JP2005527615A - ナトリウムチャンネルブロッカーの非経口適用のための新規な製剤 - Google Patents
ナトリウムチャンネルブロッカーの非経口適用のための新規な製剤 Download PDFInfo
- Publication number
- JP2005527615A JP2005527615A JP2004506859A JP2004506859A JP2005527615A JP 2005527615 A JP2005527615 A JP 2005527615A JP 2004506859 A JP2004506859 A JP 2004506859A JP 2004506859 A JP2004506859 A JP 2004506859A JP 2005527615 A JP2005527615 A JP 2005527615A
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- cyclodextrin
- biii
- acid
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 title abstract description 6
- 239000000203 mixture Substances 0.000 title abstract description 6
- 239000003195 sodium channel blocking agent Substances 0.000 title description 2
- VCCBCXVFGHTDQN-UODBTFMRSA-N BIII-890CL Chemical compound O([C@H](CN1[C@@H]2CC3=C(O)C=CC=C3[C@](C2(C)C)(C)CC1)C)CC1=CC=CC=C1 VCCBCXVFGHTDQN-UODBTFMRSA-N 0.000 claims abstract description 35
- 150000003839 salts Chemical class 0.000 claims abstract description 17
- 238000007911 parenteral administration Methods 0.000 claims abstract description 4
- 229920000858 Cyclodextrin Polymers 0.000 claims description 35
- 239000008194 pharmaceutical composition Substances 0.000 claims description 25
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 24
- 239000013543 active substance Substances 0.000 claims description 22
- 150000001261 hydroxy acids Chemical class 0.000 claims description 18
- JVFGXECLSQXABC-UHFFFAOYSA-N ac1l3obq Chemical compound O1C(C(C2O)O)C(COCC(C)O)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC(C(O)C2O)C(COCC(O)C)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC2C(O)C(O)C1OC2COCC(C)O JVFGXECLSQXABC-UHFFFAOYSA-N 0.000 claims description 10
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 8
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims description 7
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 6
- 239000011975 tartaric acid Substances 0.000 claims description 6
- 235000002906 tartaric acid Nutrition 0.000 claims description 6
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 5
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 5
- 239000001630 malic acid Substances 0.000 claims description 5
- 235000011090 malic acid Nutrition 0.000 claims description 5
- 235000015165 citric acid Nutrition 0.000 claims description 4
- 239000004310 lactic acid Substances 0.000 claims description 4
- 235000014655 lactic acid Nutrition 0.000 claims description 4
- -1 HP-γ-CD Chemical compound 0.000 claims description 3
- UWKTVIXWZRROOI-VLIWAZBPSA-N chembl2401795 Chemical compound Cl.O([C@H](CN1[C@@H]2CC3=C(O)C=CC=C3[C@](C2(C)C)(C)CC1)C)CC1=CC=CC=C1 UWKTVIXWZRROOI-VLIWAZBPSA-N 0.000 claims description 3
- 238000001990 intravenous administration Methods 0.000 claims description 3
- 208000006011 Stroke Diseases 0.000 claims 7
- 238000000034 method Methods 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
- 238000002347 injection Methods 0.000 description 12
- 239000007924 injection Substances 0.000 description 12
- 239000002585 base Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000008215 water for injection Substances 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- BDKLKNJTMLIAFE-UHFFFAOYSA-N 2-(3-fluorophenyl)-1,3-oxazole-4-carbaldehyde Chemical compound FC1=CC=CC(C=2OC=C(C=O)N=2)=C1 BDKLKNJTMLIAFE-UHFFFAOYSA-N 0.000 description 5
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 5
- 229930195725 Mannitol Natural products 0.000 description 5
- 239000000594 mannitol Substances 0.000 description 5
- 235000010355 mannitol Nutrition 0.000 description 5
- 235000017281 sodium acetate Nutrition 0.000 description 5
- 229940087562 sodium acetate trihydrate Drugs 0.000 description 5
- 229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 230000009918 complex formation Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229940097362 cyclodextrins Drugs 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 239000001116 FEMA 4028 Substances 0.000 description 1
- 229920004482 WACKER® Polymers 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 1
- 229960004853 betadex Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000006931 brain damage Effects 0.000 description 1
- 231100000874 brain damage Toxicity 0.000 description 1
- 208000029028 brain injury Diseases 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000000324 neuroprotective effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- 229940125794 sodium channel blocker Drugs 0.000 description 1
- RIRRNZUBFFOHHQ-UHFFFAOYSA-M sodium;phosphoric acid;acetate Chemical compound [Na+].CC([O-])=O.OP(O)(O)=O RIRRNZUBFFOHHQ-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009424 thromboembolic effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10223783A DE10223783A1 (de) | 2002-05-29 | 2002-05-29 | Neue Formulierung zur parenteralen Applikation eines Na-Kanal-Blockers |
| PCT/EP2003/005399 WO2003099336A1 (de) | 2002-05-29 | 2003-05-23 | Formulierung zur parenteralen applikation eines na-kanal-blockers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005527615A true JP2005527615A (ja) | 2005-09-15 |
| JP2005527615A5 JP2005527615A5 (cg-RX-API-DMAC7.html) | 2006-07-13 |
Family
ID=29432393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004506859A Pending JP2005527615A (ja) | 2002-05-29 | 2003-05-23 | ナトリウムチャンネルブロッカーの非経口適用のための新規な製剤 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1511517B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2005527615A (cg-RX-API-DMAC7.html) |
| AR (1) | AR040134A1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE373492T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003237664A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2487150A1 (cg-RX-API-DMAC7.html) |
| DE (2) | DE10223783A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2294295T3 (cg-RX-API-DMAC7.html) |
| PE (1) | PE20040066A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW200400029A (cg-RX-API-DMAC7.html) |
| UY (1) | UY27823A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2003099336A1 (cg-RX-API-DMAC7.html) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06199691A (ja) * | 1992-11-27 | 1994-07-19 | Boehringer Ingelheim Internatl Gmbh | 安定化スーパーオキシドジスムターゼ組成物 |
| JPH07291806A (ja) * | 1993-04-23 | 1995-11-07 | Boehringer Mannheim Gmbh | シクロデキストリン−殺生物剤複合体 |
| JPH09506889A (ja) * | 1993-12-22 | 1997-07-08 | コミツサリア タ レネルジー アトミーク | 抗てんかん剤として使用可能なジベンザゼピン類を水溶性にするためのアミノシクロデキストリン類の使用 |
| JP2001516747A (ja) * | 1997-09-12 | 2001-10-02 | ベーリンガー インゲルハイム ファルマ コマンディトゲゼルシャフト | 置換１，２，３，４，５，６−ヘキサヒドロ−２，６−メタノ−３−ベンゾアゾシン−１０−オール、それらの調製方法及び医薬組成物としてのそれらの使用 |
| JP2004504360A (ja) * | 2000-07-24 | 2004-02-12 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | １−（５−ｔｅｒｔ−ブチル−２−Ｐ−トリル−２Ｈ−ピラゾール−３−イル）−３−［４−（２−モルホリン−４−イル−エトキシ）−ナフタレン−１−イル］−ウレアの改良された経口製剤 |
| JP2005531573A (ja) * | 2002-05-29 | 2005-10-20 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | クロベネチンの非経口的用途用の新規製剤 |
-
2002
- 2002-05-29 DE DE10223783A patent/DE10223783A1/de not_active Withdrawn
-
2003
- 2003-05-23 AU AU2003237664A patent/AU2003237664A1/en not_active Abandoned
- 2003-05-23 EP EP03735445A patent/EP1511517B1/de not_active Expired - Lifetime
- 2003-05-23 CA CA002487150A patent/CA2487150A1/en not_active Abandoned
- 2003-05-23 WO PCT/EP2003/005399 patent/WO2003099336A1/de not_active Ceased
- 2003-05-23 JP JP2004506859A patent/JP2005527615A/ja active Pending
- 2003-05-23 DE DE50308227T patent/DE50308227D1/de not_active Expired - Fee Related
- 2003-05-23 ES ES03735445T patent/ES2294295T3/es not_active Expired - Lifetime
- 2003-05-23 AT AT03735445T patent/ATE373492T1/de not_active IP Right Cessation
- 2003-05-27 PE PE2003000511A patent/PE20040066A1/es not_active Application Discontinuation
- 2003-05-27 UY UY27823A patent/UY27823A1/es not_active Application Discontinuation
- 2003-05-28 TW TW092114414A patent/TW200400029A/zh unknown
- 2003-05-28 AR ARP030101863A patent/AR040134A1/es not_active Application Discontinuation
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06199691A (ja) * | 1992-11-27 | 1994-07-19 | Boehringer Ingelheim Internatl Gmbh | 安定化スーパーオキシドジスムターゼ組成物 |
| JPH07291806A (ja) * | 1993-04-23 | 1995-11-07 | Boehringer Mannheim Gmbh | シクロデキストリン−殺生物剤複合体 |
| JPH09506889A (ja) * | 1993-12-22 | 1997-07-08 | コミツサリア タ レネルジー アトミーク | 抗てんかん剤として使用可能なジベンザゼピン類を水溶性にするためのアミノシクロデキストリン類の使用 |
| JP2001516747A (ja) * | 1997-09-12 | 2001-10-02 | ベーリンガー インゲルハイム ファルマ コマンディトゲゼルシャフト | 置換１，２，３，４，５，６−ヘキサヒドロ−２，６−メタノ−３−ベンゾアゾシン−１０−オール、それらの調製方法及び医薬組成物としてのそれらの使用 |
| JP2004504360A (ja) * | 2000-07-24 | 2004-02-12 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | １−（５−ｔｅｒｔ−ブチル−２−Ｐ−トリル−２Ｈ−ピラゾール−３−イル）−３−［４−（２−モルホリン−４−イル−エトキシ）−ナフタレン−１−イル］−ウレアの改良された経口製剤 |
| JP2005531573A (ja) * | 2002-05-29 | 2005-10-20 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | クロベネチンの非経口的用途用の新規製剤 |
Non-Patent Citations (1)
| Title |
|---|
| JPN6009068248, Ｔｒｅｎｄｓ ｉｎ Ｐｈａｒｍａｃｏｌｏｇｉｃａｌ Ｓｃｉｅｎｃｅｓ, 1995, ｖｏｌ．１６, ３０９−３１６ * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE50308227D1 (de) | 2007-10-31 |
| DE10223783A1 (de) | 2003-12-11 |
| EP1511517A1 (de) | 2005-03-09 |
| ES2294295T3 (es) | 2008-04-01 |
| AU2003237664A1 (en) | 2003-12-12 |
| EP1511517B1 (de) | 2007-09-19 |
| PE20040066A1 (es) | 2004-03-22 |
| ATE373492T1 (de) | 2007-10-15 |
| WO2003099336A1 (de) | 2003-12-04 |
| AR040134A1 (es) | 2005-03-16 |
| CA2487150A1 (en) | 2003-12-04 |
| UY27823A1 (es) | 2003-12-31 |
| TW200400029A (en) | 2004-01-01 |
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