CN1543350A - 糖半抗原和聚集的蛋白载体的免疫原性结合物 - Google Patents

糖半抗原和聚集的蛋白载体的免疫原性结合物 Download PDF

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Publication number
CN1543350A
CN1543350A CNA028160711A CN02816071A CN1543350A CN 1543350 A CN1543350 A CN 1543350A CN A028160711 A CNA028160711 A CN A028160711A CN 02816071 A CN02816071 A CN 02816071A CN 1543350 A CN1543350 A CN 1543350A
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China
Prior art keywords
conjunction
thing
haptens
carrier
weight
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Pending
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CNA028160711A
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English (en)
Chinese (zh)
Inventor
����ˡ�J������˹
马克·J·克兰茨
��B���ʸ��ڿ�
迈克尔·B·朗格内克
R���Ƹ�̩
拉奥·R·科根泰
希廷翁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncothyreon Canada Inc
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Biomira Inc
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Publication date
Application filed by Biomira Inc filed Critical Biomira Inc
Publication of CN1543350A publication Critical patent/CN1543350A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/001172—Sialyl-Thomson-nouvelle antigen [sTn]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CNA028160711A 2001-08-14 2002-08-05 糖半抗原和聚集的蛋白载体的免疫原性结合物 Pending CN1543350A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31185001P 2001-08-14 2001-08-14
US60/311,850 2001-08-14

Publications (1)

Publication Number Publication Date
CN1543350A true CN1543350A (zh) 2004-11-03

Family

ID=23208785

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA028160711A Pending CN1543350A (zh) 2001-08-14 2002-08-05 糖半抗原和聚集的蛋白载体的免疫原性结合物

Country Status (6)

Country Link
US (1) US20040247608A1 (enExample)
EP (1) EP1429785A4 (enExample)
JP (1) JP2005526692A (enExample)
CN (1) CN1543350A (enExample)
CA (1) CA2454853A1 (enExample)
WO (1) WO2003015796A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102276662A (zh) * 2010-06-09 2011-12-14 北京大学 唾液酸(α-(2→6))-D-吡喃糖衍生物及其合成方法和应用
CN106526188A (zh) * 2016-11-09 2017-03-22 百奥森（江苏）食品安全科技有限公司 一种食品中沙丁胺醇的检测试剂盒
CN106645697A (zh) * 2016-11-09 2017-05-10 百奥森（江苏）食品安全科技有限公司 一种食品中玉米赤霉醇的检测试剂盒

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1677773A1 (en) * 2003-10-14 2006-07-12 Biomira, Inc. Combination therapy for cancer
RU2666141C2 (ru) 2013-09-17 2018-09-06 Оби Фарма, Инк. Композиции углеводной вакцины для индукции иммунного ответа и их применение при лечении рака
AU2015317889B2 (en) * 2014-09-15 2021-06-03 Obi Pharma, Inc. Immunogenic/therapeutic glycoconjugate compositions and uses thereof
JP2018532990A (ja) 2015-09-04 2018-11-08 オービーアイ ファーマ，インコーポレイテッド グリカンアレイおよび使用の方法
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
US11041017B2 (en) 2016-03-29 2021-06-22 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
KR20250048399A (ko) 2016-04-22 2025-04-08 오비아이 파머 인코퍼레이티드 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에 의한 암 면역요법
WO2018022933A1 (en) 2016-07-27 2018-02-01 Obi Pharma, Inc. Immunogenic/therapeutic glycan compositions and uses thereof
EP3491026A4 (en) 2016-07-29 2020-07-29 OBI Pharma, Inc. HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND PROCESSES
JP2019535731A (ja) 2016-11-21 2019-12-12 オービーアイ ファーマ，インコーポレイテッド コンジュゲートさせた生物学的分子、医薬組成物及び方法
US11203645B2 (en) 2018-06-27 2021-12-21 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407912A (en) * 1993-04-19 1995-04-18 Akzo, N.V. Method of treating bladder cancer with a keyhole limpet hemocyanin composition with enhanced anti-tumor activity
AU2247095A (en) * 1994-04-12 1995-10-30 Biomira Inc. Cellular immune response-specific antigens and uses therefor
CA2189356A1 (en) * 1994-05-02 1995-11-09 Ting Chi Wong Process for preparation of glycosides of tumor-associated carbohydrate antigens
CA2324616A1 (en) * 1998-03-25 1999-09-30 Sloan-Kettering Institute For Cancer Research Trimeric antigenic o-linked glycopeptide conjugates, methods of preparation and uses thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102276662A (zh) * 2010-06-09 2011-12-14 北京大学 唾液酸(α-(2→6))-D-吡喃糖衍生物及其合成方法和应用
WO2011153815A1 (zh) * 2010-06-09 2011-12-15 北京大学 唾液酸(α-(2→6))-D-吡喃糖衍生物及其合成方法和应用
CN102276662B (zh) * 2010-06-09 2014-05-14 北京大学 唾液酸(α-(2→6))-D-吡喃糖衍生物及其合成方法和应用
US9695208B2 (en) 2010-06-09 2017-07-04 Peking University Sialic acid (A-(2-6))-D-aminopyranose derivatives, synthesis methods and uses thereof
CN106526188A (zh) * 2016-11-09 2017-03-22 百奥森（江苏）食品安全科技有限公司 一种食品中沙丁胺醇的检测试剂盒
CN106645697A (zh) * 2016-11-09 2017-05-10 百奥森（江苏）食品安全科技有限公司 一种食品中玉米赤霉醇的检测试剂盒

Also Published As

Publication number Publication date
US20040247608A1 (en) 2004-12-09
EP1429785A4 (en) 2005-12-14
CA2454853A1 (en) 2003-02-27
JP2005526692A (ja) 2005-09-08
EP1429785A1 (en) 2004-06-23
WO2003015796A1 (en) 2003-02-27

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