CN1301714C - 酰氨基亚链烯基酰胺衍生物在功能性内脏能动性疾病中的应用 - Google Patents

酰氨基亚链烯基酰胺衍生物在功能性内脏能动性疾病中的应用 Download PDF

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Publication number
CN1301714C
CN1301714C CNB038034859A CN03803485A CN1301714C CN 1301714 C CN1301714 C CN 1301714C CN B038034859 A CNB038034859 A CN B038034859A CN 03803485 A CN03803485 A CN 03803485A CN 1301714 C CN1301714 C CN 1301714C
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CN
China
Prior art keywords
hydrogen
phenyl
methyl
alkyl
indol
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB038034859A
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English (en)
Chinese (zh)
Other versions
CN1627947A (zh
Inventor
J·R·福扎德
E·韦伯
H-J·普凡库赫
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Novartis AG
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Novartis AG
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Publication of CN1627947A publication Critical patent/CN1627947A/zh
Application granted granted Critical
Publication of CN1301714C publication Critical patent/CN1301714C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
CNB038034859A 2002-02-08 2003-02-07 酰氨基亚链烯基酰胺衍生物在功能性内脏能动性疾病中的应用 Expired - Fee Related CN1301714C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0203061.7A GB0203061D0 (en) 2002-02-08 2002-02-08 Organic compounds
GB0203061.7 2002-02-08

Publications (2)

Publication Number Publication Date
CN1627947A CN1627947A (zh) 2005-06-15
CN1301714C true CN1301714C (zh) 2007-02-28

Family

ID=9930743

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038034859A Expired - Fee Related CN1301714C (zh) 2002-02-08 2003-02-07 酰氨基亚链烯基酰胺衍生物在功能性内脏能动性疾病中的应用

Country Status (18)

Country Link
US (2) US20050203164A1 (https=)
EP (2) EP1476167A1 (https=)
JP (2) JP2005516994A (https=)
KR (2) KR20100100994A (https=)
CN (1) CN1301714C (https=)
AU (1) AU2003244446B2 (https=)
BR (1) BR0307479A (https=)
CA (1) CA2471964A1 (https=)
GB (1) GB0203061D0 (https=)
IL (2) IL162816A0 (https=)
MX (1) MXPA04007640A (https=)
NO (1) NO20043735L (https=)
NZ (1) NZ534231A (https=)
PL (1) PL370255A1 (https=)
RU (1) RU2353356C2 (https=)
TW (1) TWI330177B (https=)
WO (1) WO2003066062A1 (https=)
ZA (1) ZA200404960B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0203061D0 (en) * 2002-02-08 2002-03-27 Novartis Ag Organic compounds
EP1686985A2 (en) 2003-10-27 2006-08-09 Novartis AG Use of neurokinin antagonists in the treatment of urinary incontinence
CN101568331A (zh) 2006-09-08 2009-10-28 奥尔制药有限公司 减少或缓解消化道炎症的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1119101A (zh) * 1994-06-03 1996-03-27 伊莱利利公司 噻吩并[1，5]苯并二氨杂䓬的用途
CN1179102A (zh) * 1995-03-24 1998-04-15 伊莱利利公司 2－甲基－噻吩并－苯并二氮杂䓬口服制剂
US5929067A (en) * 1995-02-22 1999-07-27 Novartis Ag 1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists
US6319917B1 (en) * 1996-08-22 2001-11-20 Novartis Ag Acylaminoalkenylene-amide derivatives as NK1 and NK2 antagonists
CN1333771A (zh) * 1998-11-20 2002-01-30 明治制果株式会社 苯并噁唑衍生物及含有该衍生物作为有效成份的药物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217996A (en) * 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
GB9525296D0 (en) * 1995-12-11 1996-02-07 Merck Sharp & Dohme Therapeutic agents
GB9708484D0 (en) * 1997-04-25 1997-06-18 Merck Sharp & Dohme Therapeutic agents
PL191496B1 (pl) * 1997-07-02 2006-05-31 Merck & Co Inc Odmiana polimorficzna 2-(R)-{1-(R) -[3,5-bis(trifluorometylo)-fenylo]etoksy} -3-(S)-(4-fluoro) fenylo-4-[3-(5-okso-1H,4H-1,2,4-triazolo)metylo] morfoliny, sposób jej wytwarzania, zawierająca ją kompozycja farmaceutyczna i jej zastosowanie
RU2161894C1 (ru) * 1999-08-10 2001-01-20 НИФ "Ультрасан" Лечебно-профилактическая композиция
GB0010958D0 (en) 2000-05-05 2000-06-28 Novartis Ag Organic compounds
US20040058914A1 (en) * 2000-12-22 2004-03-25 Takayuki Doi Combination drugs
GB0203061D0 (en) * 2002-02-08 2002-03-27 Novartis Ag Organic compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1119101A (zh) * 1994-06-03 1996-03-27 伊莱利利公司 噻吩并[1，5]苯并二氨杂䓬的用途
US5929067A (en) * 1995-02-22 1999-07-27 Novartis Ag 1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists
CN1179102A (zh) * 1995-03-24 1998-04-15 伊莱利利公司 2－甲基－噻吩并－苯并二氮杂䓬口服制剂
US6319917B1 (en) * 1996-08-22 2001-11-20 Novartis Ag Acylaminoalkenylene-amide derivatives as NK1 and NK2 antagonists
CN1333771A (zh) * 1998-11-20 2002-01-30 明治制果株式会社 苯并噁唑衍生物及含有该衍生物作为有效成份的药物

Also Published As

Publication number Publication date
KR20040081492A (ko) 2004-09-21
US20070293473A1 (en) 2007-12-20
GB0203061D0 (en) 2002-03-27
EP2216025A3 (en) 2010-11-10
JP2005516994A (ja) 2005-06-09
EP2216025A2 (en) 2010-08-11
KR20100100994A (ko) 2010-09-15
ZA200404960B (en) 2006-05-31
TWI330177B (en) 2010-09-11
NO20043735L (no) 2004-09-07
PL370255A1 (en) 2005-05-16
EP1476167A1 (en) 2004-11-17
MXPA04007640A (es) 2004-11-10
JP2010241835A (ja) 2010-10-28
IL162816A (en) 2010-11-30
RU2004127132A (ru) 2005-06-10
US20050203164A1 (en) 2005-09-15
RU2353356C2 (ru) 2009-04-27
WO2003066062A1 (en) 2003-08-14
AU2003244446A1 (en) 2003-09-02
TW200302818A (en) 2003-08-16
AU2003244446B2 (en) 2006-08-10
CA2471964A1 (en) 2003-08-14
HK1077749A1 (en) 2006-02-24
BR0307479A (pt) 2004-12-07
IL162816A0 (en) 2005-11-20
NZ534231A (en) 2007-02-23
CN1627947A (zh) 2005-06-15

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