JP2005520566A - Ｃｒｉｐｔｏ特異的抗体 - Google Patents

Ｃｒｉｐｔｏ特異的抗体 Download PDF

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Publication number
JP2005520566A
JP2005520566A JP2003580477A JP2003580477A JP2005520566A JP 2005520566 A JP2005520566 A JP 2005520566A JP 2003580477 A JP2003580477 A JP 2003580477A JP 2003580477 A JP2003580477 A JP 2003580477A JP 2005520566 A JP2005520566 A JP 2005520566A
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JP
Japan
Prior art keywords
antibody
cripto
tumor
antibodies
group
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Pending
Application number
JP2003580477A
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English (en)
Japanese (ja)
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JP2005520566A5 (https=
Inventor
ミチェル サニコラ−ナデル，
アドキンス，ヒーザー
スティーブン ドナルド ミクラス，
ポウル レイホーン，
スーザン ゲイル シファー，
ケビン ピー． ウィリアム，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Biogen MA Inc
Original Assignee
Biogen Inc
Biogen Idec Inc
Biogen Idec MA Inc
Biogen MA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2002/011950 external-priority patent/WO2002088170A2/en
Application filed by Biogen Inc, Biogen Idec Inc, Biogen Idec MA Inc, Biogen MA Inc filed Critical Biogen Inc
Publication of JP2005520566A publication Critical patent/JP2005520566A/ja
Publication of JP2005520566A5 publication Critical patent/JP2005520566A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2003580477A 2002-03-22 2002-10-01 Ｃｒｉｐｔｏ特異的抗体 Pending JP2005520566A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36700202P 2002-03-22 2002-03-22
PCT/US2002/011950 WO2002088170A2 (en) 2001-04-26 2002-04-17 Cripto blocking antibodies and uses thereof
PCT/US2002/031462 WO2003083041A2 (en) 2002-03-22 2002-10-01 Cripto-specific antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009020949A Division JP2009161539A (ja) 2002-03-22 2009-01-30 Ｃｒｉｐｔｏ特異的抗体

Publications (2)

Publication Number Publication Date
JP2005520566A true JP2005520566A (ja) 2005-07-14
JP2005520566A5 JP2005520566A5 (https=) 2006-01-12

Family

ID=29586137

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003580477A Pending JP2005520566A (ja) 2002-03-22 2002-10-01 Ｃｒｉｐｔｏ特異的抗体

Country Status (4)

Country Link
EP (1) EP1494693B1 (https=)
JP (1) JP2005520566A (https=)
AU (1) AU2002334799B2 (https=)
WO (1) WO2003083041A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011522224A (ja) * 2008-04-21 2011-07-28 メルク・シャープ・エンド・ドーム・コーポレイション 膵ベータ細胞質量生物マーカー
JP2014223079A (ja) * 2007-07-13 2014-12-04 バク アイピー ベスローテン フェンノートシャップ 哺乳動物ＩｇＧと結合する単一ドメイン抗原結合タンパク質

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US7582299B2 (en) 2001-04-26 2009-09-01 Biogen Idec Ma Inc. Cripto-specific antibodies
PL207087B1 (pl) * 2001-04-26 2010-10-29 Biogen Przeciwciało, które wiąże się swoiście z białkiem Cripto, zawierająca je kompozycja farmaceutyczna i zastosowanie przeciwciała
NZ544924A (en) 2003-06-27 2009-03-31 Biogen Idec Inc Modified binding molecules comprising connecting peptides
DK1670511T3 (da) 2003-09-15 2009-11-23 Res Dev Foundation Cripto-antagonisme af activin- og TGF-B-signalering
EP2478912B1 (en) 2003-11-06 2016-08-31 Seattle Genetics, Inc. Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy
WO2005047327A2 (en) 2003-11-12 2005-05-26 Biogen Idec Ma Inc. NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
NZ579482A (en) 2004-06-01 2011-02-25 Genentech Inc Antibody drug conjugates and methods
DK1791565T3 (en) 2004-09-23 2016-08-01 Genentech Inc Cysteingensplejsede antibodies and conjugates
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
EP1838736B1 (en) 2005-01-05 2013-03-06 Biogen Idec MA Inc. Cripto binding molecules
US20100041032A1 (en) * 2006-04-28 2010-02-18 Biogen Idec Ma Inc. Composition and methods for the detection of cripto-3
WO2008150530A2 (en) * 2007-06-01 2008-12-11 Biogen Idec Ma Inc. Cripto binding molecules
JP2013504585A (ja) 2009-09-09 2013-02-07 セントローズ， エルエルシー 細胞外標的化薬物複合体
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Cited By (3)

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Publication number Priority date Publication date Assignee Title
JP2014223079A (ja) * 2007-07-13 2014-12-04 バク アイピー ベスローテン フェンノートシャップ 哺乳動物ＩｇＧと結合する単一ドメイン抗原結合タンパク質
US10259886B2 (en) 2007-07-13 2019-04-16 Bac Ip B.V. Single-domain antigen-binding proteins that bind mammalian IgG
JP2011522224A (ja) * 2008-04-21 2011-07-28 メルク・シャープ・エンド・ドーム・コーポレイション 膵ベータ細胞質量生物マーカー

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Publication number Publication date
EP1494693A4 (en) 2006-08-02
WO2003083041A2 (en) 2003-10-09
WO2003083041A3 (en) 2003-12-04
AU2002334799A1 (en) 2003-10-13
AU2002334799B2 (en) 2009-05-07
EP1494693A2 (en) 2005-01-12
EP1494693B1 (en) 2010-12-08
WO2003083041A8 (en) 2004-09-16

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