JP2005529590A - ＡＲＥ含有ｍＲＮＡとＨｕＲタンパク質の結合のインヒビターの同定方法 - Google Patents
ＡＲＥ含有ｍＲＮＡとＨｕＲタンパク質の結合のインヒビターの同定方法 Download PDFInfo
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
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- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
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| US8460864B2 (en) | 2003-01-21 | 2013-06-11 | Ptc Therapeutics, Inc. | Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same |
| US9068234B2 (en) | 2003-01-21 | 2015-06-30 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating gene expression |
| US8426194B2 (en) | 2003-01-21 | 2013-04-23 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating VEGF expression |
| DE10353803A1 (de) * | 2003-11-14 | 2005-06-23 | Oligene Gmbh | Diagnostische, prognostische und therapeutische Verfahren bei der Untersuchung und Therapie maligner Tumoren |
| US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| SG184755A1 (en) | 2004-03-15 | 2012-10-30 | Ptc Therapeutics Inc | Carboline derivatives useful in the inhibition of angiogenesis |
| US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| US20090005419A1 (en) * | 2005-03-03 | 2009-01-01 | Manfred Auer | Organic Compounds |
| US8283115B1 (en) | 2007-06-20 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation |
| US8283116B1 (en) | 2007-06-22 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation |
| KR20100012714A (ko) * | 2008-07-29 | 2010-02-08 | 재단법인서울대학교산학협력재단 | Ｒｎａ 분자와 단백질 사이의 상호작용을 조절하는 물질을동정하기 위한 분석 방법 |
| US20100209341A1 (en) | 2009-02-18 | 2010-08-19 | Csl Limited | Treatment of chronic inflammatory conditions |
| KR20130032866A (ko) * | 2010-02-18 | 2013-04-02 | 더 유니버시티 오브 멜버른 | 만성 염증 상태의 치료 |
| US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| CA2821992A1 (en) | 2010-10-01 | 2012-04-05 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| HRP20220250T1 (hr) | 2011-10-03 | 2022-04-29 | Modernatx, Inc. | Modificirani nukleozidi, nukleotidi i nukleinske kiseline, te njihove uporabe |
| SI2791160T1 (sl) | 2011-12-16 | 2022-07-29 | Modernatx, Inc. | Sestave modificirane MRNA |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| AU2013243952A1 (en) | 2012-04-02 | 2014-10-30 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| SMT202200337T1 (it) | 2012-11-26 | 2022-09-14 | Modernatx Inc | Rna modificato al livello del terminale |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| US10323076B2 (en) | 2013-10-03 | 2019-06-18 | Modernatx, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| CN117448332B (zh) * | 2023-08-07 | 2025-06-24 | 大连理工大学 | 一种利用RNA结合蛋白增强mRNA蛋白表达的序列优化方法 |
Citations (2)
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| JPH1115230A (ja) * | 1997-06-24 | 1999-01-22 | Ricoh Co Ltd | 回転型現像装置 |
| US20020165186A1 (en) * | 2000-12-20 | 2002-11-07 | Joachim Hauber | Compounds that affect CD83 expression, pharmaceutical compositions comprising said compounds and methods for identifying said compounds |
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| US5444149A (en) * | 1992-05-11 | 1995-08-22 | Duke University | Methods and compositions useful in the recognition, binding and expression of ribonucleic acids involved in cell growth, neoplasia and immunoregulation |
| US5733728A (en) * | 1995-08-18 | 1998-03-31 | Regents Of The University Of Colorado | Detecting and treating heart failure |
| US6107029A (en) | 1996-07-31 | 2000-08-22 | Message Pharmaceticals, Inc. | Universal method for detecting interactions between RNA molecules and RNA binding proteins |
| US6180604B1 (en) * | 1996-08-21 | 2001-01-30 | Micrologix Biotech Inc. | Compositions and methods for treating infections using analogues of indolicidin |
| WO1998039484A1 (en) | 1997-03-05 | 1998-09-11 | Scriptgen Pharmaceuticals, Inc. | Screen employing fluorescence anisotropy to identify compounds with affinity for nucleic acids |
| CA2229449A1 (en) * | 1997-04-25 | 1998-10-25 | Takeda Chemical Industries, Ltd. | Novel receptor protein and its use |
| AU766146B2 (en) | 1998-05-26 | 2003-10-09 | University Of Medicine And Dentistry Of New Jersey | System for reproducing and modulating stability and turnover of RNA molecules |
| GB9828709D0 (en) | 1998-12-24 | 1999-02-17 | Novartis Ag | Assay |
| ATE275727T1 (de) | 1999-04-29 | 2004-09-15 | Coley Pharm Gmbh | Screening nach modulatoren der funktion von immunstimulatorischer dna |
| WO2001012213A2 (en) | 1999-08-13 | 2001-02-22 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Ttp-related zinc finger domains and methods of use |
| US20020127550A1 (en) | 1999-11-10 | 2002-09-12 | Anthony Giordano | Nucleic acid sequences and methods for identifying compounds that affect rna/rna binding protein interactions and mrna functionality |
| AUPQ483599A0 (en) | 1999-12-23 | 2000-02-03 | University Of Western Australia, The | Mrna binding motif |
| US20040023231A1 (en) | 2000-04-12 | 2004-02-05 | Abu-Khabar Khalid S. | System for identifying and analyzing expression of are-containing genes |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH1115230A (ja) * | 1997-06-24 | 1999-01-22 | Ricoh Co Ltd | 回転型現像装置 |
| US20020165186A1 (en) * | 2000-12-20 | 2002-11-07 | Joachim Hauber | Compounds that affect CD83 expression, pharmaceutical compositions comprising said compounds and methods for identifying said compounds |
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| EP1497327A2 (en) | 2005-01-19 |
| AU2003226820A8 (en) | 2003-10-27 |
| WO2003087815A3 (en) | 2004-09-23 |
| WO2003087815A2 (en) | 2003-10-23 |
| AU2003226820A1 (en) | 2003-10-27 |
| US20060008802A1 (en) | 2006-01-12 |
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