AU2003237882B2 - Amines that inhibit a mammalian anandamide transporter, and methods of use thereof - Google Patents

Amines that inhibit a mammalian anandamide transporter, and methods of use thereof Download PDF

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Publication number
AU2003237882B2
AU2003237882B2 AU2003237882A AU2003237882A AU2003237882B2 AU 2003237882 B2 AU2003237882 B2 AU 2003237882B2 AU 2003237882 A AU2003237882 A AU 2003237882A AU 2003237882 A AU2003237882 A AU 2003237882A AU 2003237882 B2 AU2003237882 B2 AU 2003237882B2
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compound
occurrence
aryl
heteroaryl
cycloalkyl
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AU2003237882A1 (en
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Brian A. Aquila
Seth Hopkins
Curtis A. Lockshin
Fengjiang Wang
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Sunovion Pharmaceuticals Inc
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Sunovion Pharmaceuticals Inc
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Assigned to SUNOVION PHARMACEUTICALS INC. reassignment SUNOVION PHARMACEUTICALS INC. Request to Amend Deed and Register Assignors: SEPRACOR INC.
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
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    • C07—ORGANIC CHEMISTRY
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
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    • C40—COMBINATORIAL TECHNOLOGY
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
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  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Structural Engineering (AREA)
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  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Physics & Mathematics (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
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AU2003237882A 2002-05-16 2003-05-15 Amines that inhibit a mammalian anandamide transporter, and methods of use thereof Ceased AU2003237882B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38104102P 2002-05-16 2002-05-16
US60/381,041 2002-05-16
PCT/US2003/015581 WO2003097573A1 (en) 2002-05-16 2003-05-15 Amines that inhibit a mammalian anandamide transporter, and methods of use thereof

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AU2003237882A1 AU2003237882A1 (en) 2003-12-02
AU2003237882B2 true AU2003237882B2 (en) 2010-04-08

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AU2003237882A Ceased AU2003237882B2 (en) 2002-05-16 2003-05-15 Amines that inhibit a mammalian anandamide transporter, and methods of use thereof

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US (3) US7049329B2 (enExample)
EP (1) EP1509489B1 (enExample)
JP (1) JP4488350B2 (enExample)
KR (1) KR101087883B1 (enExample)
AT (1) ATE516263T1 (enExample)
AU (1) AU2003237882B2 (enExample)
CA (1) CA2486055C (enExample)
MX (1) MXPA04011390A (enExample)
NZ (2) NZ570989A (enExample)
WO (1) WO2003097573A1 (enExample)

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WO2002078629A2 (en) * 2001-03-29 2002-10-10 Emory University Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning
US7049329B2 (en) * 2002-05-16 2006-05-23 Sepracor Inc. Amines that inhibit a mammalian anandamide transporter, and methods of use thereof
FR2864080B1 (fr) * 2003-12-23 2006-02-03 Sanofi Synthelabo Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique
FR2866888B1 (fr) 2004-02-26 2006-05-05 Sanofi Synthelabo Derives de alkylpiperazine- et alkylhomopiperazine- carboxylates, leur preparation et leur application en therapeutique
US20060084659A1 (en) * 2004-10-19 2006-04-20 Michael Davis Augmentation of psychotherapy with cannabinoid reuptake inhibitors
WO2006116773A2 (en) * 2005-04-28 2006-11-02 The Regents Of The University Of California Methods, compositions, and compounds for modulation of monoacylglycerol lipase, pain, and stress-related disorders
US8980820B2 (en) 2009-01-19 2015-03-17 The Research Foundation For The State University Of New York Fatty acid binding proteins as drug targets for endocannabinoids
MX354772B (es) 2011-08-19 2018-03-21 Univ California Inhibidores de la amida de acidos grasos (faah) restringidos perifericamente por bifenil metasustituido.
EP3988540A1 (en) 2014-04-07 2022-04-27 The Regents of the University of California Inhibitors of fatty acid amide hydrolase (faah) enzyme with improved oral bioavailability and their use as medicaments
FR3071833B1 (fr) * 2017-09-29 2020-01-03 Universite Paris-Sud Nouveau procede de synthese d'amines tertiaires dissymetriques
US10414721B1 (en) 2018-06-04 2019-09-17 University Of Bern Inhibitor of endocannabinoid cellular reuptake

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US2778826A (en) * 1954-04-26 1957-01-22 Rohm & Haas Preparation of basic nitrogen compounds
DE4219975A1 (de) * 1992-06-19 1993-12-23 Basf Ag Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
US5977180A (en) 1994-07-11 1999-11-02 Pate; David W. Anandamide analog compositions and method of treating intraocular hypertension using same
US5688825A (en) 1996-05-31 1997-11-18 University Of Connecticut Anandamide amidase inhibitors as analgesic agents
JP3824735B2 (ja) * 1997-05-13 2006-09-20 ポーラ化成工業株式会社 アミン誘導体
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WO1999064389A1 (en) * 1998-06-09 1999-12-16 Alexandros Makriyannis Inhibitors of the anandamide transporter as analgesic agents
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MXPA04011390A (es) 2005-02-17
US20090163593A1 (en) 2009-06-25
KR20050012246A (ko) 2005-01-31
WO2003097573A1 (en) 2003-11-27
JP2005526133A (ja) 2005-09-02
US7671087B2 (en) 2010-03-02
CA2486055A1 (en) 2003-11-27
JP4488350B2 (ja) 2010-06-23
ATE516263T1 (de) 2011-07-15
US7511073B2 (en) 2009-03-31
CA2486055C (en) 2012-03-06
US20040048907A1 (en) 2004-03-11
EP1509489B1 (en) 2011-07-13
NZ537225A (en) 2008-09-26
NZ570989A (en) 2010-01-29
EP1509489A4 (en) 2007-03-21
EP1509489A1 (en) 2005-03-02
AU2003237882A1 (en) 2003-12-02
US7049329B2 (en) 2006-05-23
KR101087883B1 (ko) 2011-11-30
US20060281742A1 (en) 2006-12-14

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