JP2005526133A5 - - Google Patents
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- Publication number
- JP2005526133A5 JP2005526133A5 JP2004505307A JP2004505307A JP2005526133A5 JP 2005526133 A5 JP2005526133 A5 JP 2005526133A5 JP 2004505307 A JP2004505307 A JP 2004505307A JP 2004505307 A JP2004505307 A JP 2004505307A JP 2005526133 A5 JP2005526133 A5 JP 2005526133A5
- Authority
- JP
- Japan
- Prior art keywords
- occurrence
- independently
- heteroaryl
- aryl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 50
- 125000003342 alkenyl group Chemical group 0.000 claims 25
- 125000003118 aryl group Chemical group 0.000 claims 25
- 125000001072 heteroaryl group Chemical group 0.000 claims 25
- 125000000753 cycloalkyl group Chemical group 0.000 claims 23
- -1 nitroso, nitro , Sulfhydryl Chemical group 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000003710 aryl alkyl group Chemical group 0.000 claims 16
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 16
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 7
- SOWBFZRMHSNYGE-UHFFFAOYSA-N Monoamide-Oxalic acid Natural products NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 claims 7
- 125000002252 acyl group Chemical group 0.000 claims 7
- 125000004442 acylamino group Chemical group 0.000 claims 7
- 125000004423 acyloxy group Chemical group 0.000 claims 7
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 7
- 125000003282 alkyl amino group Chemical group 0.000 claims 7
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 7
- 125000004414 alkyl thio group Chemical group 0.000 claims 7
- 125000000304 alkynyl group Chemical group 0.000 claims 7
- LGEQQWMQCRIYKG-DOFZRALJSA-N anandamide Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCO LGEQQWMQCRIYKG-DOFZRALJSA-N 0.000 claims 7
- LGEQQWMQCRIYKG-UHFFFAOYSA-N arachidonic acid ethanolamide Natural products CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCCO LGEQQWMQCRIYKG-UHFFFAOYSA-N 0.000 claims 7
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 7
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 7
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 7
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- 239000000126 substance Substances 0.000 claims 7
- 125000004001 thioalkyl group Chemical group 0.000 claims 7
- 238000000691 measurement method Methods 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 4
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 2
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 claims 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 2
- SXIFAEWFOJETOA-UHFFFAOYSA-N 4-hydroxy-butyl Chemical group [CH2]CCCO SXIFAEWFOJETOA-UHFFFAOYSA-N 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 201000006474 Brain Ischemia Diseases 0.000 claims 1
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 1
- 208000006561 Cluster Headache Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000032456 Hemorrhagic Shock Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000008238 Muscle Spasticity Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 206010049771 Shock haemorrhagic Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000010399 Wasting Syndrome Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 208000018912 cluster headache syndrome Diseases 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000002518 glial effect Effects 0.000 claims 1
- 208000013403 hyperactivity Diseases 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010036596 premature ejaculation Diseases 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 208000018198 spasticity Diseases 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38104102P | 2002-05-16 | 2002-05-16 | |
| PCT/US2003/015581 WO2003097573A1 (en) | 2002-05-16 | 2003-05-15 | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005526133A JP2005526133A (ja) | 2005-09-02 |
| JP2005526133A5 true JP2005526133A5 (enExample) | 2006-06-29 |
| JP4488350B2 JP4488350B2 (ja) | 2010-06-23 |
Family
ID=29550057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004505307A Expired - Fee Related JP4488350B2 (ja) | 2002-05-16 | 2003-05-15 | 哺乳類アナンダミド輸送体を阻害するアミン、およびその使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7049329B2 (enExample) |
| EP (1) | EP1509489B1 (enExample) |
| JP (1) | JP4488350B2 (enExample) |
| KR (1) | KR101087883B1 (enExample) |
| AT (1) | ATE516263T1 (enExample) |
| AU (1) | AU2003237882B2 (enExample) |
| CA (1) | CA2486055C (enExample) |
| MX (1) | MXPA04011390A (enExample) |
| NZ (2) | NZ537225A (enExample) |
| WO (1) | WO2003097573A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7750030B2 (en) * | 2001-03-29 | 2010-07-06 | Michael Davis | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
| JP4488350B2 (ja) * | 2002-05-16 | 2010-06-23 | セプラコール インク． | 哺乳類アナンダミド輸送体を阻害するアミン、およびその使用方法 |
| FR2864080B1 (fr) * | 2003-12-23 | 2006-02-03 | Sanofi Synthelabo | Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique |
| FR2866888B1 (fr) * | 2004-02-26 | 2006-05-05 | Sanofi Synthelabo | Derives de alkylpiperazine- et alkylhomopiperazine- carboxylates, leur preparation et leur application en therapeutique |
| US20060084659A1 (en) * | 2004-10-19 | 2006-04-20 | Michael Davis | Augmentation of psychotherapy with cannabinoid reuptake inhibitors |
| WO2006116773A2 (en) * | 2005-04-28 | 2006-11-02 | The Regents Of The University Of California | Methods, compositions, and compounds for modulation of monoacylglycerol lipase, pain, and stress-related disorders |
| WO2010083532A1 (en) * | 2009-01-19 | 2010-07-22 | The Research Foundaton Of State University Of New York | Fatty acid binding proteins as drug targets for modulation of endocannabinoids |
| AU2012299060B2 (en) | 2011-08-19 | 2017-06-01 | Fondazione Istituto Italiano Di Tecnologia | Meta-substituted biphenyl peripherally restricted FAAH inhibitors |
| WO2015157313A1 (en) | 2014-04-07 | 2015-10-15 | The Regents Of The University Of California | Inhibitors of fatty acid amide hydrolase (faah) enzyme with improved oral bioavailability and their use as medicaments |
| FR3071833B1 (fr) * | 2017-09-29 | 2020-01-03 | Universite Paris-Sud | Nouveau procede de synthese d'amines tertiaires dissymetriques |
| US10414721B1 (en) | 2018-06-04 | 2019-09-17 | University Of Bern | Inhibitor of endocannabinoid cellular reuptake |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US504455A (en) | 1893-09-05 | Storage-battery | ||
| US2601275A (en) * | 1949-10-29 | 1952-06-24 | Givaudan Corp | Aromatic chlorethylamines and their salts |
| US2778826A (en) * | 1954-04-26 | 1957-01-22 | Rohm & Haas | Preparation of basic nitrogen compounds |
| DE4219975A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| US5977180A (en) | 1994-07-11 | 1999-11-02 | Pate; David W. | Anandamide analog compositions and method of treating intraocular hypertension using same |
| US5688825A (en) | 1996-05-31 | 1997-11-18 | University Of Connecticut | Anandamide amidase inhibitors as analgesic agents |
| JP3824735B2 (ja) * | 1997-05-13 | 2006-09-20 | ポーラ化成工業株式会社 | アミン誘導体 |
| US6200951B1 (en) * | 1998-03-12 | 2001-03-13 | Icos Corporation | Chitinase chitin-binding fragments |
| WO1999064389A1 (en) * | 1998-06-09 | 1999-12-16 | Alexandros Makriyannis | Inhibitors of the anandamide transporter as analgesic agents |
| US6335023B1 (en) * | 1999-06-30 | 2002-01-01 | Ruey J. Yu | Oligosaccharide aldonic acids and their topical use |
| US6696412B1 (en) * | 2000-01-20 | 2004-02-24 | Cubist Pharmaceuticals, Inc. | High purity lipopeptides, Lipopeptide micelles and processes for preparing same |
| US20020019444A1 (en) | 2000-05-08 | 2002-02-14 | Edward Hogestatt | Anandamide and structurally related lipids as vanilloid receptor modulators |
| EA200201167A1 (ru) | 2000-06-02 | 2003-06-26 | Пфайзер Продактс Инк. | Производные гигромицина а для лечения бактериальных и протозойных инфекций |
| FR2824324B1 (fr) * | 2001-05-04 | 2003-08-15 | Aventis Pharma Sa | Nouveaux derives d'azole ou de triazole, leur procede de preparation et leur application comme medicaments anti-fongiques |
| JP4488350B2 (ja) * | 2002-05-16 | 2010-06-23 | セプラコール インク． | 哺乳類アナンダミド輸送体を阻害するアミン、およびその使用方法 |
-
2003
- 2003-05-15 JP JP2004505307A patent/JP4488350B2/ja not_active Expired - Fee Related
- 2003-05-15 EP EP03736639A patent/EP1509489B1/en not_active Expired - Lifetime
- 2003-05-15 WO PCT/US2003/015581 patent/WO2003097573A1/en not_active Ceased
- 2003-05-15 AU AU2003237882A patent/AU2003237882B2/en not_active Ceased
- 2003-05-15 NZ NZ537225A patent/NZ537225A/en not_active IP Right Cessation
- 2003-05-15 KR KR1020047018474A patent/KR101087883B1/ko not_active Expired - Fee Related
- 2003-05-15 AT AT03736639T patent/ATE516263T1/de not_active IP Right Cessation
- 2003-05-15 MX MXPA04011390A patent/MXPA04011390A/es active IP Right Grant
- 2003-05-15 NZ NZ570989A patent/NZ570989A/en not_active IP Right Cessation
- 2003-05-15 CA CA2486055A patent/CA2486055C/en not_active Expired - Fee Related
- 2003-05-15 US US10/439,347 patent/US7049329B2/en not_active Expired - Lifetime
-
2006
- 2006-05-23 US US11/439,529 patent/US7511073B2/en not_active Expired - Lifetime
-
2009
- 2009-02-25 US US12/392,981 patent/US7671087B2/en not_active Expired - Lifetime
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