PL373400A1 - Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr) - Google Patents
Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr)Info
- Publication number
- PL373400A1 PL373400A1 PL02373400A PL37340002A PL373400A1 PL 373400 A1 PL373400 A1 PL 373400A1 PL 02373400 A PL02373400 A PL 02373400A PL 37340002 A PL37340002 A PL 37340002A PL 373400 A1 PL373400 A1 PL 373400A1
- Authority
- PL
- Poland
- Prior art keywords
- gpcr
- ligands
- protein coupled
- coupled receptors
- tetrahydrocarbozole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10164564A DE10164564B4 (en) | 2001-12-14 | 2001-12-14 | Tetrahydrocarbazole derivatives as ligands for G-protein coupled receptors (GPCR) |
US34187801P | 2001-12-21 | 2001-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL373400A1 true PL373400A1 (en) | 2005-08-22 |
Family
ID=26010882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL02373400A PL373400A1 (en) | 2001-12-14 | 2002-12-16 | Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr) |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1453803A2 (en) |
JP (1) | JP2005518375A (en) |
CN (1) | CN100500654C (en) |
AR (1) | AR037863A1 (en) |
AU (1) | AU2002361430B2 (en) |
BR (1) | BR0214958A (en) |
CA (1) | CA2468880A1 (en) |
HR (1) | HRP20040609A2 (en) |
HU (1) | HUP0500014A3 (en) |
IL (2) | IL161626A0 (en) |
MX (1) | MXPA04005768A (en) |
NO (1) | NO326692B1 (en) |
NZ (1) | NZ533430A (en) |
PL (1) | PL373400A1 (en) |
RU (1) | RU2319692C2 (en) |
TW (1) | TWI246423B (en) |
WO (1) | WO2003051837A2 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1638551T1 (en) * | 2003-05-19 | 2012-04-30 | Irm Llc | Immunosuppressant compounds and compositions |
ES2314446T3 (en) * | 2003-06-10 | 2009-03-16 | Smithkline Beecham Corporation | DERIVATIVES OF TETRAHYDROCARBAZOL AND ITS PHARMACEUTICAL USE. |
US20060074124A1 (en) | 2003-09-12 | 2006-04-06 | Andrew Napper | Methods of treating a disorder |
US20050209300A1 (en) * | 2003-09-12 | 2005-09-22 | Andrew Napper | Methods of treating a disorder |
DE102004033902A1 (en) | 2004-07-14 | 2006-02-16 | Zentaris Gmbh | New tetrahydrocarbazole compounds are neurokinin-1 receptor antagonists useful to treat or prevent e.g. pubertas praecox, hirsutism, polycystic ovary syndrome, hormone dependent neoplastic diseases and Alzheimer's disease |
PT1833791E (en) * | 2004-12-27 | 2011-10-19 | Actelion Pharmaceuticals Ltd | 2,3,4,9-tetrahydro-1h-carbazole derivatives as crth2 receptor antagonists |
BRPI0611705A2 (en) * | 2005-06-24 | 2016-11-16 | Lilly Co Eli | compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, and use of compound |
KR101411820B1 (en) * | 2006-08-07 | 2014-06-24 | 액테리온 파마슈티칼 리미티드 | (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives |
EP1967202A1 (en) * | 2007-03-05 | 2008-09-10 | AEterna Zentaris GmbH | Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity |
EP1988098A1 (en) * | 2007-04-27 | 2008-11-05 | AEterna Zentaris GmbH | Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors |
EP2095818A1 (en) | 2008-02-29 | 2009-09-02 | AEterna Zentaris GmbH | Use of LHRH antagonists at non-castrating doses |
BR112012024114B1 (en) | 2010-03-22 | 2021-02-09 | Idorsia Pharmaceuticals Ltd | COMPOUNDS DERIVED FROM 3- (HETEROARYLAMINE) -1,2,3,4-TETRAHYDRO-9H-CARBAZOLE, USE OF THE SAME, AND, PHARMACEUTICAL COMPOSITION |
CN103459389B (en) | 2011-04-14 | 2016-03-30 | 埃科特莱茵药品有限公司 | 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyridine is [1,2-a] ethychlozate derivative and its purposes as prostaglandin D 2 receptor conditioning agent also |
PE20161177A1 (en) | 2014-03-17 | 2016-11-18 | Actelion Pharmaceuticals Ltd | DERIVATIVES OF AZAINDOL ACETIC ACID AND THEIR USE AS MODULATORS OF THE PROSTAGLANDIN D2 RECEPTOR |
US9850241B2 (en) | 2014-03-18 | 2017-12-26 | Idorsia Pharmaceuticals Ltd | Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators |
TWI711616B (en) | 2015-09-15 | 2020-12-01 | 瑞士商愛杜西亞製藥有限公司 | Crystalline forms |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1418703A (en) * | 1973-06-02 | 1975-12-24 | Pfizer Ltd | 3-alkyl-9-substituted-1,2,3,4-tetrahydrocarbazoles |
EP0239306B1 (en) * | 1986-03-27 | 1993-06-02 | Merck Frosst Canada Inc. | Tetrahydrocarbazole esters |
US5607939A (en) * | 1994-04-28 | 1997-03-04 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
EP0986385A4 (en) * | 1997-06-05 | 2001-05-16 | Merck & Co Inc | Antagonists of gonadotropin releasing hormone |
-
2002
- 2002-12-16 CN CNB028241487A patent/CN100500654C/en not_active Expired - Fee Related
- 2002-12-16 HU HU0500014A patent/HUP0500014A3/en unknown
- 2002-12-16 NZ NZ533430A patent/NZ533430A/en unknown
- 2002-12-16 RU RU2004121776/04A patent/RU2319692C2/en not_active IP Right Cessation
- 2002-12-16 AU AU2002361430A patent/AU2002361430B2/en not_active Ceased
- 2002-12-16 TW TW091136440A patent/TWI246423B/en not_active IP Right Cessation
- 2002-12-16 MX MXPA04005768A patent/MXPA04005768A/en active IP Right Grant
- 2002-12-16 EP EP02796648A patent/EP1453803A2/en not_active Withdrawn
- 2002-12-16 CA CA002468880A patent/CA2468880A1/en not_active Abandoned
- 2002-12-16 WO PCT/EP2002/014344 patent/WO2003051837A2/en active Application Filing
- 2002-12-16 JP JP2003552724A patent/JP2005518375A/en active Pending
- 2002-12-16 IL IL16162602A patent/IL161626A0/en unknown
- 2002-12-16 BR BR0214958-3A patent/BR0214958A/en not_active IP Right Cessation
- 2002-12-16 PL PL02373400A patent/PL373400A1/en not_active Application Discontinuation
- 2002-12-17 AR ARP020104893A patent/AR037863A1/en unknown
-
2004
- 2004-05-26 NO NO20042198A patent/NO326692B1/en not_active IP Right Cessation
- 2004-07-05 HR HR20040609A patent/HRP20040609A2/en not_active Application Discontinuation
-
2008
- 2008-07-23 IL IL192991A patent/IL192991A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2005518375A (en) | 2005-06-23 |
CA2468880A1 (en) | 2003-06-26 |
RU2004121776A (en) | 2005-05-10 |
WO2003051837A2 (en) | 2003-06-26 |
AU2002361430B2 (en) | 2007-09-13 |
IL161626A0 (en) | 2004-09-27 |
CN1599720A (en) | 2005-03-23 |
MXPA04005768A (en) | 2004-09-10 |
HUP0500014A2 (en) | 2005-04-28 |
RU2319692C2 (en) | 2008-03-20 |
AR037863A1 (en) | 2004-12-09 |
TW200305405A (en) | 2003-11-01 |
WO2003051837A8 (en) | 2004-05-06 |
NO20042198L (en) | 2004-07-09 |
WO2003051837A3 (en) | 2004-02-26 |
AU2002361430A1 (en) | 2003-06-30 |
BR0214958A (en) | 2004-12-28 |
HRP20040609A2 (en) | 2005-06-30 |
CN100500654C (en) | 2009-06-17 |
NZ533430A (en) | 2005-12-23 |
EP1453803A2 (en) | 2004-09-08 |
NO326692B1 (en) | 2009-02-02 |
TWI246423B (en) | 2006-01-01 |
HUP0500014A3 (en) | 2010-06-28 |
IL192991A0 (en) | 2011-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |