JP2005520490A5 - - Google Patents
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- Publication number
- JP2005520490A5 JP2005520490A5 JP2003523270A JP2003523270A JP2005520490A5 JP 2005520490 A5 JP2005520490 A5 JP 2005520490A5 JP 2003523270 A JP2003523270 A JP 2003523270A JP 2003523270 A JP2003523270 A JP 2003523270A JP 2005520490 A5 JP2005520490 A5 JP 2005520490A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- seq
- amino acid
- binding domain
- lhrh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31461301P | 2001-08-24 | 2001-08-24 | |
| PCT/US2002/027061 WO2003018611A2 (en) | 2001-08-24 | 2002-08-23 | Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005520490A JP2005520490A (ja) | 2005-07-14 |
| JP2005520490A5 true JP2005520490A5 (https=) | 2006-01-05 |
| JP4319908B2 JP4319908B2 (ja) | 2009-08-26 |
Family
ID=23220660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003523270A Expired - Fee Related JP4319908B2 (ja) | 2001-08-24 | 2002-08-23 | プロテアーゼ活性化配列を含むプロアエロリシンおよび前立腺癌の治療のための使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7282476B2 (https=) |
| EP (2) | EP2518142B1 (https=) |
| JP (1) | JP4319908B2 (https=) |
| CN (1) | CN100488981C (https=) |
| AU (1) | AU2002331720B2 (https=) |
| CA (1) | CA2457903C (https=) |
| DK (1) | DK1567641T3 (https=) |
| ES (2) | ES2542888T3 (https=) |
| PT (1) | PT1567641E (https=) |
| WO (1) | WO2003018611A2 (https=) |
| ZA (1) | ZA200402319B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8809504B2 (en) * | 2002-09-03 | 2014-08-19 | Vit Lauermann | Inhibitor which is deactivatable by a reagent produced by a target cell |
| WO2004078097A2 (en) * | 2003-03-03 | 2004-09-16 | University Of Victoria Innovation And Development Corporation | Modified aerolysin linked to a lung cancer binding agent and methods of use for treating lung cancer |
| EP1694845B8 (en) | 2003-11-28 | 2017-12-20 | National Research Council of Canada | Anticarcinoma antibodies and uses thereof |
| ATE502954T1 (de) * | 2005-06-14 | 2011-04-15 | Protox Therapeutics Inc | Verfahren zur behandlung oder prävention gutartiger prostatahyperplasie unter verwendung modifizierter porenbildender proteine |
| CN100443503C (zh) * | 2005-07-18 | 2008-12-17 | 四川大学华西医院 | 人源化ctla-4单链抗体与人穿孔素通道形成肽p34的重组免疫毒素 |
| CA2630559A1 (en) * | 2005-11-21 | 2007-05-24 | Protox Therapeutics Incorporated | Modified pore-forming protein toxins and use thereof |
| US8993295B2 (en) | 2006-07-20 | 2015-03-31 | The General Hospital Corporation | Methods, compositions, and kits for the selective activation of protoxins through combinatorial targeting |
| PL2187965T3 (pl) | 2007-08-17 | 2020-05-18 | Purdue Research Foundation | Koniugaty wiążący psma ligand-łącznik i sposoby ich zastosowania |
| JP2012512183A (ja) | 2008-12-15 | 2012-05-31 | プロトックス セラピューティクス インコーポレイテッド | 改変された孔形成性タンパク質プロアエロリシンを用いた前立腺炎の処置のための方法 |
| CA2780153A1 (en) | 2009-11-09 | 2011-05-12 | Alexion Pharmaceuticals, Inc. | Reagents and methods for detecting pnh type ii white blood cells and their identification as risk factors for thrombotic disorders |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| AU2011316786A1 (en) * | 2010-10-22 | 2013-05-02 | Protox Therapeutics Corp. | Use of human serum albumin to decrease antigenicity of therapeutic proteins |
| EA201590783A1 (ru) | 2012-11-15 | 2015-11-30 | Эндосайт, Инк. | Конъюгаты для доставки лекарственных средств и способы лечения заболеваний, вызванных клетками, экспрессирующими psma |
| US9789209B2 (en) | 2013-03-14 | 2017-10-17 | The Regents Of The University Of California, Berke | Activatable membrane-interacting peptides and methods of use |
| EP3456700A1 (en) | 2013-10-18 | 2019-03-20 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| US10464970B2 (en) | 2013-10-23 | 2019-11-05 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compounds that bind to human immunodeficiency virus rev response element |
| EP3533473A3 (en) | 2013-11-14 | 2019-12-18 | Endocyte, Inc. | Compounds for positron emission tomography |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| US10596226B2 (en) * | 2015-01-16 | 2020-03-24 | The Johns Hopkins University | Albumin-proaerolysin prodrugs |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN108601817A (zh) * | 2016-01-27 | 2018-09-28 | 索飞瑞斯生物公司 | 靶向前列腺内给予prx302用于治疗前列腺癌的方法 |
| CN109790206A (zh) * | 2016-09-22 | 2019-05-21 | 分子组合公司 | 重组结合蛋白及其用途 |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| EP3694558B1 (en) | 2017-10-10 | 2024-04-10 | Medicenna Therapeutics Inc. | Il-4-fusion formulations for treatment of central nervous system (cns) tumors |
| CN112368024A (zh) | 2018-04-17 | 2021-02-12 | 恩多塞特公司 | 治疗癌症的方法 |
| CN114096264B (zh) | 2019-05-20 | 2025-03-14 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
| EP4100038A4 (en) | 2020-02-03 | 2024-02-28 | Premas Biotech Private Limited | RECOMBINANT EXPRESSION PLATFORM, CONSTRUCTS AND METHODS FOR EXPRESSING HARD-TO-EXPRESS PROTEINS (DTE-PS) |
| US11845779B2 (en) * | 2020-10-28 | 2023-12-19 | Ecole Polytechnique Federale De Lausanne (Epfl) | Mutant aerolysin and uses thereof |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US5264550A (en) | 1985-04-15 | 1993-11-23 | Scios Nova Inc. | Human anti-inflammatory phospholipase inhibitor protein |
| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US5529774A (en) | 1991-08-13 | 1996-06-25 | The Regents Of The University Of California | In vivo transfer of the HSV-TK gene implanted retroviral producer cells |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US6057133A (en) | 1992-11-24 | 2000-05-02 | G. D. Searle | Multivariant human IL-3 fusion proteins and their recombinant production |
| US5677274A (en) | 1993-02-12 | 1997-10-14 | The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services | Anthrax toxin fusion proteins and related methods |
| US5777078A (en) * | 1993-04-28 | 1998-07-07 | Worcester Foundation For Experimental Biology | Triggered pore-forming agents |
| WO1994025616A1 (en) | 1993-04-28 | 1994-11-10 | Worcester Foundation For Experimental Biology | Cell-targeted lytic pore-forming agents |
| ATE293686T1 (de) | 1993-06-04 | 2005-05-15 | Us Navy | Verfahren zur selektiven stimulierung der t- zellproliferation. |
| US5691188A (en) | 1994-02-14 | 1997-11-25 | American Cyanamid Company | Transformed yeast cells expressing heterologous G-protein coupled receptor |
| WO1995026204A1 (en) | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| CA2188675A1 (en) | 1994-04-11 | 1995-10-19 | Savio L. C. Woo | Compositions and methods for gene therapy to treat disease |
| US5866679A (en) | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
| US5599686A (en) | 1994-06-28 | 1997-02-04 | Merck & Co., Inc. | Peptides |
| US6143864A (en) * | 1994-06-28 | 2000-11-07 | Merck & Co., Inc. | Peptides |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| EP1167379A3 (en) | 1994-07-15 | 2004-09-08 | University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US6190657B1 (en) | 1995-06-07 | 2001-02-20 | Yale University | Vectors for the diagnosis and treatment of solid tumors including melanoma |
| US6066319A (en) | 1996-04-30 | 2000-05-23 | President And Fellows Of Harvard College | Drug delivery using terminal complement components |
| US6072041A (en) | 1996-06-03 | 2000-06-06 | Case Western Reserve University | Fusion proteins for protein delivery |
| US5856462A (en) | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
| US5998362A (en) | 1996-09-12 | 1999-12-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| US6368598B1 (en) | 1996-09-16 | 2002-04-09 | Jcrt Radiation Oncology Support Services, Inc. | Drug complex for treatment of metastatic prostate cancer |
| US5798218A (en) | 1996-09-24 | 1998-08-25 | University Of British Columbia Innovation And Development Corporation | Compositions and methods for the specific detection of thy-1 antigen |
| US5948750A (en) | 1996-10-30 | 1999-09-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| JP2001504334A (ja) * | 1996-11-06 | 2001-04-03 | アメリカ合衆国 | プロテアーゼ活性化可能なPseudomonas体外毒素A様プロタンパク質 |
| WO1998037919A1 (en) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
| DK1005368T3 (da) | 1997-03-10 | 2010-01-04 | Ottawa Hospital Res Inst | Anvendelse af nukleinsyrer, der indeholder ikke-metyleret CpG dinukleotid i kombination med alun som hjælpestoffer |
| EP1005376B1 (en) | 1997-03-14 | 2010-11-03 | The Children's Hospital of Philadelphia | Compositions for use in gene therapy for treatment of hemophilia |
| US6504014B1 (en) * | 1997-05-19 | 2003-01-07 | The John Hopkins University | Tissue specific prodrug |
| US6545131B1 (en) * | 1997-05-19 | 2003-04-08 | The Johns Hopkins University | Tissue specific prodrug |
| US6265540B1 (en) * | 1997-05-19 | 2001-07-24 | The Johns Hopkins University School Of Medicine | Tissue specific prodrug |
| EP1003531B1 (en) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Processes for preparing nucleic acid constructs |
| AU740597B2 (en) | 1997-07-10 | 2001-11-08 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| CA2299471C (en) * | 1997-08-15 | 2007-12-18 | Cephalon Inc. | Combination of tyrosine kinase inhibitor and chemical castration to treat prostate cancer |
| US6391305B1 (en) | 1997-09-10 | 2002-05-21 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| GB9721901D0 (en) | 1997-10-16 | 1997-12-17 | Univ Manchester | Particles |
| CA2318127A1 (en) * | 1998-01-20 | 1999-07-22 | University Of Victoria Innovation And Development Corporation | Detection of gpi anchored proteins |
| US6180356B1 (en) * | 1998-03-06 | 2001-01-30 | The Research Foundation Of State University Of Ny | Membrane pore inhibiting agents for treating infection |
| US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
| WO2000061613A2 (en) * | 1999-04-09 | 2000-10-19 | The Johns Hopkins University | Channel forming toxins as antiviral agents |
| WO2000067796A1 (en) | 1999-05-07 | 2000-11-16 | Genentech, Inc. | Treatment of autoimmune diseases with antagonists which bind to b cell surface markers |
| EP1052287A3 (en) | 1999-05-10 | 2003-07-09 | Transgene S.A. | Complex for transferring an anionic substance of interest into a cell |
| EP1052288A1 (en) | 1999-05-10 | 2000-11-15 | Transgene S.A. | Complex for transferring an anionic substance of interest into a cell |
| WO2001009165A2 (en) | 1999-07-29 | 2001-02-08 | The Johns Hopkins University | ACTIVATION OF PEPTIDE PRODRUGS BY hK2 |
| US7053042B1 (en) * | 1999-07-29 | 2006-05-30 | Samuel Denmeade | Activation of peptide prodrugs by hK2 |
| JP2003511082A (ja) | 1999-10-12 | 2003-03-25 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 第viii因子をコードするアデノ随伴ウィルスベクターとその使用法 |
| PT1225898E (pt) * | 1999-11-01 | 2003-10-31 | Alcon Inc | Composicoes farmaceuticas contendo um farmaco antibiotico de fluoroquinolona e goma xantana |
| AU2001259837A1 (en) | 2000-05-09 | 2001-11-20 | Greenville Hospital System | Therapeutic pore-forming peptides |
| US20020041880A1 (en) | 2000-07-05 | 2002-04-11 | Defeo-Jones Deborah | Method of treating cancer |
| FI116467B (fi) | 2000-09-29 | 2005-11-30 | Licentia Oy | Uudet peptidiligandit |
| WO2002038799A2 (en) | 2000-11-07 | 2002-05-16 | University Of Victoria Innovation And Development Corporation | Detection of proteases and screening for protease inhibitors |
| WO2002043773A2 (en) | 2000-12-01 | 2002-06-06 | The Johns Hopkins University | Tissue specific prodrugs |
| US7456146B2 (en) | 2001-05-09 | 2008-11-25 | Ghc Research Development Corporation | Lytic peptide prodrugs |
-
2002
- 2002-08-23 JP JP2003523270A patent/JP4319908B2/ja not_active Expired - Fee Related
- 2002-08-23 ES ES10177191.3T patent/ES2542888T3/es not_active Expired - Lifetime
- 2002-08-23 EP EP10177191.3A patent/EP2518142B1/en not_active Expired - Lifetime
- 2002-08-23 ES ES02768702T patent/ES2388170T3/es not_active Expired - Lifetime
- 2002-08-23 WO PCT/US2002/027061 patent/WO2003018611A2/en not_active Ceased
- 2002-08-23 US US10/487,115 patent/US7282476B2/en not_active Expired - Lifetime
- 2002-08-23 CA CA2457903A patent/CA2457903C/en not_active Expired - Fee Related
- 2002-08-23 EP EP02768702A patent/EP1567641B1/en not_active Expired - Lifetime
- 2002-08-23 AU AU2002331720A patent/AU2002331720B2/en not_active Ceased
- 2002-08-23 PT PT02768702T patent/PT1567641E/pt unknown
- 2002-08-23 CN CNB028166221A patent/CN100488981C/zh not_active Expired - Fee Related
- 2002-08-23 DK DK02768702.9T patent/DK1567641T3/da active
-
2004
- 2004-03-23 ZA ZA200402319A patent/ZA200402319B/xx unknown
-
2007
- 2007-09-17 US US11/856,543 patent/US7745395B2/en not_active Expired - Fee Related
-
2010
- 2010-05-27 US US12/788,913 patent/US7838266B2/en not_active Expired - Fee Related
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