JP2005517016A5 - - Google Patents
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- Publication number
- JP2005517016A5 JP2005517016A5 JP2003566009A JP2003566009A JP2005517016A5 JP 2005517016 A5 JP2005517016 A5 JP 2005517016A5 JP 2003566009 A JP2003566009 A JP 2003566009A JP 2003566009 A JP2003566009 A JP 2003566009A JP 2005517016 A5 JP2005517016 A5 JP 2005517016A5
- Authority
- JP
- Japan
- Prior art keywords
- acceptable salt
- formula
- pharmaceutically acceptable
- compound according
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000003839 salts Chemical class 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- -1 3,5-dichlorophenyl Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- YXBGSZVPUXJENU-JTSKRJEESA-N n-[(6s,7as)-7a-[(4-cyanophenyl)methyl]-2-(3,5-dichlorophenyl)-1,3-dioxo-6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-6-yl]-2-hydroxyacetamide Chemical compound C([C@]12C(=O)N(C(=O)N1C[C@H](C2)NC(=O)CO)C=1C=C(Cl)C=C(Cl)C=1)C1=CC=C(C#N)C=C1 YXBGSZVPUXJENU-JTSKRJEESA-N 0.000 claims 1
- LKJVGMXETAHJKU-AVRDEDQJSA-N n-[(6s,7as)-7a-[(4-cyanophenyl)methyl]-2-(3,5-dichlorophenyl)-1,3-dioxo-6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-6-yl]acetamide Chemical compound C([C@]12C(=O)N(C(=O)N1C[C@H](C2)NC(=O)C)C=1C=C(Cl)C=C(Cl)C=1)C1=CC=C(C#N)C=C1 LKJVGMXETAHJKU-AVRDEDQJSA-N 0.000 claims 1
- GJYXGIIWJFZCLN-UHFFFAOYSA-N octane-2,4-dione Chemical compound CCCCC(=O)CC(C)=O GJYXGIIWJFZCLN-UHFFFAOYSA-N 0.000 claims 1
- 125000006505 p-cyanobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C#N)C([H])([H])* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35430902P | 2002-02-07 | 2002-02-07 | |
| PCT/US2003/003449 WO2003066636A1 (en) | 2002-02-07 | 2003-02-06 | Inhibitors of alpha l beta 2 integrin mediated cell adhesion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005517016A JP2005517016A (ja) | 2005-06-09 |
| JP2005517016A5 true JP2005517016A5 (enExample) | 2005-12-22 |
Family
ID=27734354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003566009A Ceased JP2005517016A (ja) | 2002-02-07 | 2003-02-06 | αＬβ２インテグリン介在細胞接着阻害剤 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7375128B2 (enExample) |
| EP (1) | EP1472257B1 (enExample) |
| JP (1) | JP2005517016A (enExample) |
| KR (1) | KR100625379B1 (enExample) |
| CN (1) | CN1301255C (enExample) |
| AR (1) | AR040068A1 (enExample) |
| AT (1) | ATE411995T1 (enExample) |
| AU (1) | AU2003210862B2 (enExample) |
| BR (1) | BR0307521A (enExample) |
| CA (1) | CA2474748A1 (enExample) |
| CO (1) | CO5601028A2 (enExample) |
| DE (1) | DE60324250D1 (enExample) |
| EC (1) | ECSP045222A (enExample) |
| MX (1) | MXPA04007643A (enExample) |
| MY (1) | MY137878A (enExample) |
| NO (1) | NO20043563L (enExample) |
| NZ (1) | NZ534208A (enExample) |
| PE (1) | PE20030899A1 (enExample) |
| PL (1) | PL372328A1 (enExample) |
| RU (1) | RU2315768C2 (enExample) |
| TW (1) | TW200303200A (enExample) |
| WO (1) | WO2003066636A1 (enExample) |
| ZA (1) | ZA200405647B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7405234B2 (en) | 2002-05-17 | 2008-07-29 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
| TW200407324A (en) * | 2002-05-17 | 2004-05-16 | Bristol Myers Squibb Co | Bicyclic modulators of androgen receptor function |
| US7632858B2 (en) | 2002-11-15 | 2009-12-15 | Bristol-Myers Squibb Company | Open chain prolyl urea-related modulators of androgen receptor function |
| US7199125B2 (en) | 2003-10-02 | 2007-04-03 | Bristol-Myers Squibb Company | Spiro-cyclic compounds useful as anti-inflammatory agents |
| US7820702B2 (en) | 2004-02-04 | 2010-10-26 | Bristol-Myers Squibb Company | Sulfonylpyrrolidine modulators of androgen receptor function and method |
| US7696241B2 (en) | 2004-03-04 | 2010-04-13 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
| US7625923B2 (en) | 2004-03-04 | 2009-12-01 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
| US20080262070A1 (en) * | 2005-10-06 | 2008-10-23 | Karl Baumann | Pharmaceutically Active Tetrahydro-Pyrrolizinone Compounds |
| CN101638429B (zh) * | 2009-08-28 | 2012-01-25 | 南方医科大学 | 一种特异性识别细胞表面整合素α3β1的小分子肽 |
| US8497288B2 (en) * | 2011-05-09 | 2013-07-30 | Hoffmann-La Roche Inc. | Hexahydropyrroloimidazolone compounds |
| EP3969066B1 (en) * | 2019-05-16 | 2025-08-20 | Dispensing Dynamics International, Inc. | Fragrance dispenser |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3643748A1 (de) | 1986-12-20 | 1988-06-30 | Hoechst Ag | Bicylische imide, verfahren zu ihrer herstellung sowie ihre verwendung im pflanzenschutz |
| DE19622489A1 (de) * | 1996-06-05 | 1997-12-11 | Hoechst Ag | Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters |
| SK117499A3 (en) | 1997-03-03 | 2000-05-16 | Boehringer Ingelheim Pharma | Small molecules useful in the treatment of inflammatory and immune cell-mediated diseases, small molecules and pharmaceutical composition with their content |
| AU6780398A (en) * | 1997-03-28 | 1998-10-22 | Du Pont Merck Pharmaceutical Company, The | Heterocyclic integrin inhibitor prodrugs |
| WO1998058947A1 (en) | 1997-06-25 | 1998-12-30 | Pfizer Inc. | Dipeptide derivatives as growth hormone secretagogues |
| WO2001030781A2 (en) | 1999-10-20 | 2001-05-03 | Tanabe Seiyaku Co., Ltd. | INHIBITORS OF αLβ2 MEDIATED CELL ADHESION |
| EP1283715A1 (en) * | 2000-05-23 | 2003-02-19 | Histatek, LLC | Modulaton of alpha-6 integrin-mediated responses |
-
2003
- 2003-01-21 TW TW092101214A patent/TW200303200A/zh unknown
- 2003-01-27 MY MYPI20030269A patent/MY137878A/en unknown
- 2003-02-06 AR ARP030100379A patent/AR040068A1/es unknown
- 2003-02-06 MX MXPA04007643A patent/MXPA04007643A/es active IP Right Grant
- 2003-02-06 CA CA002474748A patent/CA2474748A1/en not_active Abandoned
- 2003-02-06 JP JP2003566009A patent/JP2005517016A/ja not_active Ceased
- 2003-02-06 NZ NZ534208A patent/NZ534208A/en unknown
- 2003-02-06 KR KR1020047010969A patent/KR100625379B1/ko not_active Expired - Fee Related
- 2003-02-06 AU AU2003210862A patent/AU2003210862B2/en not_active Ceased
- 2003-02-06 EP EP03737649A patent/EP1472257B1/en not_active Expired - Lifetime
- 2003-02-06 US US10/503,602 patent/US7375128B2/en not_active Expired - Fee Related
- 2003-02-06 PE PE2003000137A patent/PE20030899A1/es not_active Application Discontinuation
- 2003-02-06 DE DE60324250T patent/DE60324250D1/de not_active Expired - Fee Related
- 2003-02-06 RU RU2004123219/04A patent/RU2315768C2/ru not_active IP Right Cessation
- 2003-02-06 AT AT03737649T patent/ATE411995T1/de not_active IP Right Cessation
- 2003-02-06 CN CNB038034727A patent/CN1301255C/zh not_active Expired - Fee Related
- 2003-02-06 PL PL03372328A patent/PL372328A1/xx not_active Application Discontinuation
- 2003-02-06 BR BR0307521-4A patent/BR0307521A/pt not_active IP Right Cessation
- 2003-02-06 WO PCT/US2003/003449 patent/WO2003066636A1/en not_active Ceased
-
2004
- 2004-07-15 ZA ZA200405647A patent/ZA200405647B/en unknown
- 2004-08-05 CO CO04076121A patent/CO5601028A2/es unknown
- 2004-08-06 EC EC2004005222A patent/ECSP045222A/es unknown
- 2004-08-26 NO NO20043563A patent/NO20043563L/no not_active Application Discontinuation