JP2005520803A5 - - Google Patents
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- Publication number
- JP2005520803A5 JP2005520803A5 JP2003557970A JP2003557970A JP2005520803A5 JP 2005520803 A5 JP2005520803 A5 JP 2005520803A5 JP 2003557970 A JP2003557970 A JP 2003557970A JP 2003557970 A JP2003557970 A JP 2003557970A JP 2005520803 A5 JP2005520803 A5 JP 2005520803A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- chloro
- sodium
- hydroxybenzoyl
- butanoate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UQFYDAAKCZKDHS-UHFFFAOYSA-M sodium;4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate Chemical compound [Na+].OC1=CC(Cl)=CC=C1C(=O)NCCCC([O-])=O UQFYDAAKCZKDHS-UHFFFAOYSA-M 0.000 claims 18
- 229910052708 sodium Inorganic materials 0.000 claims 9
- 239000011734 sodium Substances 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 6
- 238000000634 powder X-ray diffraction Methods 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 6
- 239000000243 solution Substances 0.000 claims 6
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims 5
- 238000002844 melting Methods 0.000 claims 4
- 230000008018 melting Effects 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- GCVGCXMTCJMBHY-UHFFFAOYSA-N 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoic acid Chemical compound OC(=O)CCCNC(=O)C1=CC=C(Cl)C=C1O GCVGCXMTCJMBHY-UHFFFAOYSA-N 0.000 claims 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 3
- 238000000113 differential scanning calorimetry Methods 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 3
- -1 4-chloro-2-hydroxybenzoyl Chemical group 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical group CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000155 melt Substances 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34761002P | 2002-01-09 | 2002-01-09 | |
| PCT/US2003/000878 WO2003057650A2 (en) | 2002-01-09 | 2003-01-09 | Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005520803A JP2005520803A (ja) | 2005-07-14 |
| JP2005520803A5 true JP2005520803A5 (https=) | 2008-03-13 |
| JP4508646B2 JP4508646B2 (ja) | 2010-07-21 |
Family
ID=23364463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003557970A Expired - Fee Related JP4508646B2 (ja) | 2002-01-09 | 2003-01-09 | ４−［（４−クロロ−２−ヒドロキシベンゾイル）アミノ］ブタン酸ナトリウムの多形体 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US7227033B2 (https=) |
| EP (2) | EP1469827B1 (https=) |
| JP (1) | JP4508646B2 (https=) |
| AU (1) | AU2003223158B2 (https=) |
| CA (1) | CA2471144C (https=) |
| ES (2) | ES2412306T3 (https=) |
| WO (1) | WO2003057650A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL126318A (en) | 1996-03-29 | 2004-09-27 | Emisphere Tech Inc | Compounds and compositions for delivering active agents and some novel carrier compounds |
| US6991798B1 (en) | 1998-08-07 | 2006-01-31 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| ES2306719T3 (es) | 2000-06-29 | 2008-11-16 | Emisphere Technologies, Inc. | Compuestos y composiciones para la administracion de principios activos. |
| EP1469827B1 (en) * | 2002-01-09 | 2017-12-27 | Emisphere Technologies, Inc. | Polymorphs of sodium 4- (4-chloro-2-hydroxybenzoyl)amino butanoate |
| CA2511530C (en) * | 2003-01-06 | 2013-07-09 | Emisphere Technologies, Inc. | Night-time oral insulin therapy |
| US20050203001A1 (en) | 2004-03-05 | 2005-09-15 | Emisphere Technologies, Inc. | Oral insulin therapies and protocol |
| US20050192298A1 (en) * | 2004-02-27 | 2005-09-01 | Pfizer Inc | Crystal forms of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide |
| MXPA06013252A (es) * | 2004-05-14 | 2007-02-28 | Emisphere Tech Inc | Compuestos y composiciones para suministrar agentes activos. |
| CN1968704B (zh) | 2004-05-19 | 2010-12-08 | 爱密斯菲尔科技公司 | 局部用色甘酸制剂 |
| BRPI0510820A (pt) | 2004-05-19 | 2007-11-27 | Emisphere Tech Inc | composição farmacêutica, forma unitária de dosagem e seus usos |
| EP1773376A4 (en) | 2004-08-03 | 2009-07-01 | Emisphere Tech Inc | ANTIDIBLE ORAL INSULIN BIGUANIDE COMBINATION |
| FR2875807B1 (fr) * | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| GB0427603D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
| GB0427600D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
| AU2005321803B2 (en) | 2004-12-29 | 2012-02-09 | Emisphere Technologies, Inc. | Pharmaceutical formulations of gallium salts |
| US8110547B2 (en) | 2005-01-12 | 2012-02-07 | Emisphere Technologies, Inc. | Compositions for buccal delivery of parathyroid hormone |
| WO2007005995A2 (en) | 2005-07-05 | 2007-01-11 | Emisphere Technologies, Inc. | Compositions for buccal delivery of human growth hormone |
| JP5475443B2 (ja) * | 2006-06-28 | 2014-04-16 | エミスフェアー・テクノロジーズ・インク | 硝酸ガリウム製剤 |
| US20110039930A1 (en) | 2009-08-03 | 2011-02-17 | Emisphere Technologies, Inc. | Fast-acting naproxen composition with reduced gastrointestinal effects |
| PL2897620T3 (pl) | 2012-09-21 | 2020-11-02 | Intensity Therapeutics, Inc | Sposób leczenia nowotworu złośliwego |
| CN104902922B (zh) | 2012-11-13 | 2017-12-12 | 阿道恰公司 | 包含经取代阴离子化合物的速效胰岛素制剂 |
| FR3020947B1 (fr) * | 2014-05-14 | 2018-08-31 | Adocia | Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations |
| US9795678B2 (en) | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
| FR3043557B1 (fr) | 2015-11-16 | 2019-05-31 | Adocia | Composition a action rapide d'insuline comprenant un citrate substitue |
| JP7188798B2 (ja) * | 2018-11-29 | 2022-12-13 | Ｎｅｃソリューションイノベータ株式会社 | 座標算出装置、座標算出方法、及びプログラム |
| CN111925298B (zh) * | 2020-09-02 | 2023-05-30 | 无锡紫杉药业有限公司 | 一种4-cnab及其制备方法 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5811856B2 (ja) * | 1975-07-14 | 1983-03-04 | 中外製薬株式会社 | ２ ４− ビス （２’ − アセトキシベンズアミド ） アンソクコウサンノ イケイケツシヨウノ セイゾウホウ |
| JPS5312417A (en) * | 1976-07-20 | 1978-02-03 | Sumitomo Chem Co Ltd | Preparation of amorphous d rugs |
| US4421685A (en) | 1980-03-27 | 1983-12-20 | Eli Lilly And Company | Process for producing an insulin |
| DE3266360D1 (en) | 1981-06-16 | 1985-10-24 | Choay Sa | Medicines containing as active ingredients compounds of the arylbenzenesulfonamide-type, and processes for their preparation |
| USRE35862E (en) | 1986-08-18 | 1998-07-28 | Emisphere Technologies, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
| US5443841A (en) | 1992-06-15 | 1995-08-22 | Emisphere Technologies, Inc. | Proteinoid microspheres and methods for preparation and use thereof |
| US5629020A (en) | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
| US5583020A (en) | 1992-11-24 | 1996-12-10 | Ribozyme Pharmaceuticals, Inc. | Permeability enhancers for negatively charged polynucleotides |
| US5401516A (en) | 1992-12-21 | 1995-03-28 | Emisphere Technologies, Inc. | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
| US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| AU6819294A (en) | 1993-04-22 | 1994-11-08 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| US5534488A (en) | 1993-08-13 | 1996-07-09 | Eli Lilly And Company | Insulin formulation |
| JP3462895B2 (ja) * | 1993-11-05 | 2003-11-05 | 三井化学株式会社 | 安息香酸誘導体の多価金属塩の製造方法 |
| US5474978A (en) | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| TW487582B (en) * | 1995-08-11 | 2002-05-21 | Nissan Chemical Ind Ltd | Method for converting sparingly water-soluble medical substance to amorphous state |
| US5776888A (en) | 1997-02-07 | 1998-07-07 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| ATE383169T1 (de) | 1997-02-07 | 2008-01-15 | Emisphere Tech Inc | Komponente und zusammensetzungen zur verabreichung von wirkstoffen |
| GB9808896D0 (en) * | 1998-04-25 | 1998-06-24 | Smithkline Beecham Plc | Novel compound |
| CA2566652C (en) * | 1998-06-19 | 2008-10-21 | Teijin Limited | Polymorphic modifications of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole-carboxylic acid and processes for the preparation thereof |
| IL140930A0 (en) | 1998-08-07 | 2002-02-10 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
| JP2002534363A (ja) | 1999-01-08 | 2002-10-15 | エミスフェアー・テクノロジーズ・インク | ポリマー性デリバリー剤及びデリバリー剤化合物 |
| DE19903275A1 (de) | 1999-01-28 | 2000-08-03 | Merck Patent Gmbh | Lyophilisate mit verbesserter Rekonstituierbarkeit |
| AU3357800A (en) | 1999-02-05 | 2000-08-25 | Emisphere Technologies, Inc. | Method of preparing alkylated salicylamides |
| MXPA01008611A (es) | 1999-02-26 | 2003-06-24 | Emisphere Tech Inc | Compuestos y composiciones para suministrar agentes activos. |
| ES2235854T3 (es) * | 1999-04-05 | 2005-07-16 | Emisphere Technologies, Inc. | Sales disodicas, monohidratos y solvatos etanolicos para aportar agentes activos. |
| GB9923933D0 (en) * | 1999-10-08 | 1999-12-08 | Smithkline Beecham Lab | Novel pharmaceutical |
| GB9923934D0 (en) * | 1999-10-08 | 1999-12-08 | Smithkline Beecham Plc | Novel pharmaceutical |
| MXPA02004092A (es) | 1999-11-05 | 2003-02-12 | Emisphere Tech Inc | Compuestos y composiciones de acido fenilaminocarboxilico para administrar agentes activos. |
| JP2001240581A (ja) * | 2000-02-29 | 2001-09-04 | Senju Pharmaceut Co Ltd | アミノベンズアミド誘導体およびその用途 |
| US6900344B2 (en) | 2000-03-21 | 2005-05-31 | Emisphere Technologies, Inc. | Method of preparing alkylated salicylamides via a dicarboxylate intermediate |
| ES2306719T3 (es) * | 2000-06-29 | 2008-11-16 | Emisphere Technologies, Inc. | Compuestos y composiciones para la administracion de principios activos. |
| US6482847B2 (en) * | 2000-10-03 | 2002-11-19 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
| EP1469827B1 (en) | 2002-01-09 | 2017-12-27 | Emisphere Technologies, Inc. | Polymorphs of sodium 4- (4-chloro-2-hydroxybenzoyl)amino butanoate |
-
2003
- 2003-01-09 EP EP03719286.1A patent/EP1469827B1/en not_active Expired - Lifetime
- 2003-01-09 EP EP10012220A patent/EP2272501B1/en not_active Expired - Lifetime
- 2003-01-09 AU AU2003223158A patent/AU2003223158B2/en not_active Ceased
- 2003-01-09 JP JP2003557970A patent/JP4508646B2/ja not_active Expired - Fee Related
- 2003-01-09 WO PCT/US2003/000878 patent/WO2003057650A2/en not_active Ceased
- 2003-01-09 ES ES10012220T patent/ES2412306T3/es not_active Expired - Lifetime
- 2003-01-09 ES ES03719286.1T patent/ES2664189T3/es not_active Expired - Lifetime
- 2003-01-09 US US10/501,205 patent/US7227033B2/en not_active Expired - Lifetime
- 2003-01-09 CA CA2471144A patent/CA2471144C/en not_active Expired - Lifetime
-
2005
- 2005-07-14 US US11/183,039 patent/US7208178B2/en not_active Expired - Lifetime
-
2007
- 2007-03-14 US US11/686,341 patent/US7462368B2/en not_active Expired - Lifetime
- 2007-04-12 US US11/734,591 patent/US7420085B2/en not_active Expired - Lifetime
-
2008
- 2008-07-02 US US12/167,126 patent/US7893297B2/en not_active Expired - Fee Related
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