JP2005516606A5 - - Google Patents
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- Publication number
- JP2005516606A5 JP2005516606A5 JP2003565411A JP2003565411A JP2005516606A5 JP 2005516606 A5 JP2005516606 A5 JP 2005516606A5 JP 2003565411 A JP2003565411 A JP 2003565411A JP 2003565411 A JP2003565411 A JP 2003565411A JP 2005516606 A5 JP2005516606 A5 JP 2005516606A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- tslp
- composition
- antagonist
- agonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101000845170 Homo sapiens Thymic stromal lymphopoietin Proteins 0.000 claims 10
- 102100031294 Thymic stromal lymphopoietin Human genes 0.000 claims 10
- 239000000556 agonist Substances 0.000 claims 6
- 239000005557 antagonist Substances 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 206010062016 Immunosuppression Diseases 0.000 claims 4
- 230000001506 immunosuppresive effect Effects 0.000 claims 4
- 230000009285 allergic inflammation Effects 0.000 claims 3
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 2
- 206010016946 Food allergy Diseases 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 2
- 208000037357 HIV infectious disease Diseases 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 235000020932 food allergy Nutrition 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010039083 rhinitis Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35350902P | 2002-02-01 | 2002-02-01 | |
| PCT/US2003/002758 WO2003065985A2 (en) | 2002-02-01 | 2003-01-30 | Uses of mammalian cytokine; related reagents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009060287A Division JP5519946B2 (ja) | 2002-02-01 | 2009-03-12 | 哺乳動物のサイトカイン；関連する試薬の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005516606A JP2005516606A (ja) | 2005-06-09 |
| JP2005516606A5 true JP2005516606A5 (https=) | 2006-03-02 |
Family
ID=27734298
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003565411A Pending JP2005516606A (ja) | 2002-02-01 | 2003-01-30 | 哺乳動物のサイトカイン；関連する試薬の使用 |
| JP2009060287A Expired - Lifetime JP5519946B2 (ja) | 2002-02-01 | 2009-03-12 | 哺乳動物のサイトカイン；関連する試薬の使用 |
| JP2012138672A Pending JP2012184259A (ja) | 2002-02-01 | 2012-06-20 | 哺乳動物のサイトカイン；関連する試薬の使用 |
| JP2014103683A Pending JP2014156478A (ja) | 2002-02-01 | 2014-05-19 | 哺乳動物のサイトカイン；関連する試薬の使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009060287A Expired - Lifetime JP5519946B2 (ja) | 2002-02-01 | 2009-03-12 | 哺乳動物のサイトカイン；関連する試薬の使用 |
| JP2012138672A Pending JP2012184259A (ja) | 2002-02-01 | 2012-06-20 | 哺乳動物のサイトカイン；関連する試薬の使用 |
| JP2014103683A Pending JP2014156478A (ja) | 2002-02-01 | 2014-05-19 | 哺乳動物のサイトカイン；関連する試薬の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US20030186875A1 (https=) |
| EP (3) | EP2077277A1 (https=) |
| JP (4) | JP2005516606A (https=) |
| AU (1) | AU2003208888B2 (https=) |
| CA (1) | CA2474011C (https=) |
| DK (1) | DK2311869T3 (https=) |
| ES (1) | ES2399503T5 (https=) |
| MX (1) | MXPA04007426A (https=) |
| NZ (1) | NZ533987A (https=) |
| PT (1) | PT2311869E (https=) |
| WO (1) | WO2003065985A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861227B2 (en) * | 1998-03-19 | 2005-03-01 | Human Genome Sciences, Inc. | Antibodies to cytokine receptor common gamma chain like |
| DE69936105T3 (de) * | 1998-11-13 | 2017-07-27 | Immunex Corporation | Menschliche tslp nukleinsäuren und polypeptide |
| US6890734B2 (en) * | 2000-11-10 | 2005-05-10 | Schering Corporation | Nucleic acids encoding a cytokine receptor complex |
| PL371773A1 (en) | 2001-07-23 | 2005-06-27 | Immunex Corporation | Modified human thymic stromal lymphopoietin |
| AU2003208888B2 (en) * | 2002-02-01 | 2006-10-19 | Merck Sharp & Dohme Llc | Uses of mammalian cytokine; related reagents |
| SI1651247T1 (sl) | 2003-07-18 | 2009-02-28 | Schering Corp | Zdravljenje in diagnoza neoplazem z uporabo timusnega stromalnega limfopoietina |
| TR201901268T4 (tr) * | 2004-03-22 | 2019-02-21 | Mesoblast Int Sarl | Mezenkimal kök hücreleri ve bunların kullanımları. |
| US20050249712A1 (en) * | 2004-03-23 | 2005-11-10 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Methods for use of TSLP and agonists and antagonists thereof |
| US20060171943A1 (en) * | 2005-02-01 | 2006-08-03 | Amgen Inc. | Compositions and methods of treating fibrotic disorders |
| US8871715B2 (en) | 2005-10-14 | 2014-10-28 | Alltech, Inc. | Use of selenium compounds, especially selenium yeasts for altering cognitive function |
| GB0603683D0 (en) * | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
| JP5059119B2 (ja) * | 2006-12-14 | 2012-10-24 | シェーリング コーポレイション | 操作された抗ｔｓｌｐ抗体 |
| CN102027012A (zh) | 2007-06-20 | 2011-04-20 | Irm责任有限公司 | 用于治疗变应性疾病的方法和组合物 |
| US7982016B2 (en) | 2007-09-10 | 2011-07-19 | Amgen Inc. | Antigen binding proteins capable of binding thymic stromal lymphopoietin |
| BRPI0907501B1 (pt) | 2008-02-01 | 2021-02-23 | Ceres, Inc | construto de vetor, método para dirigir a transcrição, método de expressão de uma região de codificação exógena, método de alteração da expressão de um gene e método de produção de uma planta transgênica |
| US12331304B2 (en) | 2008-02-01 | 2025-06-17 | Ceres, Inc. | Promoter, promoter control elements, and combinations, and uses thereof |
| EP2213682A1 (en) * | 2009-01-30 | 2010-08-04 | Institut Curie | TSLP promotes immune evasion and persistence of viruses |
| ES2784123T3 (es) * | 2009-11-04 | 2020-09-22 | Merck Sharp & Dohme | Anticuerpo anti TSLP genomodificado |
| WO2012001889A1 (ja) * | 2010-06-28 | 2012-01-05 | 国立大学法人東北大学 | Tslpを恒常的に高発現する細胞、及び前記細胞を利用したtslp調節剤のスクリーニング方法 |
| WO2012007495A1 (en) | 2010-07-15 | 2012-01-19 | F. Hoffmann-La Roche Ag | Antibodies specifically binding to human tslpr and methods of use |
| JP2012032655A (ja) * | 2010-07-30 | 2012-02-16 | Fujimori Sangyo Kk | ホログラム付きラミネートフィルム及びその製造方法、これを用いた容器 |
| JP2015502917A (ja) * | 2011-10-28 | 2015-01-29 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｔｓｌｐ処置のバイオマーカーとしてのｉｌ−１９ |
| US9732151B2 (en) | 2011-11-03 | 2017-08-15 | Merck Sharp & Dohme Corp. | Biomarkers for TSLP treatment |
| HRP20210650T1 (hr) | 2015-09-09 | 2021-05-28 | Novartis Ag | Protutijela koja vežu timusni stromalni limfopoetin (tslp) i postupci uporabe protutijela |
| EA038332B1 (ru) | 2015-09-09 | 2021-08-10 | Новартис Аг | Молекулы, связывающиеся с тимусным стромальным лимфопоэтином (tslp), и способы применения таких молекул |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4732863A (en) | 1984-12-31 | 1988-03-22 | University Of New Mexico | PEG-modified antibody with reduced affinity for cell surface Fc receptors |
| US6861227B2 (en) * | 1998-03-19 | 2005-03-01 | Human Genome Sciences, Inc. | Antibodies to cytokine receptor common gamma chain like |
| US6982320B2 (en) * | 1998-03-19 | 2006-01-03 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
| US6844170B1 (en) * | 1998-03-19 | 2005-01-18 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
| JP2002526079A (ja) * | 1998-09-21 | 2002-08-20 | シェーリング コーポレイション | ヒトインターロイキン−ｂ５０、治療的使用 |
| US20030099947A1 (en) * | 1998-09-21 | 2003-05-29 | Bazan J. Fernando | Mammalian cytokines; related reagents and methods |
| DE69936105T3 (de) * | 1998-11-13 | 2017-07-27 | Immunex Corporation | Menschliche tslp nukleinsäuren und polypeptide |
| WO2001095710A1 (en) * | 2000-06-16 | 2001-12-20 | Nakanishi, Kenji | Caspase 1 gene transfer animal |
| JP5184732B2 (ja) * | 2000-06-19 | 2013-04-17 | ベス イスラエル デアコネス メディカル センター | Ｔ細胞亜集団に特異的なモノクローナル抗体およびポリクローナル抗体の組成物および使用方法 |
| US6955895B2 (en) * | 2000-06-28 | 2005-10-18 | Whitehead Institute For Biomedical Research | Thymic stromal lymphopoietin receptor molecules and uses thereof |
| US6890734B2 (en) * | 2000-11-10 | 2005-05-10 | Schering Corporation | Nucleic acids encoding a cytokine receptor complex |
| AU2003208888B2 (en) * | 2002-02-01 | 2006-10-19 | Merck Sharp & Dohme Llc | Uses of mammalian cytokine; related reagents |
-
2003
- 2003-01-30 AU AU2003208888A patent/AU2003208888B2/en not_active Expired
- 2003-01-30 EP EP09005325A patent/EP2077277A1/en not_active Withdrawn
- 2003-01-30 PT PT100118108T patent/PT2311869E/pt unknown
- 2003-01-30 EP EP10011810.8A patent/EP2311869B2/en not_active Expired - Lifetime
- 2003-01-30 MX MXPA04007426A patent/MXPA04007426A/es active IP Right Grant
- 2003-01-30 US US10/354,951 patent/US20030186875A1/en not_active Abandoned
- 2003-01-30 JP JP2003565411A patent/JP2005516606A/ja active Pending
- 2003-01-30 ES ES10011810T patent/ES2399503T5/es not_active Expired - Lifetime
- 2003-01-30 NZ NZ533987A patent/NZ533987A/en not_active IP Right Cessation
- 2003-01-30 WO PCT/US2003/002758 patent/WO2003065985A2/en not_active Ceased
- 2003-01-30 CA CA2474011A patent/CA2474011C/en not_active Expired - Lifetime
- 2003-01-30 EP EP03707610A patent/EP1487865A4/en not_active Withdrawn
- 2003-01-30 DK DK10011810.8T patent/DK2311869T3/da active
-
2006
- 2006-09-22 US US11/525,644 patent/US20070020262A1/en not_active Abandoned
-
2007
- 2007-09-24 US US11/859,989 patent/US20090017018A1/en not_active Abandoned
-
2009
- 2009-03-12 JP JP2009060287A patent/JP5519946B2/ja not_active Expired - Lifetime
- 2009-11-10 US US12/615,728 patent/US20100136003A1/en not_active Abandoned
-
2011
- 2011-03-21 US US13/052,404 patent/US20110229434A1/en not_active Abandoned
-
2012
- 2012-06-20 JP JP2012138672A patent/JP2012184259A/ja active Pending
-
2014
- 2014-05-19 JP JP2014103683A patent/JP2014156478A/ja active Pending
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