JP2005523267A5 - - Google Patents
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- Publication number
- JP2005523267A5 JP2005523267A5 JP2003565451A JP2003565451A JP2005523267A5 JP 2005523267 A5 JP2005523267 A5 JP 2005523267A5 JP 2003565451 A JP2003565451 A JP 2003565451A JP 2003565451 A JP2003565451 A JP 2003565451A JP 2005523267 A5 JP2005523267 A5 JP 2005523267A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- pharmaceutical
- pharmaceutical preparation
- surfactant
- formulation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- -1 4-methyl-1,3-thiazol-5-yl Chemical group 0.000 claims 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 6
- 239000000825 pharmaceutical preparation Substances 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- ISAVYTVYFVQUDY-UHFFFAOYSA-N 4-tert-Octylphenol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 ISAVYTVYFVQUDY-UHFFFAOYSA-N 0.000 claims 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 230000000172 allergic effect Effects 0.000 claims 2
- 239000008365 aqueous carrier Substances 0.000 claims 2
- 208000010668 atopic eczema Diseases 0.000 claims 2
- 239000004359 castor oil Substances 0.000 claims 2
- 235000019438 castor oil Nutrition 0.000 claims 2
- 239000006184 cosolvent Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000003862 glucocorticoid Substances 0.000 claims 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical group C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- 239000000043 antiallergic agent Substances 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000008121 dextrose Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000007951 isotonicity adjuster Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- UYDLBVPAAFVANX-UHFFFAOYSA-N octylphenoxy polyethoxyethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCOCCO)C=C1 UYDLBVPAAFVANX-UHFFFAOYSA-N 0.000 claims 1
- 239000013618 particulate matter Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229940113115 polyethylene glycol 200 Drugs 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/066,951 US6787532B2 (en) | 2000-08-05 | 2002-02-04 | Formulation containing anti-inflammatory androstane derivatives |
| US10/066,951 | 2002-02-04 | ||
| PCT/GB2003/000469 WO2003066026A1 (en) | 2002-02-04 | 2003-02-04 | Pharmaceutical formulation comprising an androstane derivative and a solubilising agent in an aqueous liquid carrier |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005523267A JP2005523267A (ja) | 2005-08-04 |
| JP2005523267A5 true JP2005523267A5 (https=) | 2006-01-05 |
| JP4838494B2 JP4838494B2 (ja) | 2011-12-14 |
Family
ID=27732219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003565451A Expired - Lifetime JP4838494B2 (ja) | 2002-02-04 | 2003-02-04 | 水性液体担体中にアンドロスタン誘導体及び可溶化剤を含有する医薬製剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6787532B2 (https=) |
| EP (1) | EP1471884B1 (https=) |
| JP (1) | JP4838494B2 (https=) |
| AU (1) | AU2003205850A1 (https=) |
| ES (1) | ES2654248T3 (https=) |
| WO (1) | WO2003066026A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002012266A1 (en) * | 2000-08-05 | 2002-02-14 | Glaxo Group Limited | 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents |
| GB0019172D0 (en) * | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
| US6777399B2 (en) * | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| US6759398B2 (en) * | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
| US6858596B2 (en) * | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
| UA77656C2 (en) | 2001-04-07 | 2007-01-15 | Glaxo Group Ltd | S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent |
| PT1383786E (pt) | 2001-04-30 | 2008-12-30 | Glaxo Group Ltd | Derivados anti-inflamatórios de éster 17.beta-carbotioato de androstano com um grupo éster ciclíco na posição 17.alfa |
| US20040248867A1 (en) * | 2001-06-12 | 2004-12-09 | Keith Biggadike | Novel anti-inflammatory 17.alpha.-heterocyclic-esters of 17.beta.carbothioate androstane derivatives |
| GB0125259D0 (en) * | 2001-10-20 | 2001-12-12 | Glaxo Group Ltd | Novel compounds |
| US20030129242A1 (en) * | 2002-01-04 | 2003-07-10 | Bosch H. William | Sterile filtered nanoparticulate formulations of budesonide and beclomethasone having tyloxapol as a surface stabilizer |
| US20050175545A1 (en) * | 2002-02-04 | 2005-08-11 | Keith Biggadike | Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist |
| GB0202635D0 (en) * | 2002-02-05 | 2002-03-20 | Glaxo Wellcome Mfg Pte Ltd | Formulation containing novel anti-inflammatory androstane derivative |
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| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8324192B2 (en) | 2005-11-12 | 2012-12-04 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8679545B2 (en) | 2005-11-12 | 2014-03-25 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
| RU2008124109A (ru) * | 2005-12-08 | 2010-01-20 | МДРНА, Инк. (US) | Чресслизистая доставка стабилизированных композиций эксендина |
| BRPI0710654B1 (pt) * | 2006-04-21 | 2021-11-03 | Toko Yakuhin Kogyo Kabushiki Kaisha | Preparação de adesivo para pele/mucosa do tipo gel, pulverizável, e sistema de administração usando a preparação |
| ES2775973T3 (es) | 2006-04-21 | 2020-07-28 | Toko Yakuhin Kogyo Kk | Recipiente de fluido y sistema de dispensación de fluido sin aire |
| GB0615108D0 (en) * | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel formulations |
| GB0712454D0 (en) * | 2007-06-27 | 2007-08-08 | Generics Uk Ltd | Pharmaceutical compositions |
| US20090123551A1 (en) * | 2007-11-13 | 2009-05-14 | Meritage Pharma, Inc. | Gastrointestinal delivery systems |
| US20090143343A1 (en) * | 2007-11-13 | 2009-06-04 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| EP2214679B1 (en) | 2007-11-13 | 2019-03-27 | Meritage Pharma, Inc. | Corticosteroid compositions |
| US20100216754A1 (en) * | 2007-11-13 | 2010-08-26 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
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| WO2010016931A2 (en) * | 2008-08-07 | 2010-02-11 | Plus Chemicals Sa | Polymorphs of fluticasone furoate and process for preparation thereof |
| WO2010108107A1 (en) * | 2009-03-19 | 2010-09-23 | Plus Chemicals Sa | Polymorphs of fluticasone furoate and processes for preparation thereof |
| US20110097401A1 (en) * | 2009-06-12 | 2011-04-28 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
| WO2011141929A2 (en) | 2010-05-11 | 2011-11-17 | Cadila Healthcare Limited | Aqueous pharmaceutical compositions of fluticasone and olopatadine |
| PH12022551856A1 (en) | 2020-01-22 | 2024-01-03 | Seelos Therapeutics Inc | Reducing side effects of nmda antagonists |
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-
2002
- 2002-02-04 US US10/066,951 patent/US6787532B2/en not_active Expired - Lifetime
-
2003
- 2003-02-04 ES ES03702727.3T patent/ES2654248T3/es not_active Expired - Lifetime
- 2003-02-04 US US10/503,000 patent/US20050209206A1/en not_active Abandoned
- 2003-02-04 JP JP2003565451A patent/JP4838494B2/ja not_active Expired - Lifetime
- 2003-02-04 EP EP03702727.3A patent/EP1471884B1/en not_active Expired - Lifetime
- 2003-02-04 AU AU2003205850A patent/AU2003205850A1/en not_active Abandoned
- 2003-02-04 WO PCT/GB2003/000469 patent/WO2003066026A1/en not_active Ceased
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