JP2005521705A5 - - Google Patents
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- Publication number
- JP2005521705A5 JP2005521705A5 JP2003579735A JP2003579735A JP2005521705A5 JP 2005521705 A5 JP2005521705 A5 JP 2005521705A5 JP 2003579735 A JP2003579735 A JP 2003579735A JP 2003579735 A JP2003579735 A JP 2003579735A JP 2005521705 A5 JP2005521705 A5 JP 2005521705A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- ethyl
- benzyl
- acetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 15
- 125000005843 halogen group Chemical group 0.000 claims 15
- -1 C 1 -C 6 alkyl Chemical group 0.000 claims 13
- 125000000753 cycloalkyl group Chemical group 0.000 claims 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical compound C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- 125000000579 2,2-diphenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 125000000723 dihydrobenzofuranyl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- KXKVLQRXCPHEJC-UHFFFAOYSA-N methyl acetate Chemical compound COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 125000005871 1,3-benzodioxolyl group Chemical group 0.000 claims 1
- LDUSWUXHYFJPSN-UHFFFAOYSA-N 2-[2-[3-[(2,4-dimethoxyphenyl)methyl-(2,2-diphenylethyl)amino]propyl]-1-benzofuran-6-yl]ethanol Chemical compound COC1=CC(OC)=CC=C1CN(CC(C=1C=CC=CC=1)C=1C=CC=CC=1)CCCC1=CC2=CC=C(CCO)C=C2O1 LDUSWUXHYFJPSN-UHFFFAOYSA-N 0.000 claims 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36841502P | 2002-03-27 | 2002-03-27 | |
| PCT/US2003/009039 WO2003082192A2 (en) | 2002-03-27 | 2003-03-26 | Certain pharmaceutically useful substituted aminoalkyl heterocycles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005521705A JP2005521705A (ja) | 2005-07-21 |
| JP2005521705A5 true JP2005521705A5 (https=) | 2006-05-18 |
Family
ID=28675483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003579735A Pending JP2005521705A (ja) | 2002-03-27 | 2003-03-26 | 化合物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7323494B2 (https=) |
| EP (1) | EP1490047B1 (https=) |
| JP (1) | JP2005521705A (https=) |
| AT (1) | ATE453389T1 (https=) |
| AU (1) | AU2003223340A1 (https=) |
| DE (1) | DE60330758D1 (https=) |
| ES (1) | ES2337037T3 (https=) |
| WO (1) | WO2003082192A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002024632A2 (en) * | 2000-09-18 | 2002-03-28 | Glaxo Group Limited | Substituted aminopropoxyaryl derivatives useful as agonists for lxr |
| EP1575495A4 (en) | 2002-03-27 | 2009-12-02 | Smithkline Beecham Corp | COMPOUNDS AND METHODS |
| US20050171084A1 (en) * | 2002-03-27 | 2005-08-04 | Cairns William J. | Methods of treatment with lxr modulators |
| US7560586B2 (en) | 2002-03-27 | 2009-07-14 | Smithkline Beecham Corporation | Acid and ester compounds and methods of using the same |
| AU2003220558A1 (en) | 2002-03-27 | 2004-06-03 | Smithkline Beecham Corporation | Amide compounds and methods of using the same |
| WO2004043457A1 (en) * | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
| FR2869904B1 (fr) | 2004-05-07 | 2006-07-28 | Fournier S A Sa Lab | Modulateurs des recepteurs lxr |
| IL166149A0 (en) * | 2005-01-05 | 2006-01-15 | Hadasit Med Res Service | Use of ezetimibe and amiodarone in protection against beta-amyloid neurotoxicity |
| KR20090086084A (ko) | 2006-11-30 | 2009-08-10 | 코와 가부시키가이샤 | 치환 카르비놀 화합물 |
| US7919509B2 (en) | 2008-02-29 | 2011-04-05 | Kowa Company, Ltd. | 2-oxochromene derivatives |
| US7951822B2 (en) | 2008-03-31 | 2011-05-31 | Kowa Company, Ltd. | 1,3-dihydroisobenzofuran derivatives |
| JP5371118B2 (ja) | 2008-04-30 | 2013-12-18 | 興和株式会社 | キノリン化合物 |
| AU2009252615B2 (en) | 2008-05-29 | 2013-08-15 | Kowa Company, Ltd. | Substituted carbinol compound having cyclic linker |
| KR101671046B1 (ko) | 2009-04-29 | 2016-10-31 | 코와 가부시키가이샤 | 헤테로환 링커를 갖는 카르비놀 화합물 |
| WO2012033353A2 (ko) | 2010-09-07 | 2012-03-15 | 서울대학교 산학협력단 | 세스터터핀 화합물 및 이들 물질의 용도 |
| EP3589280B1 (en) | 2017-03-03 | 2024-02-07 | Inspirna, Inc. | Formulations with improved stability |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3889545T2 (de) | 1987-10-20 | 1994-10-13 | Otsuka Pharma Co Ltd | Phenylcarbonsäure-abkömmlinge. |
| US20030153541A1 (en) * | 1997-10-31 | 2003-08-14 | Robert Dudley | Novel anticholesterol compositions and method for using same |
| US6316503B1 (en) * | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
| AU2000235960A1 (en) | 2000-02-14 | 2001-08-27 | Tularik, Inc. | Lxr modulators |
| WO2002024632A2 (en) | 2000-09-18 | 2002-03-28 | Glaxo Group Limited | Substituted aminopropoxyaryl derivatives useful as agonists for lxr |
| US7470659B2 (en) * | 2001-12-07 | 2008-12-30 | The Regents Of The University Of California | Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM) |
| WO2003049685A2 (en) * | 2001-12-07 | 2003-06-19 | The Regents Of The University Of California | Treatment for age-related macular degeneration |
| US20030229062A1 (en) * | 2001-12-07 | 2003-12-11 | The Regents Of The University Of California | Treatments for age-related macular degeneration (AMD) |
| AU2003220558A1 (en) * | 2002-03-27 | 2004-06-03 | Smithkline Beecham Corporation | Amide compounds and methods of using the same |
| US7560586B2 (en) | 2002-03-27 | 2009-07-14 | Smithkline Beecham Corporation | Acid and ester compounds and methods of using the same |
| EP1575495A4 (en) * | 2002-03-27 | 2009-12-02 | Smithkline Beecham Corp | COMPOUNDS AND METHODS |
| US20050171084A1 (en) * | 2002-03-27 | 2005-08-04 | Cairns William J. | Methods of treatment with lxr modulators |
| WO2004058175A2 (en) * | 2002-12-23 | 2004-07-15 | Irm Llc | Novel use of liver x receptor agonists |
| GB0230177D0 (en) | 2002-12-24 | 2003-02-05 | Karobio Ab | LXR beta crystal |
| EP1635773A2 (en) | 2003-06-06 | 2006-03-22 | Merck & Co., Inc. (a New Jersey corp.) | Combination therapy for the treatment of hypertension |
| EP1635832A2 (en) | 2003-06-06 | 2006-03-22 | Merck & Co., Inc. | Combination therapy for the treatment of diabetes |
| US20060189693A1 (en) | 2003-07-22 | 2006-08-24 | Barone Frank C | Methods of treatment with lxr agonists |
| JP2007500158A (ja) | 2003-07-28 | 2007-01-11 | グラクソ グループ リミテッド | Ｌｘｒアゴニストを用いる炎症性腸疾患の治療方法 |
| WO2005055998A1 (en) | 2003-12-04 | 2005-06-23 | Smithkline Beecham Corporation | Methods of treatment with lxr agonists |
| AU2004298486A1 (en) * | 2003-12-12 | 2005-06-30 | Wyeth | Quinolines useful in treating cardiovascular disease |
| US20060020036A1 (en) | 2004-06-24 | 2006-01-26 | Luc Van Rompaey | Methods and compositions to promote bone homestasis |
| WO2006004030A1 (ja) | 2004-07-02 | 2006-01-12 | Sankyo Company, Limited | 組織因子産生抑制剤 |
-
2003
- 2003-03-26 EP EP03719457A patent/EP1490047B1/en not_active Expired - Lifetime
- 2003-03-26 WO PCT/US2003/009039 patent/WO2003082192A2/en not_active Ceased
- 2003-03-26 US US10/508,822 patent/US7323494B2/en not_active Expired - Lifetime
- 2003-03-26 AU AU2003223340A patent/AU2003223340A1/en not_active Abandoned
- 2003-03-26 ES ES03719457T patent/ES2337037T3/es not_active Expired - Lifetime
- 2003-03-26 JP JP2003579735A patent/JP2005521705A/ja active Pending
- 2003-03-26 AT AT03719457T patent/ATE453389T1/de not_active IP Right Cessation
- 2003-03-26 DE DE60330758T patent/DE60330758D1/de not_active Expired - Lifetime
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