JP2005530811A5 - - Google Patents
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- Publication number
- JP2005530811A5 JP2005530811A5 JP2004507471A JP2004507471A JP2005530811A5 JP 2005530811 A5 JP2005530811 A5 JP 2005530811A5 JP 2004507471 A JP2004507471 A JP 2004507471A JP 2004507471 A JP2004507471 A JP 2004507471A JP 2005530811 A5 JP2005530811 A5 JP 2005530811A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- haloalkyl
- compound
- atoms
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims description 93
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 55
- 125000004429 atoms Chemical group 0.000 claims description 33
- 229910052760 oxygen Inorganic materials 0.000 claims description 29
- 229910052717 sulfur Inorganic materials 0.000 claims description 29
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 27
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 27
- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 24
- 229910052736 halogen Inorganic materials 0.000 claims description 24
- 150000002367 halogens Chemical class 0.000 claims description 24
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 23
- 239000011780 sodium chloride Substances 0.000 claims description 23
- 125000001424 substituent group Chemical group 0.000 claims description 23
- 125000000623 heterocyclic group Chemical group 0.000 claims description 12
- 125000001624 naphthyl group Chemical group 0.000 claims description 12
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 10
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 10
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims 28
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000003432 Bone Disease Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000002980 hyperparathyroidism Diseases 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 0 C*1c2cc(C(*)(*)NC(*)*)ccc2**1 Chemical compound C*1c2cc(C(*)(*)NC(*)*)ccc2**1 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38327002P | 2002-05-23 | 2002-05-23 | |
| US10/444,945 US7176322B2 (en) | 2002-05-23 | 2003-05-22 | Calcium receptor modulating agents |
| PCT/US2003/016384 WO2003099814A1 (en) | 2002-05-23 | 2003-05-23 | Calcium receptor modulating agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005530811A JP2005530811A (ja) | 2005-10-13 |
| JP2005530811A5 true JP2005530811A5 (US20080131398A1-20080605-C00009.png) | 2010-04-30 |
| JP4642461B2 JP4642461B2 (ja) | 2011-03-02 |
Family
ID=29586996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004507471A Expired - Fee Related JP4642461B2 (ja) | 2002-05-23 | 2003-05-23 | カルシウム受容体修飾物質 |
Country Status (12)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6908935B2 (en) * | 2002-05-23 | 2005-06-21 | Amgen Inc. | Calcium receptor modulating agents |
| WO2005065050A2 (ja) * | 2003-12-25 | 2005-07-21 | Asahi Kasei Pharma Corporation | ２環化合物 |
| GB0400781D0 (en) * | 2004-01-14 | 2004-02-18 | Novartis Ag | Organic compounds |
| EP1757582B1 (en) | 2004-05-28 | 2015-12-30 | Mitsubishi Tanabe Pharma Corporation | Arylalkylamines and process for production thereof |
| US7361789B1 (en) | 2004-07-28 | 2008-04-22 | Amgen Inc. | Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis |
| US7585886B2 (en) | 2005-05-19 | 2009-09-08 | Astellas Pharma Inc. | Pyrrolidine derivative or salt thereof |
| EP1937233B1 (en) * | 2005-09-02 | 2013-01-09 | Amgen Inc. | Modulating intestinal fluid balance using calcimimetics |
| EP1991531A1 (en) * | 2006-02-28 | 2008-11-19 | Amgen Inc. | Cinnoline and quinoxaline derivates as phosphodiesterase 10 inhibitors |
| JP5309014B2 (ja) * | 2006-03-23 | 2013-10-09 | アムジエン・インコーポレーテツド | シナカルセットの多形体の製造および使用のための方法および組成物 |
| BRPI0710814A2 (pt) * | 2006-04-20 | 2011-08-16 | Amgen Inc | formulações de emulsão estável |
| EP2139462B1 (en) | 2007-03-30 | 2014-01-22 | Amgen Inc. | Calcimimetic compounds for use in the treatment of bowel disorders |
| AU2008311974B2 (en) * | 2007-10-15 | 2013-11-21 | Amgen Inc. | Calcium receptor modulating agents |
| WO2009155527A2 (en) * | 2008-06-19 | 2009-12-23 | Progenics Pharmaceuticals, Inc. | Phosphatidylinositol 3 kinase inhibitors |
| WO2010104882A1 (en) | 2009-03-10 | 2010-09-16 | Amgen Inc. | Methods of modulating sperm motility |
| US8765676B2 (en) | 2009-05-27 | 2014-07-01 | Leo Pharma A/S | Calcium sensing receptor modulating compounds and pharmaceutical use thereof |
| JP2012528084A (ja) | 2009-05-27 | 2012-11-12 | レオ ファーマ アクティーゼルスカブ | 新規のカルシウム感知受容体調節化合物およびその医薬用途 |
| CN102958907A (zh) | 2010-06-30 | 2013-03-06 | 利奥制药有限公司 | 钙敏感受体激动化合物的新多晶型 |
| EP2588444A1 (en) | 2010-06-30 | 2013-05-08 | Leo Pharma A/S | New polymorphic form of a calcimimetic compound |
| JP2014507375A (ja) | 2010-11-26 | 2014-03-27 | レオ ファーマ アクティーゼルスカブ | カルシウム感知受容体活性化合物 |
| EP2643291A2 (en) | 2010-11-26 | 2013-10-02 | Leo Pharma A/S | Calcium-sensing receptor-active compounds |
| US20130267516A1 (en) | 2010-11-26 | 2013-10-10 | Leo Pharma A/S | Substituted cyclopentyl-azines as casr-active compounds |
| RU2013128968A (ru) | 2010-11-26 | 2015-01-10 | Лео Фарма А/С | Соединения, активные в отношении кальций-чувствительного рецептора |
| CN104583177B (zh) * | 2012-08-27 | 2016-09-07 | 卢平亚特兰蒂斯控股有限公司 | 作为钙敏感受体调节剂的芳基烷基胺化合物 |
| GB201217330D0 (en) | 2012-09-28 | 2012-11-14 | Univ Cardiff | Therapeutic for treating inflammatory lung disorders |
| JP6721499B2 (ja) | 2013-03-14 | 2020-07-15 | オステオーク インコーポレイティド | 骨の成長を促進するためのアルキルアミンハルミン誘導体 |
| AU2019320773A1 (en) | 2018-08-14 | 2021-03-04 | Osteoqc Inc. | Fluoro β-carboline compounds |
| MX2021001752A (es) | 2018-08-14 | 2021-06-23 | Osteoqc Inc | Compuestos de pirrolo-dipiridina. |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US444946A (en) * | 1891-01-20 | Method of electric welding | ||
| US143212A (en) * | 1873-09-23 | Improvement in attachments for ladies work-tables | ||
| PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
| US6031003A (en) | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US6001884A (en) | 1991-08-23 | 1999-12-14 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| DE69433714T2 (de) | 1991-08-23 | 2005-03-31 | NPS Pharmaceuticals, Inc., Salt Lake City | Kalzium - receptor aktive arylalkylamine |
| DE69233572T2 (de) | 1991-08-23 | 2006-08-31 | NPS Pharmaceuticals, Inc., Salt Lake City | Screening-Verfahren für Kalzium-Rezeptor aktive Verbindungen |
| US6011068A (en) | 1991-08-23 | 2000-01-04 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| ATE267009T1 (de) | 1993-02-23 | 2004-06-15 | Brigham & Womens Hospital | Calciumrezeptoraktive moleküle |
| AU3414295A (en) | 1994-08-19 | 1996-03-14 | Nps Pharmaceuticals, Inc. | Methods and compounds active at metabotropic glutamate receptors useful for treatment of neurological disorders and diseases |
| AU3642795A (en) | 1994-09-27 | 1996-04-19 | Merck & Co., Inc. | Endothelin receptor antagonists for the treatment of emesis |
| ES2234768T3 (es) | 1994-10-21 | 2005-07-01 | Nps Pharmaceuticals, Inc. | Compuestos capaces de modular la actividad del receptor de calcio. |
| US5585388A (en) | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
| IL120424A0 (en) | 1995-07-26 | 1997-07-13 | Nps Pharma Inc | Chimeric receptors and methods for identifying compounds active at metabotropic glutamate receptors and the use of such compounds in the treatment of neurological disorders and diseases |
| BR9708632A (pt) | 1996-04-09 | 2000-01-18 | Nps Pharma Inc | Composto calcilìticos |
| ES2326004T3 (es) | 1996-05-01 | 2009-09-28 | Nps Pharmaceuticals, Inc. | Compuestos activos de receptor de ion inorganico. |
| KR100771092B1 (ko) | 1996-07-08 | 2007-10-30 | 기린 파마 가부시끼가이샤 | 칼슘 수용체 활성 화합물 |
| BRPI9807848B8 (pt) | 1997-02-21 | 2016-05-31 | Bayer Schering Pharma Ag | compostos de arilsulfonamidas e análogos, bem como composição farmacêutica e uso dos mesmos. |
| UY24949A1 (es) | 1997-04-08 | 2001-04-30 | Smithkline Beecham Corp | Compuestos calcilíticos |
| US6103737A (en) | 1997-07-03 | 2000-08-15 | Dupont Pharmaceuticals Company | Aryl- and arylamino- substituted heterocycles as corticotropin releasing hormone antagonists |
| WO2000009491A1 (en) | 1998-08-12 | 2000-02-24 | Smithkline Beecham Corporation | Calcilytic compounds |
| JP2002527414A (ja) | 1998-10-14 | 2002-08-27 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | １，２−ジ置換シクロプロパン |
| JP4068305B2 (ja) | 1999-02-24 | 2008-03-26 | エフ．ホフマン−ラ ロシュ アーゲー | ３−フェニルピリジン誘導体、およびそのｎｋ−１受容体拮抗薬としての用途 |
| PL350427A1 (en) | 1999-02-24 | 2002-12-16 | Hoffmann La Roche | Phenyl− and pyridinyl derivatives as neurokinin 1 antagonists |
| DE60036758T2 (de) | 1999-08-04 | 2008-07-24 | Sumitomo Chemical Co., Ltd. | Verfahren zur Herstellung von optisch aktiver 3,3,3-Trifluor-2-hydroxy-2-methylpropionsäure und deren Salze |
| FR2800735B1 (fr) | 1999-11-09 | 2002-02-01 | Centre Nat Rech Scient | Nouvelles aralkyle-1,2-diamines possedant une activite calcimimetique et leur mode de preparation |
| ATE312808T1 (de) | 1999-12-18 | 2005-12-15 | Wella Ag | 2-aminoalkyl-1,4-diaminobenzol-derivate und diese verbindungen enthaltende färbemittel |
| FR2809396B1 (fr) | 2000-05-24 | 2005-10-14 | Centre Nat Rech Scient | Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation |
| DE10028402A1 (de) | 2000-06-13 | 2001-12-20 | Merck Patent Gmbh | Pyridin-2-yl-aminoalkycarbonylglycyl-beta-alanin und Derivate |
| UY26780A1 (es) | 2000-06-15 | 2002-01-31 | Pharmacia Corp | Cicloalquil avb3 antagonistas |
| CA2433100A1 (en) | 2000-12-27 | 2002-07-04 | Helmut Haning | Indole derivatives as ligands of thyroid receptors |
| CA2448160A1 (en) * | 2001-05-25 | 2002-12-05 | Queen's University At Kingston | Heterocyclic beta-amino acids and their use as anti-epileptogenic agents |
-
2003
- 2003-05-22 US US10/444,945 patent/US7176322B2/en not_active Expired - Lifetime
- 2003-05-23 AU AU2003237235A patent/AU2003237235B2/en not_active Ceased
- 2003-05-23 TW TW092114032A patent/TW200410960A/zh unknown
- 2003-05-23 AR ARP030101798A patent/AR040095A1/es unknown
- 2003-05-23 AT AT03736701T patent/ATE544762T1/de active
- 2003-05-23 WO PCT/US2003/016384 patent/WO2003099814A1/en active Application Filing
- 2003-05-23 PL PL03375559A patent/PL375559A1/xx not_active Application Discontinuation
- 2003-05-23 EP EP03736701A patent/EP1509518B1/en not_active Expired - Lifetime
- 2003-05-23 JP JP2004507471A patent/JP4642461B2/ja not_active Expired - Fee Related
- 2003-05-23 MX MXPA04011469A patent/MXPA04011469A/es active IP Right Grant
- 2003-05-23 ES ES03736701T patent/ES2378759T3/es not_active Expired - Lifetime
- 2003-05-23 CA CA002485685A patent/CA2485685C/en not_active Expired - Fee Related
