JP2005518375A - Ｇタンパク質結合受容体（ｇｐｃｒ）のためのリガンドとしてのテトラヒドロカルバゾール誘導体 - Google Patents

Ｇタンパク質結合受容体（ｇｐｃｒ）のためのリガンドとしてのテトラヒドロカルバゾール誘導体 Download PDF

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Publication number
JP2005518375A
JP2005518375A JP2003552724A JP2003552724A JP2005518375A JP 2005518375 A JP2005518375 A JP 2005518375A JP 2003552724 A JP2003552724 A JP 2003552724A JP 2003552724 A JP2003552724 A JP 2003552724A JP 2005518375 A JP2005518375 A JP 2005518375A
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JP
Japan
Prior art keywords
amino
carbonyl
tetrahydro
group
aminocarbonyl
Prior art date
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Pending
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JP2003552724A
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English (en)
Japanese (ja)
Inventor
コピッツ マルクス
ペーター ムーン ハンス
ショー ケン
ヘス−シュトゥンプ ホルガー
パウリ−ニ クラウス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeterna Zentaris GmbH
Original Assignee
Zentaris AG
Aeterna Zentaris GmbH
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Filing date
Publication date
Priority claimed from DE10164564A external-priority patent/DE10164564B4/de
Application filed by Zentaris AG, Aeterna Zentaris GmbH filed Critical Zentaris AG
Publication of JP2005518375A publication Critical patent/JP2005518375A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biophysics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2003552724A 2001-12-14 2002-12-16 Ｇタンパク質結合受容体（ｇｐｃｒ）のためのリガンドとしてのテトラヒドロカルバゾール誘導体 Pending JP2005518375A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10164564A DE10164564B4 (de) 2001-12-14 2001-12-14 Tetrahydrocarbazolderivate als Liganden für G-Protein gekoppelte Rezeptoren (GPCR)
US34187801P 2001-12-21 2001-12-21
PCT/EP2002/014344 WO2003051837A2 (fr) 2001-12-14 2002-12-16 Derives tetrahydrocarbazol servant de ligands de recepteurs couples aux proteines g (gpcr)

Publications (1)

Publication Number Publication Date
JP2005518375A true JP2005518375A (ja) 2005-06-23

Family

ID=26010882

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003552724A Pending JP2005518375A (ja) 2001-12-14 2002-12-16 Ｇタンパク質結合受容体（ｇｐｃｒ）のためのリガンドとしてのテトラヒドロカルバゾール誘導体

Country Status (17)

Country Link
EP (1) EP1453803A2 (fr)
JP (1) JP2005518375A (fr)
CN (1) CN100500654C (fr)
AR (1) AR037863A1 (fr)
AU (1) AU2002361430B2 (fr)
BR (1) BR0214958A (fr)
CA (1) CA2468880A1 (fr)
HR (1) HRP20040609A2 (fr)
HU (1) HUP0500014A3 (fr)
IL (2) IL161626A0 (fr)
MX (1) MXPA04005768A (fr)
NO (1) NO326692B1 (fr)
NZ (1) NZ533430A (fr)
PL (1) PL373400A1 (fr)
RU (1) RU2319692C2 (fr)
TW (1) TWI246423B (fr)
WO (1) WO2003051837A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006528987A (ja) * 2003-05-19 2006-12-28 アイアールエム・リミテッド・ライアビリティ・カンパニー 免疫抑制化合物および組成物
JP2010525028A (ja) * 2007-04-27 2010-07-22 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｇタンパク質共役受容体のリガンドとしての新規のテトラヒドロカルバゾール誘導体
JP2011513280A (ja) * 2008-02-29 2011-04-28 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング 非去勢用量でのｌｈｒｈアンタゴニストの使用

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007501284A (ja) * 2003-06-10 2007-01-25 スミスクライン ビーチャム コーポレーション テトラヒドロカルバゾール誘導体およびそれらの薬学的使用
US20060074124A1 (en) * 2003-09-12 2006-04-06 Andrew Napper Methods of treating a disorder
EP1677794B1 (fr) * 2003-09-12 2014-12-03 Elixir Pharmaceuticals, Inc. Procedes de traitement de troubles
DE102004033902A1 (de) * 2004-07-14 2006-02-16 Zentaris Gmbh Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
ES2369782T3 (es) * 2004-12-27 2011-12-05 Actelion Pharmaceuticals Ltd. Derivados de 2,3,4,9-tetrahidro-1h-carbazol como antagonistas del receptor crth2.
DK1902026T3 (da) * 2005-06-24 2010-04-26 Lilly Co Eli Tetrahydrocarbazol-derivater, der kan anvendes som androgen-receptor-modulatorer (SARM)
KR101411820B1 (ko) * 2006-08-07 2014-06-24 액테리온 파마슈티칼 리미티드 (3-아미노-1,2,3,4-테트라하이드로-9ｈ-카르바졸-9-일)-아세트산 유도체
EP1967202A1 (fr) * 2007-03-05 2008-09-10 AEterna Zentaris GmbH Utilisation d'antagonistes LHTH pour le traitement des symptômes de tractus urinaires faibles, en particulier la vessie hyperactive et/ou hyperactivité du détrusor
BR112012024114B1 (pt) 2010-03-22 2021-02-09 Idorsia Pharmaceuticals Ltd Compostos derivados de 3-(heteroarilamino)-1,2,3,4-tetrahidro-9h-carbazol, uso dos mesmos, e, composição farmacêutica
AU2012241442B2 (en) 2011-04-14 2017-01-12 Idorsia Pharmaceuticals Ltd 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido(1,2-a)indol acetic acid derivatives and their use as prostaglandin D2 receptor modulators
LT3119779T (lt) 2014-03-17 2018-09-10 Idorsia Pharmaceuticals Ltd Azaindolo acto rūgšties dariniai ir jų panaudojimas kaip prostaglandino d2 receptoriaus moduliatorių
TW201620909A (zh) 2014-03-18 2016-06-16 艾克泰聯製藥有限公司 氮雜吲哚乙酸衍生物及彼等作為前列腺素ｄ２受體調節劑之用途
MX2018003202A (es) 2015-09-15 2018-06-08 Idorsia Pharmaceuticals Ltd Formas cristalinas.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1418703A (en) * 1973-06-02 1975-12-24 Pfizer Ltd 3-alkyl-9-substituted-1,2,3,4-tetrahydrocarbazoles
ATE90076T1 (de) * 1986-03-27 1993-06-15 Merck Frosst Canada Inc Tetrahydrocarbazole ester.
US5607939A (en) * 1994-04-28 1997-03-04 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
CA2292881A1 (fr) * 1997-06-05 1998-12-10 Merck & Co., Inc. Antagonistes de gonadoliberine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006528987A (ja) * 2003-05-19 2006-12-28 アイアールエム・リミテッド・ライアビリティ・カンパニー 免疫抑制化合物および組成物
JP2010525028A (ja) * 2007-04-27 2010-07-22 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｇタンパク質共役受容体のリガンドとしての新規のテトラヒドロカルバゾール誘導体
JP2011513280A (ja) * 2008-02-29 2011-04-28 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング 非去勢用量でのｌｈｒｈアンタゴニストの使用

Also Published As

Publication number Publication date
WO2003051837A2 (fr) 2003-06-26
PL373400A1 (en) 2005-08-22
HUP0500014A3 (en) 2010-06-28
CN100500654C (zh) 2009-06-17
AU2002361430A1 (en) 2003-06-30
HRP20040609A2 (en) 2005-06-30
TWI246423B (en) 2006-01-01
IL161626A0 (en) 2004-09-27
AR037863A1 (es) 2004-12-09
NO20042198L (no) 2004-07-09
RU2004121776A (ru) 2005-05-10
CA2468880A1 (fr) 2003-06-26
TW200305405A (en) 2003-11-01
WO2003051837A3 (fr) 2004-02-26
EP1453803A2 (fr) 2004-09-08
BR0214958A (pt) 2004-12-28
RU2319692C2 (ru) 2008-03-20
NZ533430A (en) 2005-12-23
HUP0500014A2 (hu) 2005-04-28
AU2002361430B2 (en) 2007-09-13
WO2003051837A8 (fr) 2004-05-06
IL192991A0 (en) 2011-08-01
MXPA04005768A (es) 2004-09-10
CN1599720A (zh) 2005-03-23
NO326692B1 (no) 2009-02-02

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