JP2005520819A5 - - Google Patents
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- Publication number
- JP2005520819A5 JP2005520819A5 JP2003570774A JP2003570774A JP2005520819A5 JP 2005520819 A5 JP2005520819 A5 JP 2005520819A5 JP 2003570774 A JP2003570774 A JP 2003570774A JP 2003570774 A JP2003570774 A JP 2003570774A JP 2005520819 A5 JP2005520819 A5 JP 2005520819A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrocamptothecin
- polymorph
- pharmaceutical composition
- pharmaceutical carrier
- wavelength
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 claims 64
- 229950009213 rubitecan Drugs 0.000 claims 64
- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 239000003937 drug carrier Substances 0.000 claims 24
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 18
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 18
- 238000000634 powder X-ray diffraction Methods 0.000 claims 17
- 230000005855 radiation Effects 0.000 claims 17
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 15
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 15
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 12
- 238000000113 differential scanning calorimetry Methods 0.000 claims 9
- 238000000227 grinding Methods 0.000 claims 7
- 238000010298 pulverizing process Methods 0.000 claims 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 238000010521 absorption reaction Methods 0.000 claims 4
- 238000002329 infrared spectrum Methods 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 3
- 229910002483 Cu Ka Inorganic materials 0.000 claims 2
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 claims 2
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
- 229940127093 camptothecin Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/081,991 US6756381B2 (en) | 2002-02-21 | 2002-02-21 | Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use thereof |
| US10/081,998 US6492379B1 (en) | 2002-02-21 | 2002-02-21 | Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor |
| US10/082,003 US7049322B2 (en) | 2002-02-21 | 2002-02-21 | Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor |
| US10/081,745 US6482830B1 (en) | 2002-02-21 | 2002-02-21 | Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor |
| US10/080,530 US7071202B2 (en) | 2002-02-21 | 2002-02-21 | Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor |
| US10/267,909 US6696458B2 (en) | 2002-02-21 | 2002-10-08 | Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use thereof |
| PCT/US2003/005118 WO2003072027A2 (en) | 2002-02-21 | 2003-02-19 | Compositions and formulations of 9- nitrocamptothecin polymorphs and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005520819A JP2005520819A (ja) | 2005-07-14 |
| JP2005520819A5 true JP2005520819A5 (enExample) | 2006-04-06 |
Family
ID=27767969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003570774A Abandoned JP2005520819A (ja) | 2002-02-21 | 2003-02-19 | ９−ニトロカンプトテシン多形体の組成物および調合物並びにその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (7) | US6482830B1 (enExample) |
| EP (1) | EP1476159A4 (enExample) |
| JP (1) | JP2005520819A (enExample) |
| AU (1) | AU2003215336A1 (enExample) |
| CA (1) | CA2476630A1 (enExample) |
| WO (1) | WO2003072027A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002068398A1 (en) * | 2001-02-27 | 2002-09-06 | Teva Pharmaceutical Industries Ltd. | New crystal forms of lamotrigine and processes for their preparations |
| US8133501B2 (en) | 2002-02-08 | 2012-03-13 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled drug delivery |
| US6887270B2 (en) | 2002-02-08 | 2005-05-03 | Boston Scientific Scimed, Inc. | Implantable or insertable medical device resistant to microbial growth and biofilm formation |
| US7993390B2 (en) * | 2002-02-08 | 2011-08-09 | Boston Scientific Scimed, Inc. | Implantable or insertable medical device resistant to microbial growth and biofilm formation |
| US8685427B2 (en) | 2002-07-31 | 2014-04-01 | Boston Scientific Scimed, Inc. | Controlled drug delivery |
| US6482830B1 (en) * | 2002-02-21 | 2002-11-19 | Supergen, Inc. | Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor |
| CA2483103A1 (en) * | 2002-04-23 | 2003-11-06 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical composition containing lamotrigine particles of defined morphology |
| US8920826B2 (en) | 2002-07-31 | 2014-12-30 | Boston Scientific Scimed, Inc. | Medical imaging reference devices |
| US20040121003A1 (en) * | 2002-12-19 | 2004-06-24 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
| EP1699435A4 (en) * | 2003-09-18 | 2009-05-20 | Norton Healthcare Ltd | PARTICLE |
| US20050100529A1 (en) * | 2003-11-06 | 2005-05-12 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders |
| AR046579A1 (es) * | 2003-11-12 | 2005-12-14 | Smithkline Beecham Corp | Compuesto cristalino de topotecan, composicion farmaceutica que lo comprende, procedimiento para prepararlo y su uso para preparar dicha composicion farmaceutica |
| CN1324032C (zh) * | 2004-01-07 | 2007-07-04 | 重庆医药工业研究院有限责任公司 | 一种新的9－硝基喜树碱晶型和药物组合物 |
| US7371906B2 (en) * | 2004-08-24 | 2008-05-13 | Eastman Kodak Company | Process for photo-oxidative stability improvements |
| ITFI20050087A1 (it) * | 2005-05-02 | 2006-11-03 | Perini Fabio Spa | Metodo e dispositivo per produrre rotoli di materiale nastriforme con una fasciatura esterna |
| IL168603A (en) * | 2005-05-16 | 2011-05-31 | Resdevco Res And Dev Co | Pharmaceutical or cosmetic composition for the prevention and treatment of irritation of mucous cells or skin cells |
| US20070123539A1 (en) * | 2005-10-20 | 2007-05-31 | University Of South Florida | Treatment of Restenosis and Stenosis with Dasatinib |
| US20070099992A1 (en) * | 2005-11-03 | 2007-05-03 | Kane Lynn C N | Direct application of vitamin C to the lung tissue and respiratory passages by use of an asthma medication-type inhaler or similar inhaler |
| US20100038816A1 (en) * | 2006-08-16 | 2010-02-18 | Novartis Ag | Method of making solid dispersions of highly crystalline therapeutic compounds |
| US8307341B2 (en) * | 2007-04-25 | 2012-11-06 | International Business Machines Corporation | Generating customized documentation for a software product |
| CN103130814B (zh) * | 2011-11-25 | 2016-03-09 | 上海医药工业研究院 | 两种9-硝基喜树碱新晶型及其制备方法 |
| GB201700555D0 (en) | 2017-01-12 | 2017-03-01 | Peptinnovate Ltd | Method for the treatment of a relapsing-remitting condition |
| US12331088B2 (en) | 2017-01-12 | 2025-06-17 | Revolo Biotherapeutics Limited | Method for the treatment of a relapsing-remitting condition |
| US12358957B2 (en) | 2017-01-12 | 2025-07-15 | Revolo Biotherapeutics Limited | Method for the acute treatment of atopic dermatitis and allergic skin hypersensitivity |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3700819A (en) | 1970-12-07 | 1972-10-24 | Bell Telephone Labor Inc | Time division switching system with time slot interchange |
| US3883847A (en) | 1974-03-28 | 1975-05-13 | Bell Telephone Labor Inc | Uniform decoding of minimum-redundancy codes |
| JPH0763151B2 (ja) | 1985-09-18 | 1995-07-05 | 日本電気株式会社 | 可変長符号複号化回路 |
| US4894456A (en) * | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US5552154A (en) * | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
| US5225404A (en) * | 1989-11-06 | 1993-07-06 | New York University | Methods of treating colon tumors with tumor-inhibiting camptothecin compounds |
| US5162532A (en) * | 1990-12-20 | 1992-11-10 | North Carolina State University | Intermediates and method of making camptothecin and camptothecin analogs |
| US5559235A (en) * | 1991-10-29 | 1996-09-24 | Glaxo Wellcome Inc. | Water soluble camptothecin derivatives |
| JPH05152973A (ja) | 1991-11-28 | 1993-06-18 | Fujitsu Ltd | 可変長符号復号器 |
| JPH05173844A (ja) | 1991-12-19 | 1993-07-13 | Nec Corp | コーディングミス修正方式 |
| JP2842094B2 (ja) | 1992-10-13 | 1998-12-24 | 日本電気株式会社 | ハフマン復号回路 |
| GB9319944D0 (en) * | 1993-09-28 | 1993-11-17 | Erba Carlo Spa | Process for the preparation of 9-amino camptothecin |
| US5731316A (en) * | 1996-01-30 | 1998-03-24 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| JPH09307456A (ja) | 1996-05-09 | 1997-11-28 | Matsushita Electric Ind Co Ltd | 可変長符号復号装置及び方法 |
| US5922877A (en) * | 1997-08-05 | 1999-07-13 | The Stehlin Foundation For Cancer Research | Methods of preparing and purifying 9-nitro-20-camptothecin |
| JPH11168391A (ja) | 1997-12-04 | 1999-06-22 | Matsushita Electric Ind Co Ltd | 復号装置 |
| US6291676B1 (en) | 1999-03-03 | 2001-09-18 | University Of Kentucky Research Foundation | Water-soluble derivatives of camptothecin/homocamptothecin |
| US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
| AU2001240024A1 (en) * | 2000-03-31 | 2001-10-15 | Supergen, Inc. | Camptothecin complexes |
| US6482830B1 (en) * | 2002-02-21 | 2002-11-19 | Supergen, Inc. | Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor |
-
2002
- 2002-02-21 US US10/081,745 patent/US6482830B1/en not_active Expired - Fee Related
- 2002-02-21 US US10/081,998 patent/US6492379B1/en not_active Expired - Fee Related
- 2002-02-21 US US10/081,991 patent/US6756381B2/en not_active Expired - Fee Related
- 2002-02-21 US US10/080,530 patent/US7071202B2/en not_active Expired - Fee Related
- 2002-02-21 US US10/082,003 patent/US7049322B2/en not_active Expired - Fee Related
- 2002-10-08 US US10/267,909 patent/US6696458B2/en not_active Expired - Fee Related
-
2003
- 2003-02-19 CA CA002476630A patent/CA2476630A1/en not_active Abandoned
- 2003-02-19 AU AU2003215336A patent/AU2003215336A1/en not_active Abandoned
- 2003-02-19 JP JP2003570774A patent/JP2005520819A/ja not_active Abandoned
- 2003-02-19 WO PCT/US2003/005118 patent/WO2003072027A2/en not_active Ceased
- 2003-02-19 EP EP03711157A patent/EP1476159A4/en not_active Withdrawn
-
2006
- 2006-03-28 US US11/277,729 patent/US20060217407A1/en not_active Abandoned
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