JP2005518823A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005518823A5 JP2005518823A5 JP2003574807A JP2003574807A JP2005518823A5 JP 2005518823 A5 JP2005518823 A5 JP 2005518823A5 JP 2003574807 A JP2003574807 A JP 2003574807A JP 2003574807 A JP2003574807 A JP 2003574807A JP 2005518823 A5 JP2005518823 A5 JP 2005518823A5
- Authority
- JP
- Japan
- Prior art keywords
- oocytes
- cultured
- human
- culture medium
- essentially free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000287 oocyte Anatomy 0.000 claims 17
- 239000001963 growth media Substances 0.000 claims 7
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- JYGXADMDTFJGBT-VWUMJDOOSA-N Cortisol Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- 102100010813 EGF Human genes 0.000 claims 2
- 101700033006 EGF Proteins 0.000 claims 2
- 229940116977 Epidermal Growth Factor Drugs 0.000 claims 2
- 108050007372 Fibroblast growth factor family Proteins 0.000 claims 2
- 102000018233 Fibroblast growth factor family Human genes 0.000 claims 2
- 229940084986 Human Chorionic Gonadotropin Drugs 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 229940040129 Luteinizing Hormone Drugs 0.000 claims 2
- 102000009151 Luteinizing Hormone Human genes 0.000 claims 2
- 108010073521 Luteinizing Hormone Proteins 0.000 claims 2
- 229940082569 Selenite Drugs 0.000 claims 2
- 102000004338 Transferrin Human genes 0.000 claims 2
- 108090000901 Transferrin Proteins 0.000 claims 2
- 229960000890 hydrocortisone Drugs 0.000 claims 2
- 230000035800 maturation Effects 0.000 claims 2
- MCAHWIHFGHIESP-UHFFFAOYSA-L selenite(2-) Chemical compound [O-][Se]([O-])=O MCAHWIHFGHIESP-UHFFFAOYSA-L 0.000 claims 2
- 239000012581 transferrin Substances 0.000 claims 2
- 210000001771 Cumulus Cells Anatomy 0.000 claims 1
- 229940028334 Follicle Stimulating Hormone Drugs 0.000 claims 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 1
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims 1
- 108010084340 Gonadotropin-Releasing Hormone Proteins 0.000 claims 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 claims 1
- 102000006771 Gonadotropins Human genes 0.000 claims 1
- 108010086677 Gonadotropins Proteins 0.000 claims 1
- 229940088597 Hormone Drugs 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000002622 gonadotropin Substances 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001592 luteinising Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
Claims (15)
- 未成熟ヒト卵母細胞を成熟するまで培養する段階を含んでなる未成熟ヒト卵母細胞の体外での成熟方法であって、該未成熟卵母細胞が、内因性黄体形成ホルモンレベルの増加した女性ヒト被検体であって、かつ、巣刺激プロトコルを受けていない該被検体由来であることを特徴とする成熟方法。
- 被験体の内因性黄体形成ホルモンレベルがヒト絨毛性ゴナドトロピンもしくは黄体形成ホルモン、または両方の使用により増加したものである請求項１に記載の方法。
- ヒト絨毛性ゴナドトロピンが約５０００〜約２０，０００ＩＵの量で使用される請求項１に記載の方法。
- 未成熟ヒト卵母細胞がＭ−Ｉ期卵母細胞を含んでなる請求項１に記載の方法。
- 未成熟ヒト卵母細胞がＧＶ期卵母細胞を含んでなる請求項１に記載の方法。
- 未成熟ヒト卵母細胞がＭ−ＩＩに達するまで培養される請求項１に記載の方法。
- 卵母細胞が、無傷であるかもしくは少なくとも部分的に無傷である卵丘を有し、そして／または該卵母細胞が卵丘細胞の存在下で培養される請求項１に記載の方法。
- 卵母細胞が上皮増殖因子を本質的に含まない培養培地において培養される請求項７に記載の方法。
- 卵母細胞が繊維芽細胞増殖因子を本質的に含まない培養培地において培養される請求項７に記載の方法。
- 卵母細胞がヒトトランスフェリンを本質的に含まない培養培地において培養される請求項７に記載の方法。
- 卵母細胞がインシュリンを本質的に含まない培養培地において培養される請求項７に記載の方法。
- 卵母細胞がセレナイトを本質的に含まない培養培地において培養される請求項７に記載の方法。
- 卵母細胞がヒドロコルチゾンを本質的に含まない培養培地において培養される請求項７に記載の方法。
- 卵母細胞が上皮増殖因子、繊維芽細胞増殖因子、ヒトトランスフェリン、インシュリン、セレナイト、およびヒドロコルチゾンを本質的に含まない培養培地において培養される請求項７に記載の方法。
- 被験体がゴナドトロピン放出ホルモンアゴニスト、ヒト閉経期ゴナドトロピンもしくは卵胞刺激ホルモンで処置されていない請求項１に記載の方法。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36239502P | 2002-03-08 | 2002-03-08 | |
| PCT/CA2003/000323 WO2003076600A2 (en) | 2002-03-08 | 2003-03-07 | In vitro maturation of immature human oocytes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005518823A JP2005518823A (ja) | 2005-06-30 |
| JP2005518823A5 true JP2005518823A5 (ja) | 2006-04-20 |
Family
ID=27805171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003574807A Pending JP2005518823A (ja) | 2002-03-08 | 2003-03-07 | 未成熟ヒト卵母細胞の体外成熟 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20050208651A1 (ja) |
| EP (1) | EP1483368A2 (ja) |
| JP (1) | JP2005518823A (ja) |
| AU (1) | AU2003208232B2 (ja) |
| CA (1) | CA2477743C (ja) |
| WO (1) | WO2003076600A2 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005054449A1 (en) * | 2003-11-26 | 2005-06-16 | Applied Research Systems Ars Holding N.V. | Use of il-6-type cytokines for maturation of oocytes |
| WO2006039604A1 (en) * | 2004-09-30 | 2006-04-13 | Applied Research Systems Ars Holding, N.V. | Use of pregnancy specific glycoprotein for maturation of oocytes |
| DE602005015599D1 (de) * | 2004-09-30 | 2009-09-03 | Merck Serono Sa Coinsins | Verwendung von interleukin-17 für oozytenreifung |
| WO2010034019A1 (en) * | 2008-09-22 | 2010-03-25 | Biochemics, Inc. | Transdermal drug delivery using an osmolyte and vasoactive agent |
| EP2352543B1 (en) | 2008-12-04 | 2019-04-03 | BioChemics, Inc. | Methods and compositions for tattoo removal |
| AT510810B1 (de) * | 2010-12-09 | 2017-09-15 | Gonadosan Gmbh | Kombinationspräparat zur verbesserung der weiblichen fertilität |
| ES2774457T3 (es) * | 2014-12-19 | 2020-07-21 | Univ Brussel Vrije | Maduración in vitro de un complejo cúmulo-ovocito de mamíferos |
| WO2017143412A1 (en) * | 2016-02-24 | 2017-08-31 | Universidade Estadual Paulista "Júlioo De Mesquita Filho" - Unesp | Follicular system for in vitro oocyte maturation and kit |
| FR3061208B1 (fr) * | 2016-12-23 | 2024-04-05 | Patrick Choay Sas | Adjuvants pour milieux de culture cellulaire, notamment pour fecondation in vitro, ou pour la culture de follicules, cellules germinales males ou embryons |
| FR3065225B1 (fr) * | 2017-04-12 | 2024-04-05 | Patrick Choay Sas | Adjuvants depourvus de cytokines pour milieux de culture cellulaire, notamment pour fecondation in vitro, ou pour la culture de follicules, cellules germinales males ou embryons |
| CN110643569B (zh) * | 2019-11-29 | 2020-05-26 | 广州达瑞生殖技术有限公司 | 一种颗粒细胞剥离液及其制备方法 |
| CN114149962B (zh) * | 2021-11-25 | 2024-06-04 | 艾尔斯（浙江）医学科技有限公司 | 一种人类卵母细胞体外受精前培养方法和系列培养液与应用 |
| WO2024091707A1 (en) * | 2022-10-28 | 2024-05-02 | JangoBio, LLC | Methods of generating hormone-producing organoids and reversing hypogonadism |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987080A (en) * | 1987-11-03 | 1991-01-22 | Grob Howard S | Method for in vitro maturation of oocytes |
| IL94184A0 (en) | 1989-05-01 | 1991-01-31 | Granada Biosciences Inc | In vitro maturation of bovine oocytes |
| US5563059A (en) * | 1993-02-23 | 1996-10-08 | Genentech, Inc. | Use of human inhibin and human activin to increase the number of mature primate oocytes |
| JPH09503753A (ja) | 1993-08-03 | 1997-04-15 | セルトリックス ファーマシューティカルズ，インコーポレイテッド | 生殖障害の治療方法 |
| CA2199663C (en) * | 1997-03-11 | 2004-08-10 | Ruth Miriam Moses | In vitro maturation and fertilization of mammalian oocytes |
| AU7979098A (en) * | 1997-06-18 | 1999-01-04 | Curators Of The University Of Missouri, The | Complete activation of mammalian oocytes |
| AU760165B2 (en) * | 1998-06-22 | 2003-05-08 | Medi-Cult A/S | Assay to indicate the presence of non-fertilisable ova |
| WO2000032140A1 (en) | 1998-11-30 | 2000-06-08 | Ivf Sciences Colorado, Inc. | System and sequential culture media for in vitro fertilization |
| KR20010093280A (ko) | 1999-02-24 | 2001-10-27 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 불임증 치료 |
| ATE361091T1 (de) * | 1999-02-24 | 2007-05-15 | Novo Nordisk As | Behandlung von unfruchtbarkeit |
| JP2001017160A (ja) | 1999-07-07 | 2001-01-23 | Fuso Pharmaceutical Industries Ltd | 体外受精用培地組成物 |
| EP1235899B1 (en) | 1999-11-25 | 2007-03-21 | Novo Nordisk A/S | Treatment of human infertility |
| EP1272618A2 (en) | 2000-04-06 | 2003-01-08 | Novo Nordisk A/S | Synchronization of the cytoplasmatic and nuclear maturation of oocytes in vitro |
-
2003
- 2003-03-07 JP JP2003574807A patent/JP2005518823A/ja active Pending
- 2003-03-07 AU AU2003208232A patent/AU2003208232B2/en not_active Ceased
- 2003-03-07 EP EP03706185A patent/EP1483368A2/en not_active Withdrawn
- 2003-03-07 CA CA2477743A patent/CA2477743C/en not_active Expired - Fee Related
- 2003-03-07 US US10/506,713 patent/US20050208651A1/en not_active Abandoned
- 2003-03-07 WO PCT/CA2003/000323 patent/WO2003076600A2/en active Application Filing
-
2008
- 2008-01-04 US US11/969,522 patent/US7790459B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005518823A5 (ja) | ||
| Kattera et al. | Short coincubation of gametes in in vitro fertilization improves implantation and pregnancy rates: a prospective, randomized, controlled study | |
| Trounson et al. | Current status of IVM/IVF and embryo culture in humans and farm animals | |
| Baldassarre et al. | Advanced assisted reproduction technologies (ART) in goats | |
| Cha et al. | Pregnancies and deliveries after in vitro maturation culture followed by in vitro fertilization and embryo transfer without stimulation in women with polycystic ovary syndrome | |
| Fair et al. | Bovine oocyte diameter in relation to maturational competence and transcriptional activity | |
| Folch et al. | First birth of an animal from an extinct subspecies (Capra pyrenaica pyrenaica) by cloning | |
| Vieira et al. | Donor category and seasonal climate associated with embryo production and survival in multiple ovulation and embryo transfer programs in Holstein cattle | |
| Berland et al. | In vitro fertilization and development of cumulus oocytes complexes collected by ultrasound-guided follicle aspiration in superstimulated llamas | |
| Devreker et al. | In vitro development and metabolism of the human embryo up to the blastocyst stage | |
| CN107475181A (zh) | 未成熟卵母细胞的体外成熟培养液及其应用 | |
| Wani et al. | Ultrasonographic-guided retrieval of cumulus oocyte complexes after super-stimulation in dromedary camel (Camelus dromedarius) | |
| Cheung et al. | Effect of supplementation of leukemia inhibitory factor and epidermal growth factor on murine embryonic development in vitro, implantation, and outcome of offspring | |
| Wdowiak | Comparing antioxidant enzyme levels in follicular fluid in ICSI-treated patients | |
| Karagenc et al. | Granulocyte–macrophage colony-stimulating factor stimulates mouse blastocyst inner cell mass development only when media lack human serum albumin | |
| Carnevale et al. | In vitro production of equine embryos | |
| Berg et al. | In vitro production of bovine blastocysts by in vitro maturation and fertilization of oocytes and subsequent in vitro culture | |
| Malekshah et al. | Comparison of conditioned medium and direct co-culture of human granulosa cells on mouse embryo development | |
| Peters et al. | Trophoblast differentiation: an in vitro model for trophoblast giant cell development | |
| Evecen et al. | Adding hormones sequentially could be an effective approach for IVM of dog oocytes | |
| Luther et al. | Ovarian follicular development and oocyte quality in anestrous ewes treated with melatonin, a controlled internal drug release (CIDR) device and follicle stimulating hormone | |
| Daniel Jr | Dormant embryos of mammals | |
| Taniguchi et al. | Coculture with a human granulosa cell line enhanced the development of murine preimplantation embryos via SCF/c-kit system | |
| US20070122389A1 (en) | Stage specific follicle maturation systems | |
| Sharif et al. | Development of early bovine embryos in the isolated mouse oviduct maintained in organ culture |