JP2005526807A - 炎症性症状の治療においてｃｃｒ−３アンタゴニストとして使用するための、アリールアルキルウレア基により２位が置換されたモルホリン誘導体 - Google Patents
炎症性症状の治療においてｃｃｒ−３アンタゴニストとして使用するための、アリールアルキルウレア基により２位が置換されたモルホリン誘導体 Download PDFInfo
- Publication number
- JP2005526807A JP2005526807A JP2003579829A JP2003579829A JP2005526807A JP 2005526807 A JP2005526807 A JP 2005526807A JP 2003579829 A JP2003579829 A JP 2003579829A JP 2003579829 A JP2003579829 A JP 2003579829A JP 2005526807 A JP2005526807 A JP 2005526807A
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- dichlorobenzyl
- morpholin
- amino
- urea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XYHFNWLMOULUAT-ZDUSSCGKSA-N CC(C)(C)OC(NC[C@@H]1OCCN(Cc(cc2)cc(Cl)c2F)C1)=O Chemical compound CC(C)(C)OC(NC[C@@H]1OCCN(Cc(cc2)cc(Cl)c2F)C1)=O XYHFNWLMOULUAT-ZDUSSCGKSA-N 0.000 description 1
- BPIFCIIWUOGNMZ-NRFANRHFSA-N CC(C)(CC1)[O]1C(NNC(c1cccc(CNC(NC[C@@H]2OCCN(Cc(cc3F)ccc3F)C2)=O)c1)=O)=O Chemical compound CC(C)(CC1)[O]1C(NNC(c1cccc(CNC(NC[C@@H]2OCCN(Cc(cc3F)ccc3F)C2)=O)c1)=O)=O BPIFCIIWUOGNMZ-NRFANRHFSA-N 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N CCN(CC)CC Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 1
- JPUKXILNDGITDW-KRWDZBQOSA-N CCOC(c1cc(CNC(NC[C@@H]2OCCN(Cc(cc3)cc(Cl)c3Cl)C2)=O)ccc1F)=O Chemical compound CCOC(c1cc(CNC(NC[C@@H]2OCCN(Cc(cc3)cc(Cl)c3Cl)C2)=O)ccc1F)=O JPUKXILNDGITDW-KRWDZBQOSA-N 0.000 description 1
- MOLQIUDLNQSSHL-KRWDZBQOSA-N OC(c1cc(CNC(NC[C@@H]2OCCN(Cc(cc3Cl)ccc3Cl)C2)=O)ccc1)=O Chemical compound OC(c1cc(CNC(NC[C@@H]2OCCN(Cc(cc3Cl)ccc3Cl)C2)=O)ccc1)=O MOLQIUDLNQSSHL-KRWDZBQOSA-N 0.000 description 1
- DJVBYKUXZPCRCL-INIZCTEOSA-N [O-][N+](c(cc1)ccc1OC(NC[C@@H]1OCCN(Cc(cc2Cl)ccc2F)C1)=O)=O Chemical compound [O-][N+](c(cc1)ccc1OC(NC[C@@H]1OCCN(Cc(cc2Cl)ccc2F)C1)=O)=O DJVBYKUXZPCRCL-INIZCTEOSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0207436.7A GB0207436D0 (en) | 2002-03-28 | 2002-03-28 | Novel compounds |
| PCT/EP2003/003340 WO2003082292A1 (en) | 2002-03-28 | 2003-03-27 | Morpholine derivatives substituted at the 2-position by an arylalkylurea group for use as ccr-3 antagonists in the treatment of inflammatory conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2005526807A true JP2005526807A (ja) | 2005-09-08 |
Family
ID=9933988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003579829A Pending JP2005526807A (ja) | 2002-03-28 | 2003-03-27 | 炎症性症状の治療においてｃｃｒ−３アンタゴニストとして使用するための、アリールアルキルウレア基により２位が置換されたモルホリン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1487455A1 (zh) |
| JP (1) | JP2005526807A (zh) |
| AR (1) | AR039172A1 (zh) |
| AU (1) | AU2003226759A1 (zh) |
| GB (1) | GB0207436D0 (zh) |
| TW (1) | TW200400824A (zh) |
| WO (1) | WO2003082292A1 (zh) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007135969A1 (ja) * | 2006-05-19 | 2007-11-29 | Eisai R & D Management Co., Ltd. | ウレア系－シンナミド誘導体 |
| US7618960B2 (en) | 2005-11-24 | 2009-11-17 | Eisai R&D Management Co., Ltd. | Morpholine type cinnamide compound |
| US7667041B2 (en) | 2004-05-26 | 2010-02-23 | Eisai R&D Management Co., Ltd. | Cinnamide compound |
| US7713993B2 (en) | 2006-03-09 | 2010-05-11 | Eisai R&D Management Co., Ltd. | Multi-cycle cinnamide derivatives |
| US7737141B2 (en) | 2006-07-28 | 2010-06-15 | Eisai R&D Management Co., Ltd. | Prodrug of cinnamide compound |
| US7923563B2 (en) | 2004-10-26 | 2011-04-12 | Eisai R&D Management Co., Ltd. | Amorphous object of cinnamide compound |
| US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| US8008293B2 (en) | 2007-02-28 | 2011-08-30 | Eisai R&D Management Co., Ltd. | Bicyclic oxomorpholine derivative |
| US8048878B2 (en) | 2005-11-24 | 2011-11-01 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
| US9453000B2 (en) | 2007-08-31 | 2016-09-27 | Eisai R&D Management Co., Ltd. | Polycyclic compound |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR028948A1 (es) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
| JP4970946B2 (ja) | 2004-09-08 | 2012-07-11 | 田辺三菱製薬株式会社 | モルホリン化合物 |
| MX2008002320A (es) * | 2005-08-26 | 2008-03-14 | Astrazeneca Ab | Combinacion de compuestos que pueden ser utilizados en el tratamiento de enfermedades respiratorias, especialmente enfermedad pulmonar obstructiva cronica y asma. |
| TW200744612A (en) * | 2005-08-26 | 2007-12-16 | Astrazeneca Ab | New combination |
| WO2008103126A1 (en) * | 2007-02-23 | 2008-08-28 | Astrazeneca Ab | Novel combination of compounds to be used in the treatment of airway diseases, especially chronic obstructive pulmonary disease (copd) and asthma |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69527786T2 (de) * | 1994-05-18 | 2003-04-10 | Nisshin Seifun Group Inc | Diaminomethyliden-derivate |
| TR200101398T2 (tr) * | 1998-11-20 | 2001-09-21 | F.Hoffmann-La Roche Ag | Pirolidin türevleri-CCR-3 reseptörü antagonistleri. |
| PL362984A1 (en) * | 2000-09-29 | 2004-11-15 | Glaxo Group Limited | Compounds useful in the treatment of inflammatory diseases |
-
2002
- 2002-03-28 GB GBGB0207436.7A patent/GB0207436D0/en not_active Ceased
-
2003
- 2003-03-26 TW TW092106769A patent/TW200400824A/zh unknown
- 2003-03-27 JP JP2003579829A patent/JP2005526807A/ja active Pending
- 2003-03-27 EP EP03745296A patent/EP1487455A1/en not_active Withdrawn
- 2003-03-27 WO PCT/EP2003/003340 patent/WO2003082292A1/en not_active Application Discontinuation
- 2003-03-27 AU AU2003226759A patent/AU2003226759A1/en not_active Abandoned
- 2003-03-27 AR ARP030101084A patent/AR039172A1/es unknown
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7880009B2 (en) | 2004-05-26 | 2011-02-01 | Eisai R&D Management Co., Ltd. | Cinnamide compound |
| US7667041B2 (en) | 2004-05-26 | 2010-02-23 | Eisai R&D Management Co., Ltd. | Cinnamide compound |
| US7687640B2 (en) | 2004-05-26 | 2010-03-30 | Eisai R&D Management Co., Ltd. | Cinnamide compound |
| US7923563B2 (en) | 2004-10-26 | 2011-04-12 | Eisai R&D Management Co., Ltd. | Amorphous object of cinnamide compound |
| US7618960B2 (en) | 2005-11-24 | 2009-11-17 | Eisai R&D Management Co., Ltd. | Morpholine type cinnamide compound |
| US8048878B2 (en) | 2005-11-24 | 2011-11-01 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
| US7713993B2 (en) | 2006-03-09 | 2010-05-11 | Eisai R&D Management Co., Ltd. | Multi-cycle cinnamide derivatives |
| US7973033B2 (en) | 2006-03-09 | 2011-07-05 | Eisai R&D Management Co., Ltd. | Multi-cyclic cinnamide derivatives |
| US7897632B2 (en) | 2006-03-09 | 2011-03-01 | Eisai R&D Management Co., Ltd. | Multi-cyclic cinnamide derivatives |
| WO2007135969A1 (ja) * | 2006-05-19 | 2007-11-29 | Eisai R & D Management Co., Ltd. | ウレア系－シンナミド誘導体 |
| US7737141B2 (en) | 2006-07-28 | 2010-06-15 | Eisai R&D Management Co., Ltd. | Prodrug of cinnamide compound |
| US8008293B2 (en) | 2007-02-28 | 2011-08-30 | Eisai R&D Management Co., Ltd. | Bicyclic oxomorpholine derivative |
| US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| US9453000B2 (en) | 2007-08-31 | 2016-09-27 | Eisai R&D Management Co., Ltd. | Polycyclic compound |
Also Published As
| Publication number | Publication date |
|---|---|
| TW200400824A (en) | 2004-01-16 |
| WO2003082292A1 (en) | 2003-10-09 |
| GB0207436D0 (en) | 2002-05-08 |
| EP1487455A1 (en) | 2004-12-22 |
| AR039172A1 (es) | 2005-02-09 |
| AU2003226759A1 (en) | 2003-10-13 |
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