AU2001270822A1 - Imidazolophthalazine derivatives as ligands for gabaa receptors - Google Patents

Imidazolophthalazine derivatives as ligands for gabaa receptors

Info

Publication number
AU2001270822A1
AU2001270822A1 AU2001270822A AU7082201A AU2001270822A1 AU 2001270822 A1 AU2001270822 A1 AU 2001270822A1 AU 2001270822 A AU2001270822 A AU 2001270822A AU 7082201 A AU7082201 A AU 7082201A AU 2001270822 A1 AU2001270822 A1 AU 2001270822A1
Authority
AU
Australia
Prior art keywords
imidazolophthalazine
ligands
derivatives
gabaa receptors
gabaa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001270822A
Inventor
Richard Alexander Jelley
Tamara Ladduwahetty
Angus Murray Macleod
Andrew Madin
Francine Sternfeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Publication of AU2001270822A1 publication Critical patent/AU2001270822A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001270822A 2000-07-17 2001-07-13 Imidazolophthalazine derivatives as ligands for gabaa receptors Abandoned AU2001270822A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0017518 2000-07-17
GBGB0017518.2A GB0017518D0 (en) 2000-07-17 2000-07-17 Therapeutic agents
PCT/GB2001/003170 WO2002006285A1 (en) 2000-07-17 2001-07-13 Imidazolophthalazine derivatives as ligands for gabaa receptors

Publications (1)

Publication Number Publication Date
AU2001270822A1 true AU2001270822A1 (en) 2002-01-30

Family

ID=9895810

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001270822A Abandoned AU2001270822A1 (en) 2000-07-17 2001-07-13 Imidazolophthalazine derivatives as ligands for gabaa receptors

Country Status (5)

Country Link
US (1) US6949549B2 (en)
EP (1) EP1303516A1 (en)
AU (1) AU2001270822A1 (en)
GB (1) GB0017518D0 (en)
WO (1) WO2002006285A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0108475D0 (en) * 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
JP4561698B2 (en) * 2002-02-19 2010-10-13 小野薬品工業株式会社 Fused pyridazine derivative compound and drug containing the compound as an active ingredient
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
US10428029B2 (en) 2014-09-10 2019-10-01 Epizyme, Inc. Isoxazole carboxamide compounds
CN107344939A (en) * 2016-05-06 2017-11-14 如东赛默罗生物科技有限公司 Imidazoles [2,1-a] phthalazine derivative, its preparation method, pharmaceutical composition and purposes
HU231223B1 (en) 2018-09-28 2022-01-28 Richter Gedeon Nyrt. Bicyclic derivatives as gabaa a5 receptor modulators
US11479551B2 (en) 2019-09-12 2022-10-25 Mirati Therapeutics, Inc. MTA-cooperative PRMT5 inhibitors
US20240043418A1 (en) 2020-03-26 2024-02-08 Richter Gedeon Nyrt. 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators
CN116903611A (en) * 2022-01-26 2023-10-20 上海优理惠生医药有限公司 Phthalazinone compound, preparation method thereof, pharmaceutical composition containing phthalazinone compound and application of pharmaceutical composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT73970A (en) * 1993-03-31 1996-10-28 Basf Ag Imidazoloquinoxalinone derivatives, process for preparing them and pharmaceutical compositions of eaa antagonistic activity containing them
EA002436B1 (en) * 1996-07-25 2002-04-25 Мерк Шарп Энд Домэ Лимитед Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
EP1010273A4 (en) 1997-02-19 2006-08-23 Next Level Communications Inc Video, data and telephony gateway
GB9801234D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
WO2001092258A1 (en) * 2000-05-30 2001-12-06 Neurogen Corporation Imidazoloisoquinolines

Also Published As

Publication number Publication date
US20040147517A1 (en) 2004-07-29
GB0017518D0 (en) 2000-08-30
US6949549B2 (en) 2005-09-27
WO2002006285A1 (en) 2002-01-24
EP1303516A1 (en) 2003-04-23

Similar Documents

Publication Publication Date Title
AU2002215100A1 (en) Imidazo-pyrimidine derivatives as ligands for gaba receptors
AU2002232768A1 (en) Benzimidazole and pyridylimidazole derivatives as ligands for GABA receptors
AU2003227909A1 (en) Imidazo-triazine derivatives as ligands for gaba receptors
AU2001230584A1 (en) 1h-imidazopyridine derivatives
AU2001242744A1 (en) Diphenylalkylamine derivatives useful as opioid delta receptor ligands
AU2001230537A1 (en) Pyridoxazine derivatives
AU2002224038A1 (en) Benzimidazole derivatives
AU2001281802A1 (en) 6-phenylpyrrolopyrimidinedione derivatives
AU2001278790A1 (en) 1h-imidazopyridine derivatives
AU4439801A (en) Pyrazolo-triazine derivatives as ligands for gaba receptors
AU2002213978A1 (en) Substituted C-cyclohexylmethylamine derivatives
AU2002212301A1 (en) Diazacycloalkanedione derivatives
AU2001270822A1 (en) Imidazolophthalazine derivatives as ligands for gabaa receptors
AU2001256164A1 (en) Chroman derivatives as estrogenic compounds
AU2002212959A1 (en) Cycloalkylfluorosulfonamide derivatives
AU2001258601A1 (en) Peptoids as ligands for melanocortin receptors
AU2001289937A1 (en) Substituted 1-aminobutan-3-ol derivatives
AU2001259051A1 (en) Piperidyindoles as serotonin receptor ligands
AU3167402A (en) Aminotriazolopyridiine derivatives as adenosine receptor ligands
AU2001230565A1 (en) Perfluoroisopropylbenzene derivatives
AU2001254661A1 (en) Aminosulfonylbiphenyl derivatives
AU2001220281A1 (en) Rollerboard for road-skiing
AU2002235543A1 (en) Imidazolophthalazine derivatives as ligands for gabaa receptors
AU2001242772A1 (en) 3-substituted-4-pyrimidone derivatives
AU2003245259A1 (en) Substituted imidazole derivatives: gabaa receptor ligands