JP2005516994A5 - - Google Patents
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- Publication number
- JP2005516994A5 JP2005516994A5 JP2003565486A JP2003565486A JP2005516994A5 JP 2005516994 A5 JP2005516994 A5 JP 2005516994A5 JP 2003565486 A JP2003565486 A JP 2003565486A JP 2003565486 A JP2003565486 A JP 2003565486A JP 2005516994 A5 JP2005516994 A5 JP 2005516994A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- hydrogen
- alkyl
- azacycloheptan
- indol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- -1 C 1 -C 7 -alkyl Chemical group 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 claims 4
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000004361 3,4,5-trifluorophenyl group Chemical group [H]C1=C(F)C(F)=C(F)C([H])=C1* 0.000 claims 1
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 201000006549 dyspepsia Diseases 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000005059 halophenyl group Chemical group 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 210000001835 viscera Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 0 CC(*)[C@](C(*)=C(*)C(N)=O)N(*)C(C)=O Chemical compound CC(*)[C@](C(*)=C(*)C(N)=O)N(*)C(C)=O 0.000 description 1
- BHCJHYIMNHXLOM-WVDRJWPYSA-N CN([C@H](Cc(cc1)cc(Cl)c1Cl)/C=C/C(N[C@H](CCCCN1)C1=O)=O)C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)=O Chemical compound CN([C@H](Cc(cc1)cc(Cl)c1Cl)/C=C/C(N[C@H](CCCCN1)C1=O)=O)C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)=O BHCJHYIMNHXLOM-WVDRJWPYSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000001640 fractional crystallisation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0203061.7A GB0203061D0 (en) | 2002-02-08 | 2002-02-08 | Organic compounds |
| PCT/EP2003/001227 WO2003066062A1 (en) | 2002-02-08 | 2003-02-07 | Use of acylaminoalkenylene-amide derivatives in functional motility disorders of the viscera |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010164587A Division JP2010241835A (ja) | 2002-02-08 | 2010-07-22 | 内臓の機能的運動障害におけるアシルアミノアルケニレン−アミド誘導体の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005516994A JP2005516994A (ja) | 2005-06-09 |
| JP2005516994A5 true JP2005516994A5 (https=) | 2006-03-23 |
Family
ID=9930743
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003565486A Ceased JP2005516994A (ja) | 2002-02-08 | 2003-02-07 | 内臓の機能的運動障害におけるアシルアミノアルケニレン−アミド誘導体の使用 |
| JP2010164587A Pending JP2010241835A (ja) | 2002-02-08 | 2010-07-22 | 内臓の機能的運動障害におけるアシルアミノアルケニレン−アミド誘導体の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010164587A Pending JP2010241835A (ja) | 2002-02-08 | 2010-07-22 | 内臓の機能的運動障害におけるアシルアミノアルケニレン−アミド誘導体の使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20050203164A1 (https=) |
| EP (2) | EP1476167A1 (https=) |
| JP (2) | JP2005516994A (https=) |
| KR (2) | KR20100100994A (https=) |
| CN (1) | CN1301714C (https=) |
| AU (1) | AU2003244446B2 (https=) |
| BR (1) | BR0307479A (https=) |
| CA (1) | CA2471964A1 (https=) |
| GB (1) | GB0203061D0 (https=) |
| IL (2) | IL162816A0 (https=) |
| MX (1) | MXPA04007640A (https=) |
| NO (1) | NO20043735L (https=) |
| NZ (1) | NZ534231A (https=) |
| PL (1) | PL370255A1 (https=) |
| RU (1) | RU2353356C2 (https=) |
| TW (1) | TWI330177B (https=) |
| WO (1) | WO2003066062A1 (https=) |
| ZA (1) | ZA200404960B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0203061D0 (en) * | 2002-02-08 | 2002-03-27 | Novartis Ag | Organic compounds |
| EP1686985A2 (en) | 2003-10-27 | 2006-08-09 | Novartis AG | Use of neurokinin antagonists in the treatment of urinary incontinence |
| CN101568331A (zh) | 2006-09-08 | 2009-10-28 | 奥尔制药有限公司 | 减少或缓解消化道炎症的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5217996A (en) * | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
| US5457101A (en) * | 1994-06-03 | 1995-10-10 | Eli Lilly And Company | Thieno[1,5]benzoidiazepine use |
| MX9706394A (es) * | 1995-02-22 | 1997-11-29 | Novartis Ag | Compuestos de 1-aril-2-acilamino-etano y su uso como antagonistas de neuroquinina, especialmente neuroquinina-1. |
| CR5278A (es) * | 1995-03-24 | 1996-07-04 | Lilly Co Eli | Formulacion oral de 2-metil-tieno-benzodiacepina |
| GB9525296D0 (en) * | 1995-12-11 | 1996-02-07 | Merck Sharp & Dohme | Therapeutic agents |
| MY132550A (en) * | 1996-08-22 | 2007-10-31 | Novartis Ag | Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists |
| GB9708484D0 (en) * | 1997-04-25 | 1997-06-18 | Merck Sharp & Dohme | Therapeutic agents |
| PL191496B1 (pl) * | 1997-07-02 | 2006-05-31 | Merck & Co Inc | Odmiana polimorficzna 2-(R)-{1-(R) -[3,5-bis(trifluorometylo)-fenylo]etoksy} -3-(S)-(4-fluoro) fenylo-4-[3-(5-okso-1H,4H-1,2,4-triazolo)metylo] morfoliny, sposób jej wytwarzania, zawierająca ją kompozycja farmaceutyczna i jej zastosowanie |
| TW520370B (en) * | 1998-11-20 | 2003-02-11 | Meiji Seika Kaisha | Benzooxazole derivatives and a pharmaceutical composition containing the derivatives as an active ingredient |
| RU2161894C1 (ru) * | 1999-08-10 | 2001-01-20 | НИФ "Ультрасан" | Лечебно-профилактическая композиция |
| GB0010958D0 (en) | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
| US20040058914A1 (en) * | 2000-12-22 | 2004-03-25 | Takayuki Doi | Combination drugs |
| GB0203061D0 (en) * | 2002-02-08 | 2002-03-27 | Novartis Ag | Organic compounds |
-
2002
- 2002-02-08 GB GBGB0203061.7A patent/GB0203061D0/en not_active Ceased
-
2003
- 2003-02-07 AU AU2003244446A patent/AU2003244446B2/en not_active Ceased
- 2003-02-07 IL IL16281603A patent/IL162816A0/xx unknown
- 2003-02-07 BR BR0307479-0A patent/BR0307479A/pt not_active IP Right Cessation
- 2003-02-07 NZ NZ534231A patent/NZ534231A/en not_active IP Right Cessation
- 2003-02-07 US US10/501,496 patent/US20050203164A1/en not_active Abandoned
- 2003-02-07 TW TW092102519A patent/TWI330177B/zh not_active IP Right Cessation
- 2003-02-07 PL PL03370255A patent/PL370255A1/xx not_active Application Discontinuation
- 2003-02-07 KR KR1020107017008A patent/KR20100100994A/ko not_active Ceased
- 2003-02-07 RU RU2004127132/15A patent/RU2353356C2/ru not_active IP Right Cessation
- 2003-02-07 EP EP03737323A patent/EP1476167A1/en not_active Ceased
- 2003-02-07 CA CA002471964A patent/CA2471964A1/en not_active Abandoned
- 2003-02-07 EP EP10163570A patent/EP2216025A3/en not_active Withdrawn
- 2003-02-07 KR KR10-2004-7012191A patent/KR20040081492A/ko not_active Ceased
- 2003-02-07 JP JP2003565486A patent/JP2005516994A/ja not_active Ceased
- 2003-02-07 WO PCT/EP2003/001227 patent/WO2003066062A1/en not_active Ceased
- 2003-02-07 CN CNB038034859A patent/CN1301714C/zh not_active Expired - Fee Related
- 2003-02-07 MX MXPA04007640A patent/MXPA04007640A/es active IP Right Grant
-
2004
- 2004-06-23 ZA ZA200404960A patent/ZA200404960B/en unknown
- 2004-07-01 IL IL162816A patent/IL162816A/en not_active IP Right Cessation
- 2004-09-07 NO NO20043735A patent/NO20043735L/no not_active Application Discontinuation
-
2007
- 2007-08-23 US US11/895,226 patent/US20070293473A1/en not_active Abandoned
-
2010
- 2010-07-22 JP JP2010164587A patent/JP2010241835A/ja active Pending
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