JP2005516606A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005516606A5 JP2005516606A5 JP2003565411A JP2003565411A JP2005516606A5 JP 2005516606 A5 JP2005516606 A5 JP 2005516606A5 JP 2003565411 A JP2003565411 A JP 2003565411A JP 2003565411 A JP2003565411 A JP 2003565411A JP 2005516606 A5 JP2005516606 A5 JP 2005516606A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- tslp
- composition
- antagonist
- agonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100005288 TSLP Human genes 0.000 claims 10
- 101700027709 TSLP Proteins 0.000 claims 10
- 239000000556 agonist Substances 0.000 claims 6
- 230000003042 antagnostic Effects 0.000 claims 6
- 239000005557 antagonist Substances 0.000 claims 6
- 201000008937 atopic dermatitis Diseases 0.000 claims 6
- 206010062016 Immunosuppression Diseases 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 4
- 230000000172 allergic Effects 0.000 claims 4
- 230000001506 immunosuppresive Effects 0.000 claims 4
- 230000004054 inflammatory process Effects 0.000 claims 4
- 208000006673 Asthma Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 230000035693 Fab Effects 0.000 claims 2
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 2
- 206010016946 Food allergy Diseases 0.000 claims 2
- 208000005721 HIV Infections Diseases 0.000 claims 2
- 206010039083 Rhinitis Diseases 0.000 claims 2
- 108090001123 antibodies Proteins 0.000 claims 2
- 102000004965 antibodies Human genes 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 235000020932 food allergy Nutrition 0.000 claims 2
- 201000001820 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108010045030 monoclonal antibodies Proteins 0.000 claims 2
- 102000005614 monoclonal antibodies Human genes 0.000 claims 2
- 108091008117 polyclonal antibodies Proteins 0.000 claims 2
Claims (10)
- アレルギー性炎症を処置するための医薬の製造のためのTSLP/IL−50(配列番号1)のアンタゴニストもしくはTSLP/IL−50R(配列番号2、3)のアンタゴニストの使用であって、該アレルギー性炎症が、喘息;鼻炎;アトピー性皮膚炎;および食物アレルギーからなる群より選択される、使用。
- 請求項1に記載の使用であって、前記アンタゴニストは、以下:
a)ヒト化抗体;
b)モノクローナル抗体;
c)ポリクローナル抗体;
d)Fabフラグメント;
e)F(ab’) 2 フラグメント、
を含む、使用。 - 免疫抑制を処置するための医薬の製造のためのTSLP/IL−50(配列番号1)のアゴニストもしくはTSLP/IL−50R(配列番号2、3)のアゴニストの使用。
- 請求項3に記載の使用であって、前記免疫抑制が、HIV感染によって引き起こされる、使用。
- 請求項3または請求項4に記載の使用であって、前記アゴニストが、TSLP/IL−50(配列番号1)を含む、使用。
- アレルギー性炎症を処置するための、TSLP/IL−50(配列番号1)のアンタゴニストもしくはTSLP/IL−50R(配列番号2、3)のアンタゴニストを含む組成物であって、該アレルギー性炎症が、喘息;鼻炎;アトピー性皮膚炎;および食物アレルギーからなる群より選択される、組成物。
- 請求項6に記載の組成物であって、前記アンタゴニストは、以下:
a)ヒト化抗体;
b)モノクローナル抗体;
c)ポリクローナル抗体;
d)Fabフラグメント;
e)F(ab’) 2 フラグメント、
を含む、組成物。 - 免疫抑制を処置するための、TSLP/IL−50(配列番号1)のアゴニストもしくはTSLP/IL−50R(配列番号2、3)のアゴニストを含む、組成物。
- 請求項8に記載の組成物であって、前記免疫抑制が、HIV感染によって引き起こされる、組成物。
- 請求項8または請求項9に記載の組成物であって、前記アゴニストが、TSLP/IL−50(配列番号1)を含む、組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35350902P | 2002-02-01 | 2002-02-01 | |
PCT/US2003/002758 WO2003065985A2 (en) | 2002-02-01 | 2003-01-30 | Uses of mammalian cytokine; related reagents |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009060287A Division JP5519946B2 (ja) | 2002-02-01 | 2009-03-12 | 哺乳動物のサイトカイン;関連する試薬の使用 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005516606A JP2005516606A (ja) | 2005-06-09 |
JP2005516606A5 true JP2005516606A5 (ja) | 2006-03-02 |
Family
ID=27734298
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003565411A Pending JP2005516606A (ja) | 2002-02-01 | 2003-01-30 | 哺乳動物のサイトカイン;関連する試薬の使用 |
JP2009060287A Expired - Lifetime JP5519946B2 (ja) | 2002-02-01 | 2009-03-12 | 哺乳動物のサイトカイン;関連する試薬の使用 |
JP2012138672A Pending JP2012184259A (ja) | 2002-02-01 | 2012-06-20 | 哺乳動物のサイトカイン;関連する試薬の使用 |
JP2014103683A Pending JP2014156478A (ja) | 2002-02-01 | 2014-05-19 | 哺乳動物のサイトカイン;関連する試薬の使用 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009060287A Expired - Lifetime JP5519946B2 (ja) | 2002-02-01 | 2009-03-12 | 哺乳動物のサイトカイン;関連する試薬の使用 |
JP2012138672A Pending JP2012184259A (ja) | 2002-02-01 | 2012-06-20 | 哺乳動物のサイトカイン;関連する試薬の使用 |
JP2014103683A Pending JP2014156478A (ja) | 2002-02-01 | 2014-05-19 | 哺乳動物のサイトカイン;関連する試薬の使用 |
Country Status (11)
Country | Link |
---|---|
US (5) | US20030186875A1 (ja) |
EP (3) | EP2311869B2 (ja) |
JP (4) | JP2005516606A (ja) |
AU (1) | AU2003208888B2 (ja) |
CA (1) | CA2474011C (ja) |
DK (1) | DK2311869T3 (ja) |
ES (1) | ES2399503T5 (ja) |
MX (1) | MXPA04007426A (ja) |
NZ (1) | NZ533987A (ja) |
PT (1) | PT2311869E (ja) |
WO (1) | WO2003065985A2 (ja) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6861227B2 (en) * | 1998-03-19 | 2005-03-01 | Human Genome Sciences, Inc. | Antibodies to cytokine receptor common gamma chain like |
DK1129190T4 (en) * | 1998-11-13 | 2017-04-03 | Immunex Corp | Human TSLP DNA and polypeptides |
US6890734B2 (en) * | 2000-11-10 | 2005-05-10 | Schering Corporation | Nucleic acids encoding a cytokine receptor complex |
DK1417231T3 (da) * | 2001-07-23 | 2013-07-22 | Immunex Corp | Modificeret human thymisk stromal lymphopoietin |
EP2311869B2 (en) * | 2002-02-01 | 2020-06-17 | Merck Sharp & Dohme Corp. | Use of mammalian cytokine-related reagents |
CA2532595A1 (en) * | 2003-07-18 | 2005-01-27 | Schering Corporation | Treatment and diagnosis of neoplasms using thymic stromal lymphopoietin |
ES2643076T3 (es) * | 2004-03-22 | 2017-11-21 | Mesoblast International Sàrl | Células madre mesenquimales y sus usos |
US20050249712A1 (en) * | 2004-03-23 | 2005-11-10 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Methods for use of TSLP and agonists and antagonists thereof |
US20060171943A1 (en) * | 2005-02-01 | 2006-08-03 | Amgen Inc. | Compositions and methods of treating fibrotic disorders |
US8871715B2 (en) | 2005-10-14 | 2014-10-28 | Alltech, Inc. | Use of selenium compounds, especially selenium yeasts for altering cognitive function |
GB0603683D0 (en) * | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
EP2129690A1 (en) * | 2006-12-14 | 2009-12-09 | Schering Corporation | Engineered anti-tslp antibody |
EA201000006A1 (ru) * | 2007-06-20 | 2010-10-29 | Айрм Ллк | Способы и композиции для лечения аллергических заболеваний |
US7982016B2 (en) | 2007-09-10 | 2011-07-19 | Amgen Inc. | Antigen binding proteins capable of binding thymic stromal lymphopoietin |
US20120124701A1 (en) | 2008-02-01 | 2012-05-17 | Ceres, Inc. | Promoter, promoter control elements, and combinations, and use thereof |
EP2213682A1 (en) * | 2009-01-30 | 2010-08-04 | Institut Curie | TSLP promotes immune evasion and persistence of viruses |
CA2779384C (en) | 2009-11-04 | 2018-02-27 | Schering Corporation | Engineered anti-tslp antibody |
WO2012001889A1 (ja) * | 2010-06-28 | 2012-01-05 | 国立大学法人東北大学 | Tslpを恒常的に高発現する細胞、及び前記細胞を利用したtslp調節剤のスクリーニング方法 |
WO2012007495A1 (en) | 2010-07-15 | 2012-01-19 | F. Hoffmann-La Roche Ag | Antibodies specifically binding to human tslpr and methods of use |
JP2012032655A (ja) * | 2010-07-30 | 2012-02-16 | Fujimori Sangyo Kk | ホログラム付きラミネートフィルム及びその製造方法、これを用いた容器 |
JP2015502917A (ja) * | 2011-10-28 | 2015-01-29 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Tslp処置のバイオマーカーとしてのil−19 |
EP2773774A4 (en) | 2011-11-03 | 2015-06-10 | Merck Sharp & Dohme | BIOMARKERS FOR THE TREATMENT OF TSLP |
AU2016320748B2 (en) | 2015-09-09 | 2019-05-02 | Novartis Ag | Thymic stromal lymphopoietin (TSLP)-binding antibodies and methods of using the antibodies |
CA2996635A1 (en) | 2015-09-09 | 2017-03-16 | Novartis Ag | Thymic stromal lymphopoietin (tslp)-binding molecules and methods of using the molecules |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4732863A (en) | 1984-12-31 | 1988-03-22 | University Of New Mexico | PEG-modified antibody with reduced affinity for cell surface Fc receptors |
US6844170B1 (en) * | 1998-03-19 | 2005-01-18 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
US6861227B2 (en) * | 1998-03-19 | 2005-03-01 | Human Genome Sciences, Inc. | Antibodies to cytokine receptor common gamma chain like |
US6982320B2 (en) * | 1998-03-19 | 2006-01-03 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
CA2343979C (en) * | 1998-09-21 | 2011-11-15 | Schering Corporation | Human interleukin-b50, therapeutic uses |
US20030099947A1 (en) * | 1998-09-21 | 2003-05-29 | Bazan J. Fernando | Mammalian cytokines; related reagents and methods |
DK1129190T4 (en) * | 1998-11-13 | 2017-04-03 | Immunex Corp | Human TSLP DNA and polypeptides |
ATE336888T1 (de) * | 2000-06-16 | 2006-09-15 | Nakanishi Kenji | Caspase 1 transgenes tier |
DK1297017T3 (da) * | 2000-06-19 | 2012-09-17 | Dana Farber Cancer Inst Inc | Sammensætninger og fremgangsmåder med monoklonale og polyklonale antistoffer, der er specifikke for T-cellesubpopulationer |
AU2001271624A1 (en) * | 2000-06-28 | 2002-01-08 | Whitehead Institute For Biomedical Research | Thymic stromal lymphopoietin receptor molecules and uses thereof |
US6890734B2 (en) * | 2000-11-10 | 2005-05-10 | Schering Corporation | Nucleic acids encoding a cytokine receptor complex |
EP2311869B2 (en) * | 2002-02-01 | 2020-06-17 | Merck Sharp & Dohme Corp. | Use of mammalian cytokine-related reagents |
-
2003
- 2003-01-30 EP EP10011810.8A patent/EP2311869B2/en not_active Expired - Lifetime
- 2003-01-30 WO PCT/US2003/002758 patent/WO2003065985A2/en active Search and Examination
- 2003-01-30 ES ES10011810T patent/ES2399503T5/es not_active Expired - Lifetime
- 2003-01-30 AU AU2003208888A patent/AU2003208888B2/en not_active Expired
- 2003-01-30 US US10/354,951 patent/US20030186875A1/en not_active Abandoned
- 2003-01-30 PT PT100118108T patent/PT2311869E/pt unknown
- 2003-01-30 CA CA2474011A patent/CA2474011C/en not_active Expired - Lifetime
- 2003-01-30 DK DK10011810.8T patent/DK2311869T3/da active
- 2003-01-30 EP EP09005325A patent/EP2077277A1/en not_active Withdrawn
- 2003-01-30 NZ NZ533987A patent/NZ533987A/en not_active IP Right Cessation
- 2003-01-30 EP EP03707610A patent/EP1487865A4/en not_active Withdrawn
- 2003-01-30 MX MXPA04007426A patent/MXPA04007426A/es active IP Right Grant
- 2003-01-30 JP JP2003565411A patent/JP2005516606A/ja active Pending
-
2006
- 2006-09-22 US US11/525,644 patent/US20070020262A1/en not_active Abandoned
-
2007
- 2007-09-24 US US11/859,989 patent/US20090017018A1/en not_active Abandoned
-
2009
- 2009-03-12 JP JP2009060287A patent/JP5519946B2/ja not_active Expired - Lifetime
- 2009-11-10 US US12/615,728 patent/US20100136003A1/en not_active Abandoned
-
2011
- 2011-03-21 US US13/052,404 patent/US20110229434A1/en not_active Abandoned
-
2012
- 2012-06-20 JP JP2012138672A patent/JP2012184259A/ja active Pending
-
2014
- 2014-05-19 JP JP2014103683A patent/JP2014156478A/ja active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2005516606A5 (ja) | ||
JP2022031635A5 (ja) | ||
JP2007535490A5 (ja) | ||
JP2005512507A5 (ja) | ||
NZ597023A (en) | Monoclonal antibodies that bind to hGM-CSF and medical compositions comprising same | |
JP2009511480A5 (ja) | ||
JP2016135783A5 (ja) | ||
RU2017137872A (ru) | Композиции для ингибирования masp-2-зависимой активации комплемента | |
JP2015028021A5 (ja) | ||
JP2007527865A5 (ja) | ||
RU2010120879A (ru) | Антитела против g-белка распираторно-синцитиального вируса (rsv) | |
DK1711528T3 (da) | Behandling af cancer med hidtil ukendte anti-il 13 monoklonale antistoffer | |
JP2004536568A5 (ja) | ||
JP2004527212A5 (ja) | ||
JP2005529587A5 (ja) | ||
JP2021101720A5 (ja) | ||
JP2011184466A5 (ja) | ||
NZ712762A (en) | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to il-22 and il-22r | |
JP2015523962A5 (ja) | ||
JP2020022482A5 (ja) | ||
JP2009225799A5 (ja) | ||
JP2010526028A5 (ja) | ||
JP2003528052A5 (ja) | ||
JP2011173884A5 (ja) | ||
JP2009518005A5 (ja) |