JP2005526692A5 - - Google Patents
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- Publication number
- JP2005526692A5 JP2005526692A5 JP2003520755A JP2003520755A JP2005526692A5 JP 2005526692 A5 JP2005526692 A5 JP 2005526692A5 JP 2003520755 A JP2003520755 A JP 2003520755A JP 2003520755 A JP2003520755 A JP 2003520755A JP 2005526692 A5 JP2005526692 A5 JP 2005526692A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- hapten
- moiety
- composition
- conjugate according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 claims description 23
- 239000000178 monomer Substances 0.000 claims description 16
- 150000001720 carbohydrates Chemical class 0.000 claims description 10
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- 230000021615 conjugation Effects 0.000 claims description 6
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims description 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 4
- 239000004472 Lysine Substances 0.000 claims description 4
- 239000000539 dimer Substances 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 230000002163 immunogen Effects 0.000 claims description 4
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 239000002262 Schiff base Substances 0.000 claims description 2
- 150000004753 Schiff bases Chemical class 0.000 claims description 2
- 239000006227 byproduct Substances 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 239000003638 chemical reducing agent Substances 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims description 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 2
- WURFKUQACINBSI-UHFFFAOYSA-M ozonide Chemical compound [O]O[O-] WURFKUQACINBSI-UHFFFAOYSA-M 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 230000035484 reaction time Effects 0.000 claims description 2
- 239000013638 trimer Substances 0.000 claims description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31185001P | 2001-08-14 | 2001-08-14 | |
| PCT/US2002/024735 WO2003015796A1 (en) | 2001-08-14 | 2002-08-05 | Imunogenic conjugate of carbohydrate haptens and aggregated protein carrier |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005526692A JP2005526692A (ja) | 2005-09-08 |
| JP2005526692A5 true JP2005526692A5 (enExample) | 2006-01-12 |
Family
ID=23208785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003520755A Abandoned JP2005526692A (ja) | 2001-08-14 | 2002-08-05 | 炭水化物ハプテンの免疫原共役体および凝集タンパク質キャリヤ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040247608A1 (enExample) |
| EP (1) | EP1429785A4 (enExample) |
| JP (1) | JP2005526692A (enExample) |
| CN (1) | CN1543350A (enExample) |
| CA (1) | CA2454853A1 (enExample) |
| WO (1) | WO2003015796A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1677773A1 (en) * | 2003-10-14 | 2006-07-12 | Biomira, Inc. | Combination therapy for cancer |
| CN102276662B (zh) * | 2010-06-09 | 2014-05-14 | 北京大学 | 唾液酸(α-(2→6))-D-吡喃糖衍生物及其合成方法和应用 |
| RU2666141C2 (ru) | 2013-09-17 | 2018-09-06 | Оби Фарма, Инк. | Композиции углеводной вакцины для индукции иммунного ответа и их применение при лечении рака |
| AU2015317889B2 (en) * | 2014-09-15 | 2021-06-03 | Obi Pharma, Inc. | Immunogenic/therapeutic glycoconjugate compositions and uses thereof |
| JP2018532990A (ja) | 2015-09-04 | 2018-11-08 | オービーアイ ファーマ，インコーポレイテッド | グリカンアレイおよび使用の方法 |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| US11041017B2 (en) | 2016-03-29 | 2021-06-22 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| KR20250048399A (ko) | 2016-04-22 | 2025-04-08 | 오비아이 파머 인코퍼레이티드 | 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에 의한 암 면역요법 |
| WO2018022933A1 (en) | 2016-07-27 | 2018-02-01 | Obi Pharma, Inc. | Immunogenic/therapeutic glycan compositions and uses thereof |
| EP3491026A4 (en) | 2016-07-29 | 2020-07-29 | OBI Pharma, Inc. | HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND PROCESSES |
| CN106645697A (zh) * | 2016-11-09 | 2017-05-10 | 百奥森（江苏）食品安全科技有限公司 | 一种食品中玉米赤霉醇的检测试剂盒 |
| CN106526188A (zh) * | 2016-11-09 | 2017-03-22 | 百奥森（江苏）食品安全科技有限公司 | 一种食品中沙丁胺醇的检测试剂盒 |
| JP2019535731A (ja) | 2016-11-21 | 2019-12-12 | オービーアイ ファーマ，インコーポレイテッド | コンジュゲートさせた生物学的分子、医薬組成物及び方法 |
| US11203645B2 (en) | 2018-06-27 | 2021-12-21 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5407912A (en) * | 1993-04-19 | 1995-04-18 | Akzo, N.V. | Method of treating bladder cancer with a keyhole limpet hemocyanin composition with enhanced anti-tumor activity |
| AU2247095A (en) * | 1994-04-12 | 1995-10-30 | Biomira Inc. | Cellular immune response-specific antigens and uses therefor |
| CA2189356A1 (en) * | 1994-05-02 | 1995-11-09 | Ting Chi Wong | Process for preparation of glycosides of tumor-associated carbohydrate antigens |
| CA2324616A1 (en) * | 1998-03-25 | 1999-09-30 | Sloan-Kettering Institute For Cancer Research | Trimeric antigenic o-linked glycopeptide conjugates, methods of preparation and uses thereof |
-
2002
- 2002-08-05 CA CA002454853A patent/CA2454853A1/en not_active Abandoned
- 2002-08-05 EP EP02750420A patent/EP1429785A4/en not_active Withdrawn
- 2002-08-05 CN CNA028160711A patent/CN1543350A/zh active Pending
- 2002-08-05 WO PCT/US2002/024735 patent/WO2003015796A1/en not_active Ceased
- 2002-08-05 JP JP2003520755A patent/JP2005526692A/ja not_active Abandoned
- 2002-08-05 US US10/486,646 patent/US20040247608A1/en not_active Abandoned
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