10-05 |
2019-07-09 |
Fulcrum Therapeutics, Inc. |
P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
|
|
WO2019071147A1
(en)
|
2017-10-05 |
2019-04-11 |
Fulcrum Therapeutics, Inc. |
INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD
|
|
CA3240377A1
(en)
*
|
2021-12-08 |
2023-06-15 |
Gnanasambandam Kumaravel |
Bicyclic heteroarenes and methods of their use
|
|
CN117865965B
(zh)
*
|
2024-01-08 |
2024-06-28 |
贵州省天然产物研究中心 |
吡咯并嘧啶-4-胺和吡唑并嘧啶-4-胺衍生物及制备方法和应用
|