CA2454853A1 - Imunogenic conjugate of carbohydrate haptens and aggregated protein carrier - Google Patents
Imunogenic conjugate of carbohydrate haptens and aggregated protein carrier Download PDFInfo
- Publication number
- CA2454853A1 CA2454853A1 CA002454853A CA2454853A CA2454853A1 CA 2454853 A1 CA2454853 A1 CA 2454853A1 CA 002454853 A CA002454853 A CA 002454853A CA 2454853 A CA2454853 A CA 2454853A CA 2454853 A1 CA2454853 A1 CA 2454853A1
- Authority
- CA
- Canada
- Prior art keywords
- conjugate
- hapten
- carrier
- carbohydrate
- aldehyde
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical group N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000029069 type 2 immune response Effects 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
- A61K39/001172—Sialyl-Thomson-nouvelle antigen [sTn]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31185001P | 2001-08-14 | 2001-08-14 | |
| US60/311,850 | 2001-08-14 | ||
| PCT/US2002/024735 WO2003015796A1 (en) | 2001-08-14 | 2002-08-05 | Imunogenic conjugate of carbohydrate haptens and aggregated protein carrier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2454853A1 true CA2454853A1 (en) | 2003-02-27 |
Family
ID=23208785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002454853A Abandoned CA2454853A1 (en) | 2001-08-14 | 2002-08-05 | Imunogenic conjugate of carbohydrate haptens and aggregated protein carrier |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040247608A1 (enExample) |
| EP (1) | EP1429785A4 (enExample) |
| JP (1) | JP2005526692A (enExample) |
| CN (1) | CN1543350A (enExample) |
| CA (1) | CA2454853A1 (enExample) |
| WO (1) | WO2003015796A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1677773A1 (en) * | 2003-10-14 | 2006-07-12 | Biomira, Inc. | Combination therapy for cancer |
| CN102276662B (zh) * | 2010-06-09 | 2014-05-14 | 北京大学 | 唾液酸(α-(2→6))-D-吡喃糖衍生物及其合成方法和应用 |
| RU2666141C2 (ru) | 2013-09-17 | 2018-09-06 | Оби Фарма, Инк. | Композиции углеводной вакцины для индукции иммунного ответа и их применение при лечении рака |
| AU2015317889B2 (en) * | 2014-09-15 | 2021-06-03 | Obi Pharma, Inc. | Immunogenic/therapeutic glycoconjugate compositions and uses thereof |
| JP2018532990A (ja) | 2015-09-04 | 2018-11-08 | オービーアイ ファーマ，インコーポレイテッド | グリカンアレイおよび使用の方法 |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| US11041017B2 (en) | 2016-03-29 | 2021-06-22 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| KR20250048399A (ko) | 2016-04-22 | 2025-04-08 | 오비아이 파머 인코퍼레이티드 | 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에 의한 암 면역요법 |
| WO2018022933A1 (en) | 2016-07-27 | 2018-02-01 | Obi Pharma, Inc. | Immunogenic/therapeutic glycan compositions and uses thereof |
| EP3491026A4 (en) | 2016-07-29 | 2020-07-29 | OBI Pharma, Inc. | HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND PROCESSES |
| CN106645697A (zh) * | 2016-11-09 | 2017-05-10 | 百奥森（江苏）食品安全科技有限公司 | 一种食品中玉米赤霉醇的检测试剂盒 |
| CN106526188A (zh) * | 2016-11-09 | 2017-03-22 | 百奥森（江苏）食品安全科技有限公司 | 一种食品中沙丁胺醇的检测试剂盒 |
| JP2019535731A (ja) | 2016-11-21 | 2019-12-12 | オービーアイ ファーマ，インコーポレイテッド | コンジュゲートさせた生物学的分子、医薬組成物及び方法 |
| US11203645B2 (en) | 2018-06-27 | 2021-12-21 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5407912A (en) * | 1993-04-19 | 1995-04-18 | Akzo, N.V. | Method of treating bladder cancer with a keyhole limpet hemocyanin composition with enhanced anti-tumor activity |
| AU2247095A (en) * | 1994-04-12 | 1995-10-30 | Biomira Inc. | Cellular immune response-specific antigens and uses therefor |
| CA2189356A1 (en) * | 1994-05-02 | 1995-11-09 | Ting Chi Wong | Process for preparation of glycosides of tumor-associated carbohydrate antigens |
| CA2324616A1 (en) * | 1998-03-25 | 1999-09-30 | Sloan-Kettering Institute For Cancer Research | Trimeric antigenic o-linked glycopeptide conjugates, methods of preparation and uses thereof |
-
2002
- 2002-08-05 CA CA002454853A patent/CA2454853A1/en not_active Abandoned
- 2002-08-05 EP EP02750420A patent/EP1429785A4/en not_active Withdrawn
- 2002-08-05 CN CNA028160711A patent/CN1543350A/zh active Pending
- 2002-08-05 WO PCT/US2002/024735 patent/WO2003015796A1/en not_active Ceased
- 2002-08-05 JP JP2003520755A patent/JP2005526692A/ja not_active Abandoned
- 2002-08-05 US US10/486,646 patent/US20040247608A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040247608A1 (en) | 2004-12-09 |
| EP1429785A4 (en) | 2005-12-14 |
| CN1543350A (zh) | 2004-11-03 |
| JP2005526692A (ja) | 2005-09-08 |
| EP1429785A1 (en) | 2004-06-23 |
| WO2003015796A1 (en) | 2003-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |