DE60330758D1 - Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen - Google Patents

Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen

Info

Publication number
DE60330758D1
DE60330758D1 DE60330758T DE60330758T DE60330758D1 DE 60330758 D1 DE60330758 D1 DE 60330758D1 DE 60330758 T DE60330758 T DE 60330758T DE 60330758 T DE60330758 T DE 60330758T DE 60330758 D1 DE60330758 D1 DE 60330758D1
Authority
DE
Germany
Prior art keywords
substituted amino
amino alkyl
certain pharmaceutically
pharmaceutically valuable
alkyl heterocycles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60330758T
Other languages
German (de)
English (en)
Inventor
Scott K Thompson
James S Frazee
Lara S Kallander
Chum Ma
Joseph P Marino
Michael J Neeb
Ajita Bhat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of DE60330758D1 publication Critical patent/DE60330758D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
DE60330758T 2002-03-27 2003-03-26 Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen Expired - Lifetime DE60330758D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36841502P 2002-03-27 2002-03-27
PCT/US2003/009039 WO2003082192A2 (en) 2002-03-27 2003-03-26 Certain pharmaceutically useful substituted aminoalkyl heterocycles

Publications (1)

Publication Number Publication Date
DE60330758D1 true DE60330758D1 (de) 2010-02-11

Family

ID=28675483

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60330758T Expired - Lifetime DE60330758D1 (de) 2002-03-27 2003-03-26 Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen

Country Status (8)

Country Link
US (1) US7323494B2 (https=)
EP (1) EP1490047B1 (https=)
JP (1) JP2005521705A (https=)
AT (1) ATE453389T1 (https=)
AU (1) AU2003223340A1 (https=)
DE (1) DE60330758D1 (https=)
ES (1) ES2337037T3 (https=)
WO (1) WO2003082192A2 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004509161A (ja) * 2000-09-18 2004-03-25 グラクソ　グループ　リミテッド Ｌｘｒのアゴニストとして有用な置換アミノプロポキシアリール誘導体
AU2003226094A1 (en) 2002-03-27 2003-10-13 Smithkline Beecham Corporation Compounds and methods
EP1487776A4 (en) 2002-03-27 2005-05-25 Smithkline Beecham Corp ACID COMPOUNDS AND ESTERS AND METHODS OF USE THEREOF
US20050171084A1 (en) * 2002-03-27 2005-08-04 Cairns William J. Methods of treatment with lxr modulators
US7247748B2 (en) 2002-03-27 2007-07-24 Smithkline Corporation Amide compounds and methods of using the same
WO2004043457A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
FR2869904B1 (fr) 2004-05-07 2006-07-28 Fournier S A Sa Lab Modulateurs des recepteurs lxr
IL166149A0 (en) * 2005-01-05 2006-01-15 Hadasit Med Res Service Use of ezetimibe and amiodarone in protection against beta-amyloid neurotoxicity
ES2380499T3 (es) 2006-11-30 2012-05-14 Kowa Company. Ltd. Compuesto de Carbinol sustituido
US7919509B2 (en) 2008-02-29 2011-04-05 Kowa Company, Ltd. 2-oxochromene derivatives
US7951822B2 (en) 2008-03-31 2011-05-31 Kowa Company, Ltd. 1,3-dihydroisobenzofuran derivatives
WO2009133692A1 (ja) 2008-04-30 2009-11-05 興和株式会社 キノリン化合物
JP5541803B2 (ja) 2008-05-29 2014-07-09 興和株式会社 環状リンカーを有する置換カルビノール化合物
CN102438991B (zh) 2009-04-29 2015-08-26 兴和株式会社 具有杂环连接基的甲醇化合物
US20130274212A1 (en) 2010-09-07 2013-10-17 Snu R&Db Foundation Sesterterpene Compounds and Use Thereof
CN110494415A (zh) 2017-03-03 2019-11-22 睿治尼斯公司 具有改善的稳定性的制剂

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3889545T2 (de) 1987-10-20 1994-10-13 Otsuka Pharma Co Ltd Phenylcarbonsäure-abkömmlinge.
US20030153541A1 (en) 1997-10-31 2003-08-14 Robert Dudley Novel anticholesterol compositions and method for using same
US6316503B1 (en) * 1999-03-15 2001-11-13 Tularik Inc. LXR modulators
AU2000235960A1 (en) 2000-02-14 2001-08-27 Tularik, Inc. Lxr modulators
JP2004509161A (ja) 2000-09-18 2004-03-25 グラクソ　グループ　リミテッド Ｌｘｒのアゴニストとして有用な置換アミノプロポキシアリール誘導体
US20030229062A1 (en) 2001-12-07 2003-12-11 The Regents Of The University Of California Treatments for age-related macular degeneration (AMD)
JP2005511713A (ja) 2001-12-07 2005-04-28 ザ・リージェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア 加齢性黄斑変性についての処置
US7470659B2 (en) 2001-12-07 2008-12-30 The Regents Of The University Of California Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM)
US20050171084A1 (en) 2002-03-27 2005-08-04 Cairns William J. Methods of treatment with lxr modulators
US7247748B2 (en) 2002-03-27 2007-07-24 Smithkline Corporation Amide compounds and methods of using the same
AU2003226094A1 (en) 2002-03-27 2003-10-13 Smithkline Beecham Corporation Compounds and methods
EP1487776A4 (en) 2002-03-27 2005-05-25 Smithkline Beecham Corp ACID COMPOUNDS AND ESTERS AND METHODS OF USE THEREOF
WO2004058175A2 (en) 2002-12-23 2004-07-15 Irm Llc Novel use of liver x receptor agonists
GB0230177D0 (en) 2002-12-24 2003-02-05 Karobio Ab LXR beta crystal
EP1635832A2 (en) 2003-06-06 2006-03-22 Merck & Co., Inc. Combination therapy for the treatment of diabetes
WO2004110368A2 (en) 2003-06-06 2004-12-23 Merck & Co., Inc. Combination therapy for the treatment of hypertension
US20060189693A1 (en) 2003-07-22 2006-08-24 Barone Frank C Methods of treatment with lxr agonists
EP1653938A2 (en) 2003-07-28 2006-05-10 Glaxo Group Limited Methods of treatment of inflammatory bowel disease with lxr agonists
WO2005055998A1 (en) 2003-12-04 2005-06-23 Smithkline Beecham Corporation Methods of treatment with lxr agonists
RU2006124843A (ru) 2003-12-12 2008-01-20 Уайт (Us) Хинолины, пригодные для лечения сердечно-сосудистого заболевания
EP1758651A2 (en) 2004-06-24 2007-03-07 Galapagos N.V. Lxr agonists to promote bone homeostasis
US20080255111A1 (en) 2004-07-02 2008-10-16 Sankyo Company Limited Tissue Factor Production Inhibitor

Also Published As

Publication number Publication date
JP2005521705A (ja) 2005-07-21
US7323494B2 (en) 2008-01-29
WO2003082192A2 (en) 2003-10-09
WO2003082192A3 (en) 2003-12-18
AU2003223340A1 (en) 2003-10-13
AU2003223340A8 (en) 2003-10-13
ES2337037T3 (es) 2010-04-20
EP1490047A2 (en) 2004-12-29
EP1490047A4 (en) 2006-01-04
EP1490047B1 (en) 2009-12-30
US20050165045A1 (en) 2005-07-28
ATE453389T1 (de) 2010-01-15

Similar Documents

Publication Publication Date Title
DE60107449D1 (de) Substituierte aminopropoxyarylderivate als lxr agonisten
WO2003082205A3 (en) Compounds and methods
DE69919397D1 (de) Thrombin-inhibitoren
NL300877I2 (nl) obeticholzuur
DE60330758D1 (de) Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen
ATE297203T1 (de) Antithrombotische mitteln
EA200500814A1 (ru) Производные пирролопиримидина
TW200510441A (en) Novel compounds
DE602004008098D1 (de) Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
DE60130771D1 (de) Substituierte heterocyclische amide
MXPA05011411A (es) 1,4-diazepinas sustituidas y usos de las mismas.
HRP20070430T3 (en) (3-oxo-3,4-dihydro-quinoxalin-2-yl-amino)-benzamide derivatives and related compounds as glycogen phosphorylase inhibitors for the treatment of diabetes and obesity
EP1176958A4 (en) NEW CATHECHOLE AS AN ANTIMICROBIAL AGENT
WO2005003087A3 (en) Oxazole derivatives as antibacterial agents
PA8573501A1 (es) Derivados de benzoxazina y su empleo
ID24846A (id) Turunan-turunan bifenilamidina
ATE308540T1 (de) Antithrombosemittel
DK1209151T3 (da) 4-substituerede piperidinderivativer
WO2003093247A3 (en) Antibacterial agents
DE69329184D1 (de) Alkylsubstituierte heterocyclische Verbindungen
DE69827614D1 (de) Chinoxalindionen
TW200508211A (en) 2-naphthylimino-1,3-thiazine derivatives
IL166313A0 (en) Indoline derivatives and pharmaceutical compositions containing the same

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: GLAXOSMITHKLINE LLC, PHILADELPHIA, PA., US

8364 No opposition during term of opposition