JP2005527570A - 肺障害の治療 - Google Patents
肺障害の治療 Download PDFInfo
- Publication number
- JP2005527570A JP2005527570A JP2003581716A JP2003581716A JP2005527570A JP 2005527570 A JP2005527570 A JP 2005527570A JP 2003581716 A JP2003581716 A JP 2003581716A JP 2003581716 A JP2003581716 A JP 2003581716A JP 2005527570 A JP2005527570 A JP 2005527570A
- Authority
- JP
- Japan
- Prior art keywords
- atiii
- antithrombin iii
- lung
- lung injury
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Abstract
Description
一実施形態では、 キットは、ヒトATIIIのエアゾール形態を含む。ATIIIは、例えば血漿のような天然物に由来するものであっても、または組み換えによって製造したものであってもよい。好ましい一実施形態では、アンチトロンビンIIIは、遺伝子導入によって製造され、例えば、ATIIIは、ウシ、ヤギ、ウサギ、またはマウスといったトランスジェニック乳用動物の乳から得られたものである。
Claims (13)
- 肺損傷を治療するのに治療的に効果的な量のアンチトロンビンIIIを吸入によって投与することを含む、対象において急性肺損傷を治療する方法。
- 肺損傷が感染性急性肺損傷であることを特徴とする請求項1記載の方法。
- 肺損傷が急性呼吸窮迫症候群であることを特徴とする請求項1記載の方法。
- 肺損傷が、ウイルス物質への曝露に対して生じたものであることを特徴とする請求項1記載の方法。
- 前記ウイルス物質が緑膿菌であることを特徴とする請求項4記載の方法。
- 肺損傷が、煙およびアスベストの1つ以上に対して生じたものであることを特徴とする請求項1記載の方法。
- アンチトロンビンIIIが、超音波ネブライザーを用いて投与されることを特徴とする請求項1記載の方法。
- アンチトロンビンIIIが、血漿由来アンチトロンビンIIIであることを特徴とする請求項1記載の方法。
- アンチトロンビンIIIが、組み換えによって製造されたアンチトロンビンIIIであることを特徴とする請求項1記載の方法。
- 組み換えによって製造されたアンチトロンビンIIIが、遺伝子導入によって製造されたアンチトロンビンIIIであることを特徴とする請求項9記載の方法。
- 1回用量より多くのアンチトロンビンIIIを対象に投与することを特徴とする請求項1記載の方法。
- 体重に対して約10〜300U/kgの用量でアンチトロンビンIIIを投与することを特徴とする請求項1記載の方法。
- 体重に対して約25〜125U/kgの用量でアンチトロンビンIIIを投与することを特徴とする請求項1記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36899702P | 2002-04-01 | 2002-04-01 | |
PCT/US2003/009053 WO2003084476A2 (en) | 2002-04-01 | 2003-03-25 | Treatment of lung disorder |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011176604A Division JP2011225625A (ja) | 2002-04-01 | 2011-08-12 | 肺障害の治療 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005527570A true JP2005527570A (ja) | 2005-09-15 |
JP2005527570A5 JP2005527570A5 (ja) | 2006-05-25 |
Family
ID=29420316
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003581716A Pending JP2005527570A (ja) | 2002-04-01 | 2003-03-25 | 肺障害の治療 |
JP2011176604A Withdrawn JP2011225625A (ja) | 2002-04-01 | 2011-08-12 | 肺障害の治療 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011176604A Withdrawn JP2011225625A (ja) | 2002-04-01 | 2011-08-12 | 肺障害の治療 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20090221475A9 (ja) |
EP (1) | EP1494696A4 (ja) |
JP (2) | JP2005527570A (ja) |
KR (2) | KR20100117148A (ja) |
CN (1) | CN100384469C (ja) |
AU (3) | AU2003233428B2 (ja) |
CA (1) | CA2480790A1 (ja) |
IL (2) | IL164078A0 (ja) |
NZ (1) | NZ535487A (ja) |
WO (1) | WO2003084476A2 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050169908A1 (en) * | 2004-01-23 | 2005-08-04 | Kazunori Murakami | Use of aerosolized antithrombin to treat acute lung injury |
US20050192226A1 (en) * | 2004-02-20 | 2005-09-01 | Perenlei Enkhbaatar | Method of preventing fibrin clots in pulmonary tissue through the use of aerosolized anticoagulants |
US20050245444A1 (en) * | 2004-04-30 | 2005-11-03 | Yann Echelard | Method of using recombinant human antithrombin for neurocognitive disorders |
US20060121004A1 (en) * | 2004-12-07 | 2006-06-08 | Yann Echelard | Methods of reducing the incidence of rejection in tissue transplantation through the use of recombinant human antithrombin |
US8753882B2 (en) | 2010-10-12 | 2014-06-17 | Vetgel Technologies | Methods and compositions for treating respiratory conditions using platelet enriched plasma |
MY160298A (en) | 2010-12-30 | 2017-02-28 | Lab Francais Du Fractionnement | Glycols as pathogen inactivating agents |
ES2755181T3 (es) | 2013-02-13 | 2020-04-21 | Lab Francais Du Fractionnement | Anticuerpos anti-TNF-alfa altamente galactosilados y usos de los mismos |
WO2014140927A2 (en) | 2013-02-13 | 2014-09-18 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Proteins with modified glycosylation and methods of production thereof |
EP3016729B1 (fr) | 2013-07-05 | 2020-03-25 | Laboratoire Francais du Fractionnement et des Biotechnologies Societe Anonyme | Matrice de chromatographie d'affinité |
US11491480B2 (en) | 2014-06-13 | 2022-11-08 | Children's Medical Center Corporation | Products and methods to isolate mitochondria |
JP2022529262A (ja) * | 2019-04-15 | 2022-06-20 | チルドレンズ メディカル センター コーポレイション | ミトコンドリアを含むエアロゾル化組成物及びその使用方法 |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63132843A (ja) * | 1986-11-22 | 1988-06-04 | Green Cross Corp:The | 抗炎症剤 |
JPH06256213A (ja) * | 1993-03-03 | 1994-09-13 | Green Cross Corp:The | ヒト由来アンチトロンビン−iiiの医薬用途 |
WO1995031207A1 (en) * | 1994-05-13 | 1995-11-23 | The Trustees Of The University Of Pennsylvania | Antithrombin agents in treatment of asthma |
JPH09176040A (ja) * | 1995-12-27 | 1997-07-08 | Green Cross Corp:The | ヘパリンコファクターiiの医薬用途 |
JP2000501082A (ja) * | 1995-11-30 | 2000-02-02 | ハミルトン シビック ホスピタルズ リサーチ デベロップメント,インコーポレイテッド | グリコサミノグリカン―アンチトロンビンiii/ヘパリン補因子ii結合体 |
WO2000023569A1 (en) * | 1998-10-20 | 2000-04-27 | Children's Hospital Medical Center | Surfactant protein d for the prevention and diagnosis of pulmonary emphysema |
US6124257A (en) * | 1997-08-28 | 2000-09-26 | Lezdey; John | Method of treatment |
WO2001080633A2 (en) * | 2000-04-26 | 2001-11-01 | Children's Hospital Medical Center | Surfactant protein d for the prevention and diagnosis of pulmonary emphysema |
WO2002022150A2 (de) * | 2000-09-12 | 2002-03-21 | Beate Kehrel | Arzneimittel enthaltend aktiviertes antithrombin iii |
JP2003040797A (ja) * | 2001-07-06 | 2003-02-13 | Aventis Behring Gmbh | 抗炎症性肺疾患およびardsにおける抗トロンビン吸入のための医薬製剤 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4117078A1 (de) * | 1991-05-25 | 1992-11-26 | Boehringer Ingelheim Kg | Verfahren zur herstellung therapeutisch anwendbarer aerosole |
US6127347A (en) * | 1994-01-12 | 2000-10-03 | Univ Michigan | Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes |
US5843705A (en) * | 1995-02-21 | 1998-12-01 | Genzyme Transgenic Corporation | Transgenically produced antithrombin III |
US7045585B2 (en) * | 1995-11-30 | 2006-05-16 | Hamilton Civic Hospital Research Development Inc. | Methods of coating a device using anti-thrombin heparin |
US6063593A (en) * | 1996-11-12 | 2000-05-16 | University Of Southern California University Park Campus | TGFβ1 responsive bone marrow derived cells to express a recombinant protein |
AU2002224408B2 (en) * | 2000-10-18 | 2007-08-23 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
US20050169908A1 (en) * | 2004-01-23 | 2005-08-04 | Kazunori Murakami | Use of aerosolized antithrombin to treat acute lung injury |
US20050192226A1 (en) * | 2004-02-20 | 2005-09-01 | Perenlei Enkhbaatar | Method of preventing fibrin clots in pulmonary tissue through the use of aerosolized anticoagulants |
-
2003
- 2003-03-25 CA CA002480790A patent/CA2480790A1/en not_active Abandoned
- 2003-03-25 IL IL16407803A patent/IL164078A0/xx active IP Right Grant
- 2003-03-25 EP EP03728277A patent/EP1494696A4/en not_active Withdrawn
- 2003-03-25 US US10/396,855 patent/US20090221475A9/en not_active Abandoned
- 2003-03-25 CN CNB03807463XA patent/CN100384469C/zh not_active Expired - Fee Related
- 2003-03-25 WO PCT/US2003/009053 patent/WO2003084476A2/en active Application Filing
- 2003-03-25 AU AU2003233428A patent/AU2003233428B2/en not_active Revoked
- 2003-03-25 KR KR1020107022448A patent/KR20100117148A/ko active Application Filing
- 2003-03-25 NZ NZ535487A patent/NZ535487A/en not_active IP Right Cessation
- 2003-03-25 JP JP2003581716A patent/JP2005527570A/ja active Pending
- 2003-03-25 KR KR10-2004-7015636A patent/KR20040105838A/ko not_active Application Discontinuation
-
2004
- 2004-09-14 IL IL164078A patent/IL164078A/en not_active IP Right Cessation
-
2008
- 2008-10-31 AU AU2008243077A patent/AU2008243077A1/en not_active Withdrawn
-
2011
- 2011-08-12 JP JP2011176604A patent/JP2011225625A/ja not_active Withdrawn
- 2011-10-10 AU AU2011236070A patent/AU2011236070A1/en not_active Ceased
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63132843A (ja) * | 1986-11-22 | 1988-06-04 | Green Cross Corp:The | 抗炎症剤 |
JPH06256213A (ja) * | 1993-03-03 | 1994-09-13 | Green Cross Corp:The | ヒト由来アンチトロンビン−iiiの医薬用途 |
WO1995031207A1 (en) * | 1994-05-13 | 1995-11-23 | The Trustees Of The University Of Pennsylvania | Antithrombin agents in treatment of asthma |
JP2000501082A (ja) * | 1995-11-30 | 2000-02-02 | ハミルトン シビック ホスピタルズ リサーチ デベロップメント,インコーポレイテッド | グリコサミノグリカン―アンチトロンビンiii/ヘパリン補因子ii結合体 |
JPH09176040A (ja) * | 1995-12-27 | 1997-07-08 | Green Cross Corp:The | ヘパリンコファクターiiの医薬用途 |
US6124257A (en) * | 1997-08-28 | 2000-09-26 | Lezdey; John | Method of treatment |
WO2000023569A1 (en) * | 1998-10-20 | 2000-04-27 | Children's Hospital Medical Center | Surfactant protein d for the prevention and diagnosis of pulmonary emphysema |
WO2001080633A2 (en) * | 2000-04-26 | 2001-11-01 | Children's Hospital Medical Center | Surfactant protein d for the prevention and diagnosis of pulmonary emphysema |
WO2002022150A2 (de) * | 2000-09-12 | 2002-03-21 | Beate Kehrel | Arzneimittel enthaltend aktiviertes antithrombin iii |
JP2003040797A (ja) * | 2001-07-06 | 2003-02-13 | Aventis Behring Gmbh | 抗炎症性肺疾患およびardsにおける抗トロンビン吸入のための医薬製剤 |
Also Published As
Publication number | Publication date |
---|---|
AU2003233428A1 (en) | 2003-10-20 |
AU2003233428B2 (en) | 2008-07-31 |
AU2011236070A1 (en) | 2011-11-03 |
KR20040105838A (ko) | 2004-12-16 |
US20040192595A1 (en) | 2004-09-30 |
CN100384469C (zh) | 2008-04-30 |
EP1494696A4 (en) | 2006-01-25 |
WO2003084476A3 (en) | 2004-04-22 |
AU2008243077A1 (en) | 2008-11-27 |
CN1774258A (zh) | 2006-05-17 |
WO2003084476A2 (en) | 2003-10-16 |
IL164078A0 (en) | 2005-12-18 |
US20090221475A9 (en) | 2009-09-03 |
KR20100117148A (ko) | 2010-11-02 |
IL164078A (en) | 2011-02-28 |
NZ535487A (en) | 2008-12-24 |
JP2011225625A (ja) | 2011-11-10 |
EP1494696A2 (en) | 2005-01-12 |
CA2480790A1 (en) | 2003-10-16 |
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