MXPA04011390A - Aminas que inhiben un transportador de anandamida de mamifero, y metodos de uso de las mismas. - Google Patents

Aminas que inhiben un transportador de anandamida de mamifero, y metodos de uso de las mismas.

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Publication number
MXPA04011390A
MXPA04011390A MXPA04011390A MXPA04011390A MXPA04011390A MX PA04011390 A MXPA04011390 A MX PA04011390A MX PA04011390 A MXPA04011390 A MX PA04011390A MX PA04011390 A MXPA04011390 A MX PA04011390A MX PA04011390 A MXPA04011390 A MX PA04011390A
Authority
MX
Mexico
Prior art keywords
occurrence
further characterized
compound according
aryl
compound
Prior art date
Application number
MXPA04011390A
Other languages
English (en)
Spanish (es)
Inventor
Fengjiang Wang
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Publication of MXPA04011390A publication Critical patent/MXPA04011390A/es

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    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
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    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61P25/00Drugs for disorders of the nervous system
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    • AHUMAN NECESSITIES
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    • A61P25/16Anti-Parkinson drugs
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P27/00Drugs for disorders of the senses
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/18Antivirals for RNA viruses for HIV
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    • A61P37/02Immunomodulators
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14Radicals substituted by nitrogen atoms not forming part of a nitro radical
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    • C40B20/08Direct analysis of the library members per se by physical methods, e.g. spectroscopy
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    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
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    • C40COMBINATORIAL TECHNOLOGY
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    • C40B50/14Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
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    • C40COMBINATORIAL TECHNOLOGY
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    • C40B40/00Libraries per se, e.g. arrays, mixtures

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Structural Engineering (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
MXPA04011390A 2002-05-16 2003-05-15 Aminas que inhiben un transportador de anandamida de mamifero, y metodos de uso de las mismas. MXPA04011390A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38104102P 2002-05-16 2002-05-16
PCT/US2003/015581 WO2003097573A1 (en) 2002-05-16 2003-05-15 Amines that inhibit a mammalian anandamide transporter, and methods of use thereof

Publications (1)

Publication Number Publication Date
MXPA04011390A true MXPA04011390A (es) 2005-02-17

Family

ID=29550057

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04011390A MXPA04011390A (es) 2002-05-16 2003-05-15 Aminas que inhiben un transportador de anandamida de mamifero, y metodos de uso de las mismas.

Country Status (10)

Country Link
US (3) US7049329B2 (enExample)
EP (1) EP1509489B1 (enExample)
JP (1) JP4488350B2 (enExample)
KR (1) KR101087883B1 (enExample)
AT (1) ATE516263T1 (enExample)
AU (1) AU2003237882B2 (enExample)
CA (1) CA2486055C (enExample)
MX (1) MXPA04011390A (enExample)
NZ (2) NZ537225A (enExample)
WO (1) WO2003097573A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1383465B1 (en) * 2001-03-29 2011-08-10 Michael Davis Acute pharmacologic augmentation of psychotherapy with d-cycloserine
AU2003237882B2 (en) * 2002-05-16 2010-04-08 Sunovion Pharmaceuticals Inc. Amines that inhibit a mammalian anandamide transporter, and methods of use thereof
FR2864080B1 (fr) * 2003-12-23 2006-02-03 Sanofi Synthelabo Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique
FR2866888B1 (fr) * 2004-02-26 2006-05-05 Sanofi Synthelabo Derives de alkylpiperazine- et alkylhomopiperazine- carboxylates, leur preparation et leur application en therapeutique
US20060084659A1 (en) * 2004-10-19 2006-04-20 Michael Davis Augmentation of psychotherapy with cannabinoid reuptake inhibitors
WO2006116773A2 (en) * 2005-04-28 2006-11-02 The Regents Of The University Of California Methods, compositions, and compounds for modulation of monoacylglycerol lipase, pain, and stress-related disorders
WO2010083532A1 (en) * 2009-01-19 2010-07-22 The Research Foundaton Of State University Of New York Fatty acid binding proteins as drug targets for modulation of endocannabinoids
ES2708723T3 (es) 2011-08-19 2019-04-10 Univ California Inhibidores de FAAH restringidos de forma periférica sustituidos en posición meta por bifenilo
ES2908240T3 (es) 2014-04-07 2022-04-28 Univ California Inhibidores de la enzima amida hidrolasa de ácidos grasos (FAAH) con biodisponibilidad oral mejorada y su uso como medicamentos
FR3071833B1 (fr) * 2017-09-29 2020-01-03 Universite Paris-Sud Nouveau procede de synthese d'amines tertiaires dissymetriques
US10414721B1 (en) 2018-06-04 2019-09-17 University Of Bern Inhibitor of endocannabinoid cellular reuptake

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US504455A (en) 1893-09-05 Storage-battery
US2601275A (en) * 1949-10-29 1952-06-24 Givaudan Corp Aromatic chlorethylamines and their salts
US2778826A (en) * 1954-04-26 1957-01-22 Rohm & Haas Preparation of basic nitrogen compounds
DE4219975A1 (de) * 1992-06-19 1993-12-23 Basf Ag Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
CA2192965C (en) 1994-07-11 2007-12-04 David W. Pate Anandamide analogue compositions and method of treating intraocular hypertension using same
US5688825A (en) 1996-05-31 1997-11-18 University Of Connecticut Anandamide amidase inhibitors as analgesic agents
JP3824735B2 (ja) * 1997-05-13 2006-09-20 ポーラ化成工業株式会社 アミン誘導体
US6200951B1 (en) * 1998-03-12 2001-03-13 Icos Corporation Chitinase chitin-binding fragments
EP1084098A4 (en) * 1998-06-09 2004-12-22 Univ Connecticut INHIBITORS OF THE ANANDAMIDE TRANSPORTER AS ANALGETIC AGENT
US6335023B1 (en) * 1999-06-30 2002-01-01 Ruey J. Yu Oligosaccharide aldonic acids and their topical use
US6696412B1 (en) * 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US20020019444A1 (en) 2000-05-08 2002-02-14 Edward Hogestatt Anandamide and structurally related lipids as vanilloid receptor modulators
SK16612002A3 (sk) * 2000-06-02 2004-04-06 Pfizer Products Inc. Deriváty hygromycínu A na použitie na liečenie bakteriálnych a protozoálnych infekcií
FR2824324B1 (fr) * 2001-05-04 2003-08-15 Aventis Pharma Sa Nouveaux derives d'azole ou de triazole, leur procede de preparation et leur application comme medicaments anti-fongiques
AU2003237882B2 (en) * 2002-05-16 2010-04-08 Sunovion Pharmaceuticals Inc. Amines that inhibit a mammalian anandamide transporter, and methods of use thereof

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Publication number Publication date
NZ537225A (en) 2008-09-26
CA2486055A1 (en) 2003-11-27
US20040048907A1 (en) 2004-03-11
AU2003237882B2 (en) 2010-04-08
US7511073B2 (en) 2009-03-31
EP1509489A1 (en) 2005-03-02
ATE516263T1 (de) 2011-07-15
KR20050012246A (ko) 2005-01-31
US7049329B2 (en) 2006-05-23
JP4488350B2 (ja) 2010-06-23
AU2003237882A1 (en) 2003-12-02
NZ570989A (en) 2010-01-29
WO2003097573A1 (en) 2003-11-27
CA2486055C (en) 2012-03-06
US20060281742A1 (en) 2006-12-14
EP1509489A4 (en) 2007-03-21
JP2005526133A (ja) 2005-09-02
KR101087883B1 (ko) 2011-11-30
EP1509489B1 (en) 2011-07-13
US20090163593A1 (en) 2009-06-25
US7671087B2 (en) 2010-03-02

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