JP2005528105A5 - - Google Patents
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- JP2005528105A5 JP2005528105A5 JP2004510393A JP2004510393A JP2005528105A5 JP 2005528105 A5 JP2005528105 A5 JP 2005528105A5 JP 2004510393 A JP2004510393 A JP 2004510393A JP 2004510393 A JP2004510393 A JP 2004510393A JP 2005528105 A5 JP2005528105 A5 JP 2005528105A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- cells
- stem cells
- compound
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000000130 stem cell Anatomy 0.000 claims 51
- 239000008194 pharmaceutical composition Substances 0.000 claims 33
- 150000001875 compounds Chemical class 0.000 claims 23
- 230000000694 effects Effects 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- 125000000623 heterocyclic group Chemical group 0.000 claims 15
- 210000000265 leukocyte Anatomy 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 10
- 210000004700 fetal blood Anatomy 0.000 claims 10
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 10
- 239000003112 inhibitor Substances 0.000 claims 9
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 230000004069 differentiation Effects 0.000 claims 8
- 239000012825 JNK inhibitor Substances 0.000 claims 7
- 229940118135 JNK inhibitor Drugs 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 239000011886 peripheral blood Substances 0.000 claims 5
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 4
- 208000009527 Refractory anemia Diseases 0.000 claims 4
- 206010072684 Refractory cytopenia with unilineage dysplasia Diseases 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 210000005259 peripheral blood Anatomy 0.000 claims 4
- 208000014767 Myeloproliferative disease Diseases 0.000 claims 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 210000001671 embryonic stem cell Anatomy 0.000 claims 3
- -1 hydroxy, carboxy Chemical group 0.000 claims 3
- 210000004976 peripheral blood cell Anatomy 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 210000004991 placental stem cell Anatomy 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 230000005856 abnormality Effects 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 210000004504 adult stem cell Anatomy 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000002798 bone marrow cell Anatomy 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 230000024245 cell differentiation Effects 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 125000004963 sulfonylalkyl group Chemical group 0.000 claims 2
- 125000004001 thioalkyl group Chemical group 0.000 claims 2
- PYAXMGCRUJSCPE-UHFFFAOYSA-N 10h-naphtho[3,2-e][2,1]benzothiazol-9-one Chemical compound C12=CSN=C2C=CC2=C1C=C1CC(=O)C=CC1=C2 PYAXMGCRUJSCPE-UHFFFAOYSA-N 0.000 claims 1
- YONIZQONLRVUOF-UHFFFAOYSA-N 10h-naphtho[3,2-e][2,1]benzoxazol-9-one Chemical compound C12=CON=C2C=CC2=C1C=C1CC(=O)C=CC1=C2 YONIZQONLRVUOF-UHFFFAOYSA-N 0.000 claims 1
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 claims 1
- HOAGRTLXFSVAFE-UHFFFAOYSA-N 8,10-dihydronaphtho[3,2-e]indazol-9-one Chemical compound C1=C2C=CC3=NN=CC3=C2C=C2C1=CCC(=O)C2 HOAGRTLXFSVAFE-UHFFFAOYSA-N 0.000 claims 1
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 206010000890 Acute myelomonocytic leukaemia Diseases 0.000 claims 1
- 206010058956 Bicytopenia Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 208000031637 Erythroblastic Acute Leukemia Diseases 0.000 claims 1
- 208000036566 Erythroleukaemia Diseases 0.000 claims 1
- 208000032027 Essential Thrombocythemia Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 1
- 102100022338 Integrin alpha-M Human genes 0.000 claims 1
- 208000033835 Myelomonocytic Acute Leukemia Diseases 0.000 claims 1
- 208000033833 Myelomonocytic Chronic Leukemia Diseases 0.000 claims 1
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 1
- 206010033661 Pancytopenia Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000013544 Platelet disease Diseases 0.000 claims 1
- 208000007541 Preleukemia Diseases 0.000 claims 1
- 208000021841 acute erythroid leukemia Diseases 0.000 claims 1
- 208000011912 acute myelomonocytic leukemia M4 Diseases 0.000 claims 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
- 125000001118 alkylidene group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 238000010322 bone marrow transplantation Methods 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000010902 chronic myelomonocytic leukemia Diseases 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 1
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 150000003949 imides Chemical class 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 206010028537 myelofibrosis Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- XGXNTJHZPBRBHJ-UHFFFAOYSA-N n-phenylpyrimidin-2-amine Chemical compound N=1C=CC=NC=1NC1=CC=CC=C1 XGXNTJHZPBRBHJ-UHFFFAOYSA-N 0.000 claims 1
- 208000004235 neutropenia Diseases 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 238000012261 overproduction Methods 0.000 claims 1
- 210000004214 philadelphia chromosome Anatomy 0.000 claims 1
- 210000002826 placenta Anatomy 0.000 claims 1
- 208000037244 polycythemia vera Diseases 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 208000003476 primary myelofibrosis Diseases 0.000 claims 1
- 210000004765 promyelocyte Anatomy 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 206010043554 thrombocytopenia Diseases 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 0 */C1=C(/*)\C(\*)=N\C(\CCCC(C=C2)=C*(C3*C3)C=C2C(N(*)*)=O)=C\C*1 Chemical compound */C1=C(/*)\C(\*)=N\C(\CCCC(C=C2)=C*(C3*C3)C=C2C(N(*)*)=O)=C\C*1 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38425002P | 2002-05-30 | 2002-05-30 | |
| US43483302P | 2002-12-19 | 2002-12-19 | |
| PCT/US2003/017319 WO2003102151A2 (en) | 2002-05-30 | 2003-05-30 | Modulating cell differentiation and treating myeloprolifertive disorders with jnk/mkk inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005528105A JP2005528105A (ja) | 2005-09-22 |
| JP2005528105A5 true JP2005528105A5 (enExample) | 2006-07-27 |
Family
ID=29715319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004510393A Pending JP2005528105A (ja) | 2002-05-30 | 2003-05-30 | 細胞分化をモジュレートするため、並びに骨髄増殖性疾患及び骨髄異形成症候群を治療するためのｊｎｋ又はｍｋｋ阻害剤の使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040028660A1 (enExample) |
| EP (1) | EP1525308A4 (enExample) |
| JP (1) | JP2005528105A (enExample) |
| KR (1) | KR20050008757A (enExample) |
| CN (1) | CN1668733A (enExample) |
| AU (1) | AU2003231950A1 (enExample) |
| CA (1) | CA2488013A1 (enExample) |
| MX (1) | MXPA04011851A (enExample) |
| WO (1) | WO2003102151A2 (enExample) |
Families Citing this family (107)
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|---|---|---|---|---|
| US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| US20080152629A1 (en) * | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
| EP2305795B1 (en) * | 2000-12-06 | 2019-07-03 | Celularity, Inc. | Method of collecting placental stem cells |
| WO2002064755A2 (en) * | 2001-02-14 | 2002-08-22 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| AU2002243980B2 (en) | 2001-02-14 | 2007-08-23 | Robert J. Hariri | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
| AU2002258734A1 (en) * | 2001-04-13 | 2002-10-28 | Wyeth Holdings Corporation | Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography |
| EP1487436A4 (en) * | 2002-03-08 | 2009-06-03 | Signal Pharm Inc | POLYTHERAPY FOR TREATING, PREVENTING OR MANAGING PROLIFERATIVE DISORDERS AND CANCERS |
| US20050148034A1 (en) * | 2002-04-12 | 2005-07-07 | Hariri Robert J. | Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds |
| US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| US8034831B2 (en) * | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
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| BRPI0407427A (pt) * | 2003-02-13 | 2006-01-24 | Anthrogenesis Corp | Método para tratar um paciente e para tratar a mielodisplasia |
| US20100158880A1 (en) * | 2008-12-19 | 2010-06-24 | Ethicon, Incorporated | Regeneration and repair of neural tissue following injury |
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| US8518390B2 (en) | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
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- 2003-05-30 JP JP2004510393A patent/JP2005528105A/ja active Pending
- 2003-05-30 CA CA002488013A patent/CA2488013A1/en not_active Abandoned
- 2003-05-30 AU AU2003231950A patent/AU2003231950A1/en not_active Abandoned
- 2003-05-30 CN CNA038172674A patent/CN1668733A/zh active Pending
- 2003-05-30 MX MXPA04011851A patent/MXPA04011851A/es not_active Application Discontinuation
- 2003-05-30 US US10/449,248 patent/US20040028660A1/en not_active Abandoned
- 2003-05-30 KR KR10-2004-7019520A patent/KR20050008757A/ko not_active Withdrawn
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