IL192991A0 - Use of tetrahydrocarbazole derivatives for the manufacture of medicanents for treating gonadotropin-releasing hormone - Google Patents
Use of tetrahydrocarbazole derivatives for the manufacture of medicanents for treating gonadotropin-releasing hormoneInfo
- Publication number
- IL192991A0 IL192991A0 IL192991A IL19299108A IL192991A0 IL 192991 A0 IL192991 A0 IL 192991A0 IL 192991 A IL192991 A IL 192991A IL 19299108 A IL19299108 A IL 19299108A IL 192991 A0 IL192991 A0 IL 192991A0
- Authority
- IL
- Israel
- Prior art keywords
- medicanents
- manufacture
- releasing hormone
- tetrahydrocarbazole derivatives
- gonadotropin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Pregnancy & Childbirth (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10164564A DE10164564B4 (en) | 2001-12-14 | 2001-12-14 | Tetrahydrocarbazole derivatives as ligands for G-protein coupled receptors (GPCR) |
| US34187801P | 2001-12-21 | 2001-12-21 | |
| PCT/EP2002/014344 WO2003051837A2 (en) | 2001-12-14 | 2002-12-16 | Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL192991A0 true IL192991A0 (en) | 2011-08-01 |
Family
ID=26010882
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16162602A IL161626A0 (en) | 2001-12-14 | 2002-12-16 | Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr) |
| IL192991A IL192991A0 (en) | 2001-12-14 | 2008-07-23 | Use of tetrahydrocarbazole derivatives for the manufacture of medicanents for treating gonadotropin-releasing hormone |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16162602A IL161626A0 (en) | 2001-12-14 | 2002-12-16 | Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr) |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1453803A2 (en) |
| JP (1) | JP2005518375A (en) |
| CN (1) | CN100500654C (en) |
| AR (1) | AR037863A1 (en) |
| AU (1) | AU2002361430B2 (en) |
| BR (1) | BR0214958A (en) |
| CA (1) | CA2468880A1 (en) |
| HR (1) | HRP20040609A2 (en) |
| HU (1) | HUP0500014A3 (en) |
| IL (2) | IL161626A0 (en) |
| MX (1) | MXPA04005768A (en) |
| NO (1) | NO326692B1 (en) |
| NZ (1) | NZ533430A (en) |
| PL (1) | PL373400A1 (en) |
| RU (1) | RU2319692C2 (en) |
| TW (1) | TWI246423B (en) |
| WO (1) | WO2003051837A2 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004103309A2 (en) * | 2003-05-19 | 2004-12-02 | Irm Llc | Immunosuppressant compounds and compositions |
| JP2007501284A (en) * | 2003-06-10 | 2007-01-25 | スミスクライン ビーチャム コーポレーション | Tetrahydrocarbazole derivatives and their pharmaceutical use |
| WO2005026112A2 (en) * | 2003-09-12 | 2005-03-24 | Elixir Pharmaceuticals, Inc. | Methods of treating a disorder |
| US20060074124A1 (en) | 2003-09-12 | 2006-04-06 | Andrew Napper | Methods of treating a disorder |
| DE102004033902A1 (en) | 2004-07-14 | 2006-02-16 | Zentaris Gmbh | New tetrahydrocarbazole compounds are neurokinin-1 receptor antagonists useful to treat or prevent e.g. pubertas praecox, hirsutism, polycystic ovary syndrome, hormone dependent neoplastic diseases and Alzheimer's disease |
| RU2404163C2 (en) * | 2004-12-27 | 2010-11-20 | Актелион Фармасьютиклз Лтд | 2,3,4,9-tetrahydro-1h-carbazole derivatives as crth2 receptor antagonists |
| PT1902026E (en) * | 2005-06-24 | 2010-03-17 | Lilly Co Eli | Tetrahydrocarbazole derivatives useful as androgen receptor modulators (sarm) |
| PL2051962T3 (en) * | 2006-08-07 | 2012-03-30 | Actelion Pharmaceuticals Ltd | (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives |
| EP1967202A1 (en) * | 2007-03-05 | 2008-09-10 | AEterna Zentaris GmbH | Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity |
| EP1988098A1 (en) * | 2007-04-27 | 2008-11-05 | AEterna Zentaris GmbH | Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors |
| EP2095818A1 (en) * | 2008-02-29 | 2009-09-02 | AEterna Zentaris GmbH | Use of LHRH antagonists at non-castrating doses |
| US8697869B2 (en) | 2010-03-22 | 2014-04-15 | Actelion Pharmaceuticals Ltd. | 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9H-carbazole derivatives and their use as prostaglandin D2 receptor modulators |
| DK2697223T3 (en) | 2011-04-14 | 2016-09-05 | Actelion Pharmaceuticals Ltd | 7- (heteroaryl-amino) -6,7,8,9-tetrahydro-pyrido [1,2-a] indole-acetic acid derivatives and their use as prostaglandin D2 receptor |
| MX368179B (en) | 2014-03-17 | 2019-09-23 | Idorsia Pharmaceuticals Ltd | Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators. |
| CN106103437A (en) | 2014-03-18 | 2016-11-09 | 埃科特莱茵药品有限公司 | Azaindole acetogenin and the purposes as prostaglandin D 2 receptor regulator thereof |
| TWI711616B (en) | 2015-09-15 | 2020-12-01 | 瑞士商愛杜西亞製藥有限公司 | Crystalline forms |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1418703A (en) * | 1973-06-02 | 1975-12-24 | Pfizer Ltd | 3-alkyl-9-substituted-1,2,3,4-tetrahydrocarbazoles |
| DE3786030T2 (en) * | 1986-03-27 | 1993-12-02 | Merck Frosst Canada Inc | Tetrahydrocarbazole esters. |
| US5607939A (en) * | 1994-04-28 | 1997-03-04 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
| CA2292881A1 (en) * | 1997-06-05 | 1998-12-10 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
-
2002
- 2002-12-16 MX MXPA04005768A patent/MXPA04005768A/en active IP Right Grant
- 2002-12-16 CN CNB028241487A patent/CN100500654C/en not_active Expired - Fee Related
- 2002-12-16 AU AU2002361430A patent/AU2002361430B2/en not_active Ceased
- 2002-12-16 BR BR0214958-3A patent/BR0214958A/en not_active IP Right Cessation
- 2002-12-16 RU RU2004121776/04A patent/RU2319692C2/en not_active IP Right Cessation
- 2002-12-16 JP JP2003552724A patent/JP2005518375A/en active Pending
- 2002-12-16 WO PCT/EP2002/014344 patent/WO2003051837A2/en active Application Filing
- 2002-12-16 HU HU0500014A patent/HUP0500014A3/en unknown
- 2002-12-16 CA CA002468880A patent/CA2468880A1/en not_active Abandoned
- 2002-12-16 EP EP02796648A patent/EP1453803A2/en not_active Withdrawn
- 2002-12-16 NZ NZ533430A patent/NZ533430A/en unknown
- 2002-12-16 TW TW091136440A patent/TWI246423B/en not_active IP Right Cessation
- 2002-12-16 PL PL02373400A patent/PL373400A1/en not_active Application Discontinuation
- 2002-12-16 IL IL16162602A patent/IL161626A0/en unknown
- 2002-12-17 AR ARP020104893A patent/AR037863A1/en unknown
-
2004
- 2004-05-26 NO NO20042198A patent/NO326692B1/en not_active IP Right Cessation
- 2004-07-05 HR HR20040609A patent/HRP20040609A2/en not_active Application Discontinuation
-
2008
- 2008-07-23 IL IL192991A patent/IL192991A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005518375A (en) | 2005-06-23 |
| TW200305405A (en) | 2003-11-01 |
| CA2468880A1 (en) | 2003-06-26 |
| BR0214958A (en) | 2004-12-28 |
| WO2003051837A3 (en) | 2004-02-26 |
| RU2004121776A (en) | 2005-05-10 |
| CN100500654C (en) | 2009-06-17 |
| IL161626A0 (en) | 2004-09-27 |
| EP1453803A2 (en) | 2004-09-08 |
| WO2003051837A8 (en) | 2004-05-06 |
| NO326692B1 (en) | 2009-02-02 |
| PL373400A1 (en) | 2005-08-22 |
| TWI246423B (en) | 2006-01-01 |
| NZ533430A (en) | 2005-12-23 |
| HUP0500014A3 (en) | 2010-06-28 |
| AR037863A1 (en) | 2004-12-09 |
| AU2002361430B2 (en) | 2007-09-13 |
| MXPA04005768A (en) | 2004-09-10 |
| AU2002361430A1 (en) | 2003-06-30 |
| RU2319692C2 (en) | 2008-03-20 |
| HUP0500014A2 (en) | 2005-04-28 |
| HRP20040609A2 (en) | 2005-06-30 |
| NO20042198L (en) | 2004-07-09 |
| WO2003051837A2 (en) | 2003-06-26 |
| CN1599720A (en) | 2005-03-23 |
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