JP2005519873A5 - - Google Patents
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- JP2005519873A5 JP2005519873A5 JP2003543644A JP2003543644A JP2005519873A5 JP 2005519873 A5 JP2005519873 A5 JP 2005519873A5 JP 2003543644 A JP2003543644 A JP 2003543644A JP 2003543644 A JP2003543644 A JP 2003543644A JP 2005519873 A5 JP2005519873 A5 JP 2005519873A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- thixotropic
- agent
- composition
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims description 266
- 229920000642 polymer Polymers 0.000 claims description 123
- 239000003795 chemical substances by application Substances 0.000 claims description 115
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 110
- 239000002904 solvent Substances 0.000 claims description 107
- 239000013008 thixotropic agent Substances 0.000 claims description 88
- 230000009974 thixotropic effect Effects 0.000 claims description 60
- 238000000034 method Methods 0.000 claims description 58
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 53
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 41
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 36
- 150000002148 esters Chemical class 0.000 claims description 31
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 24
- 238000013268 sustained release Methods 0.000 claims description 24
- 239000012730 sustained-release form Substances 0.000 claims description 24
- 229920001577 copolymer Polymers 0.000 claims description 23
- 230000009286 beneficial effect Effects 0.000 claims description 22
- 125000001072 heteroaryl group Chemical group 0.000 claims description 21
- 159000000032 aromatic acids Chemical class 0.000 claims description 20
- 229920000249 biocompatible polymer Polymers 0.000 claims description 20
- 125000003118 aryl group Chemical group 0.000 claims description 18
- 239000004310 lactic acid Substances 0.000 claims description 18
- 235000014655 lactic acid Nutrition 0.000 claims description 18
- 125000005647 linker group Chemical group 0.000 claims description 18
- -1 aromatic alcohols Chemical class 0.000 claims description 17
- 150000008365 aromatic ketones Chemical class 0.000 claims description 8
- 239000002357 osmotic agent Substances 0.000 claims description 4
- 239000003607 modifier Substances 0.000 claims description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 21
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 10
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 8
- 235000019445 benzyl alcohol Nutrition 0.000 description 8
- 125000005907 alkyl ester group Chemical group 0.000 description 6
- 125000002947 alkylene group Chemical group 0.000 description 6
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N ethyl benzoate Chemical compound CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 description 6
- 239000003102 growth factor Substances 0.000 description 6
- 229960002903 benzyl benzoate Drugs 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 3
- 239000005711 Benzoic acid Substances 0.000 description 3
- 229920002101 Chitin Polymers 0.000 description 3
- 229920001661 Chitosan Polymers 0.000 description 3
- 108010066486 EGF Family of Proteins Proteins 0.000 description 3
- 102000018386 EGF Family of Proteins Human genes 0.000 description 3
- 229920002732 Polyanhydride Polymers 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 229920000954 Polyglycolide Polymers 0.000 description 3
- 229920001710 Polyorthoester Polymers 0.000 description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 3
- 235000010233 benzoic acid Nutrition 0.000 description 3
- 125000005842 heteroatom Chemical group 0.000 description 3
- 229920002674 hyaluronan Polymers 0.000 description 3
- 229960003160 hyaluronic acid Drugs 0.000 description 3
- 239000001630 malic acid Substances 0.000 description 3
- 235000011090 malic acid Nutrition 0.000 description 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 229920001308 poly(aminoacid) Polymers 0.000 description 3
- 229920000747 poly(lactic acid) Polymers 0.000 description 3
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 description 3
- 229920002627 poly(phosphazenes) Polymers 0.000 description 3
- 229920000768 polyamine Polymers 0.000 description 3
- 229920001610 polycaprolactone Polymers 0.000 description 3
- 229920000515 polycarbonate Polymers 0.000 description 3
- 239000004417 polycarbonate Substances 0.000 description 3
- 239000000622 polydioxanone Substances 0.000 description 3
- 229920006149 polyester-amide block copolymer Polymers 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229920001855 polyketal Polymers 0.000 description 3
- 229920006324 polyoxymethylene Polymers 0.000 description 3
- 229920002635 polyurethane Polymers 0.000 description 3
- 239000004814 polyurethane Substances 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 150000003890 succinate salts Chemical class 0.000 description 3
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 3
- 102000008076 Angiogenic Proteins Human genes 0.000 description 2
- 108010074415 Angiogenic Proteins Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 2
- 102000014150 Interferons Human genes 0.000 description 2
- 108010050904 Interferons Proteins 0.000 description 2
- 102000015696 Interleukins Human genes 0.000 description 2
- 108010063738 Interleukins Proteins 0.000 description 2
- 102000004895 Lipoproteins Human genes 0.000 description 2
- 108090001030 Lipoproteins Proteins 0.000 description 2
- 108010061100 Nucleoproteins Proteins 0.000 description 2
- 102000011931 Nucleoproteins Human genes 0.000 description 2
- 102000013275 Somatomedins Human genes 0.000 description 2
- 108010009583 Transforming Growth Factors Proteins 0.000 description 2
- 102000009618 Transforming Growth Factors Human genes 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 230000002491 angiogenic effect Effects 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 230000001028 anti-proliverative effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 239000003080 antimitotic agent Substances 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003527 fibrinolytic agent Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000003018 immunosuppressive agent Substances 0.000 description 2
- 229940125721 immunosuppressive agent Drugs 0.000 description 2
- 229940047124 interferons Drugs 0.000 description 2
- 229940047122 interleukins Drugs 0.000 description 2
- 239000003589 local anesthetic agent Substances 0.000 description 2
- 229960005015 local anesthetics Drugs 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 229940023490 ophthalmic product Drugs 0.000 description 2
- 239000002157 polynucleotide Substances 0.000 description 2
- 102000040430 polynucleotide Human genes 0.000 description 2
- 108091033319 polynucleotide Proteins 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 108010041308 Endothelial Growth Factors Proteins 0.000 description 1
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 description 1
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 108091008023 transcriptional regulators Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33630701P | 2001-11-14 | 2001-11-14 | |
| US39988202P | 2002-07-31 | 2002-07-31 | |
| PCT/US2002/036716 WO2003041757A2 (en) | 2001-11-14 | 2002-11-14 | Catheter injectable depot compositions and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005519873A JP2005519873A (ja) | 2005-07-07 |
| JP2005519873A5 true JP2005519873A5 (https=) | 2006-03-09 |
Family
ID=26990149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003543644A Pending JP2005519873A (ja) | 2001-11-14 | 2002-11-14 | カテーテル注入可能なデポー組成物およびそれらの使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7829109B2 (https=) |
| EP (1) | EP1446101B1 (https=) |
| JP (1) | JP2005519873A (https=) |
| KR (1) | KR20040058101A (https=) |
| AT (1) | ATE502621T1 (https=) |
| AU (1) | AU2002359407B2 (https=) |
| BR (1) | BR0206987A (https=) |
| CA (1) | CA2467239A1 (https=) |
| DE (1) | DE60239556D1 (https=) |
| IL (1) | IL162001A0 (https=) |
| MX (1) | MXPA04004665A (https=) |
| NO (1) | NO20033178L (https=) |
| NZ (1) | NZ533436A (https=) |
| WO (1) | WO2003041757A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8278330B2 (en) | 2002-06-25 | 2012-10-02 | Durect Corporation | Short duration depot formulations |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1372729T3 (da) | 2001-02-23 | 2009-06-22 | Genentech Inc | Nedbrydelige polymere til injektion |
| NZ533434A (en) * | 2001-11-14 | 2006-11-30 | Alza Corp | Thixotropic gel composition for injectable deposition |
| KR20040058101A (ko) | 2001-11-14 | 2004-07-03 | 알자 코포레이션 | 카테터 주입가능한 데포 조성물 및 그의 용도 |
| TWI353854B (en) * | 2002-06-25 | 2011-12-11 | Alza Corp | Short duration depot formulations |
| JP2006503004A (ja) * | 2002-07-31 | 2006-01-26 | アルザ・コーポレーション | 射出可能なデポ組成物及びその使用 |
| DE60325742D1 (de) * | 2002-07-31 | 2009-02-26 | Alza Corp | Injizierbare multimodale polymere depotzusammensetzungen und ihre verwendungen |
| ATE418323T1 (de) * | 2002-11-06 | 2009-01-15 | Alza Corp | Depot-formulierungen mit verzögerter freisetzung |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| FR2850282B1 (fr) | 2003-01-27 | 2007-04-06 | Jerome Asius | Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation |
| ATE354380T1 (de) * | 2003-02-03 | 2007-03-15 | Polaschegg Hans-Dietrich Dr Te | Zusammensetzung zur prävention von infektionen durch subkutane prothesen |
| ATE387236T1 (de) * | 2003-03-31 | 2008-03-15 | Alza Corp | Osmotische pumpe mit mitteln zum ableiten des innendrucks |
| DE602004015755D1 (de) * | 2003-03-31 | 2008-09-25 | Alza Corp | Nicht wässrige einphasige visköse vehikel und formulierungen die diese vehikel verwenden |
| CA2520766A1 (en) * | 2003-03-31 | 2004-10-21 | Alza Corporation | Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems |
| AU2004289362A1 (en) * | 2003-11-10 | 2005-05-26 | Angiotech International Ag | Intravascular devices and fibrosis-inducing agents |
| US20050106214A1 (en) * | 2003-11-14 | 2005-05-19 | Guohua Chen | Excipients in drug delivery vehicles |
| US20050281879A1 (en) * | 2003-11-14 | 2005-12-22 | Guohua Chen | Excipients in drug delivery vehicles |
| JP2007511517A (ja) * | 2003-11-14 | 2007-05-10 | アルザ・コーポレーシヨン | 薬剤と照射を受けた賦形剤の製剤の中の薬剤の酸化を最小化 |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| CA2596966A1 (en) * | 2005-02-03 | 2006-08-10 | Intarcia Therapeutics, Inc. | Implantable osmotic device for continuous delivery of suspension formulations |
| US20060216242A1 (en) * | 2005-02-03 | 2006-09-28 | Rohloff Catherine M | Suspending vehicles and pharmaceutical suspensions for drug dosage forms |
| US20070021411A1 (en) * | 2005-05-11 | 2007-01-25 | Cloyd James C | Supersaturated benzodiazepine solutions and their delivery |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| US20070048288A1 (en) * | 2005-08-30 | 2007-03-01 | Lyu Suping | Shear thinning polymer cell delivery compositions |
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| EP1976460A4 (en) | 2006-01-19 | 2012-06-20 | Warsaw Orthopedic Inc | INJECTABLE AND FORMABLE BONE REPLACEMENT MATERIALS |
| MX2008014870A (es) | 2006-05-30 | 2009-02-12 | Intarcia Therapeutics Inc | Modulador de flujo para sistema de suministro osmotico con canal interno de dos piezas. |
| EP2049081B1 (en) | 2006-08-09 | 2012-11-14 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies |
| HRP20130259T1 (hr) | 2007-04-23 | 2013-04-30 | Intarcia Therapeutics, Inc. | Suspenzijske formulacije inzulinotropnih peptida i njihove uporabe |
| DK2167039T3 (en) | 2007-05-18 | 2017-01-09 | Durect Corp | Improved depot formulations |
| EP2152315B1 (en) | 2007-05-25 | 2016-01-06 | Indivior UK Limited | Sustained delivery formulations of risperidone compounds |
| US8153112B2 (en) * | 2007-08-03 | 2012-04-10 | Warsaw Orthopedic, Inc. | Compositions and methods for treating cavity conditions |
| EP2030610A1 (en) * | 2007-08-31 | 2009-03-04 | Archimedes Development Limited | Non-aqueous pharmaceutical compositions |
| NZ583265A (en) * | 2007-08-31 | 2012-01-12 | Archimedes Dev Ltd | Pharmaceutical compositions comprising a benzodiazepine drug and a non-aqueous vehicle comprising propylene glycol and propylene carbonate |
| US20090181068A1 (en) * | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
| DK2240155T3 (da) | 2008-02-13 | 2012-09-17 | Intarcia Therapeutics Inc | Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler |
| US20100280595A1 (en) * | 2009-04-30 | 2010-11-04 | Medtronic Vascular, Inc. | Method and Device for Localized Administration of Calcium Chelating Agent |
| SMT201700583T1 (it) | 2009-09-28 | 2018-01-11 | Intarcia Therapeutics Inc | Instaurazione e/o terminazione rapida di erogazione di farmaci in modo sostanzialmente stazionario |
| NZ601749A (en) * | 2010-01-13 | 2014-11-28 | Georg Bischof | Composition for producing a temporary intestinal occlusion |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| US20150032088A1 (en) | 2012-01-24 | 2015-01-29 | The Methodist Hospital Research Institute | Sustained drug delivery from solid state compositions with nanochannel membranes |
| CN102716470B (zh) * | 2012-06-28 | 2015-02-04 | 中国人民解放军第三军医大学第三附属医院 | 一种治疗周围神经损伤的药物组合物 |
| US9827321B2 (en) | 2012-08-14 | 2017-11-28 | The Trustees Of The University Of Pennsylvania | Stabilizing shear-thinning hydrogels |
| HK1220628A1 (zh) | 2013-03-11 | 2017-05-12 | Durect Corporation | 包含高粘度液体载体的可注射控制释放组合物 |
| US20140308352A1 (en) | 2013-03-11 | 2014-10-16 | Zogenix Inc. | Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material |
| JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
| RU2760007C2 (ru) | 2016-05-16 | 2021-11-22 | Интарсия Терапьютикс, Инк. | Полипептиды, селективные к рецепторам глюкагона, и способы их применения |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| CN110225762A (zh) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
| AU2019250128A1 (en) | 2018-10-15 | 2020-04-30 | Avent Inc. | Compositions, systems, kits, and methods for neural ablation |
| JP2023515918A (ja) | 2020-01-13 | 2023-04-17 | デュレクト コーポレーション | 不純物が低減された徐放性薬物送達システム及び関連の方法 |
| CA3203561A1 (en) | 2021-01-12 | 2022-07-21 | Adrian Neil Verity | Sustained release drug delivery systems and related methods |
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-
2002
- 2002-11-14 KR KR10-2003-7009401A patent/KR20040058101A/ko not_active Ceased
- 2002-11-14 US US10/295,603 patent/US7829109B2/en not_active Expired - Fee Related
- 2002-11-14 WO PCT/US2002/036716 patent/WO2003041757A2/en not_active Ceased
- 2002-11-14 MX MXPA04004665A patent/MXPA04004665A/es not_active Application Discontinuation
- 2002-11-14 BR BR0206987-3A patent/BR0206987A/pt not_active IP Right Cessation
- 2002-11-14 AU AU2002359407A patent/AU2002359407B2/en not_active Ceased
- 2002-11-14 AT AT02793942T patent/ATE502621T1/de not_active IP Right Cessation
- 2002-11-14 JP JP2003543644A patent/JP2005519873A/ja active Pending
- 2002-11-14 DE DE60239556T patent/DE60239556D1/de not_active Expired - Lifetime
- 2002-11-14 NZ NZ533436A patent/NZ533436A/en unknown
- 2002-11-14 CA CA002467239A patent/CA2467239A1/en not_active Abandoned
- 2002-11-14 EP EP02793942A patent/EP1446101B1/en not_active Expired - Lifetime
- 2002-11-14 IL IL16200102A patent/IL162001A0/xx unknown
-
2003
- 2003-07-11 NO NO20033178A patent/NO20033178L/no not_active Application Discontinuation
-
2010
- 2010-10-18 US US12/925,408 patent/US20110046606A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8278330B2 (en) | 2002-06-25 | 2012-10-02 | Durect Corporation | Short duration depot formulations |
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