JP4319908B2 - プロテアーゼ活性化配列を含むプロアエロリシンおよび前立腺癌の治療のための使用方法 - Google Patents
プロテアーゼ活性化配列を含むプロアエロリシンおよび前立腺癌の治療のための使用方法 Download PDFInfo
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- JP4319908B2 JP4319908B2 JP2003523270A JP2003523270A JP4319908B2 JP 4319908 B2 JP4319908 B2 JP 4319908B2 JP 2003523270 A JP2003523270 A JP 2003523270A JP 2003523270 A JP2003523270 A JP 2003523270A JP 4319908 B2 JP4319908 B2 JP 4319908B2
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- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
- A61K39/001194—Prostate specific antigen [PSA]
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- A—HUMAN NECESSITIES
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- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
- A61K39/001195—Prostate specific membrane antigen [PSMA]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Proteomics, Peptides & Aminoacids (AREA)
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- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (2)
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| US31461301P | 2001-08-24 | 2001-08-24 | |
| PCT/US2002/027061 WO2003018611A2 (en) | 2001-08-24 | 2002-08-23 | Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer |
Publications (3)
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| JP2005520490A JP2005520490A (ja) | 2005-07-14 |
| JP2005520490A5 JP2005520490A5 (https=) | 2006-01-05 |
| JP4319908B2 true JP4319908B2 (ja) | 2009-08-26 |
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| JP2003523270A Expired - Fee Related JP4319908B2 (ja) | 2001-08-24 | 2002-08-23 | プロテアーゼ活性化配列を含むプロアエロリシンおよび前立腺癌の治療のための使用方法 |
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| EP (2) | EP1567641B1 (https=) |
| JP (1) | JP4319908B2 (https=) |
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| CA (1) | CA2457903C (https=) |
| DK (1) | DK1567641T3 (https=) |
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| PT (1) | PT1567641E (https=) |
| WO (1) | WO2003018611A2 (https=) |
| ZA (1) | ZA200402319B (https=) |
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| US8809504B2 (en) * | 2002-09-03 | 2014-08-19 | Vit Lauermann | Inhibitor which is deactivatable by a reagent produced by a target cell |
| EP1610824A2 (en) * | 2003-03-03 | 2006-01-04 | University Of Victoria Innovation And Development Corporation | Modified aerolysin linked to a lung cancer binding agent and methods of use for treating lung cancer |
| EP1694845B8 (en) | 2003-11-28 | 2017-12-20 | National Research Council of Canada | Anticarcinoma antibodies and uses thereof |
| EP1891093B1 (en) * | 2005-06-14 | 2011-03-23 | Protox Therapeutics Incorporated | Method of treating or preventing benign prostatic hyperplasia using modified pore-forming proteins |
| CN100443503C (zh) * | 2005-07-18 | 2008-12-17 | 四川大学华西医院 | 人源化ctla-4单链抗体与人穿孔素通道形成肽p34的重组免疫毒素 |
| CA2630559A1 (en) * | 2005-11-21 | 2007-05-24 | Protox Therapeutics Incorporated | Modified pore-forming protein toxins and use thereof |
| US8993295B2 (en) | 2006-07-20 | 2015-03-31 | The General Hospital Corporation | Methods, compositions, and kits for the selective activation of protoxins through combinatorial targeting |
| EP4464384A3 (en) | 2007-08-17 | 2025-01-08 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| WO2010069060A1 (en) * | 2008-12-15 | 2010-06-24 | Protox Therapeutics Inc. | Method for treating prostatitis utilizing modified pore-forming protein proaerolysin |
| EP2499494B1 (en) * | 2009-11-09 | 2017-03-08 | Alexion Pharmaceuticals, Inc. | Reagents and methods for detecting pnh type ii white blood cells and their identification as risk factors for thrombotic disorders |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| WO2012054929A2 (en) * | 2010-10-22 | 2012-04-26 | Protox Therapeutics Corp. | Use of human serum albumin to decrease antigenicity of therapeutic proteins |
| BR112015011118B1 (pt) | 2012-11-15 | 2022-12-13 | Endocyte, Inc | Conjugado; composição farmacêutica; e uso de um conjugado |
| WO2014160037A2 (en) | 2013-03-14 | 2014-10-02 | The Regents Of The University Of California | Activatable membrane-interacting peptides and methods of use |
| LT4095130T (lt) | 2013-10-18 | 2024-04-25 | Novartis Ag | Žymėti prostatos specifinio membranos antigeno (psma) inhibitoriai, jų naudojimas kaip vizualizavimo medžiagų ir farmacinių medžiagų prostatos vėžiui gydyti |
| WO2015061573A1 (en) | 2013-10-23 | 2015-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Compounds that bind to human immunodeficiency virus rev response element |
| BR112016010927A2 (pt) | 2013-11-14 | 2017-08-08 | Endocyte Inc | Conjugado de fórmula |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| WO2016115415A1 (en) * | 2015-01-16 | 2016-07-21 | The Johns Hopkins University | Albumin-proaerolysin prodrugs |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CA3012459A1 (en) * | 2016-01-27 | 2017-08-03 | Sophiris Bio Inc. | A method for targeted intraprostatic administration of prx302 for treatment of prostate cancer |
| US10717772B2 (en) * | 2016-09-22 | 2020-07-21 | Molecular Partners Ag | Recombinant binding proteins targeting HER2 and serum albumin, and their uses |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| WO2019073299A1 (en) | 2017-10-10 | 2019-04-18 | Medicenna Therapeutics, Inc. | IL-4 FUSION FORMULATIONS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) TUMORS |
| US12208102B2 (en) | 2018-04-17 | 2025-01-28 | Endocyte, Inc. | Methods of treating cancer |
| CN114096264B (zh) | 2019-05-20 | 2025-03-14 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
| CA3169961A1 (en) | 2020-02-03 | 2021-08-12 | Premas Biotech Private Limited | Recombinant expression platform, constructs and methods for expression of difficult to express proteins (dte-ps) |
| US11845779B2 (en) * | 2020-10-28 | 2023-12-19 | Ecole Polytechnique Federale De Lausanne (Epfl) | Mutant aerolysin and uses thereof |
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| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
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| US5529774A (en) | 1991-08-13 | 1996-06-25 | The Regents Of The University Of California | In vivo transfer of the HSV-TK gene implanted retroviral producer cells |
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- 2002-08-23 CN CNB028166221A patent/CN100488981C/zh not_active Expired - Fee Related
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2004
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2010
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Also Published As
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| JP2005520490A (ja) | 2005-07-14 |
| US7745395B2 (en) | 2010-06-29 |
| US20040235095A1 (en) | 2004-11-25 |
| EP1567641B1 (en) | 2012-05-23 |
| ES2542888T3 (es) | 2015-08-12 |
| US20080089869A1 (en) | 2008-04-17 |
| AU2002331720B2 (en) | 2007-10-11 |
| EP2518142A1 (en) | 2012-10-31 |
| US7838266B2 (en) | 2010-11-23 |
| HK1178563A1 (en) | 2013-09-13 |
| US7282476B2 (en) | 2007-10-16 |
| US20100234300A1 (en) | 2010-09-16 |
| CN1636017A (zh) | 2005-07-06 |
| EP1567641A4 (en) | 2005-12-28 |
| CN100488981C (zh) | 2009-05-20 |
| ZA200402319B (en) | 2005-08-30 |
| WO2003018611A2 (en) | 2003-03-06 |
| WO2003018611A3 (en) | 2005-06-30 |
| EP1567641A2 (en) | 2005-08-31 |
| ES2388170T3 (es) | 2012-10-09 |
| CA2457903C (en) | 2018-04-17 |
| CA2457903A1 (en) | 2003-03-06 |
| PT1567641E (pt) | 2012-08-21 |
| EP2518142B1 (en) | 2015-07-15 |
| DK1567641T3 (da) | 2012-08-27 |
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